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1. 发明专利

SE9701454D0 未知
公开(公告)号：SE9701454D0
公开(公告)日：1997-04-18
申请号：SE9701454
申请日：1997-04-18
申请人： ULF LINDAHL , JIN PING LI
发明人： LINDAHL ULF , LI JIN-PING
IPC分类号： C12N15/09 , C12N5/10 , C12N9/90 , C12N
摘要： An isolated or recombinant DNA sequence coding for a mammalian, including human, glucuronyl C5-epimarase or a functional derivative thereof capable of converting D-glucuronic acid (GlcA) to L-iduronic acid (IdoA); a recombinant expression vector comprising such DNA sequence; a host cell transformed with such recombinant expression vector; a process for the manufacture of a glucuronyl C5-epimerase or functional derivative thereof capable of converting GlcA to IdoA, comprising cultivation of a cell-line transformed with such recombinant expression vector; and a glucuronyl C5-epimerase or functional derivative thereof prepared by such process.

2. 发明专利

AU7094898A Dna sequence coding for a mammalian glucuronyl c5-epimerase and a process for its production 未知
公开(公告)号：AU7094898A
公开(公告)日：1998-11-13
申请号：AU7094898
申请日：1998-04-17
申请人： ULF LINDAHL , JIN PING LI
发明人： LINDAHL ULF , LI JIN-PING
IPC分类号： C12N15/09 , C12N5/10 , C12N9/90
摘要： An isolated or recombinant DNA sequence coding for a mammalian, including human, glucuronyl C5-epimarase or a functional derivative thereof capable of converting D-glucuronic acid (GlcA) to L-iduronic acid (IdoA); a recombinant expression vector comprising such DNA sequence; a host cell transformed with such recombinant expression vector; a process for the manufacture of a glucuronyl C5-epimerase or functional derivative thereof capable of converting GlcA to IdoA, comprising cultivation of a cell-line transformed with such recombinant expression vector; and a glucuronyl C5-epimerase or functional derivative thereof prepared by such process.

3. 发明专利

SE9503862D0 未知
公开(公告)号：SE9503862D0
公开(公告)日：1995-11-01
申请号：SE9503862
申请日：1995-11-01
申请人： HANDELSHUSET ULF LINDAHL AB
发明人： KRONHEFFER AAKE
IPC分类号： E04B20060101 , E04B

4. 发明专利

AU718472B2 DNA sequence coding for a mammalian glucuronyl C5-epimerase and a process for its production 未知
公开(公告)号：AU718472B2
公开(公告)日：2000-04-13
申请号：AU7094898
申请日：1998-04-17
申请人： ULF LINDAHL , JIN PING LI
发明人： LINDAHL ULF , LI JIN-PING
IPC分类号： C12N15/09 , C12N5/10 , C12N9/90
摘要： An isolated or recombinant DNA sequence coding for a mammalian, including human, glucuronyl C5-epimarase or a functional derivative thereof capable of converting D-glucuronic acid (GlcA) to L-iduronic acid (IdoA); a recombinant expression vector comprising such DNA sequence; a host cell transformed with such recombinant expression vector; a process for the manufacture of a glucuronyl C5-epimerase or functional derivative thereof capable of converting GlcA to IdoA, comprising cultivation of a cell-line transformed with such recombinant expression vector; and a glucuronyl C5-epimerase or functional derivative thereof prepared by such process.

5. 发明授权

US06764844B1 DNA sequence encoding a novel glucuronyl C5-epimerase 失效
标题翻译：编码新型葡萄糖醛酸C5-差向异构酶的DNA序列
公开(公告)号：US06764844B1
公开(公告)日：2004-07-20
申请号：US09403269
申请日：1999-10-18
申请人： Ulf Lindahl , Jing-ping Li
发明人： Ulf Lindahl , Jing-ping Li
IPC分类号： C12N990
CPC分类号： C12N9/90
摘要： An isolated or recombinant DNA sequence coding for a mammalian, including human, glucuronyl C5-epimerase or a functional derivative thereof capable or converting D-glucuronyl acid (GlcA) to L-iduronic acid (IdoA); a recombinant expression vector comprising such DNA sequence; a host cell transformed with such recombinant expression vector; a process for manufacture of a glucuronyl C5-epimerase or functional derivative thereof capable of coverting GlcA to IdoA, comprising cultivation of a cell-line transformed with such recombinant expression vector; and a glucuronyl C5-epimerase or functional derivative thereof prepared by such process.
摘要翻译：编码哺乳动物，包括能够将D-葡萄糖醛酸（GlcA）转化为L-艾杜糖醛酸（IdoA）的人，葡糖醛酸C5-差向异构酶或其功能衍生物的分离或重组DNA序列; 包含这种DNA序列的重组表达载体; 用这种重组表达载体转化的宿主细胞; 制备能够将GlcA覆盖至IdoA的葡糖醛酸C5-差向异构酶或其功能性衍生物的方法，包括用这种重组表达载体转化的细胞系的培养; 和通过这种方法制备的葡糖醛酸C5-差向异构酶或其功能性衍生物。

6. 发明申请

US20110154511A1 HEPARANASE DEFICIENT NON-HUMAN MAMMALS 有权
标题翻译： HEPARANASE缺乏非人类哺乳动物
公开(公告)号：US20110154511A1
公开(公告)日：2011-06-23
申请号：US12937091
申请日：2009-04-09
申请人： Jin-ping LI , Ulf Lindahl
发明人： Jin-ping LI , Ulf Lindahl
IPC分类号： A61K49/00 , A01K67/027 , C12N5/10 , C12N15/63
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N9/2402 , C12N15/8509 , C12Y302/01166
摘要： The invention relates to cells and transgenic non-human mammals having at least one disrupted heparanase allele. The invention further relates to methods of screening therapeutic drug candidates utilizing the heparanase deficient non-human mammals and cells.
摘要翻译：本发明涉及具有至少一种破坏性肝素酶等位基因的细胞和转基因非人哺乳动物。本发明还涉及利用乙酰肝素酶缺乏的非人哺乳动物和细胞筛选治疗药物候选物的方法。

7. 发明授权

US06887698B2 Glucuronyl C5-epimerase, DNA encoding the same and uses thereof 失效
标题翻译：葡糖醛酸C5-差向异构酶，编码其的DNA及其用途
公开(公告)号：US06887698B2
公开(公告)日：2005-05-03
申请号：US10005647
申请日：2001-12-07
申请人： Markku Jalkanen , Kamel El Darwish , Ulf Lindahl , Jin-ping Li
发明人： Markku Jalkanen , Kamel El Darwish , Ulf Lindahl , Jin-ping Li
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/90 , C12N15/61
CPC分类号： C12N9/90 , C12Y501/03012
摘要： The invention is directed to a novel purified mouse C5-epimerase, fragments thereof, nucleic acids encoding the same and the recombinant production thereof. The invention is also directed to fragments of such epimerase, especially N-terminal fragments that are useful in fusion protein constructs to enhance the activity of recombinantly-produced heterologous epimerase enzymes.
摘要翻译：本发明涉及新型纯化的小鼠C5-差向异构酶，其片段，编码它们的核酸及其重组生产。本发明还涉及这种差向异构酶的片段，特别是可用于融合蛋白构建体以增强重组产生的异源差向异构酶的活性的N-末端片段。

8. 发明申请

US20050181434A1 Glucuronyl C5-epimerase, DNA encoding the same and uses thereof 失效
公开(公告)号：US20050181434A1
公开(公告)日：2005-08-18
申请号：US11102643
申请日：2005-04-11
申请人： Markku Jalkanen , Kamel El Darwish , Ulf Lindahl , Jin-ping Li
发明人： Markku Jalkanen , Kamel El Darwish , Ulf Lindahl , Jin-ping Li
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/90 , C12N15/61 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/90 , C12Y501/03012
摘要： The invention is directed to a novel purified mouse C5-epimerase, fragments thereof, nucleic acids encoding the same and the recombinant production thereof. The invention is also directed to fragments of such epimerase, especially N-terminal fragments that are useful in fusion protein constructs to enhance the activity of recombinantly-produced heterologous epimerase enzymes.

9. 发明授权

US08809620B2 Heparanase deficient non-human mammals 有权
标题翻译：肝素酶缺乏非人哺乳动物
公开(公告)号：US08809620B2
公开(公告)日：2014-08-19
申请号：US12937091
申请日：2009-04-09
申请人： Jin-ping Li , Ulf Lindahl , Israel Vlodavsky , Eyal Zcharia
发明人： Jin-ping Li , Ulf Lindahl , Israel Vlodavsky , Eyal Zcharia
IPC分类号： A01K67/027 , A01K67/02
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N9/2402 , C12N15/8509 , C12Y302/01166
摘要： The invention relates to cells and transgenic non-human mammals having at least one disrupted heparanase allele. The invention further relates to methods of screening therapeutic drug candidates utilizing the heparanase deficient non-human mammals and cells.
摘要翻译：本发明涉及具有至少一种破坏性肝素酶等位基因的细胞和转基因非人哺乳动物。本发明还涉及利用乙酰肝素酶缺乏的非人哺乳动物和细胞筛选治疗药物候选物的方法。

10. 发明申请

US20100261253A1 Glucuronyl C5-Epimerase, DNA encoding the same and uses thereof 审中-公开
标题翻译：葡糖醛酸C5-异源分化酶，编码它们的DNA及其用途
公开(公告)号：US20100261253A1
公开(公告)日：2010-10-14
申请号：US12216602
申请日：2008-07-08
申请人： Markku Jalkanen , Kamel El Darwish , Ulf Lindahl , Jin-Ping Li
发明人： Markku Jalkanen , Kamel El Darwish , Ulf Lindahl , Jin-Ping Li
IPC分类号： C12N9/90 , C12N15/61 , C12N15/63 , C12N5/07
CPC分类号： C12N9/90 , C12Y501/03012
摘要： The invention is directed to a novel purified mouse C5-epimerase, fragments thereof, nucleic acids encoding the same and the recombinant production thereof. The invention is also directed to fragments of such epimerase, especially N-terminal fragments that are useful in fusion protein constructs to enhance the activity of recombinantly-produced heterologous epimerase enzymes.
摘要翻译：本发明涉及新型纯化的小鼠C5-差向异构酶，其片段，编码它们的核酸及其重组生产。本发明还涉及这种差向异构酶的片段，特别是可用于融合蛋白构建体以增强重组产生的异源差向异构酶的活性的N-末端片段。

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