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1. 发明授权

US06875860B2 Method for purifying 5′ -protected thymidines and novel derivatives thereof 失效
标题翻译： 5'保护胸腺嘧啶及其新型衍生物的纯化方法
公开(公告)号：US06875860B2
公开(公告)日：2005-04-05
申请号：US10144802
申请日：2002-05-15
申请人： Hironori Komatsu , Toshiyuki Kouno , Katsutoshi Tsuchiya , Hiroharu Tanikawa , Hiroki Ishibashi
发明人： Hironori Komatsu , Toshiyuki Kouno , Katsutoshi Tsuchiya , Hiroharu Tanikawa , Hiroki Ishibashi
IPC分类号： C07H19/067 , C07H19/06 , C07H19/073 , B01D9/02
CPC分类号： C07H19/06
摘要： This invention provides a method for efficiently purifying 5′-protected thymidines which cannot be efficiently purified by the prior art. Impurities can be separated by obtaining crystals including a carbonyl-containing solvent to provide a highly pure 5′-protected thymidine. Thus, this invention allows 5′-protected thymidines, which cannot be purified in an industrial scale by the prior art, to be easily provided with a high purity in a large scale.
摘要翻译：本发明提供了一种有效提纯现有技术无法有效纯化的5'保护的胸腺嘧啶的方法。可以通过获得包含含羰基溶剂的晶体来分离杂质，以提供高度纯的5'-保护的胸苷。因此，本发明允许通过现有技术不能以工业规模纯化的5受保护的胸苷以容易的大规模提供高纯度。

2. 发明授权

US09397572B2 Control apparatus for DC-DC converter 有权
标题翻译： DC-DC转换器控制装置
公开(公告)号：US09397572B2
公开(公告)日：2016-07-19
申请号：US13561453
申请日：2012-07-30
申请人： Yuuki Suzuki , Toshiyuki Kouno , Shinya Goto
发明人： Yuuki Suzuki , Toshiyuki Kouno , Shinya Goto
IPC分类号： H02M3/335 , H02M1/32 , H02J7/14 , H02M1/00
CPC分类号： H02M3/33507 , H02J7/1423 , H02M1/32 , H02M2001/0022
摘要： An apparatus controls a DC-DC converter that converts an input voltage to an output voltage. The DC-DC converter includes a switching element having a duty ratio controlled by the apparatus to regulate the output voltage, a first transformer, a second transformer and a capacitor. A terminal voltage applied between input and output terminals of the switching element varies depending on the duty ratio and the input voltage. The apparatus may be configured to: limit the duty ratio in response to the input voltage represented by a modulated signal; enable the DC-DC converter to continue to convert the input voltage to the output voltage when an abnormal condition of the modulated signal is determined; and limit the duty ratio of the switching element when the abnormal condition is determined. Main and sub switching elements of the switching element and the capacitor are disposed between the first and second transformers.
摘要翻译：一种装置控制将输入电压转换为输出电压的DC-DC转换器。 DC-DC转换器包括具有由该装置控制的负载比来调节输出电压的开关元件，第一变压器，第二变压器和电容器。施加在开关元件的输入和输出端子之间的端子电压根据占空比和输入电压而变化。该装置可以被配置为：响应于由调制信号表示的输入电压来限制占空比; 当确定调制信号的异常状态时，使DC-DC转换器继续将输入电压转换为输出电压; 并且在确定异常状态时限制开关元件的占空比。开关元件和电容器的主开关元件和副开关元件设置在第一和第二变压器之间。

3. 发明申请

US20060009635A1 Method for purifying 5' -protected 2' -deoxypurine nucleosides 失效
标题翻译： 5'保护的2'-脱氧嘌呤核苷的纯化方法
公开(公告)号：US20060009635A1
公开(公告)日：2006-01-12
申请号：US11204009
申请日：2005-08-16
申请人： Hironori Komatsu , Toshiyuki Kouno , Katsutoshi Tsuchiya
发明人： Hironori Komatsu , Toshiyuki Kouno , Katsutoshi Tsuchiya
IPC分类号： C07H19/22 , C07H19/048
CPC分类号： C07H19/16 , C07H1/06
摘要： A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5′ protected 2′-deoxypurine nucleoside at a high purity. This invention enables synthesis of highly purified, protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.
摘要翻译：一种有效纯化5'保护的2'-脱氧嘌呤核苷的方法，其有效生产以前是困难的。通过获得5'保护的2'-脱氧嘌呤核苷作为包含具有腈结构的溶剂的夹杂晶体以便以高纯度纯化5'保护的2'-脱氧嘌呤核苷可以分离杂质。本发明能够容易地大规模合成高纯度的保护的脱氧嘌呤核苷，其先前通过柱色谱法进行。

4. 发明授权

US06958391B2 Method for purifying 5′-protected 2′-deoxypurine nucleosides 失效
标题翻译： 5'-保护的2'-脱氧嘌呤核苷的纯化方法
公开(公告)号：US06958391B2
公开(公告)日：2005-10-25
申请号：US10120500
申请日：2002-04-12
申请人： Hironori Komatsu , Toshiyuki Kouno , Katsutoshi Tsuchiya
发明人： Hironori Komatsu , Toshiyuki Kouno , Katsutoshi Tsuchiya
IPC分类号： C07H19/173 , C07H1/06 , C07H19/16 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C07H19/16 , C07H1/06
摘要： A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5′ protected 2′-deoxypurine nucleoside at a high purity. This invention enables synthesis of highly purified protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.
摘要翻译：一种有效纯化5'保护的2'-脱氧嘌呤核苷的方法，其有效生产以前是困难的。通过获得5'保护的2'-脱氧嘌呤核苷作为包含具有腈结构的溶剂的夹杂晶体以便以高纯度纯化5'保护的2'-脱氧嘌呤核苷可以分离杂质。本发明能够容易地大规模合成高度纯化的保护的脱氧嘌呤核苷，其先前通过柱色谱法进行。

5. 发明授权

US06880230B2 Method for manufacturing yoke of electric rotating machine 有权
标题翻译：电动旋转机械轭铁的制造方法
公开(公告)号：US06880230B2
公开(公告)日：2005-04-19
申请号：US10304549
申请日：2002-11-26
申请人： Takenobu Kawakami , Keijirou Suzuki , Toshiyuki Kouno , Yoshihiro Atsumi
发明人： Takenobu Kawakami , Keijirou Suzuki , Toshiyuki Kouno , Yoshihiro Atsumi
IPC分类号： H02K15/03 , H02K15/00 , H02K15/14 , H02K15/16
CPC分类号： H02K15/03 , Y10T29/49009 , Y10T29/49075 , Y10T29/53143
摘要： A yoke in a motor includes a cylindrical yoke housing having a closed end and two magnets that is located in the yoke housing. The magnets are fixed to the yoke housing with adhesive. The adhesive is applied a at least to each adhering area of the yoke housing that is to be adhered to the corresponding magnet or to an adhering area of the each magnet that is to be adhered to the yoke housing. The adhesive is spread to the adhering areas of the yoke housing and each magnet by sliding the adhering areas on each other. Therefore, the magnets are firmly fixed to the yoke housing with a small amount of adhesive.
摘要翻译：电动机中的磁轭包括具有闭合端的圆柱形磁轭壳体和位于磁轭壳体中的两个磁体。磁铁用粘合剂固定在轭架上。粘合剂至少施加到要被粘附的轭壳体的每个粘附区域到相应的磁体或者要粘附到轭架的每个磁体的粘附区域。粘合剂通过使粘合区域彼此滑动而扩散到轭壳体和每个磁体的粘合区域。因此，磁体用少量的粘合剂牢固地固定到轭壳体上。

6. 发明申请

US20060249073A1 Method of heat treatment and heat treatment apparatus 审中-公开
标题翻译：热处理和热处理装置的方法
公开(公告)号：US20060249073A1
公开(公告)日：2006-11-09
申请号：US10548825
申请日：2004-03-10
申请人： Yasushi Asaoka , Tadaaki Kaneko , Nakatsu Sano , Hiroshi Kawai , Tomohira Iwazaki , Seiji Yamaguchi , Hiroyuki Matsumoto , Toshiyuki Kouno
发明人： Yasushi Asaoka , Tadaaki Kaneko , Nakatsu Sano , Hiroshi Kawai , Tomohira Iwazaki , Seiji Yamaguchi , Hiroyuki Matsumoto , Toshiyuki Kouno
IPC分类号： C30B23/00 , C30B25/00 , C30B28/12 , C30B28/14
CPC分类号： C30B33/02 , C30B19/00 , C30B29/36
摘要： The present invention is a method suitable for heat treatment, or a heat treatment method for growing single crystal silicon carbide by a liquid phase epitaxial method, wherein a monocrystal silicon carbide substrate as a seed crystal and a polycrystal silicon carbide substrate are piled up, placed inside a closed container, and subjected to high-temperature heat treatment, by which very thin metallic silicon melt layer is interposed between the monocrystal silicon carbide substrate and the polycrystal silicon carbide substrate during heat treatment, and single crystal silicon carbide is liquid-phase epitaxially grown on the monocrystal silicon carbide substrate. The closed container is in advance heated to a temperature exceeding approximately 800° C. in an preheating chamber kept at a pressure of approximately 10−5 Pa or lower, the closed container is reduced in pressure to approximately 10−5 Pa or lower, and the container is transported and placed in the heat chamber, which is in advance heated to a prescribed temperature in a range from approximately 1400° C. to 2300° C., in a vacuum at a pressure of approximately 10−2 Pa or lower or in an inert gas atmosphere at a prescribed reduced pressure, by which the monocrystal silicon carbide substrate and the polycrystal silicon carbide substrate are heated in a short time to a prescribed temperature in a range from approximately 1400° C. to 2300° C. to produce single crystal silicon carbide which is free of fine grain boundaries and approximately 1/cm2 or lower in density of micropipe defects on the surface. Further, the present invention is heat treatment equipment used in carrying out the heat treatment method.
摘要翻译：本发明是适用于热处理的方法，或通过液相外延法生长单晶碳化硅的热处理方法，其中堆积作为晶种的单晶碳化硅基板和多晶碳化硅基板，放置在密闭容器内，进行高温热处理，在热处理过程中，在单晶碳化硅基板和多晶碳化硅基板之间插入非常薄的金属硅熔融层，单晶碳化硅是液相外延生长在单晶碳化硅衬底上。在保持在约10 -5 Pa或更低的压力的预热室中，将密封容器预先加热至超过约800℃的温度，将密封容器减压至约10℃ 低于-5℃，并且将容器输送并放置在预先加热到约1400℃至2300℃范围内的规定温度的加热室中，在在大约10 -2 Pa或更低的压力下或在惰性气体气氛中以规定的减压下的真空，单晶碳化硅衬底和多晶碳化硅衬底在短时间内被加热时间达到在约1400℃至2300℃的范围内的规定温度，以产生不含细晶粒边界和约1 / cm 2或更低密度的单晶碳化硅表面上存在微管缺陷。此外，本发明是用于实施热处理方法的热处理设备。

7. 发明授权

US07074917B2 Method for purifying 5′ -protected 2′ -deoxypurine nucleosides 失效
公开(公告)号：US07074917B2
公开(公告)日：2006-07-11
申请号：US11204009
申请日：2005-08-16
申请人： Hironori Komatsu , Toshiyuki Kouno , Katsutoshi Tsuchiya
发明人： Hironori Komatsu , Toshiyuki Kouno , Katsutoshi Tsuchiya
IPC分类号： C07H19/00
CPC分类号： C07H19/16 , C07H1/06
摘要： A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5′ protected 2′-deoxypurine nucleoside at a high purity. This invention enables synthesis of highly purified, protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.

8. 发明申请

US20130027978A1 CONTROL APPARATUS FOR DC-DC CONVERTER 有权
标题翻译： DC-DC转换器的控制装置
公开(公告)号：US20130027978A1
公开(公告)日：2013-01-31
申请号：US13561453
申请日：2012-07-30
申请人： Yuuki Suzuki , Toshiyuki Kouno , Shinya Goto
发明人： Yuuki Suzuki , Toshiyuki Kouno , Shinya Goto
IPC分类号： H02M3/24
CPC分类号： H02M3/33507 , H02J7/1423 , H02M1/32 , H02M2001/0022
摘要： An apparatus that controls a DC-DC converter including a switching element of which duty ratio is controlled by the apparatus to regulate the output voltage includes: acquiring device for acquiring the input voltage; converting device for converting the input voltage to a modulated signal representing the input voltage; first limiting section for limiting the duty ratio of the switching element in response to the input voltage represented by the modulated signal; first determining section for determining whether or not the modulated signal is in abnormal condition; and enabling section for enabling the DC-DC converter to continue to convert the input voltage to the output voltage when the determining section determines the abnormal condition. The enabling section includes second limiting section for limiting the duty ratio of the switching element, the second limiting section limits the duty ratio of the switching element when the determining section determines the abnormal condition.
摘要翻译：一种控制DC-DC转换器的装置，包括：由装置控制占空比以调节输出电压的开关元件，包括：用于获取输入电压的获取装置; 转换装置，用于将输入电压转换成表示输入电压的调制信号; 第一限制部分，用于响应于由调制信号表示的输入电压来限制开关元件的占空比; 第一确定部分，用于确定调制信号是否处于异常状态; 以及启用部分，用于当确定部分确定异常状况时，使得DC-DC转换器继续将输入电压转换为输出电压。使能部分包括用于限制开关元件的占空比的第二限制部分，当确定部分确定异常状态时，第二限制部分限制开关元件的占空比。

9. 发明授权

US06822090B2 Process for the preparation of cytidine derivatives 失效
标题翻译：胞苷衍生物的制备方法
公开(公告)号：US06822090B2
公开(公告)日：2004-11-23
申请号：US10009805
申请日：2002-03-06
申请人： Kunihiko Morizane , Hiroharu Tanikawa , Toshiyuki Kouno , Hironori Komatsu , Nobuyuki Fukazawa
发明人： Kunihiko Morizane , Hiroharu Tanikawa , Toshiyuki Kouno , Hironori Komatsu , Nobuyuki Fukazawa
IPC分类号： C07H19067
CPC分类号： C07H19/06
摘要： An efficient method for producing cytidine derivatives that took away the previous drawbacks by efficiently synthesizing cytidine derivatives by utilizing a tertiary amine can be provided.
摘要翻译：可以提供通过利用叔胺有效合成胞苷衍生物来产生胞苷衍生物的有效方法，其消除了以前的缺点。

10. 发明授权

US5136042A Process for the preparation of thiazolecarboxylic acid chlorides 失效
标题翻译：制备噻唑烷酮酸氯化物的方法
公开(公告)号：US5136042A
公开(公告)日：1992-08-04
申请号：US465167
申请日：1990-02-01
申请人： Toshiaki Kuwatsuka , Seiichi Watanabe , Yoshinori Tanaka , Toshiyuki Kouno , Katsutoshi Ishikawa
发明人： Toshiaki Kuwatsuka , Seiichi Watanabe , Yoshinori Tanaka , Toshiyuki Kouno , Katsutoshi Ishikawa
IPC分类号： C07D277/56
CPC分类号： C07D277/56
摘要： Disclosed herein is a process for the preparation of a thiazolecarboxylic acid chloride represented by the following general formula (II): ##STR1## wherein R.sub.1 represents a hydrogen or halogen atom, a lower alkyl group, a lower alkoxy group, or a lower alkyl group substituted by a halogen atom or lower alkoxy group, and R.sub.2 represents a hydrogen atom, a lower alkyl group, or a lower alkyl group substituted by a halogen atom or lower alkoxy group, which comprises reacting a thiazolecarboxylic acid represented by the following general formula (I): ##STR2## wherein R.sub.1 and R.sub.2 have the same meanings as defined with respect to formula (II), with phosgene or trichloromethyl chloroformate in the presence or absence of a catalyst.

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