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1. 发明专利

DE69927201T2 未知
公开(公告)号：DE69927201T2
公开(公告)日：2006-06-29
申请号：DE69927201
申请日：1999-04-13
申请人： LUCENT TECHNOLOGIES INC , MAX PLANCK GESELLSCHAFT , UNIV YALE NEW HAVEN
发明人： CAPASSO FEDERICO , YI CHO ALFRED , FAIST JEROME , GMACHL CLAIRE F , NARIMANOV EVGUENI E , NOECKEL JENS U , SIVCO DEBORAH LEE , STONE ALFRED DOUGLAS
IPC分类号： H01S3/06 , H01S5/00 , H01S3/08 , H01S3/083 , H01S5/065 , H01S5/10 , H01S5/30 , H01S5/323 , H01S5/343
摘要： A solid state laser comprises a cavity resonator in the form of a generally cylindrical body and, located within the resonator, an active region which generates lasing light when suitably pumped. The resonator has a relatively high effective refractive index (n > 2 and typically n > 3) is sufficiently deformed from circularity so as to support at least one librational mode (e.g., a V-shaped or a bow-tie mode, the latter being presently preferred for generating relatively high power, directional outputs). Specifically described is a Group III-V compound semiconductor, quantum cascade (QC), micro-cylinder laser in which the resonator has a flattened quadrupolar deformation from circularity. This laser exhibits both a highly directional output emission and a three-order of magnitude increase in optical output power compared to conventional semiconductor micro-cylinder QC lasers having circularly symmetric resonators.

2. 发明专利

DE60026321D1 未知
公开(公告)号：DE60026321D1
公开(公告)日：2006-04-27
申请号：DE60026321
申请日：2000-08-11
申请人： UNIV YALE NEW HAVEN
发明人： KAUFMAN C , ROTH E , LIZARDI M , FENG LI , LATIMER DARIN R
IPC分类号： C12Q1/68 , G01N33/53 , A61K38/00 , C07K14/705 , C12N15/09 , G01N33/566
摘要： Disclosed is a method for the comprehensive analysis of nucleic acid samples and a detector composition for use in the method. The method, referred to as Binary Encoded Sequence Tags (BEST), involves generation of a set of nucleic acid fragments; adding an adaptor to the ends containing recognition site for cleavage at a site offset from the recognition site; cleaving the fragment to generate fragments having a plurality sticky ends; indexing of the fragments into sets based on the sequence of sticky ends. The fragments are indexed by adding a offset adaptor to newly generated ends. A different adaptor will be coupled to each different sticky end. The resulting fragments-which will have defined ends, be of equal lengths (in preferred embodiment), and a central sequence derived from the source nucleic acid molecule-are binary sequence tags. The binary sequence tags can be used and further analyzed in numerous ways. For example, the binary sequence tags can be captured by hybridization and coupling, preferably by ligation, to a probe. The probe is preferably immobilized in an array or on sortable beads. One form of the BEST method, referred to as modification assisted analysis of binary sequence tags (MAABST), assesses modification of sequences in nucleic acid molecules by detecting differential cleavage based on the presence or absence of modification in the molecules.

3. 发明专利

DE69924472D1 未知
公开(公告)号：DE69924472D1
公开(公告)日：2005-05-04
申请号：DE69924472
申请日：1999-01-20
申请人： UNIV YALE NEW HAVEN
发明人： HUSZAR B
IPC分类号： A01K67/02 , A61D19/00 , C12N5/00 , C12N5/071 , G01N33/48 , A01N1/02 , C07F9/48 , C07D317/22 , A61D19/02
摘要： A process and system for selecting mature sperm for assisted reproduction techniques such as intracytoplasmic sperm injection comprises applying a binding substrate specific to mature sperm to a surface; applying a sperm suspension to the surface; and contacting the sperm suspension and the mature sperm binding substrate on the surface. The process then comprises permitting mature sperm from the sperm suspension to bind to the mature sperm binding substrate at a periphery thereof; and removing bound sperm from the periphery of the mature sperm binding substrate. Preferably, the mature sperm binding substrate is a fluid and comprises hyaluronic acid or a salt thereof, a polysaccharide, a glycosaminoglycan, a zona pellucida component, zona protein of the egg membrane or a structural or functional homolog or analog of the sperm-binding elements of the female reproductive tract or the zona pellucida, a proteoglycan, or an antibody to a protein receptor for mature sperm.

4. 发明专利

DE69533921D1 未知
公开(公告)号：DE69533921D1
公开(公告)日：2005-02-17
申请号：DE69533921
申请日：1995-03-22
申请人： ALEXION PHARMA INC , UNIV YALE NEW HAVEN
发明人： ROLLINS A , SMITH R , SQUINTO P
IPC分类号： A61M1/36 , C07K16/18 , A61K39/00 , A61K39/395 , C07K16/00
摘要： The use of anti-C5 antibodies to reduce the dysfunction of the immune and hemostatic systems associated with extracorporeal circulation procedures, such as, cardiopulmonary bypass procedures, is disclosed. The antibodies have been found to significantly reduce complement activation, platelet activation, leukocyte activation, and platelet-leukocyte adhesion associated with such procedures.

5. 发明专利

DE69133393D1 未知
公开(公告)号：DE69133393D1
公开(公告)日：2004-07-15
申请号：DE69133393
申请日：1991-09-06
申请人： UNIV CALIFORNIA , UNIV YALE NEW HAVEN
发明人： BAEKKESKOV STEINUNN , AANSTOOT HENK-JAN , DECAMILLI PIETRO , FOLLI FRANCO , SOLIMENA MICHELE
IPC分类号： G01N33/53 , A61K35/14 , A61K35/17 , A61K38/00 , A61K39/385 , C07K14/725 , C12N9/88 , G01N33/543 , G01N33/564 , G01N33/573 , G01N33/58 , G01N33/60 , G01N33/68
摘要： Assays for the detection of diabetes and prediabetic status rely on exposing patient serum samples to purified ligand capable of binding autoantibodies specific for a 64kD autoantigen present on pancreatic &bgr;-cells. The purified ligand is usually purified glutamic acid decarboxylase (GAD) or a fragment or analog thereof. Preferably, the assays will detect the presence of antibodies to both lower molecular weight GAD and higher molecular weight GAD since diabetic and prediabetic status may be associated with only one of these two forms. The assays can be performed using conventional protocols, such as radioimmunoassay, enzyme-linked immunosorbent assay, and enzyme assay. Methods for treating diabetes comprise administering pharmaceutical compositions including the purified ligand, particularly when coupled to an immunoglobulin or lymphoid cell to induce tolerance. Alternatively, tolerance may be induced by administering attenuated T-helper cells, or isolated T-cell receptors, where the T-helper cells have been isolated based on their reactivity with GAD or equivalent ligand.

6. 发明专利

DE69815661D1 未知
公开(公告)号：DE69815661D1
公开(公告)日：2003-07-24
申请号：DE69815661
申请日：1998-01-30
申请人： UNIV YALE NEW HAVEN
发明人： HAFF THOMAS , RADDING M , REDDY GURUCHARAN , WARD DAVID
IPC分类号： C07K14/47 , C07K16/18 , G01N33/15 , G01N33/50 , G01N33/574

7. 发明专利

DE69815380D1 未知
公开(公告)号：DE69815380D1
公开(公告)日：2003-07-10
申请号：DE69815380
申请日：1998-10-21
申请人： UNIV YALE NEW HAVEN
发明人： SARTORELLI C , SHYAM KRISHNAMRUTHY , PENKETH G , CHEN SHU-HUI
IPC分类号： A61K31/661 , A61K31/27 , A61P35/00 , A61P35/02 , C07C311/53 , C07C311/61 , C07F9/09 , C07F9/12 , A61K31/325 , C07C271/44 , C07C271/48 , C07K14/58 , A23L1/30 , C07K16/18
摘要： The present invention relates to a compound of the formula wherein R1 and R2 are selected from lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms; R3 is a substituted or unsubstituted lower alkyl group having 1-6 carbons; and R4 is selected from substituted or unsubstituted lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms. The present invention also relates to a pharmaceutical composition comprising the above compound, as well as a method of treating tumor cells with the compound.

8. 发明专利

DE69623969D1 ANTITUMORALE 2-AMINOCARBONYL-1,2-BIS (METHYLSULFONYL)-1-(SUBSTITUIERTE) HYDRAZINE 未知
公开(公告)号：DE69623969D1
公开(公告)日：2002-10-31
申请号：DE69623969
申请日：1996-07-02
申请人： UNIV YALE NEW HAVEN
发明人： SARTORELLI C , SHYAM KRISHNAMURTHY , PENKETH G
IPC分类号： A61K31/18 , A61K31/22 , A61P35/00 , C07C311/55 , C07C317/50
摘要： The present invention relates to novel 2-aminocarbonyl-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines and 2-aminocarbonyl-1,2-bis(methylsulfonyl)-1-methylhydrazines, and their use to treat malignant tumors. The agents are especially useful in the treatment of animal and human cancers. Two preferred agents in this class, especially for use in the treatment of tumors are 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-(2-chloroethyl)aminocarbonylhydrazine and 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-methylaminocarbonylhydrazine. These agents are characterized by the following: they are incapable of undergoing inactivation by the denitrosation mechanism proposed for the inactivation of the CNUs; they are incapable of generating a hydroxyethylating species by the mechanism proposed for the CNUs; and they are capable of chloroethylation or methylation and carbamoylation.

9. 发明专利

DE69612013T2 未知
公开(公告)号：DE69612013T2
公开(公告)日：2001-08-02
申请号：DE69612013
申请日：1996-11-21
申请人： UNIV YALE NEW HAVEN
发明人： LIZARDI PAUL M , CAPLAN MICHAEL
IPC分类号： C12N15/09 , C12Q1/68

10. 发明专利

DE69330285D1 未知
公开(公告)号：DE69330285D1
公开(公告)日：2001-07-05
申请号：DE69330285
申请日：1993-03-10
申请人： UNIV YALE NEW HAVEN
发明人： PAWELEK MASON , BOLOGNIA LYNN
IPC分类号： A61K8/34 , A61K8/44 , A61K8/64 , A61K8/67 , A61K31/195 , A61Q17/04 , A61Q19/02 , A61K7/48

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