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1. 发明申请

WO2010113025A3 DIAGNOSIS OF GLUTEN-INDUCED AUTOIMMUNE DISEASES 审中-公开
标题翻译：谷氨酸引起的自身免疫疾病的诊断
公开(公告)号：WO2010113025A3
公开(公告)日：2010-11-25
申请号：PCT/IB2010000742
申请日：2010-04-01
申请人： UNIV DEBRECEN , KORPONAY-SZABO ILMA , FESUES LASZLO , BAGOSSI PETER , CSOSZ EVA , KIRALY ROBERT , SIMON-VECSEI ZSOFIA , MAEKI MARKKU
发明人： KORPONAY-SZABO ILMA , FESUES LASZLO , BAGOSSI PETER , CSOSZ EVA , KIRALY ROBERT , SIMON-VECSEI ZSOFIA , MAEKI MARKKU
IPC分类号： G01N33/573 , C07K16/40
CPC分类号： G01N33/573 , G01N2800/24
摘要： The invention relates to selective diagnosis of gluten-induced autoimmune diseases by binding assays utilizing the main celiac epitope present on proteins of the transglutaminase family.
摘要翻译：本发明涉及通过利用存在于转谷氨酰胺酶家族的蛋白质上的主要乳糜泻抗原表位的结合测定来选择性诊断谷蛋白诱导的自身免疫疾病。

2. 发明申请

WO2007144679A3 COMPOUNDS, KITS AND METHODS FOR CONFERRING CYTOPROTECTION 审中-公开
标题翻译：化合物，作用和方法进行细胞周期调控
公开(公告)号：WO2007144679A3
公开(公告)日：2009-06-18
申请号：PCT/HU2007000055
申请日：2007-06-14
申请人： UNIV DEBRECEN , NAGY LASZLO , SZATMARI ISTVAN
发明人： NAGY LASZLO , SZATMARI ISTVAN
IPC分类号： A61K45/06 , A61P35/00
CPC分类号： A61K45/06 , A61K49/0021
摘要： ABCG2, a member of the ATP-Binding Cassette transporters has been identified as a protective pump against endogenous and exogenous toxic agents. ABCG2 was shown to be expressed at high levels in stem cells, and variably regulated during cell differentation. It is demonstrated herein that functional ABCG2 is expressed in human monocyte-derived dendritic cells by the activation of a nuclear hormone receptor, PPARg. The present results uncovered a mechanism by which up-regulation of functional ABCG2 expression can be achieved via exogenous or endogenous activation of the lipid activated transcription factor, PPARg. Thus the invention relates to combined treatments by PPARg agonists and cytotoxic drugs transportable by ABCG2, various treatments in the field of neoplastic diseases as well as cell therapy, including autologous cell therapy, as well as kits and composition therefor. Method for protecting cells against cytotoxic drugs are also provided.
摘要翻译： ABCG2是ATP结合盒转运蛋白的成员，已被确定为针对内源性和外源性毒性物质的保护性泵。显示ABCG2在干细胞中以高水平表达，并且在细胞分化期间可变地调节。本文证明功能性ABCG2通过激活核激素受体PPARg在人单核细胞衍生的树突状细胞中表达。本研究结果揭示了通过脂质激活转录因子PPARg的外源或内源激活可以实现功能性ABCG2表达上调的机制。因此，本发明涉及PPARg激动剂和可通过ABCG2运输的细胞毒性药物，肿瘤疾病领域的各种治疗以及包括自体细胞治疗在内的细胞治疗以及试剂盒及其组合物的组合治疗。还提供了用于保护细胞免受细胞毒性药物的方法。

3. 发明申请

WO2010116196A3 DIAGNOSISOF AND TREATMENT GLUTEN-INDUCED AUTOIMMUNE DISEASES 审中-公开
标题翻译：诊断和治疗由谷氨酸引起的自身免疫疾病
公开(公告)号：WO2010116196A3
公开(公告)日：2010-12-02
申请号：PCT/HU2010000036
申请日：2010-04-01
申请人： UNIV DEBRECEN , KORPONAY-SZABO ILMA , FESUES LASZLO , BAGOSSI PETER , CSOSZ EVA , KIRALY ROBERT , SIMON-VECSEI ZSOFIA , MAEKI MARKKU
发明人： KORPONAY-SZABO ILMA , FESUES LASZLO , BAGOSSI PETER , CSOSZ EVA , KIRALY ROBERT , SIMON-VECSEI ZSOFIA , MAEKI MARKKU
IPC分类号： G01N33/573 , C07K16/40
CPC分类号： G01N33/573 , C07K16/40 , G01N2800/24
摘要： The invention relates to selective diagnosis of gluten-induced autoimmune diseases by binding assays utilizing the main celiac epitope present on proteins of the transglutaminase family. The invention also relates to treatment of gluten-induced autoimmune diseases by inhibiting binding of celiac autoantibodies by therapeutic compounds.
摘要翻译：本发明涉及通过利用存在于转谷氨酰胺酶家族的蛋白质上的主要乳糜泻抗原表位的结合测定来选择性诊断谷蛋白诱导的自身免疫疾病。本发明还涉及通过抑制治疗性化合物与乳糜泻自身抗体的结合来治疗麸质诱导的自身免疫性疾病。

4. 发明申请

WO2004101776A3 NOVEL USES OF PPAR MODULATORS AND PROFESSIONAL APCS MANIPULATED BY THE SAME 审中-公开
标题翻译： PPAR调节剂的新用途及其操作的专业APCS
公开(公告)号：WO2004101776A3
公开(公告)日：2005-05-12
申请号：PCT/IB2004050707
申请日：2004-05-14
申请人： UNIV DEBRECEN , NAGY LASZLO , SZATMARI ISTVAN , RAJNAVOELGYI EVA , GOGOLAK PETER , RETHI BENCE
发明人： NAGY LASZLO , SZATMARI ISTVAN , RAJNAVOELGYI EVA , GOGOLAK PETER , RETHI BENCE
IPC分类号： A61K35/12 , A61K47/48 , A61P31/00 , A61P37/00 , C12N5/0784 , C12N5/08 , A61K31/00 , A61K35/14
CPC分类号： C12N5/0639 , A61K47/6901 , A61K2035/122 , A61K2035/124 , C12N5/064 , C12N2501/385
摘要： PPAR modulator treatment in monocyte derived APC cells the expression pattern of certain cell surface molecules, e.g. of CD 1 gene family, and the cytokine secretion pattern altered. The invention relates to a manipulated professional antigen presenting cell (APC) having increased expression of a CD1 type II molecule, preferably at least a CDld molecule, relative to a control non manipulated cell. The invention further relates to the use of PPARg modulators in the preparation of a pharmaceutical composition or kit for the treatment of a disease treatable by activation of CDld restricted T-cells, e.g. in autoimmune diseases, allergies, post-transplant conditions or infectious diseases, or in the treatment of a neoplastic disease, e.g. skin cancer, hematological tumors, colorectal carcinoma, and therapeutic compositions and kits therefor. Furthermore, the invention relates to methods of manipulating professional apcs and kits therefor.
摘要翻译：单核细胞衍生的APC细胞中的PPAR调节剂治疗某些细胞表面分子的表达模式，例如，的CD 1基因家族，细胞因子分泌模式发生改变。本发明涉及相对于对照非操纵细胞，具有增加CD1型II分子表达，优选至少一种CDld分子的操作的专业抗原呈递细胞（APC）。本发明还涉及PPARg调节剂在制备药物组合物或试剂盒中的用途，所述药物组合物或试剂盒用于治疗通过激活CDld限制性T细胞可治疗的疾病，例如，自身免疫性疾病，过敏症，移植后状况或感染性疾病，或治疗肿瘤性疾病，例如，皮肤癌，血液肿瘤，结肠直肠癌，及其治疗组合物和试剂盒。此外，本发明涉及操纵专业apcs及其套件的方法。

5. 发明申请

WO2007083173A3 MONONUCLEOTIDES AND MONONUCLEOSIDES FOR USE IN THERAPY 审中-公开
标题翻译：单药和单克剂在治疗中的使用
公开(公告)号：WO2007083173A3
公开(公告)日：2013-10-17
申请号：PCT/HU2007000004
申请日：2007-01-19
申请人： UNIV DEBRECEN , ARADI JANOS , FESUES LASZLO , BECK ZOLTAN
发明人： ARADI JANOS , FESUES LASZLO , BECK ZOLTAN
IPC分类号： C07H19/06 , A61K31/7064 , C07H19/073 , C07H19/09 , C07H19/10
CPC分类号： C07H19/06 , C07H19/067 , C07H19/073 , C07H19/09 , C07H19/10
摘要： The present invention relates to thiolated pyrimidine-mononucleotides and pyrimidine- mononucleosides and their use as therapeutic agents. More closely, the present invention relates to therapeutic applications of 4-thio-uridine, its analogues, ribo- and deoxyribonucleotide derivatives and their various further derivatives, and also to these compounds for use in the therapeutic applications. Preferably, the subject of this invention is the use of these compounds and preparations containing these compounds as antiproliferative and/or antiviral agents.
摘要翻译：本发明涉及硫醇化的嘧啶 - 单核苷酸和嘧啶 - 单核苷类及其作为治疗剂的用途。更详细地说，本发明涉及4-硫代 - 尿苷及其类似物，核糖核酸衍生物和脱氧核糖核苷衍生物及其各种其它衍生物的治疗应用，也涉及用于治疗应用的这些化合物。优选地，本发明的主题是这些化合物和含有这些化合物的制剂作为抗增生和/或抗病毒剂的用途。

6. 发明申请

WO2013124700A2 COMPOSITION CONTAINING HEPATOPROTECTIVE SYLIBUM MARIANUM SEED OIL AND PROCEDURE FOR PREPARATION OF SEED OIL 审中-公开
标题翻译：含有保护性海藻酸盐油的组合物和种子油的制备方法
公开(公告)号：WO2013124700A2
公开(公告)日：2013-08-29
申请号：PCT/HU2013000019
申请日：2013-02-22
申请人： UNIV DEBRECEN , UNIV DE VEST VASILE GOLDIS DIN ARAD
发明人： HERMENEAN ANCA , ARDELEAN AUREL , ZSUGA MIKLOS , KEKI SANDOR , DEAK GYOERGY , POPESCU CRISTINA , UJHELYI ZOLTAN , BACSKAY ILDIKO , ARDELEAN GAVRIL , COSTACHE MARIETA , DINISCHIOUTU ANCA , TURCUS VIOLETA , MIHALI CIPRIAN , VECSERNYES MIKLOS , FENYVESI FERENC , KISS TIMEA , VARADI JUDIT , SIPOSNE FEHER PALMA
CPC分类号： A61K31/366
摘要： The invention relates to a pharmaceutical composition comprising oil isolated from Silybum marianum seed as active substance as well as pharmaceutical vehicles and/or excipients. The invention also relates to preparation of oil isolated from Silybum marianum seed.
摘要翻译：本发明涉及包含从水飞蓟种子作为活性物质以及药物载体和/或赋形剂分离的油的药物组合物。本发明还涉及从水飞蓟种子分离的油的制备。

7. 发明公开

EP2834268A4 MODIFIED PEPTIDE TOXINS 有权
标题翻译：改性肽
公开(公告)号：EP2834268A4
公开(公告)日：2015-11-18
申请号：EP12843911
申请日：2012-10-29
申请人： UNIV DEBRECEN , UNIV SZEGED
发明人： VARGA ZOLTÁN , PANYI GYÖRGY , TÓTH GÁBOR , RÁKOSI KINGA
IPC分类号： C07K14/435 , A61K38/17 , A61P3/10 , A61P17/06 , A61P25/00
CPC分类号： C07K14/43522 , A61K38/00
摘要： The invention relates to toxin peptides capable of selectively inhibiting a Kv1.3 potassium channel protein. The toxin peptides of the invention are modified anuroctonus scorpion toxin peptides.
摘要翻译：本发明涉及能够选择性抑制Kv1.3钾通道蛋白的毒素肽。本发明的毒素肽是修饰的蝎毒蝎毒素肽。

8. 发明专利

AU2003233018A1 POLYMERIC PRODUCT FOR FILM FORMATION 未知
公开(公告)号：AU2003233018A1
公开(公告)日：2003-11-10
申请号：AU2003233018
申请日：2003-04-24
申请人： UNIV DEBRECEN
发明人： BORBELY JANOS , UVEGES ANDREA KECZANNE , SZATMATRI MIHALY
IPC分类号： C08F2/00 , C08F8/00 , C08F8/30 , C08F257/02 , C08F265/04 , C08F265/06 , C08F285/00
摘要： The present invention relates to core/shell vinyl polymers wherein an at least partially crosslinked core is formed from a monovinyl monomer and/or a di/tri/ or higher multivinyl monomer wherein the degree of crosslinking in the core ranges from slight to high depending on the ratio of monovinyl and/or di/tri/ or higher multivinyl monomers, and wherein the outer shell is formed from a monovinyl and/or a di/tri/ or higher multi-vinyl monomer that optionally may be crosslinked, and wherein the outer shell has on its surface linear or branched C.sub.3-C.sub.30 alkyl chains formed from substituted vinyl monomers.

9. 发明专利

AU2003233018A8 Polymeric product for film formation 未知
公开(公告)号：AU2003233018A8
公开(公告)日：2003-11-10
申请号：AU2003233018
申请日：2003-04-24
申请人： UNIV DEBRECEN
发明人： UVEGES ANDREA KECZANNE , SZATMARI MIHALY , BORBELY JANOS
IPC分类号： C08F2/00 , C08F8/00 , C08F8/30 , C08F257/02 , C08F265/04 , C08F265/06 , C08F285/00
摘要： The present invention relates to core/shell vinyl polymers wherein an at least partially crosslinked core is formed from a monovinyl monomer and/or a di/tri/ or higher multivinyl monomer wherein the degree of crosslinking in the core ranges from slight to high depending on the ratio of monovinyl and/or di/tri/ or higher multivinyl monomers, and wherein the outer shell is formed from a monovinyl and/or a di/tri/ or higher multi-vinyl monomer that optionally may be crosslinked, and wherein the outer shell has on its surface linear or branched C.sub.3-C.sub.30 alkyl chains formed from substituted vinyl monomers.

10. 发明专利

CA2757598A1 DIAGNOSIS AND TREATMENT OF GLUTEN-INDUCED AUTOIMMUNE DISEASES 未知
公开(公告)号：CA2757598A1
公开(公告)日：2010-10-14
申请号：CA2757598
申请日：2010-04-01
申请人： UNIV DEBRECEN
发明人： KORPONAY-SZABO ILMA , FESUES LASZLO , BAGOSSI PETER , CSOESZ EVA , KIRALY ROBERT , SIMON-VECSEI ZSOFIA , MAEKI MARKKU
IPC分类号： G01N33/573 , C07K16/40
摘要： The invention relates to selective diagnosis of gluten-induced autoimmune diseases by binding assays utilizing the main celiac epitope present on proteins of the transglutaminase family. The invention also relates to treatment of gluten-induced autoimmune diseases by inhibiting binding of celiac autoantibodies by therapeutic compounds.

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