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1. 发明授权

US09132130B2 Purine derivative and antitumor agent using same 有权
标题翻译：嘌呤衍生物和抗肿瘤剂
公开(公告)号：US09132130B2
公开(公告)日：2015-09-15
申请号：US13266681
申请日：2010-04-28
申请人： Toshiaki Suzuki , Hideki Satoh , Toshiyuki Matsuno , Kenichi Saitoh , Soichi Ohta , Manami Masuda , Shinichi Yaguchi , Ichiro Koshimizu , Yuriko Watanabe , Yoshie Minowa , Masayuki Takahashi , Tomoyoshi Kayou
发明人： Toshiaki Suzuki , Hideki Satoh , Toshiyuki Matsuno , Kenichi Saitoh , Soichi Ohta , Manami Masuda , Shinichi Yaguchi , Ichiro Koshimizu , Yuriko Watanabe , Yoshie Minowa , Masayuki Takahashi , Tomoyoshi Kayou
IPC分类号： A61K31/52 , C07D473/36 , C07D487/12 , C07D473/24 , A61K31/5377
CPC分类号： A61K31/52 , A61K31/5377 , C07D473/24
摘要： Disclosed are: a novel purine derivative, a composition thereof, a method for treating tumor using the purine derivative, and an antitumor agent using the purine derivative. Specifically disclosed is a compound represented by formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, or a prodrug thereof.
摘要翻译：公开了一种新型嘌呤衍生物，其组合物，使用嘌呤衍生物治疗肿瘤的方法，以及使用嘌呤衍生物的抗肿瘤剂。具体公开的是由式（I）表示的化合物或其药学上可接受的盐，溶剂合物或水合物或其前药。

2. 发明申请

US20140171452A1 METHODS FOR TREATING DEPRESSION, NEURODEGENERATION, INHIBITING AMYLOID BETA DEPOSITION, DELAYING SENESCENCE, AND EXTENDING LIFE SPANS WITH HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：用于治疗衰老，神经细胞减少，抑制淀粉样蛋白沉积，延迟感觉和延长生命间隔的方法用异源化合物
公开(公告)号：US20140171452A1
公开(公告)日：2014-06-19
申请号：US14178425
申请日：2014-02-12
申请人： Yoshimasa YAMAGUCHI , Ryogo YUI , Toshiyuki MATSUNO , Kenichi SAITOH , Hitoshi MIYASHITA , Takeshi NAGATA
发明人： Yoshimasa YAMAGUCHI , Ryogo YUI , Toshiyuki MATSUNO , Kenichi SAITOH , Hitoshi MIYASHITA , Takeshi NAGATA
IPC分类号： A61K31/437 , A61K31/4745 , A61K31/519 , A61K31/444 , A61K31/429
CPC分类号： A61K31/437 , A61K31/40 , A61K31/4015 , A61K31/425 , A61K31/426 , A61K31/429 , A61K31/438 , A61K31/444 , A61K31/4745 , A61K31/495 , A61K31/519 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D513/04 , C07D513/20
摘要： Disclosed is an antidepressant, neuroprotectant, amyloid β deposition inhibitor, or age retardant composition containing a heterocyclic compound having the general formula (I):
摘要翻译：公开了一种抗抑郁药，神经保护剂，淀粉样蛋白沉积抑制剂或含有具有通式（I）的杂环化合物的阻燃剂组合物：

3. 发明授权

US08563715B2 Pyrimidine derivative having cell protecting effect and uses thereof 失效
标题翻译：具有细胞保护作用的嘧啶衍生物及其用途
公开(公告)号：US08563715B2
公开(公告)日：2013-10-22
申请号：US12935391
申请日：2009-03-31
申请人： Takeshi Nagata , Toshiaki Suzuki , Akira Yoshimura , Naoto Tadano , Toshiyuki Matsuno , Hideki Satoh , Kenichi Saitoh , Soichi Ohta
发明人： Takeshi Nagata , Toshiaki Suzuki , Akira Yoshimura , Naoto Tadano , Toshiyuki Matsuno , Hideki Satoh , Kenichi Saitoh , Soichi Ohta
IPC分类号： C07D239/26 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/4545 , A61K31/496 , A61K31/506 , A61P25/00
CPC分类号： C07D239/50 , C07D239/46 , C07D239/48 , C07D239/49 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D409/06 , C07D417/04 , C07D495/04
摘要： [Problem] To provide a prophylactic/therapeutic agent against, for example, nerve diseases and the like such as ischemic brain disease and neurodegenerative disease, or a prophylactic/therapeutic agent against diseases against which antioxidant action is effective, as a cell protecting agent, in particular as an inhibitor of brain cell damage or brain cell death.[Means of Solving the Problem]A compound represented by Formula (1), or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof:
摘要翻译：作为细胞保护剂，可以提供例如神经疾病等缺血性脑病和神经退行性疾病的预防/治疗剂或抗氧化剂作用有效的疾病的预防/治疗剂，特别是作为脑细胞损伤或脑细胞死亡的抑制剂。解决问题的方法由式（1）表示的化合物或其药学上可接受的盐，溶剂化物，水合物或前药：

4. 发明申请

US20120325883A1 CONNECTING ROD FRACTURE SPLITTING METHOD AND APPARATUS THEREFOR 审中-公开
标题翻译：连接骨折分割方法及其设备
公开(公告)号：US20120325883A1
公开(公告)日：2012-12-27
申请号：US13530195
申请日：2012-06-22
申请人： Tatsushi KAIHO , Shigenori YAMADA , Osahiko HORII , Toshiyuki MATSUNO , Satoru KOBAYASHI
发明人： Tatsushi KAIHO , Shigenori YAMADA , Osahiko HORII , Toshiyuki MATSUNO , Satoru KOBAYASHI
IPC分类号： B26F3/00
CPC分类号： F16C7/02 , F16C9/045 , Y10T225/10 , Y10T225/35
摘要： The connecting rod as a vehicle engine component is manufactured by a connecting rod fracture splitting method. The connecting rod is provided with a large end portion, a small end portion and a rod portion connecting the large and small end portions, the large end portion being provided with a connecting rod body and a cap which are split from each other along a fracture-split surface formed thereto. The connecting rod is subjected to fracture splitting by inserting a large end-side shaft into a through hole formed in the large end portion, fixing the large end-side shaft to a large end-side support, inserting a small end-side shaft into a through hole formed in the small end portion, fixing the small end-side shaft to a small end-side support, and pulling at least one of the large end-side support and small end-side support away from another one of both the supports.
摘要翻译：作为车辆发动机部件的连杆通过连杆断裂方法制造。连杆具有大的端部，小端部和连接大小端部的杆部，大端部设置有沿着断裂线彼此分离的连杆体和帽部形成的平面表面。连接杆通过将大型端侧轴插入形成在大端部的通孔中而进行断裂，将大端侧轴固定在大端侧支撑件上，将小端侧轴插入形成在所述小端部的通孔，将所述小端侧轴固定在小端侧支撑体上，并将所述大端侧支撑体和小端侧支撑体中的至少一方远离所述两端部支持。

5. 发明申请

US20110219613A1 CONNECTING ROD FRACTURE SPLITTING APPARATUS AND FRACTURE SPLITTING METHOD 失效
标题翻译：连接骨折分割装置和骨折分割方法
公开(公告)号：US20110219613A1
公开(公告)日：2011-09-15
申请号：US13022024
申请日：2011-02-07
申请人： Shigenori Yamada , Osahiko Horii , Toshiyuki Matsuno
发明人： Shigenori Yamada , Osahiko Horii , Toshiyuki Matsuno
IPC分类号： B21D53/84 , B23P19/00
CPC分类号： F16C9/045 , Y10T29/49288 , Y10T29/53683 , Y10T225/30 , Y10T225/371
摘要： A fracture splitting jig is fitted into a crank pin hole of a connecting rod, and a fracture load is applied in a longitudinal direction of the connecting rod via the fracture splitting jig to thereby fracture a big end of the connecting rod. A mandrel as the fracture splitting jig is divided into four parts to be separable from each other in a longitudinal direction of the connecting rod and in a direction orthogonal to the longitudinal direction. When the big end is fractured, a fractured portion thereof is allowed to come in contact with a predetermined portion of the fracture splitting jig.
摘要翻译：断裂夹具装配在连杆的曲柄销孔中，通过断裂夹具沿连杆的长度方向施加断裂载荷，从而破坏连杆的大端。作为断裂夹具的心轴被分成四个部分，以在连杆的纵向方向上和沿与纵向方向正交的方向彼此分离。当大端部断裂时，其断裂部分与断裂分割夹具的预定部分接触。

6. 发明授权

US07901822B2 Fuel cell and voltage supply method 失效
标题翻译：燃料电池和电压供应方式
公开(公告)号：US07901822B2
公开(公告)日：2011-03-08
申请号：US10558573
申请日：2004-06-01
申请人： Toshiyuki Matsuno , Chiaki Kanai
发明人： Toshiyuki Matsuno , Chiaki Kanai
IPC分类号： H01M8/04 , H01M8/24
CPC分类号： H01M8/249 , H01M8/04604 , H01M8/0488 , H01M8/04925 , H01M8/0494
摘要： Disclosed herein are a fuel cell and a voltage supply method which are designed to supply power to various electric circuits in a stable manner.The fuel cell of stack structure with output terminals attached to different generating elements as mentioned above produces a potential across the output electrodes which corresponds to the number of generating cells connected in series. The output terminals are connected respectively to the potential regulators varying in the allowable voltage range and the ratio of voltage conversion. A large output voltage is obtained if the generating units are connected in series, and a large output current is obtained if the generating units are connected in parallel. Thus the fuel cell can supply an adequate amount of power in response to load operation.
摘要翻译：这里公开了一种燃料电池和电压供给方法，其被设计成以稳定的方式向各种电路供电。如上所述，具有连接到不同发电元件的输出端子的堆叠结构的燃料电池在输出电极上产生对应于串联连接的发电单元的数量的电位。输出端子分别连接到电压调节器，其允许电压范围和电压转换比率变化。如果生成单元串联连接，则获得大的输出电压，并且如果发电单元并联连接则获得大的输出电流。因此，燃料电池可以响应于负载操作而提供足够的功率。

7. 发明申请

US20100267700A1 IMMUNOSUPPRESSIVE AGENT AND ANTI-TUMOR AGENT COMPRISING HETEROCYCLIC COMPOUND AS ACTIVE INGREDIENT 有权
标题翻译：含有作为活性成分的杂环化合物的免疫抑制剂和抗肿瘤剂
公开(公告)号：US20100267700A1
公开(公告)日：2010-10-21
申请号：US12785683
申请日：2010-05-24
申请人： Kazuhiko Haruta , Shinichi Yaguchi , Toshiyuki Matsuno , Yoshio Tsuchida , Tetsuo Watanabe , Kimitomo Yoshioka , Ryogo Yui
发明人： Kazuhiko Haruta , Shinichi Yaguchi , Toshiyuki Matsuno , Yoshio Tsuchida , Tetsuo Watanabe , Kimitomo Yoshioka , Ryogo Yui
IPC分类号： A61K31/551 , A61K31/5377 , C07D413/14 , A61P37/06 , A61P35/00 , A61P17/00 , A61P19/02
CPC分类号： C07D403/04 , A61K31/5377 , C07D403/14 , C07D413/14
摘要： A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.
摘要翻译：一种在患有免疫疾病的哺乳动物中免疫抑制的新方法，包括向哺乳动物施用治疗有效量的由通式（I）表示的杂环化合物（其中X或其它变量如说明书中所定义）或公开了其药学上可接受的盐。还公开了由通式（II）表示的新型杂环化合物（其中X或其它变量如本说明书中所定义）或其药学上可接受的盐。

8. 发明申请

US20080103157A1 METHODS FOR TREATING DEPRESSION, NEURODEGENERATION, INHIBITING AMYLOID BETA DEPOSITION, DELAYING SENESCENCE, AND EXTENDING LIFE SPANS WITH HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：用于治疗衰老，神经细胞减少，抑制淀粉样蛋白沉积，延迟感觉和延长生命间隔的方法用异源化合物
公开(公告)号：US20080103157A1
公开(公告)日：2008-05-01
申请号：US11872408
申请日：2007-10-15
申请人： Yoshimasa Yamaguchi , Ryogo Yui , Toshiyuki Matsuno , Kenichi Saitoh , Hitoshi Miyashita , Takeshi Nagata
发明人： Yoshimasa Yamaguchi , Ryogo Yui , Toshiyuki Matsuno , Kenichi Saitoh , Hitoshi Miyashita , Takeshi Nagata
IPC分类号： A61K31/437 , A61K31/438 , A61K31/519 , A61P25/00
CPC分类号： A61K31/437 , A61K31/40 , A61K31/4015 , A61K31/425 , A61K31/426 , A61K31/429 , A61K31/438 , A61K31/444 , A61K31/4745 , A61K31/495 , A61K31/519 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D513/04 , C07D513/20
摘要： Disclosed is an antidepressant, neuroprotectant, amyloid β deposition inhibitor, or age retardant composition containing a heterocyclic compound having the general formula (I):
摘要翻译：公开了一种抗抑郁药，神经保护剂，淀粉样蛋白β沉积抑制剂或含有通式（I）的杂环化合物的阻燃剂组合物：

9. 发明申请

US20070244110A1 Treatment of prostate cancer, melanoma or hepatic cancer 审中-公开
标题翻译：前列腺癌，黑色素瘤或肝癌的治疗
公开(公告)号：US20070244110A1
公开(公告)日：2007-10-18
申请号：US11404078
申请日：2006-04-14
申请人： Shinichi Yaguchi , Ichiro Koshimizu , Hisashi Yoshimi , Toshiyuki Matsuno , Tetsuo Watanabe , Yoshio Tsuchida , Kenichi Saitoh
发明人： Shinichi Yaguchi , Ichiro Koshimizu , Hisashi Yoshimi , Toshiyuki Matsuno , Tetsuo Watanabe , Yoshio Tsuchida , Kenichi Saitoh
IPC分类号： A61K31/5377
CPC分类号： A61K31/5377
摘要： The present application describes a method of treating prostate cancer, melanoma or hepatic cancer in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of the heterocyclic compound represented by Formula I or its pharmaceutically acceptable salt:
摘要翻译：本申请描述了在有需要的受试者中治疗前列腺癌，黑素瘤或肝癌的方法，所述方法包括向所述受试者施用治疗有效量的由式I表示的杂环化合物或其药学上可接受的盐：

10. 发明申请

US20060009440A1 Heterocyclic compounds and antitumor drugs containing the same as the active ingredient 有权
标题翻译：含有与活性成分相同的杂环化合物和抗肿瘤药物
公开(公告)号：US20060009440A1
公开(公告)日：2006-01-12
申请号：US10532245
申请日：2003-10-24
申请人： Seiichiro Kawashima , Toshiyuki Matsuno , Shinichi Yaguchi , Yoshio Tsuchida , Kenichi Saitoh , Hiroya Sasahara , Tetsuo Watanabe
发明人： Seiichiro Kawashima , Toshiyuki Matsuno , Shinichi Yaguchi , Yoshio Tsuchida , Kenichi Saitoh , Hiroya Sasahara , Tetsuo Watanabe
IPC分类号： A61K31/33
CPC分类号： A61K31/5377 , C07D403/04 , C07D403/14
摘要： The present invention relates to heterocyclic compounds represented by the formula I wherein X represents nitrogen atom or CH; R1 represents halogen atom or hydroxyl; R2 represents hydrogen atom, hydroxyl or amino; R3 represents morpholino (which may be substituted with one or two C1-C6 alkyl), pyrrolidinyl (which may be substituted with hydroxy C1-C6 alkyl) or NR6R7 [R6 represents C1-C6 alkyl and R7 represents piperidinyl (which may be substituted with C1-C6 alkyl)]; R4 and R5 each represents hydrogen atom or C1-C6 alkyl, with the proviso that R2 is hydrogen atom and R3 is pyrrolidinyl (which may be substituted with hydroxy C1-C6 alkyl) when R1 is hydroxyl
摘要翻译：本发明涉及由式I表示的杂环化合物，其中X表示氮原子或CH; R 1表示卤素原子或羟基; R 2表示氢原子，羟基或氨基; R 3表示吗啉代（其可以被一个或两个C 1 -C 6烷基取代），吡咯烷基（其可以被羟基 C 1 -C 6烷基）或NR 6 R 7 - [R 6 - 表示C 1 -C 6烷基，R 7表示哌啶基（其可以被C 1 -C 6烷基取代）烷基）]; R 4和R 5各自代表氢原子或C 1 -C 6烷基，条件是R R 2是氢原子，R 3是吡咯烷基（其可以被羟基C 1 -C 6烷基取代））当R 1为羟基时

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