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1. 发明申请

WO2015166194A3 METHOD FOR DETERMINING THE LENGTH POLYMORPHISM OF THE CR1 RECEPTOR 审中-公开
标题翻译：确定CR1受体长度多态性的方法
公开(公告)号：WO2015166194A3
公开(公告)日：2016-01-07
申请号：PCT/FR2015051171
申请日：2015-04-30
申请人： UNIV REIMS CHAMPAGNE ARDENNE
发明人： COHEN JACQUES HENRI MAX , KISSERLI AYMERIC JEAN-MARIE ALBERT MARCEL , REVEIL BRIGITTE , DURET VALÉRIE , MAHMOUDI RACHID
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： The invention relates to a method for determining the length polymorphism of the CR1 receptor including three domains — LHR A, LHR C and LHR D — and n LHR B domains, wherein n is an integer between 0 and 3. Genetic material is used to amplify, by means of a single pair of specific primers, a first segment of the LHR B domain (variant segment B) and a second segment belonging to at least one other domain, (non-variant segment), said variant segment B and said non-variant segment having, outside of the hybridisation areas of said primers, at least three nucleotide differences. The number of amplicons of variant segment B and of the non-variant segment is deduced using a quantitative tool, the ratio of variant B to non-variant differing according to the length polymorphism of the CR1 receptor.
摘要翻译：本发明涉及一种确定CR1受体长度多态性的方法，包括三个结构域--HRR A，LHR C和LHR D - 和n LHR B结构域，其中n为0至3之间的整数。遗传物质用于扩增，通过单对特异性引物，LHR B结构域（变体区段B）的第一区段和属于至少一个其他结构域（非变体区段）的第二区段，所述变体区段B和所述非 - 变异区段在所述引物的杂交区域外具有至少三个核苷酸差异。使用定量工具推导变体区段B和非变异区段的扩增子的数目，根据CR1受体的长度多态性，变体B与非变体的比例不同。

2. 发明申请

WO2009081069A3 POLYCLONAL ANTIBODY DIRECTED AGAINST THE ELASTIN BINDING PROTEIN AND METHOD FOR OBTAINING SAME 审中-公开
标题翻译：针对ELASTIN结合蛋白的多克隆抗体及其获得方法
公开(公告)号：WO2009081069A3
公开(公告)日：2009-08-20
申请号：PCT/FR2008052385
申请日：2008-12-19
申请人： UNIV REIMS CHAMPAGNE ARDENNE U , BLANCHEVOYE CHARLOTTE , DELACOUX FREDERIC , DUCA LAURENT , DEVY JEROME , SARTELET HERVE , DEBELLE LAURENT
发明人： BLANCHEVOYE CHARLOTTE , DELACOUX FREDERIC , DUCA LAURENT , DEVY JEROME , SARTELET HERVE , DEBELLE LAURENT
IPC分类号： C07K16/18 , C07K14/705
CPC分类号： C07K16/28
摘要： The invention concerns a polyclonal antibody directed against EBP (elastin binding protein), that can be obtained by means of a method comprising the immunization of a non-human mammal with a recombinant protein, comprising an antigenic fragment of EBP fused to a carrier protein, and the purification of the resulting serum by separation of the immunoglobulins G (IgGs) from the serum and elimination of the antibodies directed against the carrier protein.
摘要翻译：本发明涉及针对EBP（弹性蛋白结合蛋白）的多克隆抗体，其可以通过包含用重组蛋白免疫非人哺乳动物的方法获得，包括与载体蛋白融合的EBP的抗原性片段，以及通过从血清中分离免疫球蛋白G（IgGs）并消除针对载体蛋白的抗体来纯化所得血清。

3. 发明申请

WO2009016289A3 DEVICE AND METHOD FOR MONITORING THE VIBRATORY STATE OF A ROTATING MACHINE 审中-公开
标题翻译：用于监测旋转机器的振动状态的装置和方法
公开(公告)号：WO2009016289A3
公开(公告)日：2009-04-30
申请号：PCT/FR2008000910
申请日：2008-06-26
申请人： UNIV REIMS CHAMPAGNE ARDENNE , MARCONNET PATRICK , POTTIER BERNARD , RASOLOFONDRAIBE LANTO
发明人： MARCONNET PATRICK , POTTIER BERNARD , RASOLOFONDRAIBE LANTO
IPC分类号： G01M13/04 , G01H11/00 , G01M7/00
CPC分类号： G01M13/045 , F16C19/527 , G01H11/00
摘要： The present invention relates to a device for monitoring the vibrations generated by a bearing of a machine formed by two coaxial races, an outer race and an inner race, with one fixed with respect to the frame of a machine and the other rotating, between which races is trapped at least one rolling element which is able to move, vibrations generated by other members of the machine having a respective frequency signature passing through this bearing, characterized in that the device comprises at least one non-conductive positioning means mounted on an element in contact with an element of the bearing, the positioning means positioning a conductive element, forming a first plate of a capacitor to form a capacitive sensor, at a distance from a conductive part of a race of the bearing, forming the second plate of the capacitor, and the positioning means being secured to a partitioning means so as to create an insulating medium between these two plates.
摘要翻译：本发明涉及一种用于监测由两个同轴圈，一个外圈和一个内圈形成的机器的轴承所产生的振动的装置，其中一个相对于机器的框架固定并且另一个旋转，所述滚道被限制在至少一个能够移动的滚动元件中，所述机器的其它构件所产生的振动具有穿过该轴承的相应频率特征，其特征在于，所述装置包括至少一个非导电定位装置，所述非导电定位装置安装在元件与所述轴承的元件接触，所述定位装置将导电元件定位，形成电容器的第一板以形成电容式传感器，与所述轴承的座圈的导电部分相距一段距离，形成所述第二板的所述第二板电容器，定位装置固定在分隔装置上，以便在这两个板之间形成绝缘介质。

4. 发明申请

WO2008009795A2 BACTERIA HAVING PROTECTING ACTIVITY AGAINST BOTRYTIS CINEREA 审中-公开
标题翻译：具有保护活性的啤酒酵母菌的细菌
公开(公告)号：WO2008009795A2
公开(公告)日：2008-01-24
申请号：PCT/FR2007001183
申请日：2007-07-10
申请人： UNIV REIMS CHAMPAGNE ARDENNE U , TROTEL-AZIZ PATRICIA , AZIZ AZIZ , MAGNIN-ROBERT MARYLINE , GOGNIES SABINE , AIT BARKA ESSAID
发明人： TROTEL-AZIZ PATRICIA , AZIZ AZIZ , MAGNIN-ROBERT MARYLINE , GOGNIES SABINE , AIT BARKA ESSAID
IPC分类号： A01N63/00
CPC分类号： A01N63/00
摘要： The invention relates to bacteria having protecting activity against Botrytis cinerea: said bacteria are selected from the strains Acinetobacter, Bacillus, Pantoea and Pseudomonas. Application in the biological control of Botrytis cinerea.
摘要翻译：本发明涉及对灰葡萄孢（Botrytis cinerea）具有保护活性的细菌：所述细菌选自不动杆菌属，芽孢杆菌属，泛菌属和假单胞菌属。在灰葡萄孢的生物防治中的应用。

5. 发明申请

WO2004072027A2 CHEMICAL DERIVATIVES BINDING VERY SPECIFICALLY WITH G-QUADRUPLEX DNA STRUCTURES AND USE THEREOF AS A SPECIFIC ANTI-CANCER AGENT 审中-公开
标题翻译：化学衍生物与G-四联体DNA结构结合非常明确，并将其用作特异性抗癌药
公开(公告)号：WO2004072027A2
公开(公告)日：2004-08-26
申请号：PCT/FR2004000260
申请日：2004-02-05
申请人： AVENTIS PHARMA SA , CENTRE NAT RECH SCIENT , MUSEUM NAT D HISTOIRE NATURELL , INST CURIE , COMMISSARIAT ENERGIE ATOMIQUE , UNIV REIMS CHAMPAGNE ARDENNE , HITTINGER AUGUSTIN , CAULFIELD THOMAS , MAILLIET PATRICK , BOUCHARD HERVE , MANDINE ELIANE , MERGNY JEAN-LOUIS , GUITTAT LIONEL , RIOU JEAN-FRANCOIS , GOMEZ DENNIS , BELMOKHTAR CHAFKE
发明人： HITTINGER AUGUSTIN , CAULFIELD THOMAS , MAILLIET PATRICK , BOUCHARD HERVE , MANDINE ELIANE , MERGNY JEAN-LOUIS , GUITTAT LIONEL , RIOU JEAN-FRANCOIS , GOMEZ DENNIS , BELMOKHTAR CHAFKE
IPC分类号： A61K45/06 , A61P35/00 , A61P37/00 , C07D215/38 , C07D401/12 , C07D401/14 , C07D
CPC分类号： C07D401/12 , A61K45/06 , C07D215/38 , C07D401/14
摘要： The invention relates to cancer therapy and concerns novel anti-cancer agents exhibiting a highly specific action mechanism. The invention also relates to novel chemical compounds and the therapeutic use thereof in man. The invention describes the preparation of heterocylic diamides of general formula (IB) as highly specific G quadruplex DNA ligands and the use thereof as telomerase inhibitors in man. (IB) nitrogenous aromatic cycle comprising a nitrogen atom in a quaternary form (NR3)p CO distributor (CO)m NR'3)qu X- aromatic or non-aromatic cycle.
摘要翻译：本发明涉及癌症治疗并且涉及展现出高度特异性作用机制的新型抗癌剂。本发明还涉及新型化合物及其在人体中的治疗用途。本发明描述了通式（IB）的杂环二酰胺作为高度特异的G四链体DNA配体的制备及其在人体中作为端粒酶抑制剂的用途。（IB）包含氮原子的季氮形式（NR 3）p CO分配器（CO）m NR'3）q-芳族或非芳族循环的含氮芳族环。

6. 发明申请

WO03060834A2 SURVEILLANCE ASSISTANCE DEVICE FOR HIGH-RISK SITE 审中-公开
标题翻译：监控高风险协助设备
公开(公告)号：WO03060834A2
公开(公告)日：2003-07-24
申请号：PCT/FR0204516
申请日：2002-12-20
申请人： UNIV REIMS CHAMPAGNE ARDENNE , CARRE-MENETRIER VERONIQUE , GELLOT FRANCOIS , ZAYTOON JANAN
发明人： CARRE-MENETRIER VERONIQUE , GELLOT FRANCOIS , ZAYTOON JANAN
IPC分类号： G07C9/00
CPC分类号： G07C9/00103 , G07C9/00904
摘要： The invention concerns a surveillance assistance device for high-risk site, comprising a plurality of sectors inside which are carried out various activities, accessible through doors equipped or not with access control means, and wherein persons are likely, whether authorized or not to penetrate into said sectors. It comprises means for: collecting data concerning the premises to be watched, namely the type(s) of activity being currently performed, the passage(s) of different persons through one of the doors equipped with access control means, and the status, open or closed, of the doors; establishing on the basis of said data location and/or probable location of said persons in the various sectors of said premises; displaying one or several unauthorized persons present or probabilities of one or several unauthorized persons present in one or the other of said sectors.
摘要翻译：本发明涉及一种用于高风险场所的监视辅助装置，包括多个扇区，其内部进行各种活动，可通过配有门禁装置的门进行访问，并且其中人员有可能被授权或不会渗入说行业。它包括：收集有关待监视场所的数据，即当前正在执行的活动类型，通过配备有访问控制装置的一个门的不同人员的通道，以及状态，打开或关闭; 根据所述人员在所述处所的各个部门的所述数据位置和/或可能的位置建立; 显示存在于一个或另一个所述扇区中的一个或多个未授权人员或一个或多个未经授权的人员的概率。

7. 发明申请

WO2008081115A3 METHOD AND DEVICE FOR TAKING SHOTS USING A PLURALITY OF OPTOELECTRONIC SENSORS 审中-公开
标题翻译：使用多个光电子传感器拍摄照片的方法和装置
公开(公告)号：WO2008081115A3
公开(公告)日：2008-09-18
申请号：PCT/FR2007002002
申请日：2007-12-05
申请人： TELERELIEF , UNIV REIMS CHAMPAGNE ARDENNE , DEBONS DIDIER , LUCAS LAURENT , REMION YANNICK
发明人： DEBONS DIDIER , LUCAS LAURENT , REMION YANNICK
IPC分类号： H04N13/00
CPC分类号： H04N13/0246 , H04N13/0242 , H04N13/0296
摘要： The method of the invention can be used for taking shots using a plurality of optoelectronic sensors (O i to O' i ) in order to create a final sequence of combined images that can be displayed on screens adapted to this image combination. It comprises the physical or virtual distribution of the optoelectronic sensors (O i to O' i ) on a virtual arc of circle having a radius R corresponding to the distance between the optical centre of each of the sensors (O i to O' i ) and the point (C) in the area of the scene shot on which at least one of said sensors, or reference sensor, is focused, the length of the chord (Cori) between two successive optical centres being constant whatever the length of the radius R.
摘要翻译：本发明的方法可以用于使用多个光电传感器（O _{i 至O'_{i ）进行拍摄，以便创建最终的组合图像序列，可以显示在适合该图像组合的屏幕上。它包括光电传感器（O _{i 到O'_{i ）的物理或虚拟分布，其半径R对应于光学元件之间的距离在拍摄场景的区域中的每个传感器（O i 到o' i ）的中心和点（C），其中至少一个所述传感器，或参考传感器被聚焦时，无论半径R的长度如何，两个连续光学中心之间的弦长（Cori）都是恒定的。}}}}

8. 发明申请

WO2007045767A3 USE OF AN AGENT FOR STIMULATING THE DEFENSE SYSTEM OF PLANTS AND PRODUCTION THEREOF 审中-公开
标题翻译：使用代理商刺激植物防御系统及其生产
公开(公告)号：WO2007045767A3
公开(公告)日：2007-08-02
申请号：PCT/FR2006002353
申请日：2006-10-19
申请人： UNIV REIMS CHAMPAGNE ARDENNE U , DOREY STEPHAN , BAILLIEUL FABIENNE , CLEMENT CHRISTOPHE , VARNIER ANNE-LISE , TERGANIER MALK
发明人： DOREY STEPHAN , BAILLIEUL FABIENNE , CLEMENT CHRISTOPHE , VARNIER ANNE-LISE , TERGANIER MALK
IPC分类号： A01N43/16 , A01N63/00 , A01N63/02
CPC分类号： A01N43/16 , A01N63/02
摘要： The invention relates to the use of rhamnolipids R1 and/or R2 as an agent for stimulating natural defense reactions of plants and to a method for producing such an agent. The invention is for use particularly in combating pathogenic microorganisms such as fungi.
摘要翻译：本发明涉及鼠李糖脂R1和/或R2作为刺激植物的天然防御反应的试剂的用途以及生产这种试剂的方法。本发明特别用于防治病原微生物如真菌。

9. 发明申请

WO2008056066A3 DEVICE AND METHOD FOR MONITORING THE VIBRATORY CONDITION OF A ROTATING MACHINE 审中-公开
标题翻译：用于监测旋转机械的振动条件的装置和方法
公开(公告)号：WO2008056066A3
公开(公告)日：2008-07-24
申请号：PCT/FR2007001807
申请日：2007-10-31
申请人： UNIV REIMS CHAMPAGNE ARDENNE , MARCONNET PATRICK , POTTIER BERNARD , RASOLOFONDRAIBE LANTO
发明人： MARCONNET PATRICK , POTTIER BERNARD , RASOLOFONDRAIBE LANTO
IPC分类号： G01M13/04
CPC分类号： G01M13/045 , F16C19/06 , F16C19/527
摘要： The invention relates to a device comprising a mechanical bearing including two coaxial bushings, i.e. an outer one (1) and an inner one (2) with one bushing being fixed relative to the frame of the machine and the other being capable of rotation, a rolling member (3) being trapped between the bushings and capable of displacement, characterised in that the device comprises at least one positioning non-conductive means (4) tightly mounted on the bearing bushing that is fixed relative to the frame of the machine, said non-conductive positioning means (4) including at least one positioning housing for at least one conductive member, defining a first capacitor armature (5) at a distance from the conductive portion of the rotating bushing, and defining the second capacitor armature (6), said non-conductive positioning means (4) being connected to at least one partitioning means (8), the partitioning means (8) defining a space (7) between the armatures (5, 6) that forms a dielectric insulating environment and sealing said insulating environment while being in contact with a portion of the surface of the rotating bushing.
摘要翻译：本发明涉及一种包括机械轴承的装置，该机械轴承包括两个同轴衬套，即外部一个（1）和内部一个（2），其中一个衬套相对于机器的框架固定，另一个可以旋转，滚动构件（3）被捕获在衬套之间并且能够移动，其特征在于，所述装置包括至少一个紧固地安装在相对于机器框架固定的轴承衬套上的定位非导电装置（4）非导电定位装置（4）包括用于至少一个导电构件的至少一个定位壳体，其限定距离旋转衬套的导电部分一定距离的第一电容器电枢（5），并且限定第二电容器衔铁（6），所述非导电定位装置（4）连接到至少一个分隔装置（8），所述分隔装置（8）在所述电枢（5,6）之间形成空间（7），所述电枢形成绝缘绝缘体并且与所述旋转衬套的表面的一部分接触而密封所述绝缘环境。

10. 发明申请

WO2007107654A1 CYCLOPEPTIDE WITH ANTI-CANCER ACTIVITY DERIVED FROM COLLAGEN TYPE IV 审中-公开
标题翻译：具有来自胶原型IV的抗癌活性的环磷酰胺
公开(公告)号：WO2007107654A1
公开(公告)日：2007-09-27
申请号：PCT/FR2007000487
申请日：2007-03-22
申请人： UNIV REIMS CHAMPAGNE ARDENNE , MONBOISSE JEAN-CLAUDE PAUL LOU , RAMONT LAURENT GABRIEL EMILE , BRASSART SYLVIE ANNE YVONNE , FLOQUET NICOLAS JOSEPH GILBERT , THEVENARD JESSICA ANDREE MIREI
发明人： MONBOISSE JEAN-CLAUDE PAUL LOU , RAMONT LAURENT GABRIEL EMILE , BRASSART SYLVIE ANNE YVONNE , FLOQUET NICOLAS JOSEPH GILBERT , THEVENARD JESSICA ANDREE MIREI
IPC分类号： C07K7/64 , A61K38/12 , C07K5/12
CPC分类号： C07K7/64 , C07K5/126
摘要： The present invention relates to a cyclopeptide characterized in that it comprises the YSNS amino acid sequence, and more particularly a cyclopentapeptide which forms a ß-bend structure at the YSNS amino acids. In one specific embodiment, the cyclopeptide of the invention is capable of binding to the aVß3-integrin. The application also claims the use of a cyclopeptide of the invention in the treatment of cancer, and more particularly in the treatment of the various forms of melanoma, and also in the manufacture of a medicament for treating cancer. Finally, the application describes the use of a cyclopeptide of the invention for inhibiting or reducing angiogenesis, and more particularly in tumours, and also in the manufacture of a medicament for inhibiting or reducing angiogenesis.
摘要翻译：本发明涉及一种环肽，其特征在于它包含YSNS氨基酸序列，更具体地说是在YSNS氨基酸处形成β-弯曲结构的环戊肽。在一个具体实施方案中，本发明的环肽能够结合aVβ3整联蛋白。本申请还要求本发明的环肽在癌症的治疗中的用途，更具体地说是治疗各种形式的黑素瘤，还涉及制备用于治疗癌症的药物。最后，本申请描述了本发明的环肽用于抑制或减少血管生成，尤其是在肿瘤中的用途，以及用于制备抑制或减少血管生成的药物。

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