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1. 发明申请

US20110208500A1 Methods and computer software for detecting splice variants 有权
公开(公告)号：US20110208500A1
公开(公告)日：2011-08-25
申请号：US13100397
申请日：2011-05-04
申请人： Alan Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson Clark
发明人： Alan Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson Clark
IPC分类号： G06G7/48
CPC分类号： G06F19/20
摘要： Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.

2. 发明申请

US20060084105A1 Arrays for detection of products of mRNA splicing 审中-公开
标题翻译：用于检测mRNA剪接产物的数组
公开(公告)号：US20060084105A1
公开(公告)日：2006-04-20
申请号：US11271536
申请日：2005-11-09
申请人： Manuel Ares , Tyson Clark , Charles Sugnet , Valerie Welch
发明人： Manuel Ares , Tyson Clark , Charles Sugnet , Valerie Welch
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6895 , C07H21/04 , C12Q1/6809 , C12Q2600/158 , C12Q2600/166 , C12Q2565/501 , C12Q2539/105
摘要： The invention features an array comprising at least one set of nucleic acid probes for detection of gene products that are produced by mRNA splicing of a selected gene, wherein each probe set is specific for a selected gene, and wherein the probe set minimally comprises a splice junction probe and either an intron probe or an exon probe. The splice junction probe hybridizes specifically to a sequence corresponding to a preselected, non-genomic sequence present in a product of mRNA splicing, while the intron probe hybridizes specifically to a sequence corresponding to an intronic sequence present in unspliced mRNA. The exon probe hybridizes specifically to a sequence corresponding to an exonic sequence of the gene. The intron probe and the exon probe may each serve as an internal control. The invention also features methods of using the array to analyze mRNA splice products in a sample.
摘要翻译：本发明的特征在于包括至少一组核酸探针的阵列，用于检测通过选择的基因的mRNA剪接产生的基因产物，其中每个探针组对于所选择的基因是特异性的，并且其中探针组最小化包括剪接连接探针和内含子探针或外显子探针。剪接结探针特异性地与对应于存在于mRNA剪接产物中的预选非基因组序列的序列杂交，而内含子探针与对应于未剪接的mRNA中存在的内含子序列的序列杂交。外显子探针特异性地与对应于该基因的外显子序列的序列杂交。内含子探针和外显子探针可以各自用作内部对照。本发明还具有使用阵列分析样品中的mRNA剪接产物的方法。

3. 发明申请

US20120185178A1 Methods and Computer Software for Detecting Splice Variants 审中-公开
标题翻译：用于检测接头变体的方法和计算机软件
公开(公告)号：US20120185178A1
公开(公告)日：2012-07-19
申请号：US13431021
申请日：2012-03-27
申请人： Alan Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson Clark
发明人： Alan Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson Clark
IPC分类号： G06F19/20 , G06F17/10
CPC分类号： G06F19/20
摘要： Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.
摘要翻译：公开了用于分析可选拼接的方法和软件产品。一般来说，这些方法涉及将探针组或外显子强度标准化为基因的表达水平测量。该方法可用于鉴定组织特异性选择性剪接事件。

4. 发明申请

US20070148667A1 Methods and computer software for detecting splice variants 有权
标题翻译：用于检测拼接变体的方法和计算机软件
公开(公告)号：US20070148667A1
公开(公告)日：2007-06-28
申请号：US11538054
申请日：2006-10-02
申请人： Alan Williams , Simon Cawley , John Blume , Hui Wang , Tyson Clark
发明人： Alan Williams , Simon Cawley , John Blume , Hui Wang , Tyson Clark
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G06F19/20
摘要： Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.
摘要翻译：公开了用于分析可选拼接的方法和软件产品。一般来说，这些方法涉及将探针组或外显子强度标准化为基因的表达水平测量。该方法可用于鉴定组织特异性选择性剪接事件。

5. 发明授权

US10275568B2 Methods and computer software for detecting splice variants 有权
公开(公告)号：US10275568B2
公开(公告)日：2019-04-30
申请号：US13431021
申请日：2012-03-27
申请人： Alan Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson Clark
发明人： Alan Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson Clark
IPC分类号： G06F19/20
摘要： Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.

6. 发明授权

US07962291B2 Methods and computer software for detecting splice variants 有权
标题翻译：用于检测拼接变体的方法和计算机软件
公开(公告)号：US07962291B2
公开(公告)日：2011-06-14
申请号：US11538054
申请日：2006-10-02
申请人： Alan Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson Clark
发明人： Alan Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson Clark
IPC分类号： G06F19/00 , C12N15/11
CPC分类号： G06F19/20
摘要： Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.
摘要翻译：公开了用于分析选择性拼接的方法和软件产品。一般来说，这些方法涉及将探针组或外显子强度标准化为基因的表达水平测量。该方法可用于鉴定组织特异性选择性剪接事件。

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