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1. 发明专利

JPH11253179A NEW GLUCOSAMINIDASE 失效
公开(公告)号：JPH11253179A
公开(公告)日：1999-09-21
申请号：JP32433398
申请日：1998-10-09
申请人： SMITHKLINE BEECHAM CORP , SMITHKLINE BEECHAM PLC , UNIV SHEFFIELD
发明人： FOSTER SIMON J , BURNHAM MARTIN K R
IPC分类号： G01N33/50 , A61K31/00 , A61K35/76 , A61K38/43 , A61K39/00 , A61K39/085 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P9/00 , A61P11/00 , A61P13/00 , A61P17/00 , A61P19/00 , A61P19/02 , A61P25/00 , A61P27/00 , A61P27/02 , A61P31/00 , A61P31/04 , C07K14/31 , C07K16/12 , C07K16/40 , C12N1/21 , C12N9/24 , C12N9/78 , C12N15/09 , C12N15/55 , C12Q1/34 , G01N33/15 , G01N33/68 , G11B5/48 , G11B21/16
摘要： PROBLEM TO BE SOLVED: To obtain a new polypeptide having high identity of a nucleic acid encoding a glucosaminidase polypeptide containing a specific amino acid sequence, useful for searching an antibacterial compound, treating and diagnosing an infection with a bacterium of the genus Streptococcus, etc. SOLUTION: This new isolated polynucleotide comprises a polypeptide having at least 70% identity of a polynucleotide encoding a polypeptide containing an amino acid sequence of the formula, a polynucleotide having at least 70% identity of a polynucleotide encoding the same mature polypeptide as that expressed by a glucosaminidase gene contained in Streptococcus aureus of deposited strain, etc., and is useful for screening an antibacterial compound, treating and diagnosing an infection with Streptococcus aureus, etc. The polynucleotide is obtained by probing the chromosome DNA library of Streptococcus aureus with a partial sequence-derived labeled oligonucleotide.

2. 发明专利

JPS5917329A Formation of tomography image 失效
标题翻译：形成图像图像
公开(公告)号：JPS5917329A
公开(公告)日：1984-01-28
申请号：JP7417883
申请日：1983-04-28
申请人： Brian Hilton Brown , David Charles Barber , Ian Leslie Freeston , Univ Sheffield
发明人： BROWN BRIAN HILTON , BARBER DAVID CHARLES , FREESTON IAN LESLIE
IPC分类号： A61B5/05 , A61B5/053
CPC分类号： A61B5/0536

3. 发明专利

GB2516725B Neck Orthosis 未知
公开(公告)号：GB2516725B
公开(公告)日：2015-10-28
申请号：GB201408252
申请日：2014-05-09
申请人： UNIV SHEFFIELD , UNIV SHEFFIELD HALLAM , SHEFFIELD TEACHING HOSPITALS
发明人： REED ALEXANDER HEATHCLIFF , LANGLEY JOSEPH , STANTON ANDREW , HERON NICOLA , MCDERMOTT CHRISTOPHER
IPC分类号： A61F5/055 , A61F5/058

4. 发明专利

GB2516725A Neck Orthosis 未知
公开(公告)号：GB2516725A
公开(公告)日：2015-02-04
申请号：GB201408252
申请日：2014-05-09
申请人： UNIV SHEFFIELD , UNIV SHEFFIELD HALLAM , SHEFFIELD TEACHING HOSPITALS
发明人： REED ALEXANDER HEATHCLIFF , LANGLEY JOSEPH , STANTON ANDREW , HERON NICOLA , MCDERMOTT CHRISTOPHER
IPC分类号： A61F5/055 , A61F5/058
摘要： A neck orthosis used in a head support system 980 and a method for supporting a head of a patient having a medical condition comprises a body 100 made of a material which is flexible and stretchy, having a releasable fastener, which may be hook and loop, and shaped to cause the neck orthosis snuggly to conform to the anatomy of the patient. The head support system includes a plurality of differently shaped and stiffness support struts 822, 834, 832 & 824 which are releasably attached in a variety of positions to the neck orthosis, for example by a hook and loop system, to provide different types of support to the head of the patient. An aperture or alternative material may be incorporated in the body to relieve pressure on the larynx.

5. 发明专利

GB201308366D0 Neck Orthosis 未知
公开(公告)号：GB201308366D0
公开(公告)日：2013-06-19
申请号：GB201308366
申请日：2013-05-09
申请人： UNIV SHEFFIELD , UNIV SHEFFIELD HALLAM , SHEFFIELD TEACHING HOSPITALS

6. 发明专利

GB201408252D0 Neck Orthosis 未知
公开(公告)号：GB201408252D0
公开(公告)日：2014-06-25
申请号：GB201408252
申请日：2014-05-09
申请人： UNIV SHEFFIELD , SHEFFIELD TEACHING HOSPITALS , UNIV SHEFFIELD HALLAM

7. 发明申请

WO2009144487A3 IMPROVEMENTS TO MASS SPECTROMETRY 审中-公开
标题翻译：改进质谱分析
公开(公告)号：WO2009144487A3
公开(公告)日：2010-02-11
申请号：PCT/GB2009050532
申请日：2009-05-18
申请人： UNIV SHEFFIELD HALLAM , CLENCH MALCOLM , ATKINSON SALLY , OAKES KEITH
发明人： CLENCH MALCOLM , ATKINSON SALLY , OAKES KEITH
IPC分类号： H01J49/16
CPC分类号： H01J49/164
摘要： Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) apparatus and method comprising a laser (100) and a multimode optical fiber (101) to deliver a laser beam to a MADLI ion source (104). A vibration coupling (109) is provided at a region along the length of optical fiber (101) to impart an oscillatory vibrational motion at the optical fibre (101) to move the irradiation intensity maxima at the sample (104) to increase the effective irradiation surface area. The present apparatus and method provide increased imaging sensitivity and a corresponding reduction in data acquisition times.
摘要翻译：包括激光器（100）和多模光纤（101）的矩阵辅助激光解吸/电离质谱成像（MALDI-MSI）装置和方法，以将激光束传送到MADLI离子源（104）。在沿着光纤（101）的长度的区域处设置振动耦合（109），以在光纤（101）处施加振荡振动，以移动样品（104）处的最大辐射强度，以增加有效辐射表面积。本装置和方法提供增加的成像灵敏度和数据采集时间的相应减少。

8. 发明申请

WO2009153596A2 ALLOYS 审中-公开
标题翻译：合金
公开(公告)号：WO2009153596A2
公开(公告)日：2009-12-23
申请号：PCT/GB2009050692
申请日：2009-06-17
申请人： UNIV SHEFFIELD , TSAKIROPOULOS PANOS
发明人： TSAKIROPOULOS PANOS
IPC分类号： C22C27/02
CPC分类号： C22C27/02
摘要： A first multi phase niobium silicide alloy composition consists essentially of: from 15 to 24 at% of Si; from 0 to 25 at% of one or more sp outer electron configuration element which is not Si; from 1 to 26 at% of one or more sd outer electron configuration element which is not Nb; and a balance of Nb, interstitials and impurities. This alloy may be used to increase the creep resistance of an article, for example a gas turbine engine blade. A second multi phase niobium silicide alloy composition consists essentially of: from 1 to 24 at% of Si; from 0 to 34 at% of one or more sp outer electron configuration element which is not Si; from 19.5 to 48.5 at% of one or more sd outer electron configuration element which is not Nb or Cr; from 0.5 to 9 at% Cr; and a balance of Nb, interstitials and impurities. This alloy may be used to increase the creep resistance and/or to increase the oxidation resistance of an article, for example a gas turbine engine blade.
摘要翻译：第一多相铌硅化物合金组合物基本上由以下组成：15至24at％的Si; 0〜25at％的不是Si的一种或多种sp外电子构型元素; 1〜26at％的不是Nb的一个或多个sd外部电子构造元素; 以及Nb，间隙和杂质的平衡。该合金可用于增加制品（例如燃气涡轮发动机叶片）的抗蠕变性。第二多相铌硅化物合金组合物基本上由1至24at％的Si组成; 0〜34at％的不是Si的一种或多种sp外电子构型元素; 一个或多个不是Nb或Cr的sd外部电子构造元素的19.5至48.5at％; 0.5至9原子％Cr; 以及Nb，间隙和杂质的平衡。该合金可用于增加制品（例如燃气涡轮发动机叶片）的抗蠕变性和/或增加抗氧化性。

9. 发明申请

WO2009115838A2 SPECIMEN HOLDER ASSEMBLY 审中-公开
标题翻译：样品座组件
公开(公告)号：WO2009115838A2
公开(公告)日：2009-09-24
申请号：PCT/GB2009050253
申请日：2009-03-16
申请人： UNIV SHEFFIELD , MOEBUS GUENTER , WEI GUAN , XU XIAOJING , WANG JING JING , GAY RALPH , LOCKWOOD AIDEN JAMES , INKSON BEVERLEY
发明人： MOEBUS GUENTER , WEI GUAN , XU XIAOJING , WANG JING JING , GAY RALPH , LOCKWOOD AIDEN JAMES , INKSON BEVERLEY
IPC分类号： H01J37/20 , H01J37/26
CPC分类号： H01J37/20 , G21K7/00 , H01J37/26 , H01J2237/20207 , H01J2237/20214 , H01J2237/20221 , H01J2237/20242 , H01J2237/20264 , H01J2237/20285 , H01J2237/20292 , H01J2237/2617 , H02N2/0095
摘要： A specimen holder assembly suitable for tomographic inspection of a specimen in a transmission electron microscope comprising: a body portion in the form of an elongate member arranged to be removably insertable into the column of the microscope; and a manipulator portion having a first axis, the manipulator portion comprising: a specimen mount portion configured to support the specimen; a specimen translation assembly operable to translate the specimen mount portion with respect to the body portion; and a specimen rotation assembly coupled to the body portion and to the specimen translation assembly, the specimen rotation assembly being operable to rotate the specimen translation assembly relative to the body portion about the first axis.
摘要翻译：一种适用于透射电子显微镜中的样本的层析成像检查的样本保持器组件，包括：细长构件形式的本体部分，其布置成可移除地插入显微镜的柱中; 以及具有第一轴的机械手部，所述机械手部包括：被配置为支撑所述试样的试样安装部; 样本翻译组件，其可操作以相对于所述主体部分平移所述样本安装部分; 以及联接到所述主体部分和所述样本平移组件的样本旋转组件，所述样本旋转组件可操作以使所述样本平移组件相对于所述主体部分围绕所述第一轴线旋转。

10. 发明申请

WO2009019469A3 PYRROLIDINES AS CATALYST COMPOUNDS 审中-公开
标题翻译：吡咯啉作为催化剂化合物
公开(公告)号：WO2009019469A3
公开(公告)日：2009-04-02
申请号：PCT/GB2008002663
申请日：2008-08-05
申请人： UNIV SHEFFIELD , JONES SIMON , GAUTIER FRANCOIS-MOANA
发明人： JONES SIMON , GAUTIER FRANCOIS-MOANA
IPC分类号： C07D401/06 , C07C209/28 , C07C209/52
CPC分类号： C07D403/06 , C07B2200/07 , C07C209/28 , C07C209/52 , C07C213/02 , C07C2601/14 , C07C2602/10 , C07C211/48 , C07C217/84
摘要： The present invention relates to compounds for use as catalysts, methods for producing said compounds and the use of said compounds as catalysts in catalytic processes including, but not limited to, the asymmetric reduction of imine and enamine compounds and/or the reductive animation of ketone compounds. A compound for use as a catalyst has the formula (I) wherein: R1, R2, R3, R4 and R5 are each separately selected from the group consisting of hydrogen, alkyl and aryl; X is oxygen or sulfur; and Z has the formula (II) wherein: R6 and R7 are each separately selected from the group consisting of hydrogen, alkoxy, nitro, halogen, alkyl and aryl, or R6 and R7 are linked to form a cyclic group; and Y is oxygen, sulfur or NR10 in which R10 is selected from the group consisting of hydrogen, alkyl and aryl.
摘要翻译：本发明涉及用作催化剂的化合物，所述化合物的制备方法和所述化合物在催化方法中的用途，包括但不限于亚胺和烯胺化合物的不对称还原和/或酮的还原动力化合物。用作催化剂的化合物具有式（I），其中：R 1，R 2，R 3，R 4和R 5各自独立地选自氢，烷基和芳基; X是氧或硫; 并且Z具有式（II），其中：R 6和R 7各自独立地选自氢，烷氧基，硝基，卤素，烷基和芳基，或者R 6和R 7连接形成环状基团; 并且Y是氧，硫或NR 10，其中R 10选自氢，烷基和芳基。

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