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1. 发明授权

US07421105B2 Method for staining corneocytes, method for preparing corneocytes specimen and skin analysis system 有权
标题翻译：染色角膜细胞的方法，制备角膜细胞标本和皮肤分析系统的方法
公开(公告)号：US07421105B2
公开(公告)日：2008-09-02
申请号：US10848233
申请日：2004-05-18
申请人： Yoshikazu Hirai , Kenya Hirayama , Nobuo Kashibuchi , Sonoko Kawasaki , Hiroaki Imai , Yoko Zemba , Takanori Takahashi , Seiichi Takaya , Chikako Kamata , Toshikazu Yagi , Jiro Yabusaki
发明人： Yoshikazu Hirai , Kenya Hirayama , Nobuo Kashibuchi , Sonoko Kawasaki , Hiroaki Imai , Yoko Zemba , Takanori Takahashi , Seiichi Takaya , Chikako Kamata , Toshikazu Yagi , Jiro Yabusaki
IPC分类号： G06K9/00 , G01N1/30 , G01N33/48 , C12N5/08
CPC分类号： G01N1/30 , G01N2001/302 , G06F19/00
摘要： A method for preparing corneocites specimen, which comprises stripping off corneocites from the surface of a skin using an adhesive material, staining the corneocites in a solution of stain in solvent containing a water-miscible organic solvent, and mounting the stained corneocites into an oil and fat constituent and/or composition that is liquid at 1 atm, 25° C.
摘要翻译：一种制备角膜炎样品的方法，该方法包括使用粘合剂材料从皮肤表面剥离角质结，将含有水混溶性有机溶剂的溶剂中的污渍溶液中的角膜炎染色，并将染色的角质层装入油中，在1atm，25℃下为液体的脂肪成分和/或组合物

2. 发明授权

US5573989A Process for producing olefin oxides 失效
公开(公告)号：US5573989A
公开(公告)日：1996-11-12
申请号：US286337
申请日：1994-08-05
申请人： Keisuke Sugita , Toshikazu Yagi
发明人： Keisuke Sugita , Toshikazu Yagi
IPC分类号： B01J29/89 , C07D301/08 , C07D301/10 , B01J29/04
CPC分类号： C07D301/08 , B01J29/89 , C07D301/10
摘要： A process for producing an olefin oxide comprising oxidizing a corresponding lower olefin with molecular oxygen in the gas phase in the presence of a crystalline metallosilicate having supported thereon at least one salt selected from the group consisting of alkali metal salts of nitric acid, alkaline earth metal salts of nitric acid, silver salts of nitric acid and silver salts of nitrous acid. Said process can produce an olefin oxide at a high selectivity.

3. 发明授权

US5525741A Process for producing olefin oxides 失效
标题翻译：生产烯烃氧化物的方法
公开(公告)号：US5525741A
公开(公告)日：1996-06-11
申请号：US427589
申请日：1995-04-24
申请人： Keisuke Sugita , Toshikazu Yagi
发明人： Keisuke Sugita , Toshikazu Yagi
IPC分类号： B01J29/89 , C07D301/08 , C07D301/10 , C07D303/04
CPC分类号： C07D301/08 , B01J29/89 , C07D301/10
摘要： A process for producing an olefin oxide comprising oxidizing a corresponding lower olefin with molecular oxygen in the gas phase in the presence of a crystalline metallosilicate having supported thereon at least one salt selected from the group consisting of alkali metal salts of nitric acid, alkaline earth metal salts of nitric acid, silver salts of nitric acid and silver salts of nitrous acid. Said process can produce an olefin oxide at a high selectivity.
摘要翻译：一种生产烯烃氧化物的方法，包括在结晶金属硅酸盐的存在下在气相中用分子氧氧化相应的低级烯烃，所述结晶金属硅酸盐在其上负载有至少一种选自硝酸，碱土金属的碱金属盐硝酸盐，硝酸银盐和亚硝酸银盐。所述方法可以高选择性生产烯烃氧化物。

4. 发明申请

US20100187292A1 METHOD AND APPARATUS FOR POSITIONING PLATE MEMBERS TO BE BUTT-WELDED 失效
标题翻译：用于定位要焊接的板材的方法和装置
公开(公告)号：US20100187292A1
公开(公告)日：2010-07-29
申请号：US12717414
申请日：2010-03-04
申请人： Kenji IIMURA , Tomoo Mizuno , Katsura Oowaki , Hirotaka Kanazawa , Chikamasa Iwamoto , Toshikazu Yagi , Hirotaka Shirai
发明人： Kenji IIMURA , Tomoo Mizuno , Katsura Oowaki , Hirotaka Kanazawa , Chikamasa Iwamoto , Toshikazu Yagi , Hirotaka Shirai
IPC分类号： B23K37/04
CPC分类号： B23K37/0408 , B23K37/0461
摘要： It is made possible to position plate members to be butt-welded for formation of weld line in a small amount of time so as to enhance working capacity of butt welding.Plate members 17 are respectively rested on first and second tables 1A and 1B relatively movable toward and away from each other. The plate members 17 are caused to abut against reference positioning members 16a and 16b of reference positioning devices protruded ahead of and over opposing ends 1′ of the tables 1A and 1B so that opposing ends of the plate members 17 are positioned in protrusion ahead of the opposing ends 1′ of the tables 1A and 1B, and the plate members 17 are positioned laterally. Then, the positioned plate members 17 are locked on the tables 1A and 1B. After the reference positioning devices are retracted, the tables 1A and 1B are relatively moved toward each other to cause the opposing ends of the plate members 17 to abut together for formation of weld line X.
摘要翻译：可以在少量的时间内将板构件定位成对接焊接以形成焊接线，以便提高对接焊接的工作能力。板构件17分别搁置在彼此相对移动和相离移动的第一和第二台1A和1B上。使板构件17抵靠在台1A和1B的相对端1'上方突出的基准定位装置的基准定位构件16a和16b，使得板构件17的相对端位于工作台1A和1B的相对端1'和板构件17横向定位。然后，将定位的板构件17锁定在台1A和1B上。在参考定位装置缩回之后，台1A和1B彼此相对移动，使得板构件17的相对端抵靠在一起以形成焊接线X.

5. 发明授权

US06348617B1 Method for purifying pyruvic acid compounds 失效
标题翻译：丙酮酸化合物的纯化方法
公开(公告)号：US06348617B1
公开(公告)日：2002-02-19
申请号：US09284263
申请日：1999-06-21
申请人： Hideki Ushio , Motoo Hazama , Toshikazu Yagi , Akihiko Nakamura , Masahiko Mizuno
发明人： Hideki Ushio , Motoo Hazama , Toshikazu Yagi , Akihiko Nakamura , Masahiko Mizuno
IPC分类号： C09C6966
CPC分类号： C07C67/343 , C07C67/60 , C07C69/716
摘要： The present invention is directed to a method for purifying pyruvic acid compounds, which method comprises reacting a pyruvic acid compound of general formula (I): wherein R1 is an optionally substituted lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl group, an aryl group, or a heterocyclic group, and R2 is a lower alkyl group, with a bisulfite of general formula (II): MHSO3 (II) wherein M is NH4 or an alkali metal, to give a bisulfite adduct of the pyruvic acid compound and then decomposing the adduct with an acid. According to the present invention, pyruvic acid compounds can be purified by simple and easy procedures without using purification techniques such as distillation or column chromatography, and the above method is advantageous as a process for the production on an industrial scale.
摘要翻译：本发明涉及一种纯化丙酮酸化合物的方法，该方法包括使通式（I）的丙酮酸化合物：其中R 1为任选取代的低级烷基，低级烯基，低级炔基，环烷基，芳基或杂环基，R2是低级烷基，与通式（II）的亚硫酸氢盐反应：其中M是NH 4或碱金属，得到丙酮酸化合物的亚硫酸氢盐加合物和然后用酸分解加合物。根据本发明，丙酮酸化合物可以通过简单且简单的方法纯化，而不使用蒸馏或柱色谱法等纯化技术，上述方法作为工业规模生产的方法是有利的。

6. 发明授权

US08598370B2 Process for producing threo-3-(3,4-dihydroxyphenyl)-L-serine 有权
标题翻译：制备苏-30-（3,4-二羟基苯基）-L-丝氨酸的方法
公开(公告)号：US08598370B2
公开(公告)日：2013-12-03
申请号：US13380205
申请日：2010-06-29
申请人： Toshikazu Yagi , Koji Koyama , Masanori Itoh
发明人： Toshikazu Yagi , Koji Koyama , Masanori Itoh
IPC分类号： A61K31/4166 , C07D209/48
CPC分类号： C07D209/48 , C07C227/18 , C07C227/30 , C07C229/36
摘要： The present invention provides a process for producing Droxidopa or a pharmaceutically acceptable salt thereof comprising a step of reacting threo-N-phthaloyl-3-(3,4-dihydroxyphenyl)-L-serine represented by the formula (1) with methylamine, whereby a process for producing threo-3-(3,4-dihydroxyphenyl)-L-serine (common name: Droxidopa), which is useful as an agent for treatment of peripheral orthostatic hypotension or an agent for treatment of Parkinson's disease, with high production efficiency and without requiring troublesome operations.
摘要翻译：本发明提供了一种制备Droxidopa或其药学上可接受的盐的方法，其包括使由式（1）表示的N-邻苯二甲酰基-3-（3,4-二羟基苯基）-L-丝氨酸与甲胺反应的步骤，由此制备可用作治疗周围直立性低血压药物或治疗帕金森病药物的3-（3,4-二羟基苯基）-L-丝氨酸（通用名：Droxidopa）的方法，产量高效率并且不需要麻烦的操作。

7. 发明授权

US07784666B2 Method and apparatus for positioning plate members to be butt-welded 失效
标题翻译：用于定位待对接的板构件的方法和装置
公开(公告)号：US07784666B2
公开(公告)日：2010-08-31
申请号：US11916541
申请日：2005-06-06
申请人： Kenji Iimura , Tomoo Mizuno , Katsura Oowaki , Hirotaka Kanazawa , Chikamasa Iwamoto , Toshikazu Yagi , Hirotaka Shirai
发明人： Kenji Iimura , Tomoo Mizuno , Katsura Oowaki , Hirotaka Kanazawa , Chikamasa Iwamoto , Toshikazu Yagi , Hirotaka Shirai
IPC分类号： B23K1/14 , B23K1/18 , B23K5/22 , B23K37/00 , B23K1/00 , B23K9/02
CPC分类号： B23K37/0408 , B23K37/0461
摘要： Plate members 17 are respectively rested on first and second tables 1A and 1B relatively movable toward and away from each other. The plate members 17 are caused to abut against reference positioning members 16a and 16b of reference positioning devices protruded ahead of and over opposing ends 1′ of the tables 1A and 1B so that opposing ends of the plate members 17 are positioned ahead of the opposing ends 1′ of the tables 1A and 1B, and the plate members 17 are positioned laterally. Then, the positioned plate members 17 are locked on the tables 1A and 1B. After the reference positioning devices are retracted, the tables 1A and 1B are relatively moved toward each other to cause the opposing ends of the plate members 17 to abut together for formation of weld line X.
摘要翻译：板构件17分别搁置在彼此相对移动和相离移动的第一和第二台1A和1B上。使板构件17抵靠在台1A和1B的相对端1'上方突出的基准定位装置的基准定位构件16a和16b，使得板构件17的相对端位于相对端的前方 1'和板构件17横向定位。然后，将定位的板构件17锁定在台1A和1B上。在参考定位装置缩回之后，台1A和1B彼此相对移动，使得板构件17的相对端抵靠在一起以形成焊接线X.

8. 发明申请

US20080265007A1 Method and Apparatus for Positioning Plate Members to Be Butt-Welded 失效
标题翻译：定位板构件对接焊接的方法和装置
公开(公告)号：US20080265007A1
公开(公告)日：2008-10-30
申请号：US11916541
申请日：2005-06-06
申请人： Kenji Iimura , Tomoo Mizuno , Katsura Oowaki , Hirotaka Kanazawa , Chikamasa Iwamoto , Toshikazu Yagi , Hirotaka Shirai
发明人： Kenji Iimura , Tomoo Mizuno , Katsura Oowaki , Hirotaka Kanazawa , Chikamasa Iwamoto , Toshikazu Yagi , Hirotaka Shirai
IPC分类号： B23K31/02 , B23K37/04
CPC分类号： B23K37/0408 , B23K37/0461
摘要： It is made possible to position plate members to be butt-welded for formation of weld line in a small amount of time so as to enhance working capacity of butt welding.Plate members 17 are respectively rested on first and second tables 1A and 1B relatively movable toward and away from each other. The plate members 17 are caused to abut against reference positioning members 16a and 16b of reference positioning devices protruded ahead of and over opposing ends 1′ of the tables 1A and 1B so that opposing ends of the plate members 17 are positioned in protrusion ahead of the opposing ends 1′ of the tables 1A and 1B, and the plate members 17 are positioned laterally. Then, the positioned plate members 17 are locked on the tables 1A and 1B. After the reference positioning devices are retracted, the tables 1A and 1B are relatively moved toward each other to cause the opposing ends of the plate members 17 to abut together for formation of weld line X.
摘要翻译：可以在少量的时间内将板构件定位成对接焊接以形成焊接线，以便提高对接焊接的工作能力。板构件17分别搁置在彼此相对移动且相对移动的第一和第二台1A和1B上。使板构件17抵靠在桌子1A和1B的相对端1'上方突出的基准定位构件16a和16b，使得板构件17的相对端位于在桌子1A和1B的相对端部1'之前的突起，并且板构件17横向定位。然后，定位的板构件17被锁定在工作台1A和1B上。在参考定位装置缩回之后，桌子1A和1B彼此相对移动，以使板构件17的相对端部紧贴在一起形成焊缝X.

9. 发明授权

US07425427B2 Method for staining corneocytes, method for preparing corneocytes specimen and skin analysis system 有权
标题翻译：染色角膜细胞的方法，制备角膜细胞标本和皮肤分析系统的方法
公开(公告)号：US07425427B2
公开(公告)日：2008-09-16
申请号：US10847761
申请日：2004-05-18
申请人： Yoshikazu Hirai , Kenya Hirayama , Nobuo Kashibuchi , Sonoko Kawasaki , Hiroaki Imai , Yoko Zemba , Takanori Takahashi , Seiichi Takaya , Chikako Kamata , Toshikazu Yagi , Jiro Yabusaki
发明人： Yoshikazu Hirai , Kenya Hirayama , Nobuo Kashibuchi , Sonoko Kawasaki , Hiroaki Imai , Yoko Zemba , Takanori Takahashi , Seiichi Takaya , Chikako Kamata , Toshikazu Yagi , Jiro Yabusaki
IPC分类号： G01N1/30 , G01N33/48 , C12N5/08
CPC分类号： G01N1/30 , G01N2001/302 , G06F19/00
摘要： A method for preparing corneocytes specimen, which comprises stripping off corneocytes from the surface of a skin using an adhesive material, staining the corneocytes in a solution of stain in solvent containing a water-miscible organic solvent, and mounting the stained corneocytes into an oil and fat constituent and/or composition that is liquid at 1 atm, 25° C.
摘要翻译：一种制备角膜细胞标本的方法，其包括使用粘合剂材料从皮肤表面剥离角质细胞，将染色溶液中的角质细胞染色在含有水混溶性有机溶剂的溶剂中，并将染色的角膜细胞装入油中，在1atm，25℃下为液体的脂肪成分和/或组合物

10. 发明授权

US07828194B2 Method for positioning plate members to be butt-welded 失效
标题翻译：定位要对接的板件的方法
公开(公告)号：US07828194B2
公开(公告)日：2010-11-09
申请号：US12717414
申请日：2010-03-04
申请人： Kenji Iimura , Tomoo Mizuno , Katsura Oowaki , Hirotaka Kanazawa , Chikamasa Iwamoto , Toshikazu Yagi , Hirotaka Shirai
发明人： Kenji Iimura , Tomoo Mizuno , Katsura Oowaki , Hirotaka Kanazawa , Chikamasa Iwamoto , Toshikazu Yagi , Hirotaka Shirai
IPC分类号： B23K5/22 , B23K37/00 , B23K1/14
CPC分类号： B23K37/0408 , B23K37/0461
摘要： Plate members 17 are respectively rested on first and second tables IA and IB relatively movable toward and away from each other. The plate members 17 are caused to abut against reference positioning members 16a and 16b of reference positioning devices protruded ahead of and over opposing ends 1′ of the tables IA and IB so that opposing ends of the plate members 17 are positioned in protrusion ahead of the opposing ends 1′ of the tables IA and IB, and the plate members 17 are positioned laterally. Then, the positioned plate members 17 are locked on the tables IA and IB. After the reference positioning devices are retracted, the tables IA and IB are relatively moved toward each other to cause the opposing ends of the plate members 17 to abut together for formation of weld line X.
摘要翻译：板构件17分别搁置在第一和第二台1A和1B上，可相对于彼此相对移动并远离彼此。使板构件17抵靠在台1A和1B的相对端1'上方突出的基准定位装置的基准定位构件16a和16b，使得板构件17的相对端位于台1A和1B的相对端1'和板构件17横向定位。然后，将定位的板构件17锁定在台1A和1B上。在参考定位装置缩回之后，台1A和1B相对移动，使得板构件17的相对端抵靠在一起以形成焊接线X.

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