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1. 发明专利

JPS5539798A PRODUCTION FO LOW AMINE CONTENT FOOD * LUXURY FOOD AND FEEDSTUFF 失效
公开(公告)号：JPS5539798A
公开(公告)日：1980-03-19
申请号：JP11347579
申请日：1979-09-04
申请人： UNDERBERG EMIL
发明人： ANDOREASU REMUKE
IPC分类号： A23C9/123 , A23C19/06 , A23C19/068 , A23K1/00 , A23K1/16 , A23K1/165 , A23L2/84 , A23L5/20 , A23L27/24 , A23L29/00 , C12C5/00 , C12C7/00 , C12C11/02 , C12C12/00
摘要： A process for producing foodstuffs, beverages and forages with a reduced content of biogen amines and preferably with a reduced content of histamine is described. People with good health are able to degradate histamine which they take up with food by a histaminase. Nevertheless, many people, female and male, are not able to perform a sufficient degradation of the histamine and if these people take up histamine this results in severe troubles, like headache, a development of gastric ulcera, diarrhoea, as well as several kinds of allergic reactions. If histamine is present in forages, like e.g. in silo-fodder, then the histamine passes over into the milk and accordingly also into the diary and products, so that it is desired to have not only foodstuffs but also forages available with low histamine levels or completely histamine free. It now was found out unexpectedly that foodstuffs, beverages and forages having a drastically reduced histamine content or being completely free of histamine can be prepared by adding during any desired step of the preparation of the foodstuff, beverage or forage a microorganism which performs a transamination or desamination of histidine, or an enzyme which results in a transamination or desamination of histidine. According to said process the histidine can e.g. be converted by a primary splitting off of ammonia into the innocuous glutamic acid. The new process is especially important for the production of such foodstuffs, beverages or forages, in which an essential step in the course of the preparation of said products is a conversion performed by a micro-organism like e.g. an alcoholic fermentation or a lactic fermentation. The naturally occurring microorganism strains generally perform a decarboxylation of histidine present in the starting material forming the undesired histamine. The new process makes it possible to produce such foodstuffs, beverages and forages which generally have a high histamine content, like e.g. alcoholic beverages, sour-milk products, pickled cabbage and silo-fodder, nearly or completely free of histamine.

2. 发明授权

EP0170880B1 Verfahren zur Herstellung von Aminooxydase enthaltendem Material, bzw. Aminooxydase, aus Mikroorganismen, solche Produkte und deren Verwendung zum Abbau von Histamin in Nahrungsmitteln, Getränken und Futtermitteln 无效
标题翻译：从微生物生产含氨基氧化酶的材料或氨基酸酶的方法，这些产品及其在食品和饮料中降解组氨酸的用途
公开(公告)号：EP0170880B1
公开(公告)日：1991-02-06
申请号：EP85108206.5
申请日：1985-07-03
申请人： Underberg, Emil
发明人： Underberg, Emil , Lembke, Andreas
IPC分类号： C12N9/06 , C12P39/00 , A23L1/015 , C12H1/00 , A23K1/00
CPC分类号： C12N9/0022 , A23K10/10 , A23L5/25 , C12H1/003 , C12P39/00 , Y10S435/853 , Y10S435/921

3. 发明公开

EP0170880A1 Verfahren zur Herstellung von Aminooxydase enthaltendem Material, bzw. Aminooxydase, aus Mikroorganismen, solche Produkte und deren Verwendung zum Abbau von Histamin in Nahrungsmitteln, Getränken und Futtermitteln 无效
标题翻译：一种用于制备含有Aminooxydase材料或Aminooxydase，从微生物，例如产品及其组胺在食品，饮料和动物饲料的降解使用过程。
公开(公告)号：EP0170880A1
公开(公告)日：1986-02-12
申请号：EP85108206.5
申请日：1985-07-03
申请人： Underberg, Emil
发明人： Underberg, Emil , Lembke, Andreas
IPC分类号： C12N9/06 , C12P39/00 , A23L1/015 , C12H1/00 , A23K1/00
CPC分类号： C12N9/0022 , A23K10/10 , A23L5/25 , C12H1/003 , C12P39/00 , Y10S435/853 , Y10S435/921
摘要： Es wird ein Verfahren zur Herstellung von Histaminase, bzw. eines Histaminase enthaltenden Materiales, ausgehend von Mikroorganismen beschrieben. Histaminase ist eine Diaminoxydase, die Histamin abbaut.
Bei dem Verfahren wird ein Mikroorganismus, der in seinen Zellen Histaminase bildet, gezüchtet, und sobald eine ausreichende Anzahl von Mikroorganismen vorhanden ist, werden diese aus dem Zuchtmedium abgetrennt. Anhaftende Mengen des Zuchtmediums werden entfernt und die Zellen zerkleinert. Diese können getrocknet und gekühlt aufbewahrt werden oder zur Herstellung von höhere Mengen an Histaminase enthaltenden Produkten oder reiner Histaminase enthaltenden Produkten oder reiner Histaminase verwendet werden. Bevorzugt wird eine Mischkultur aus mindestens einem Milchsäurebakterium und mindestens einer Hefe in einem Lactose enthaltendem Zuchtmedium gezüchtet.
Mit den gewonnenen, Aminooxidase enthaltenden und aus Aminooxydase bestehenden Produkten kann in Nahrungsmitteln und Futtermitteln vorhandenes Histamin unter Bildung unschädlicher Produkte abgebaut werden.
摘要翻译：提供了一种用于制备histaminase的，或来自微生物的描述的含histaminase材料的方法。 Histaminase是二胺氧化酶，能分解组胺。在这个过程中，微生物形成在其细胞中histaminase，培养的，并且一旦微生物的足够数量存在时，它们被从培养基中分离出来。培养基的量附着除去，将细胞破碎。这些可以被干燥和储存冷藏或用于生产较高量的含有histaminase产品或者含有纯产品或histaminase纯histaminase使用。至少一种乳酸菌和至少一种酵母的混合培养物是优选在含乳糖的培养基中培养。用含有和由Aminooxydase现有组胺的教训，氨基氧化酶制品可以减少形成无害的产品在食品和饲料。

4. 发明专利

DE2822906C2 未知
公开(公告)号：DE2822906C2
公开(公告)日：1991-03-28
申请号：DE2822906
申请日：1978-05-26
申请人： UNDERBERG, EMIL, DIETLIKON, CH
发明人： UNDERBERG, EMIL, DIETLIKON, CH , LEMBKE, ANDREAS, PROF. DR. DR., 2420 EUTIN, DE
IPC分类号： C12G1/06 , C12H1/14

5. 发明专利

DE3581674D1 未知
公开(公告)号：DE3581674D1
公开(公告)日：1991-03-14
申请号：DE3581674
申请日：1985-07-03
申请人： UNDERBERG EMIL
发明人： UNDERBERG EMIL , LEMBKE ANDREAS
IPC分类号： A23K1/00 , A23K10/10 , A23L5/20 , C12H1/00 , C12H1/15 , C12N9/06 , C12P39/00 , A23L1/015
摘要： A process for the preparation of histaminase, respectively a histaminase containing material, is described. Histaminase is a diamine-oxidase which metabolizes histamine. According to the process at least one microorganism which produces in its cells histaminase, is cultivated and as soon as a sufficient number of microorganisms has grown, the microorganisms are isolated from the culture medium. Adhering culture medium is removed from the microorganisms and the microorganism cells are broken up and comminuted. The product can be dried in the vacuum, cooled and stored or it can be used to produce products having a higher content of histaminase or to produce a pure histaminase. Preferably a mixture of microorganisms is cultivated which contains at least one microorganism selected from the group lactobacillus and at least one yeast selected from the group candida. The histaminase containing products, respectively the histaminase, are used for metabolizing histamine in foodstuffs, beverages and forages yielding corresponding histamine free products in which the histamine had been metabolized forming not harmful metabolization products.

6. 发明专利

IT1122949B 未知
公开(公告)号：IT1122949B
公开(公告)日：1986-04-30
申请号：IT2544979
申请日：1979-09-03
申请人： UNDERBERG EMIL
发明人： LEMBKE ANDREAS
IPC分类号： A23C9/123 , A23C19/06 , A23C19/068 , A23K1/00 , A23K1/16 , A23K1/165 , A23L2/84 , A23L5/20 , A23L27/24 , A23L29/00 , C12C5/00 , C12C7/00 , C12C11/02 , C12C12/00 , A23L
摘要： A process for producing foodstuffs, beverages and forages with a reduced content of biogen amines and preferably with a reduced content of histamine is described. People with good health are able to degradate histamine which they take up with food by a histaminase. Nevertheless, many people, female and male, are not able to perform a sufficient degradation of the histamine and if these people take up histamine this results in severe troubles, like headache, a development of gastric ulcera, diarrhoea, as well as several kinds of allergic reactions. If histamine is present in forages, like e.g. in silo-fodder, then the histamine passes over into the milk and accordingly also into the diary and products, so that it is desired to have not only foodstuffs but also forages available with low histamine levels or completely histamine free. It now was found out unexpectedly that foodstuffs, beverages and forages having a drastically reduced histamine content or being completely free of histamine can be prepared by adding during any desired step of the preparation of the foodstuff, beverage or forage a microorganism which performs a transamination or desamination of histidine, or an enzyme which results in a transamination or desamination of histidine. According to said process the histidine can e.g. be converted by a primary splitting off of ammonia into the innocuous glutamic acid. The new process is especially important for the production of such foodstuffs, beverages or forages, in which an essential step in the course of the preparation of said products is a conversion performed by a micro-organism like e.g. an alcoholic fermentation or a lactic fermentation. The naturally occurring microorganism strains generally perform a decarboxylation of histidine present in the starting material forming the undesired histamine. The new process makes it possible to produce such foodstuffs, beverages and forages which generally have a high histamine content, like e.g. alcoholic beverages, sour-milk products, pickled cabbage and silo-fodder, nearly or completely free of histamine.

7. 发明专利

MX6665E 未知
公开(公告)号：MX6665E
公开(公告)日：1985-10-07
申请号：MX836579
申请日：1979-09-04
申请人： UNDERBERG EMIL
发明人： LEMBKE ANDREAS
IPC分类号： A23C9/123 , A23C19/06 , A23C19/068 , A23K1/00 , A23K1/16 , A23K1/165 , A23L2/84 , A23L5/20 , A23L27/24 , A23L29/00 , C12C5/00 , C12C7/00 , C12C11/02 , C12C12/00 , C12G1/02 , C12G3/08 , A23C9/12 , A23L1/218 , C12C11/04
摘要： A process for producing foodstuffs, beverages and forages with a reduced content of biogen amines and preferably with a reduced content of histamine is described. People with good health are able to degradate histamine which they take up with food by a histaminase. Nevertheless, many people, female and male, are not able to perform a sufficient degradation of the histamine and if these people take up histamine this results in severe troubles, like headache, a development of gastric ulcera, diarrhoea, as well as several kinds of allergic reactions. If histamine is present in forages, like e.g. in silo-fodder, then the histamine passes over into the milk and accordingly also into the diary and products, so that it is desired to have not only foodstuffs but also forages available with low histamine levels or completely histamine free. It now was found out unexpectedly that foodstuffs, beverages and forages having a drastically reduced histamine content or being completely free of histamine can be prepared by adding during any desired step of the preparation of the foodstuff, beverage or forage a microorganism which performs a transamination or desamination of histidine, or an enzyme which results in a transamination or desamination of histidine. According to said process the histidine can e.g. be converted by a primary splitting off of ammonia into the innocuous glutamic acid. The new process is especially important for the production of such foodstuffs, beverages or forages, in which an essential step in the course of the preparation of said products is a conversion performed by a micro-organism like e.g. an alcoholic fermentation or a lactic fermentation. The naturally occurring microorganism strains generally perform a decarboxylation of histidine present in the starting material forming the undesired histamine. The new process makes it possible to produce such foodstuffs, beverages and forages which generally have a high histamine content, like e.g. alcoholic beverages, sour-milk products, pickled cabbage and silo-fodder, nearly or completely free of histamine.

8. 发明专利

HU183030B PROCESS FOR PREPARING FOODSTUFFS AND DRINKS POOR IN BIOGENIC AMINES BY MEANS OF LACTOUS AND/OR ALCOHOLIC FERMENTATIONS 未知
公开(公告)号：HU183030B
公开(公告)日：1984-04-28
申请号：HUUE000095
申请日：1979-09-03
申请人： UNDERBERG EMIL
发明人： LEMBKE ANDREAS
IPC分类号： A23C9/123 , A23C19/06 , A23C19/068 , A23K1/00 , A23K1/16 , A23K1/165 , A23L2/84 , A23L5/20 , A23L27/24 , A23L29/00 , C12C5/00 , C12C7/00 , C12C11/02 , C12C12/00 , A23B7/10 , A23C7/04 , A23L1/00 , A23L3/00
摘要： A process for producing foodstuffs, beverages and forages with a reduced content of biogen amines and preferably with a reduced content of histamine is described. People with good health are able to degradate histamine which they take up with food by a histaminase. Nevertheless, many people, female and male, are not able to perform a sufficient degradation of the histamine and if these people take up histamine this results in severe troubles, like headache, a development of gastric ulcera, diarrhoea, as well as several kinds of allergic reactions. If histamine is present in forages, like e.g. in silo-fodder, then the histamine passes over into the milk and accordingly also into the diary and products, so that it is desired to have not only foodstuffs but also forages available with low histamine levels or completely histamine free. It now was found out unexpectedly that foodstuffs, beverages and forages having a drastically reduced histamine content or being completely free of histamine can be prepared by adding during any desired step of the preparation of the foodstuff, beverage or forage a microorganism which performs a transamination or desamination of histidine, or an enzyme which results in a transamination or desamination of histidine. According to said process the histidine can e.g. be converted by a primary splitting off of ammonia into the innocuous glutamic acid. The new process is especially important for the production of such foodstuffs, beverages or forages, in which an essential step in the course of the preparation of said products is a conversion performed by a micro-organism like e.g. an alcoholic fermentation or a lactic fermentation. The naturally occurring microorganism strains generally perform a decarboxylation of histidine present in the starting material forming the undesired histamine. The new process makes it possible to produce such foodstuffs, beverages and forages which generally have a high histamine content, like e.g. alcoholic beverages, sour-milk products, pickled cabbage and silo-fodder, nearly or completely free of histamine.

9. 发明专利

ES483819A1 PROCEDIMIENTO PARA LA PRODUCCION DE ALIMENTOS, PRODUCTOS ALIMENTICIOS ESTIMULANTES Y PIENSOS POBRES EN AMINAS 未知
公开(公告)号：ES483819A1
公开(公告)日：1980-09-01
申请号：ES483819
申请日：1979-09-01
申请人： UNDERBERG EMIL
IPC分类号： A23C9/123 , A23C19/06 , A23C19/068 , A23K1/00 , A23K1/16 , A23K1/165 , A23L2/84 , A23L5/20 , A23L27/24 , A23L29/00 , C12C5/00 , C12C7/00 , C12C11/02 , C12C12/00 , A23P1/00
摘要： Procedimiento para la producción de alimentos, productos alimenticios estimulantes y piensos que son pobres en aminas biogenas, caracterizado en que se añade un microorganismo durante cualquier etapa de la producción del alimento, producto alimenticio estimulante o pienso que causa una transaminación o desaminación de histidina, o que añade una enzima que produce la transaminación o desaminación de histidina.

10. 发明专利

DK368479A 未知
公开(公告)号：DK368479A
公开(公告)日：1980-03-05
申请号：DK368479
申请日：1979-09-03
申请人： UNDERBERG EMIL
发明人： LEMBKE A
IPC分类号： A23C9/123 , A23C19/06 , A23C19/068 , A23K1/00 , A23K1/16 , A23K1/165 , A23L2/84 , A23L5/20 , A23L27/24 , A23L29/00 , C12C5/00 , C12C7/00 , C12C11/02 , C12C12/00 , A23L
摘要： A process for producing foodstuffs, beverages and forages with a reduced content of biogen amines and preferably with a reduced content of histamine is described. People with good health are able to degradate histamine which they take up with food by a histaminase. Nevertheless, many people, female and male, are not able to perform a sufficient degradation of the histamine and if these people take up histamine this results in severe troubles, like headache, a development of gastric ulcera, diarrhoea, as well as several kinds of allergic reactions. If histamine is present in forages, like e.g. in silo-fodder, then the histamine passes over into the milk and accordingly also into the diary and products, so that it is desired to have not only foodstuffs but also forages available with low histamine levels or completely histamine free. It now was found out unexpectedly that foodstuffs, beverages and forages having a drastically reduced histamine content or being completely free of histamine can be prepared by adding during any desired step of the preparation of the foodstuff, beverage or forage a microorganism which performs a transamination or desamination of histidine, or an enzyme which results in a transamination or desamination of histidine. According to said process the histidine can e.g. be converted by a primary splitting off of ammonia into the innocuous glutamic acid. The new process is especially important for the production of such foodstuffs, beverages or forages, in which an essential step in the course of the preparation of said products is a conversion performed by a micro-organism like e.g. an alcoholic fermentation or a lactic fermentation. The naturally occurring microorganism strains generally perform a decarboxylation of histidine present in the starting material forming the undesired histamine. The new process makes it possible to produce such foodstuffs, beverages and forages which generally have a high histamine content, like e.g. alcoholic beverages, sour-milk products, pickled cabbage and silo-fodder, nearly or completely free of histamine.

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