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1. 发明申请

WO2009112934A9 NOVEL SPINEL STRUCTURE MATERIALS 审中-公开
标题翻译：新型螺旋结构材料
公开(公告)号：WO2009112934A9
公开(公告)日：2010-08-05
申请号：PCT/IB2009000497
申请日：2009-03-12
申请人： UNIV WITWATERSRAND JOHANNESBUR , LOWTHER JOHN EDWARD , OKEKE ONYEKWELU
发明人： LOWTHER JOHN EDWARD , OKEKE ONYEKWELU
IPC分类号： C01B21/082 , C09K3/14 , G02F1/00
CPC分类号： G02F1/0018 , C01B21/0821 , C01B21/0825 , C01P2002/32 , C01P2002/77 , C01P2006/90 , C09K3/1409

2. 发明申请

WO2010061284A3 A CONTROLLED RELEASE INTRAVAGINAL POLYMERIC PHARMACEUTICAL DOSAGE FORM 审中-公开
标题翻译：控制释放阴道内聚合物药物剂型
公开(公告)号：WO2010061284A3
公开(公告)日：2010-10-28
申请号：PCT/IB2009007583
申请日：2009-11-30
申请人： UNIV WITWATERSRAND JOHANNESBUR , NDESENDO VALENCE M K , PILLAY VINESS , CHOONARA YAHYA ESSOP
发明人： NDESENDO VALENCE M K , PILLAY VINESS , CHOONARA YAHYA ESSOP
IPC分类号： A61K9/00 , A61K9/20 , A61K9/50
CPC分类号： A61K9/0034 , A61K31/00
摘要： This invention relates to a controlled release, intravaginal, pharmaceutical dosage form. The dosage form consists of at least one desired pharmaceutically active ingredient which is admixed with a combination of biocompatible and biodegradable polymers and shaped for insertion into the vagina of a patient. The polymers are selected so as to biodegrade at a predetermined rate and, on biodegrading, the pharmaceutically active ingredient is released.
摘要翻译：本发明涉及控释阴道内药物剂型。该剂型由至少一种所需的药物活性成分组成，其与生物相容性和生物可降解性聚合物的组合混合并且被成形为插入患者的阴道中。选择聚合物以便以预定的速率生物降解，并且在生物降解时释放药物活性成分。

3. 发明申请

WO2009034439A3 BIOREACTOR FOR MESOPHILIC AND/OR THERMOPHILIC FERMENTATION 审中-公开
标题翻译：生物反应器用于中性和/或热亲水性发酵
公开(公告)号：WO2009034439A3
公开(公告)日：2009-12-03
申请号：PCT/IB2008002331
申请日：2008-09-09
申请人： UNIV WITWATERSRAND JOHANNESBUR , GRAY VINCENT MYLES
发明人： GRAY VINCENT MYLES
IPC分类号： C12M1/107
CPC分类号： C12M21/04 , C12M23/34 , C12M25/20 , C12M29/24
摘要： This invention relates to a bioreactor for producing high rates of hydrogen from plant biomass. It also relates to the rapid screening, selection and isolation of biofilm forming mesophilic and/or thermophilic bacteria or bacteria consortia that generate high levels of hydrogen from plant biomass or from soluble hydrolysates derived from the hydolysis of cellulosic materials including hemicellulose. The reactor comprises a primary reactor vessel having a bed of hydrogen producing bacteria towards its base located within a secondary reactor vessel which functions as a hydrogen gas collector and as a clarifier and separator. The plant biomass may be one or a mixture of insoluble cellulosic material and a hydrolysate derived from hydrolysis of cellulosic material. In one embodiment the bed of the primary reactor vessel is fluidised by recycling hydrogen gas saturated plant biomass effluent from the secondary reactor vessel to the primary reactor vessel.
摘要翻译：本发明涉及用于从植物生物质产生高速氢气的生物反应器。它还涉及生物膜形成的嗜温和/或嗜热细菌或细菌聚生体的快速筛选，选择和分离，其从植物生物质或源自纤维素材料（包括半纤维素）的水解产生的可溶性水解产物产生高水平的氢。该反应器包括一个主反应器容器，该反应器容器具有朝向其基部的产氢细菌床，该反应器位于次级反应器容器内，该反应器容器用作氢气收集器和澄清器和分离器。植物生物质可以是不溶性纤维素材料和来源于纤维素材料水解的水解产物中的一种或混合物。在一个实施方案中，通过将来自次级反应器容器的氢气饱和植物生物质流出物再循环至主反应器容器来使主反应器容器的床流化。

4. 发明申请

WO2008068584A2 A HETEROGENEOUSLY CONFIGURED MULTIPARTICULATE GASTROINTESTINAL DRUG DELIVERY SYSTEM 审中-公开
标题翻译：异构配体多功能胃肠给药系统
公开(公告)号：WO2008068584A2
公开(公告)日：2008-06-12
申请号：PCT/IB2007003727
申请日：2007-12-03
申请人： UNIV WITWATERSRAND JOHANNESBUR , DU TOIT LISA CLAIRE , DANCKWERTS MICHAEL PAUL , PILLAY VINESS , COOPPAN SHIVAAN , CHOONARA YAHYA ESSOP
发明人： DU TOIT LISA CLAIRE , DANCKWERTS MICHAEL PAUL , PILLAY VINESS , COOPPAN SHIVAAN , CHOONARA YAHYA ESSOP
IPC分类号： A61K9/16 , A61K9/50 , A61K31/495
CPC分类号： A61K31/495 , A61K9/5084
摘要： This invention relates to a heterogeneously configured multiparticulate drug delivery system for gastrointestinal delivery of at least one or a combination of active pharmaceutical compositions. The system comprises a multiplicity of enterosoluble or gastrosoluble multiparticulates loaded with the active pharmaceutical composition or compositions for the site-specific delivery of said active pharmaceutical composition or compositions to a specific region in the gastrointestinal tract of a human or animal body. The system can be supplied as reconstitutable granules which are reconstituted immediately before oral administration.
摘要翻译：本发明涉及用于胃肠递送活性药物组合物的至少一种或组合的非均匀配置的多颗粒药物递送系统。该系统包含负载有活性药物组合物或组合物的多种肠溶性或胃溶性多颗粒，用于将所述活性药物组合物或组合物的位点特异性递送至人或动物体的胃肠道中的特定区域。该系统可以作为在口服给药之前立即重建的可重构颗粒提供。

5. 发明申请

WO2010061288A3 POLYMERIC PHARMACEUTICAL DOSAGE FORM IN SUSTAINED RELEASE 审中-公开
标题翻译：聚合物药物剂型在持续释放
公开(公告)号：WO2010061288A3
公开(公告)日：2010-10-28
申请号：PCT/IB2009007598
申请日：2009-11-30
申请人： UNIV WITWATERSRAND JOHANNESBUR , PILLAY VINESS , CHOONARA YAHYA ESSOP , SIBEKO BONGANI , HARILALL SHERI-LEE , PILLAY SAMANTHA , MODI GIRISH , IYUKE SUNNY ESAYEGBEMU , NAIDOO DINESH
发明人： PILLAY VINESS , CHOONARA YAHYA ESSOP , SIBEKO BONGANI , HARILALL SHERI-LEE , PILLAY SAMANTHA , MODI GIRISH , IYUKE SUNNY ESAYEGBEMU , NAIDOO DINESH
IPC分类号： A61K9/00 , A61K9/19 , A61K9/51 , A61K9/70
CPC分类号： A61K9/5153 , A61K9/0085 , A61K9/19 , A61K9/5138 , A61K9/70
摘要： This invention relates to a polymeric pharmaceutical dosage form for the delivery, in use, of at least one pharmaceutical composition in a rate-modulated and site-specific manner. The dosage form comprises a biodegradable, polymeric, scaffold incorporating loaded with at least one active pharmaceutical ingredient (API). The polymer or polymers making up the scaffold degrade in a human or animal body in response to or in the absence of specific biological stimuli and, on degradation, release the API or APIs in an area where said stimuli are encountered. Preferably the polymeric scaffold is formed from poly (D1L- lactide) (PLA) and polymethacrylate (Eudragit S100/ES100) polymers.
摘要翻译：本发明涉及用于在使用中以速率调节和位点特异性方式递送至少一种药物组合物的聚合物药物剂型。所述剂型包含一种可生物降解的聚合物，其包含加载有至少一种活性药物成分（API）的支架。构成支架的聚合物或聚合物在人或动物体内响应于或不存在特定生物刺激而降解，并且在降解时，在遇到所述刺激的区域中释放API或API。优选地，聚合物支架由聚（D1L-丙交酯）（PLA）和聚甲基丙烯酸酯（Eudragit S100 / ES100）聚合物形成。

6. 发明申请

WO2009153634A1 A TRANSMUCOSAL DELIVERY SYSTEM 审中-公开
标题翻译：转运系统
公开(公告)号：WO2009153634A1
公开(公告)日：2009-12-23
申请号：PCT/IB2009005831
申请日：2009-06-03
申请人： UNIV WITWATERSRAND JOHANNESBUR , REDDY DESHIKA , PILLAY VINESS , CHOONARA YAHYA
发明人： REDDY DESHIKA , PILLAY VINESS , CHOONARA YAHYA
IPC分类号： A61K9/19 , A61K31/135
CPC分类号： A61K9/006 , A61K9/19 , A61K31/135
摘要： This invention relates to a multi-configured, transmucosal pharmaceutical dosage form and, more particularly, to a pharmaceutical dosage form which has a single monolithic/heterogeneous layer or a plurality of such layers. The dosage form is suitable for the delivery of one or more pharmaceutical compositions via the buccal, sublingual, rectal, vaginal or transmucosal delivery route in a human or animal body. It provides for selected delivery profiles resulting from, but not limited to, a porosity-enabled composite matrix of one or more layers/components of the pharmaceutical composition/s. The invention also provides for a method of manufacturing said transmucosal pharmaceutical dosage form in a plurality of configurations.
摘要翻译：本发明涉及多构型的透粘膜药物剂型，更具体地说，涉及具有单个整体/异质层或多个这样的层的药物剂型。剂型适合于通过人或动物体内的颊，舌下，直肠，阴道或经粘膜递送途径递送一种或多种药物组合物。它提供了由但不限于药物组合物的一个或多个层/组分的孔隙率复合基质产生的选定的递送曲线。本发明还提供一种以多种构型制造所述经粘膜药物剂型的方法。

7. 发明专利

ZA200402492B Mobile facility. 未知
公开(公告)号：ZA200402492B
公开(公告)日：2005-10-11
申请号：ZA200402492
申请日：2004-03-30
申请人： UNIV WITWATERSRAND JOHANNESBUR
发明人： RUDOLPH MICHAEL JOHN
IPC分类号： B60P20060101 , B60P

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