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1. 发明授权

US2265868A Protection of apparatus from lightning disturbances 失效
标题翻译：保护设备免受雷电干扰
公开(公告)号：US2265868A
公开(公告)日：1941-12-09
申请号：US20960238
申请日：1938-05-23
申请人： UNIV WITWATERSRAND JHB
发明人： JAMIESON SCHONLAND BASIL FERDI
IPC分类号： H03F1/54
CPC分类号： H03F1/54

2. 发明申请

WO2008142543A9 CODED APERTURE MASKS FOR RADIATION-BASED MEDICAL IMAGING 审中-公开
标题翻译：用于基于辐射的医学成像的编码孔径掩模
公开(公告)号：WO2008142543A9
公开(公告)日：2009-02-05
申请号：PCT/IB2008001278
申请日：2008-05-22
申请人： UNIV WITWATERSRAND JHB , MARWALA TSHILIDZI , RUBIN DAVID MILTON , STARFIELD DAVID MARK
发明人： MARWALA TSHILIDZI , RUBIN DAVID MILTON , STARFIELD DAVID MARK
IPC分类号： A61B6/00 , G01T1/00
CPC分类号： G01T1/295 , A61B6/4258 , A61B6/583
摘要： This invention relates to a coded aperture mask for use in diagnostic nuclear medicine imaging. The coded aperture mask consists of a sheet of radiation opaque mask material having a series of apertures extending therethrough. The thickness of mask material has an attenuation percentage of less than 75% and, in a preferred embodiment, about equal to 29%. The coded aperture mask also, in a preferred embodiment, has a lead attenuation tube and has a projection of the smallest hole occupying the same area as a single pixel of a detector. The invention extends to a diagnostic nuclear medicine imaging system which uses a 16 bit gamma camera as a radiation detector.
摘要翻译：本发明涉及用于诊断核医学成像的编码孔径掩模。编码孔径掩模由具有延伸穿过其中的一系列孔的辐射不透明掩模材料片组成。掩模材料的厚度具有小于75％的衰减百分比，并且在优选实施例中，大约等于29％。在优选实施例中，编码孔径掩模还具有引线衰减管，并且具有与检测器的单个像素占据相同面积的最小孔的突起。本发明扩展到使用16位伽马照相机作为辐射检测器的诊断性核医学成像系统。

3. 发明申请

WO2006067572A3 A METHOD FOR DIAGNOSING AND MONITORING CELLULAR RESERVOIRS OF DISEASE 审中-公开
标题翻译：一种诊断和监测疾病细胞储存的方法
公开(公告)号：WO2006067572A3
公开(公告)日：2006-08-10
申请号：PCT/IB2005003738
申请日：2005-12-12
申请人： UNIV WITWATERSRAND JHB , SCOTT LESLEY ERICA
发明人： SCOTT LESLEY ERICA
IPC分类号： G01N33/50 , G01N1/30 , G06F19/00
CPC分类号： G01N33/5091 , G01N33/5094 , G01N33/56988 , G01N33/582 , G01N2333/70514 , G01N2333/70596 , Y02A90/24
摘要： The invention provides an assay for diagnosing and/or monitoring a viral infection or disease in a patient, the assay including the steps of mixing a sample of leucocytes with a fluorescent cell membrane-permeable dye which stains RNA or both DNA and RNA within the leucocytes; identifying from all the leucocytes at least two of the three major sub-populations of leucoytes selected from the group consisting of monocytes, granulocytes and lymphocytes; determining the fluorescence intensity for each of the identified sub-populations; and comparing the fluorescence intensity of at least two cell sub-populations to each other to obtain at least one of the following ratios: monocytes : granulocytes, monocytes : lymphocytes, and granulocytes lymphocytes. The viral infection may be HIV and the disease may be AIDS. The invention also provides a method of monitoring the cellular viral,parasitic or bacterial reservoir of a patient with a viral or bacterial infection by the steps described above. A, kit for performing the assay or method is also provided.
摘要翻译：本发明提供了用于诊断和/或监测患者的病毒感染或疾病的测定法，所述测定包括将白细胞样品与荧光细胞膜可渗透染料混合的步骤，所述染色剂在白细胞内染色RNA或DNA和RNA两者 ; 从所有白细胞中鉴定选自单核细胞，粒细胞和淋巴细胞的白细胞的三个主要亚群中的至少两个; 确定每个所识别的亚种群的荧光强度; 并将至少两个细胞亚群的荧光强度相互比较以获得以下比例中的至少一种：单核细胞：粒细胞，单核细胞：淋巴细胞和粒细胞淋巴细胞。病毒感染可能是艾滋病毒，该疾病可能是艾滋病。本发明还提供了通过上述步骤监测具有病毒或细菌感染的患者的细胞病毒，寄生或细菌储库的方法。还提供了用于进行测定或方法的试剂盒。

4. 发明申请

WO2016059547A3 METHOD OF MANUFACTURING AN OBJECT WITH MICROCHANNELS PROVIDED THERETHROUGH 审中-公开
标题翻译：用微通道制造物体的方法提供了这种方法
公开(公告)号：WO2016059547A3
公开(公告)日：2016-06-09
申请号：PCT/IB2015057821
申请日：2015-10-13
申请人： UNIV WITWATERSRAND JHB
发明人： HAMWEENDO AGRIPA , BOTEF IONEL
IPC分类号： B81C1/00
CPC分类号： H01L23/46 , B81C1/00071 , C23C24/04 , C23F1/00 , F28F3/12 , F28F2260/02 , H01L21/4878 , H01L23/467 , H01L23/473
摘要： This invention relates to a method of manufacturing an object with microchannels provides therethrough, and more particularly, but not exclusively, to a method of manufacturing a micro heat exchanger with microchannels provided therethrough. The method includes the steps of providing a metal base layer made from a first metal; forming a plurality of spaced apart ridges, made from a second metal, on the base layer; depositing more of the first metal onto the ridges in order to cover the ridges; and removing the ridges using a chemical etching process so as to produce microchannels in a body made of the first metal.
摘要翻译：本发明涉及一种制造具有微通道的物体的方法，更具体但非排他性地涉及一种制造具有穿过其中的微通道的微型热交换器的方法。该方法包括以下步骤：提供由第一金属制成的金属基底层; 在基层上形成由第二金属制成的多个间隔开的脊; 将更多的第一金属沉积到脊上以覆盖脊; 以及使用化学蚀刻工艺去除脊部以在由第一金属制成的主体中产生微通道。

5. 发明申请

WO2011027335A1 YEAST CELL IMMOBILIZATION 审中-公开
标题翻译：酵母细胞固定化
公开(公告)号：WO2011027335A1
公开(公告)日：2011-03-10
申请号：PCT/IB2010054025
申请日：2010-09-07
申请人： UNIV WITWATERSRAND JHB , MAMVURA TIRIVAVIRI AUGUSTINE , IYUKE SUNNY ESAYEGBEMU , SIBANDA VUSUMUZI , YAH YAH CLARENCE
发明人： MAMVURA TIRIVAVIRI AUGUSTINE , IYUKE SUNNY ESAYEGBEMU , SIBANDA VUSUMUZI , YAH YAH CLARENCE
IPC分类号： C12N1/02 , C12C11/09 , C12N11/08
CPC分类号： C12N1/02 , B82Y5/00 , C12C12/04 , C12N11/08
摘要： The invention describes a method for the immobilization of yeast cells in a fermentation reaction wherein carbon nanostructures are added to the reaction solution facilitating flocculation and the consequent immobilization of the yeast cells.
摘要翻译：本发明描述了一种用于在发酵反应中固定酵母细胞的方法，其中将碳纳米结构加入反应溶液中促进絮凝和随后固定酵母细胞。

6. 发明申请

WO2007034287A3 ORAMUCOSAL PHARMACEUTICAL DOSAGE FORM 审中-公开
标题翻译： ORAMUCOSAL PHARMACEUTICAL剂型
公开(公告)号：WO2007034287A3
公开(公告)日：2009-04-16
申请号：PCT/IB2006002585
申请日：2006-09-19
申请人： UNIV WITWATERSRAND JHB , PATEL RUPAL , PILLAY VINESS , DANCKWERTS MICHAEL PAUL
发明人： PATEL RUPAL , PILLAY VINESS , DANCKWERTS MICHAEL PAUL
IPC分类号： A61K9/20
CPC分类号： A61K9/0056 , A61K9/0002 , A61K9/006 , A61K9/2054 , A61K9/2095 , A61K47/38
摘要： This invention relates to an oramucosal pharmaceutical dosage form in the form of a wafer. The wafer comprises a porous, hydroscopic, muco-adhesive polymeric matrix with at least one desired pharmaceutically active compound added thereto. The polymer is selected from a number of polymers having different dissolution rates and, in use when taken orally, the matrix adheres to an oramucosal surface to dissolve over a predetermined period of time to release the pharmaceutically active compound. The invention also extends to a method of manufacturing an oramucosal pharmaceutical dosage form in the form of a wafer which involves freeze drying or lyophilisation.
摘要翻译：本发明涉及以晶片形式的粘膜下药物剂型。该晶片包括多孔，吸湿性粘膜粘合的聚合物基质，其中加入至少一种所需的药物活性化合物。聚合物选自许多具有不同溶解速率的聚合物，并且在使用时口服时，基质粘附到粘膜表面以在预定的时间内溶解以释放药学活性化合物。本发明还延伸到一种以晶片形式制造粘膜下药物剂型的方法，其包括冷冻干燥或冻干。

7. 发明公开

EP2646006A4 A PHARMACEUTICAL DOSAGE FORM 有权
标题翻译： ARZNEIMITTELDARREICHUNGSFORM
公开(公告)号：EP2646006A4
公开(公告)日：2014-06-25
申请号：EP11842556
申请日：2011-11-28
申请人： UNIV WITWATERSRAND JHB
发明人： SHAIKH RUBINA PERVEEN , PILLAY VINESS , CHOONARA YAHYA ESSOP , DU TOIT LISA CLAIRE
IPC分类号： A61K9/70 , A61K9/00 , A61K9/24
CPC分类号： A61K9/00 , A61K9/006 , A61K9/0065
摘要： A pH responsive and mucoadhesive pharmaceutical dosage form for the release of a pharmaceutically active agent is described. The dosage form includes a mucoadhesive layer for site-specific mucoadhesion, a water-insoluble outer layer, and an intermediate layer including one or more pharmaceutically active agents for site-specific delivery. The different membranous layers perform different functions in order to create a drug delivery system which is able to deliver a drug to a specific site, for a particular period of time and with a specific drug release pattern. The dosage form can have two or more intermediate layers, each layer comprising an active agent. The mucoadhesive layer can also include an active agents. The dosage form is preferably an oral or buccal delivery form for release of the active agent into the gastro intestinal tract. The intermediate layer can be an electrospun fibrous membrane layer containing the active agent.

8. 发明公开

EP2643020A4 A DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：EP2643020A4
公开(公告)日：2014-11-12
申请号：EP11843763
申请日：2011-11-28
申请人： UNIV WITWATERSRAND JHB
发明人： DU TOIT LISA CLAIRE , PILLAY VINESS , CHOONARA YAHYA ESSOP , GOVENDER THIRUMALA , CARMICHAEL TREVOR ROBIN
IPC分类号： A61K47/30 , A61K31/00 , A61K31/405 , A61K31/496 , A61K47/36 , A61P29/00 , A61P31/00
CPC分类号： A61K9/0051 , A61K9/0024 , A61K31/405 , A61K31/496 , A61K45/06 , A61K47/32 , A61K47/36

9. 发明公开

EP2643057A4 AN IMPLANT FOR THE CONTROLLED RELEASE OF PHARMACEUTICALLY ACTIVE AGENTS 审中-公开
标题翻译：植入物药物的控释
公开(公告)号：EP2643057A4
公开(公告)日：2014-05-21
申请号：EP11843032
申请日：2011-11-28
申请人： UNIV WITWATERSRAND JHB
发明人： WADEE AMEENA , PILLAY VINESS , CHOONARA YAHYA ESSOP , DU TOIT LISA CLAIRE
IPC分类号： A61P35/00 , A61K9/10 , A61K9/50 , A61K47/32 , A61P25/04 , A61P29/00
CPC分类号： A61K9/0024 , A61K9/5026 , A61K31/519 , A61K45/06 , A61K47/32

10. 发明公开

EP2642985A4 POLYMERIC MATRIX OF POLYMER-LIPID NANOPARTICLES AS A PHARMACEUTICAL DOSAGE FORM 审中-公开
标题翻译：聚合物基体聚合物，脂质纳米粒AS药物剂型
公开(公告)号：EP2642985A4
公开(公告)日：2014-05-07
申请号：EP11842468
申请日：2011-11-28
申请人： UNIV WITWATERSRAND JHB
发明人： NGWULUKA NDIDI , PILLAY VINESS , CHOONARA YAHYA ESSOP , DU TOIT LISA CLAIRE
IPC分类号： A61K9/51 , A61K47/32 , A61K47/36 , A61K47/38 , A61P25/16
CPC分类号： A61K47/32 , A61K9/2077 , A61K9/513 , A61K31/198

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