专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1984003947A1 METHOD FOR DETECTING AND MEASURING BY FLUORESCENCE A CELLULAR ENDOCYTOSIS DEPENDING ON PROTEINS OF THE CELL MEMBRANE 审中-公开
标题翻译：通过荧光检测和测量依赖于细胞膜蛋白质的细胞内源性肿瘤的方法
公开(公告)号：WO1984003947A1
公开(公告)日：1984-10-11
申请号：PCT/FR1984000094
申请日：1984-04-06
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ... , LESERMAN, Lee, Daniel , TRUNEH, Alemseged , BARBET, Jacques , MACHY, Patrick, Simon, Jacques
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ...
IPC分类号： G01N33/54
CPC分类号： G01N33/48 , G01N33/5432 , G01N33/56966 , G01N33/586
摘要： Method for detecting and measuring a cellular endocytosis by contacting with a predetermined ligand cells to be analyzed, which comprises contacting those cells and said ligand with liposomes modified by covalent coupling to a molecule itself capable of fixing on said ligand and retaining by encapsulation a fluorochrome solution, characterized in that the fluorochrome concentration of the encapsulated solution is initially sufficiently high to ensure a self-extinction of its fluorescence and in that is measured the suppression at least partial of the self-extinction of the fluorescence which results from the internalization of said modified liposomes.

2. 发明申请

WO2004098524A2 LIPID PLATINUM COMPLEXES AND METHODS OF USE THEREOF 审中-公开
标题翻译： LIPID PLATINUM复合物及其使用方法
公开(公告)号：WO2004098524A2
公开(公告)日：2004-11-18
申请号：PCT/US2004013727
申请日：2004-05-03
申请人： ARONEX PHARMACERUTICALS INC , DZIEWISZEK KRZYSZTOF J , TRUNEH ALEMSEGED
发明人： DZIEWISZEK KRZYSZTOF J , TRUNEH ALEMSEGED
IPC分类号： A61K20060101 , A61K9/127 , C07F15/00 , A61K
CPC分类号： C07F15/0093 , A61K9/127
摘要： This invention provides novel lipid platinum complexes, liposomally encapsulated lipid platinum complexes, pharmaceutical compositions comprising a lipid platinum complex, and methods for treating cancer using a lipid platinum complex. Kits comprising a unit dosage form of a compound or composition of the invention are also provided.
摘要翻译：本发明提供新颖的脂质铂络合物，脂质体包封的脂质铂络合物，包含脂质铂络合物的药物组合物，以及使用脂质铂复合物治疗癌症的方法。还提供了包含本发明化合物或组合物的单位剂型的试剂盒。

3. 发明申请

WO1993001193A1 MARINE COMPOUNDS AS HIV INHIBITORS 审中-公开
标题翻译：海洋化合物作为艾滋病毒抑制剂
公开(公告)号：WO1993001193A1
公开(公告)日：1993-01-21
申请号：PCT/US1992005517
申请日：1992-06-30
申请人： SMITHKLINE BEECHAM CORPORATION , MAI, Shing, Huey , NAGULAPALLI, Vasant, Kumar , PATIL, Ashok, D. , TRUNEH, Alemseged , WESTLEY, John, W.
发明人： SMITHKLINE BEECHAM CORPORATION
IPC分类号： C07D487/16
CPC分类号： C07D487/16 , C07D519/00
摘要： The present invention discloses novel marine compounds, and derivatives thereof, which inhibit HIV-1 infection.
摘要翻译：本发明公开了抑制HIV-1感染的新型海洋化合物及其衍生物。

4. 发明申请

WO2008146101A1 LIGANDS OF HVEM FOR TREATING HEMATOLOGIC MALIGNANCIES AND AUTOIMMUNE DISEASES 审中-公开
标题翻译： HVEM用于治疗血液恶性肿瘤和自身免疫疾病的配体
公开(公告)号：WO2008146101A1
公开(公告)日：2008-12-04
申请号：PCT/IB2007/053425
申请日：2007-06-01
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , OLIVE, Daniel , TRUNEH, Alemseged
发明人： OLIVE, Daniel , TRUNEH, Alemseged
IPC分类号： A61K39/00 , C07K14/705 , C07K16/00
CPC分类号： C07K16/2878 , A61K38/191 , A61K39/39558 , C07K14/70575 , C07K2317/73 , C07K2317/75 , A61K2300/00
摘要： The present invention relates to ligands of HVEM for the treatment of hematologic malignancies, in particular Chronic lymphocytic leukaemia, and for the treatment of autoimmune diseases.
摘要翻译：本发明涉及HVEM的配体，用于治疗血液恶性肿瘤，特别是慢性淋巴细胞性白血病，并用于治疗自身免疫性疾病。

5. 发明申请

WO2008145754A2 LIGANDS OF HVEM FOR TREATING HEMATOLOGIC MALIGNANCIES AND AUTOIMMUNE DISEASES 审中-公开
标题翻译：用于治疗血液恶性疾病和自发性疾病的HVEM系统
公开(公告)号：WO2008145754A2
公开(公告)日：2008-12-04
申请号：PCT/EP2008/056756
申请日：2008-06-02
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , UNIVERSITE DE LA MEDITERRANEE , OLIVE, Daniel , TRUNEH, Alemseged , PASERO, Christine
发明人： OLIVE, Daniel , TRUNEH, Alemseged , PASERO, Christine
IPC分类号： A61K39/00 , C07K14/705 , C07K16/00
CPC分类号： C07K16/2878 , A61K38/191 , A61K39/39558 , C07K14/70575 , C07K2317/73 , C07K2317/75 , A61K2300/00
摘要： The present invention relates to ligands of HVEM for the treatment of hematologic malignancies, in particular Chronic lymphocytic leukaemia, and for the treatment of autoimmune diseases.
摘要翻译：本发明涉及用于治疗血液恶性肿瘤，特别是慢性淋巴细胞性白血病和用于治疗自身免疫性疾病的HVEM的配体。

6. 发明申请

WO1992009625A1 CONFORMATIONALLY CONSTRAINED PEPTIDES I 审中-公开
标题翻译：一致的约束肽
公开(公告)号：WO1992009625A1
公开(公告)日：1992-06-11
申请号：PCT/US1991008873
申请日：1991-11-27
申请人： SMITHKLINE BEECHAM CORPORATION , THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY ... , BHATNAGAR, Pradip, Kumar , JARLAIS, Renee, Louise, Des , DIXON, James, Scott , HENDRICKSON, Wayne, Arthur , KOPPLE, Kenneth, D. , KWONG, Peter , PEISHOFF, Catherine, Elizabeth , RYU, Seong-Eon , TRUNEH, Alemseged , SWEET, Raymond, W.
发明人： SMITHKLINE BEECHAM CORPORATION , THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY ...
IPC分类号： C07K05/10
CPC分类号： C07K14/70514 , A61K38/00 , C07K16/00 , C07K2319/00
摘要： The present invention discloses compounds that inhibit HIV infection by mimicking stereochemical regions of the CD4 receptor protein.
摘要翻译：本发明公开了通过模拟CD4受体蛋白质的立体化学区域来抑制HIV感染的化合物。

7. 发明授权

EP2157981B1 LIGANDS OF HVEM FOR TREATING HEMATOLOGIC MALIGNANCIES 有权
标题翻译： HVEM可用于治疗恶性血液病配体
公开(公告)号：EP2157981B1
公开(公告)日：2013-08-14
申请号：EP08760343.7
申请日：2008-06-02
申请人： Olive, Daniel , Truneh, Alemseged
发明人： OLIVE, Daniel , TRUNEH, Alemseged , PASERO, Christine
IPC分类号： A61K39/395 , A61K38/19 , C07K14/705 , C07K16/28 , A61P35/02
CPC分类号： C07K16/2878 , A61K38/191 , A61K39/39558 , C07K14/70575 , C07K2317/73 , C07K2317/75 , A61K2300/00

8. 发明申请

WO2008145754A3 LIGANDS OF HVEM FOR TREATING HEMATOLOGIC MALIGNANCIES AND AUTOIMMUNE DISEASES 审中-公开
标题翻译：用于治疗血液恶性疾病和自发性疾病的HVEM系统
公开(公告)号：WO2008145754A3
公开(公告)日：2009-07-30
申请号：PCT/EP2008056756
申请日：2008-06-02
申请人： INST NAT SANTE RECH MED , UNIV AIX MARSEILLE II , OLIVE DANIEL , TRUNEH ALEMSEGED , PASERO CHRISTINE
发明人： OLIVE DANIEL , TRUNEH ALEMSEGED , PASERO CHRISTINE
IPC分类号： A61K39/395 , A61P35/02 , A61P37/06 , C07K14/705 , C07K16/28
CPC分类号： C07K16/2878 , A61K38/191 , A61K39/39558 , C07K14/70575 , C07K2317/73 , C07K2317/75 , A61K2300/00
摘要： The present invention relates to ligands of HVEM for the treatment of hematologic malignancies, in particular Chronic lymphocytic leukaemia, and for the treatment of autoimmune diseases.
摘要翻译：本发明涉及用于治疗血液恶性肿瘤，特别是慢性淋巴细胞性白血病和用于治疗自身免疫性疾病的HVEM的配体。

9. 发明申请

WO2006084248A3 COMPOSITIONS COMPRISING A PLATINUM COMPLEX, LIPID, AND SURFACTANT 审中-公开
标题翻译：包含铂复合物，脂质和表面活性剂的组合物
公开(公告)号：WO2006084248A3
公开(公告)日：2006-12-07
申请号：PCT/US2006004152
申请日：2006-02-06
申请人： ANTIGENICS INC , TRUNEH ALEMSEGED , DZIEWISZEK KRZYSZTOF , LUI GUI
发明人： TRUNEH ALEMSEGED , DZIEWISZEK KRZYSZTOF , LUI GUI
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/19
摘要： Disclosed are compositions comprising a lipid, a surfactant, and a platinum complex having the formula II: Pt R K9/ \ K7 (II) wherein R6 and R7 each independently represent a leaving group; wherein R8 and R9 are each amines substituted by a group selected from a substituted or unsubstituted alkyl, -aryl, -arylalkyl, heteroalkyl, heterocyclyl, heteroaryl, heteroarylalkyl, -alkenyl, -cycloalkyl, or -cycloalkenyl groups having between 4 and 20 carbon atoms; or R8 and R9 are linked together as represented by formula (Ha): (Ha) and wherein said lipid is capable of forming a liposome. The compositions of the invention are more stable (e.g., resistant to solids formation) than are conventional liposomal platinum compositions which do not contain a surfactant. Also disclosed are methods for making the compositions and the use of the compositions for treating or preventing cancer.
摘要翻译：公开了包含脂质，表面活性剂和具有式II的铂络合物的组合物：其中R 6和R 7各自独立地表示离去基团; 其中R8和R9各自被选自取代或未取代的烷基，芳基， - 芳基烷基，杂烷基，杂环基，杂芳基，杂芳基烷基， - 烯基， - 环烷基或具有4-20个碳原子的 - 环烯基 ; 或者R 8和R 9连接在一起，如式（IIa）所示：（IIa），并且其中所述脂质能够形成脂质体。本发明的组合物比不含表面活性剂的常规脂质体铂组合物更稳定（例如耐固体形成）。还公开了制备组合物和组合物用于治疗或预防癌症的方法。

10. 发明申请

WO2005028496A2 VACCINE FOR TREATMENT AND PREVENTION OF HERPES SIMPLEX VIRUS INFECTION 审中-公开
标题翻译：疫苗用于治疗和预防疱疹单纯疱疹病毒感染
公开(公告)号：WO2005028496A2
公开(公告)日：2005-03-31
申请号：PCT/US2004/029908
申请日：2004-09-13
申请人： ANTIGENICS, INC. , TRUNEH, Alemseged , LEVEY, Daniel, L. , MO, Xiaoyan , LECLAIR, Kenneth, P. , KASHI, Ramesh, S. , LIU, Chuanliang
发明人： TRUNEH, Alemseged , LEVEY, Daniel, L. , MO, Xiaoyan , LECLAIR, Kenneth, P. , KASHI, Ramesh, S. , LIU, Chuanliang
IPC分类号： C07K
CPC分类号： A61K39/245 , A61K36/185 , A61K39/00 , A61K39/12 , A61K39/39 , A61K39/395 , A61K45/06 , A61K2039/555 , A61K2039/55566 , A61K2039/55577 , A61K2039/55583 , C07K14/005 , C12N2710/16622 , C12N2710/16634 , C12N2710/16671
摘要： The present invention relates to methods and compositions for the prevention and treatment of herpes virus infections. The invention provides antigenic peptides, and pharmaceutical compositions comprising complexes of antigenic peptides and adjuvants that can activate an immune response against herpes viruses. The invention also provides methods of making the antigenic peptides and complexes of antigenic peptides and adjuvants. Methods of use of the pharmaceutical compositions are also provided.
摘要翻译：本发明涉及用于预防和治疗疱疹病毒感染的方法和组合物。本发明提供了抗原肽和包含抗原肽和佐剂的复合物的药物组合物，其可以激活针对疱疹病毒的免疫应答。本发明还提供了制备抗原肽和佐剂的抗原肽和复合物的方法。还提供了药物组合物的使用方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式