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1. 发明申请

WO2006008706A3 AN ALTERNATE OXIDANT FOR A DELAY COMPOSITION 审中-公开
标题翻译：用于延迟组合物的替代氧化剂
公开(公告)号：WO2006008706A3
公开(公告)日：2006-03-23
申请号：PCT/IB2005052329
申请日：2005-07-13
申请人： UNIV PRETORIA , KALOMBO LONJI , DEL FABBRO OLINTO GIUSEPPE , CONRADIE CORNELIUS DU PLOOY , FOCKE WALTER WILHELM
发明人： KALOMBO LONJI , DEL FABBRO OLINTO GIUSEPPE , CONRADIE CORNELIUS DU PLOOY , FOCKE WALTER WILHELM
IPC分类号： C06C5/06 , C06B33/00
CPC分类号： C06C5/06 , C06B33/00
摘要： This invention relates to an alternate oxidant for a delay composition, and more particularly to a delay composition including a fuel and an oxidant in the form of antimony hexitatridecoxide having the formula Sb
摘要翻译：本发明涉及一种用于延迟组合物的替代氧化剂，更具体地说，涉及一种延迟组合物，其包括燃料和氧化锑，其形式为锑六

2. 发明申请

WO0100554A3 NAPHTHOQUINONE DERIVATIVES AND THEIR USE IN THE TREATMENT AND CONTROL OF TUBERCULOSIS 审中-公开
标题翻译：萘醌衍生物及其在治疗和控制结核病中的应用
公开(公告)号：WO0100554A3
公开(公告)日：2001-07-05
申请号：PCT/IB0000837
申请日：2000-06-22
申请人： UNIV PRETORIA , MEYER JACOBUS JOHANNES MARION , LALL NAMRITA
发明人： MEYER JACOBUS JOHANNES MARION , LALL NAMRITA
IPC分类号： A61P31/06 , A61K31/122 , C07C50/32
CPC分类号： A61K31/122 , Y10S514/924
摘要： Naphthoquinone derivatives of Formula (1): wherein, R represents an OH group, methyl ether, ethyl ether or a similar ether; R1 represents a methyl, ethyl or similar aliphatic hydrocarbon derivative; R2 and R3 each independently represent hydrogen or a group selected from: (A), (B), or (C) wherein R5 represents an OH group, methyl ether, ethyl ether or a similar ether and R6 represents a methyl, ethyl or similar aliphatic hydrocarbon derivative; R4 represents hydrogen or a group selected from: (D), (E) or (F) wherein R7 represents an OH group, methyl ether, ethyl ether or a similar ether and R8 represents a methyl, ethyl or similar aliphatic hydrocarbon derivative; or pharmaceutically acceptable salts thereof, are useful for the treatment and/or control of a tuberculosis in a patient caused by Mycobacterium tuberculosis .
摘要翻译：式（1）的萘醌衍生物：其中，R代表OH基，甲基醚，乙基醚或类似的醚; R1表示甲基，乙基或类似的脂族烃衍生物; R2和R3各自独立地表示氢或选自（A），（B）或（C）的基团，其中R5表示OH基，甲基醚，乙基醚或类似的醚，并且R6表示甲基，乙基或类似基团脂族烃衍生物; R4代表氢或选自（D），（E）或（F）的基团，其中R7代表OH基团，甲基醚，乙基醚或类似的醚，R8代表甲基，乙基或类似的脂族烃衍生物; 或其药学上可接受的盐可用于治疗和/或控制由结核分枝杆菌引起的患者中的结核病。

3. 发明申请

WO2014033625A2 ORAL CARE 审中-公开
标题翻译：口腔护理
公开(公告)号：WO2014033625A2
公开(公告)日：2014-03-06
申请号：PCT/IB2013058016
申请日：2013-08-27
申请人： UNIV PRETORIA
发明人： HENLEY-SMITH CYNTHIA JOAN , LALL NAMRITA , BOTHA FRANCINA SUSANNA , HUSSEIN AHMED ABDEL-FATTAH
CPC分类号： A61K8/97 , A01N35/04 , A01N43/16 , A01N65/00 , A01N65/28 , A61K8/35 , A61K36/61 , A61K2800/59 , A61Q11/00 , C12Q1/02
摘要： The invention relates to oral care. In particular the invention relates to an oral care composition for inhibiting the growth of potentially pathogenic oral microorganisms, said composition comprising an extract of Heteropyxis natalensis. The invention further relates to an oral care composition which includes Heteropyxis natalensis in combination with other essential oils and plant extracts.
摘要翻译：本发明涉及口腔护理。特别地，本发明涉及一种用于抑制潜在致病性口腔微生物生长的口腔护理组合物，所述组合物包含异of藜提取物。本发明还涉及一种口腔护理组合物，其包括与其他精油和植物提取物组合的异镰孢。

4. 发明申请

WO2009147632A2 NEW COMPOUNDS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的新化合物
公开(公告)号：WO2009147632A2
公开(公告)日：2009-12-10
申请号：PCT/IB2009052348
申请日：2009-06-03
申请人： CSIR , UNIV PRETORIA , AGRICULTURAL RESEARCH COUNCIL , BODE MOIRA , VLEGGAAR ROBERT , GATES PAUL J , SCHULTZ R ANITRA , NAICKER DHARMARAI , FOURIE NEL
发明人： BODE MOIRA , VLEGGAAR ROBERT , GATES PAUL J , SCHULTZ R ANITRA , NAICKER DHARMARAI , FOURIE NEL
IPC分类号： C07C215/18 , A61K31/132 , A61K31/133 , C07C311/18 , C07C317/18 , C07D317/20
CPC分类号： C07C311/18 , C07B2200/07 , C07C215/18 , C07C317/18 , C07D319/06
摘要： The invention provides a method of preparing the stereoisomers of 1,11-diamino-6-aza- undecane-2,4,8,10-tetraol.
摘要翻译：本发明提供了制备1,11-二氨基-6-氮杂 - 十一烷-2,4,8,10-四醇的立体异构体的方法。

5. 发明申请

WO2007141705A3 PLANT PROMOTERS 审中-公开
标题翻译：工厂促销
公开(公告)号：WO2007141705A3
公开(公告)日：2008-06-19
申请号：PCT/IB2007052002
申请日：2007-05-28
申请人： MONDI BUSINESS PAPER SOUTH AFR , UNIV PRETORIA , MYBURG ALEXANDER ANDREW , RANIK MARTIN , CREUX NICOLE MARIE
发明人： MYBURG ALEXANDER ANDREW , RANIK MARTIN , CREUX NICOLE MARIE
IPC分类号： A01H5/00 , C12N15/82
CPC分类号： C12N15/8216 , C12N9/1059
摘要： The invention relates to isolated and characterized full-length plant promoters from Eucalyptus. The promoters regulate expression of the cellulose synthase (CesA) family of genes, which are involved in wood and fibre formation in trees. The CesA promoter set of the invention offers regulatory sequences of varying strengths which also have the potential to direct tissue-specific expression of transgenes in the same ratios and with a similar tempero-spatial profile as in Eucalyptus spp. The promoters as described herein can be used to express transgenes in a very specific ratio that mimics the ratio of the CesA genes and allow modular expression of such transgenes. The invention also relates to expression cassettes, vectors and transgenic plants containing said promoters, and to a method for the production of said transgenic plants and seeds.
摘要翻译：本发明涉及来自桉树的分离和表征的全长植物启动子。启动子调节纤维素合成酶（CesA）家族的表达，这些基因涉及树木中的木材和纤维形成。本发明的CesA启动子组提供了不同强度的调控序列，其也具有以相同比例直接组织特异性表达转基因并具有与桉树属类似的温度 - 空间分布的潜力。如本文所述的启动子可用于以非常特定的比例表达转基因，其模拟CesA基因的比例并允许这种转基因的模块表达。本发明还涉及含有所述启动子的表达盒，载体和转基因植物，以及用于产生所述转基因植物和种子的方法。

6. 发明申请

WO2007052238A8 CHIMERIC ANTIGENS AND VACCINES 审中-公开
标题翻译： CHIMERIC抗生素和疫苗
公开(公告)号：WO2007052238A8
公开(公告)日：2007-06-21
申请号：PCT/IB2006054143
申请日：2006-11-07
申请人： UNIV PRETORIA , HUISMANS HENK , MAREE FRANCOIS
发明人： HUISMANS HENK , MAREE FRANCOIS
IPC分类号： C07K14/43
CPC分类号： C12N15/62 , A61K39/12 , A61K39/135 , A61K39/15 , A61K39/21 , A61K2039/5256 , A61K2039/5258 , A61K2039/552 , A61K2039/55566 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2710/14043 , C12N2720/12122 , C12N2720/12134 , C12N2770/32122 , C12N2770/32134
摘要： The invention provides a chimeric antigen which includes an orbivirus VP7 polypeptide with a foreign peptide inserted into a top domain region of said orbivirus VP7 polypeptide. The chimeric antigen in accordance may be used for treating or preventing a disease such as foot and mouth disease, African horsesickness, or bluetongue disease. The invention also extends to a method of inducing an immune response in a subject by administering an effective amount of an immunogenic composition comprising the chimeric antigen and a pharmaceutically acceptable carrier or diluent to the subject thereby to elicit or induce said immune response.
摘要翻译：本发明提供了一种嵌合抗原，其包括具有插入到所述轮状病毒VP7多肽的顶部结构域中的外源肽的轮状病毒VP7多肽。根据本发明的嵌合抗原可用于治疗或预防诸如脚mouth病，非洲马迹或蓝舌病的疾病。本发明还延伸到通过向受试者施用有效量的包含嵌合抗原和药学上可接受的载体或稀释剂的免疫原性组合物来诱导受试者的免疫应答的方法，从而引发或诱导所述免疫应答。

7. 发明申请

WO2014132137A3 TRANSGENIC CELL SELECTION 审中-公开
标题翻译：转基因细胞选择
公开(公告)号：WO2014132137A3
公开(公告)日：2014-12-04
申请号：PCT/IB2014000994
申请日：2014-02-28
申请人： UNIVERSITÉ DE GENÈVE , UNIV PRETORIA
发明人： KRAUSE KARL-HEINZ , SUTER DAVID , SALMON PATRICK , MYBURGH RENIER , PEPPER MICHAEL
IPC分类号： C12N15/65
CPC分类号： C12N15/65 , A61K31/17 , A61K31/517 , A61K35/28 , A61K48/00 , A61N5/1084 , C12N15/1034
摘要： Methods for selecting transgenic cells comprising two or more drug resistance genes with a combination of cytotoxic drugs (e.g., trimetrexate (TMTX) and hydroxyurea (HU)). Such selection can be completed in vitro or in vivo. Transgenic cells and vectors comprising combinations of resistance genes are also provided. Transgenic cells of the embodiments can be used as cell based therapeutics, such as for treatment of HIV infection.
摘要翻译：用于选择包含细胞毒性药物（例如三甲氧甲酰胺（TMTX）和羟基脲（HU））的组合的两种或更多种耐药性基因的转基因细胞的方法。这样的选择可以在体外或体内完成。还提供了包含抗性基因组合的转基因细胞和载体。实施方案的转基因细胞可用作基于细胞的治疗剂，例如用于治疗HIV感染。

8. 发明申请

WO2012007903A3 A METHOD OF DETECTING SURROGATE MARKERS FOR ACTIVE TUBERCULOSIS IN A SERUM SAMPLE 审中-公开
标题翻译：检测血清样本中主动管腔的血浆标记物的方法
公开(公告)号：WO2012007903A3
公开(公告)日：2012-03-22
申请号：PCT/IB2011053108
申请日：2011-07-12
申请人： UNIV PRETORIA , VERSCHOOR JAN ADRIANUS , BEUKES MERVYN
发明人： VERSCHOOR JAN ADRIANUS , BEUKES MERVYN
IPC分类号： G01N33/543 , G01N33/569
CPC分类号： G01N33/53 , C07K16/44 , C07K2317/23 , C07K2317/33 , C07K2317/622 , G01N33/558 , G01N33/5695
摘要： The invention provides a method of detecting surrogate markers for active tuberculosis in a serum sample. The surrogate markers are selected from serum mycolic acid antigen, serum anti-mycolic acid antibodies or both. The method includes the steps of combining the serum sample with a labelled monoclonal immunoglobulin antibody or fragment thereof to mycolic acids to produce a combined serum sample, the antibody or fragment thereof not substantially cross-reacting with cholesterol and the label being selected so that binding of the labelled antibody to immobilized mycolic acid antigen of mycobacterial origin produces a detectable signal and combining a blank sample with the labelled monoclonal immunoglobulin antibody or fragment thereof to mycolic acid to produce a combined blank sample. The method includes exposing both samples to immobilised mycolic acid antigen of mycobacterial origin or a synthetic analogue or analogues thereof so that the labelled immunoglobulin antibodies or fragments thereof in each sample bind to the immobilised antigen to produce detectable signals. If the surrogate markers are present, the signal produced by the blank sample will be stronger than that produced by the serum sample because of inhibition of binding of the labelled antibody in the serum sample arising from prior binding of the labelled antibody with the mycolic acid antigen in the serum sample or by competitive binding of serum anti- mycolic acid antibodies in the serum sample to the immobilised mycolic acid antigen or both.
摘要翻译：本发明提供一种检测血清样品中活性结核病替代标记物的方法。替代标记选自血清霉酚酸抗原，血清抗霉菌酸抗体或两者。该方法包括以下步骤：将血清样品与标记的单克隆免疫球蛋白抗体或其片段组合成霉菌酸以产生组合的血清样品，所述抗体或其片段与胆固醇基本上不交叉反应，并且所述标签被选择为使得分枝杆菌来源的固定的霉菌酸抗原的标记抗体产生可检测信号，并将空白样品与标记的单克隆免疫球蛋白抗体或其片段组合成霉菌酸以产生组合的空白样品。该方法包括将两个样品暴露于分枝杆菌来源的固定的霉菌酸抗原或其合成的类似物或类似物，使得每个样品中的标记的免疫球蛋白抗体或其片段与固定的抗原结合以产生可检测的信号。如果存在替代标记，则空白样品产生的信号将比由血清样品产生的信号更强，因为抑制标记的抗体在标记抗体与霉菌酸抗原的先前结合之间产生的血清样品中的结合在血清样品中或通过血清样本中血清抗霉菌酸抗体与固定的霉菌酸抗原或两者的竞争性结合。

9. 发明申请

WO2011141879A3 MODULATION OF SIGNALS 审中-公开
标题翻译：信号调制
公开(公告)号：WO2011141879A3
公开(公告)日：2012-03-08
申请号：PCT/IB2011052066
申请日：2011-05-11
申请人： UNIV PRETORIA , DHUNESS KAHESH , MAHARAJ BODHASWAR TIKANATH JUGPERSHAD
发明人： DHUNESS KAHESH , MAHARAJ BODHASWAR TIKANATH JUGPERSHAD
IPC分类号： H04K1/10 , H04L27/28
CPC分类号： H04L27/18 , H04L5/0007 , H04L27/2614 , H04L27/2628 , H04L27/2634 , H04L27/2649
摘要： An orthogonal frequency division multiplexing (OFDM) modulation method, which includes phase modulating both the real and imaginary components of an OFDM signal.
摘要翻译：正交频分复用（OFDM）调制方法，其包括对OFDM信号的实分量和虚分量进行相位调制。

10. 发明申请

WO2010048394A3 VACCINE AGAINST AFRICAN HORSE SICKNESS VIRUS 审中-公开
标题翻译：疫苗对非洲人恶心的病毒
公开(公告)号：WO2010048394A3
公开(公告)日：2010-08-19
申请号：PCT/US2009061669
申请日：2009-10-22
申请人： MERIAL LTD , UNIV CALIFORNIA , UNIV PRETORIA , MINKE JULES MAARTEN , AUDONNET JEAN-CHRISTOPHE , GUTHRIE ALAN JOHN , MACLACHLAN NIGEL JAMES , YAO JIANSHENG
发明人： MINKE JULES MAARTEN , AUDONNET JEAN-CHRISTOPHE , GUTHRIE ALAN JOHN , MACLACHLAN NIGEL JAMES , YAO JIANSHENG
IPC分类号： C07K14/14
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N15/86 , C12N2710/24043 , C12N2720/12122 , C12N2720/12134
摘要： The present invention provides vectors that contain and express in vivo the genes encoding VP2 and VP5 of African Horse Sickness Virus or an epitope thereof that elicits an immune response in a horse against African horse sickness virus, compositions comprising said vectors, methods of vaccination against African horse sickness virus, and kits for use with such methods and compositions.
摘要翻译：本发明提供了在体内含有和表达编码非洲马疾病病毒VP2和VP5的基因或其在马中针对非洲马病病毒引起免疫应答的表位的载体，包含所述载体的组合物，针对非洲的疫苗接种方法马病病毒，以及用于此类方法和组合物的试剂盒。

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