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1. 发明授权

US08497252B2 Compositions comprising cardiac stem cells overexpressing specific microRNAs and methods of their use in repairing damaged myocardium 有权
标题翻译：包含过表达特定microRNA的心脏干细胞的组合物及其在修复受损心肌中的用途
公开(公告)号：US08497252B2
公开(公告)日：2013-07-30
申请号：US13487974
申请日：2012-06-04
申请人： Toru Hosoda , Piero Anversa , Annarosa Leri , Jan Kajstura
发明人： Toru Hosoda , Piero Anversa , Annarosa Leri , Jan Kajstura
IPC分类号： C12N15/11 , C12N5/02 , A61K35/12
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0657 , C12N5/0662 , C12N2501/42 , C12N2501/998 , Y10S977/913
摘要： The invention provides compositions comprising modified stem cells containing a transgene that affects the expression of at least one gene that inhibits or promotes cardiomyogenesis. In particular, the invention discloses compositions comprising cardiac stem cells, wherein said cardiac stem cells comprise a transgene encoding a microRNA. The compositions of the invention find use in the treatment of cardiovascular disorders, such as myocardial infarction. Methods of repairing damaged myocardium in a subject using the modified stem cells are also disclosed.
摘要翻译：本发明提供包含修饰的干细胞的组合物，该干细胞含有影响抑制或促进心肌发生的至少一种基因的表达的转基因。特别地，本发明公开了包含心脏干细胞的组合物，其中所述心脏干细胞包含编码微小RNA的转基因。本发明的组合物可用于治疗心血管疾病，例如心肌梗死。还公开了使用修饰的干细胞修复受试者的损伤心肌的方法。

2. 发明授权

US08193161B2 Compositions comprising cardiac stem cells overexpressing specific micrornas and methods of their use in repairing damaged myocardium 有权
标题翻译：组合物包含过表达特定微核的心脏干细胞及其用于修复受损心肌的方法
公开(公告)号：US08193161B2
公开(公告)日：2012-06-05
申请号：US12480861
申请日：2009-06-09
申请人： Toru Hosoda , Piero Anversa , Annarosa Leri , Jan Kajstura
发明人： Toru Hosoda , Piero Anversa , Annarosa Leri , Jan Kajstura
IPC分类号： C12N15/11 , C12N5/02 , A61K35/12
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0657 , C12N5/0662 , C12N2501/42 , C12N2501/998 , Y10S977/913
摘要： The invention provides compositions comprising modified stem cells containing a transgene that affects the expression of at least one gene that inhibits or promotes cardiomyogenesis. In particular, the invention discloses compositions comprising cardiac stem cells, wherein said cardiac stem cells comprise a transgene encoding a microRNA. The compositions of the invention find use in the treatment of cardiovascular disorders, such as myocardial infarction. Methods of repairing damaged myocardium in a subject using the modified stem cells are also disclosed.
摘要翻译：本发明提供包含修饰的干细胞的组合物，该干细胞含有影响抑制或促进心肌发生的至少一种基因的表达的转基因。特别地，本发明公开了包含心脏干细胞的组合物，其中所述心脏干细胞包含编码微小RNA的转基因。本发明的组合物可用于治疗心血管疾病，例如心肌梗死。还公开了使用修饰的干细胞修复受试者的损伤心肌的方法。

3. 外观设计

USD613192S1 Controller with sensor for air cleaner 有权
标题翻译：带空气净化器的传感器控制器
公开(公告)号：USD613192S1
公开(公告)日：2010-04-06
申请号：US29337434
申请日：2009-05-21
申请人： Toru Hosoda , Kohei Tomita , Takeshi Ashida , Hidetomo Ohtsuki , Koyuru Nakano
设计人： Toru Hosoda , Kohei Tomita , Takeshi Ashida , Hidetomo Ohtsuki , Koyuru Nakano

4. 发明申请

US20060224353A1 Multiple sensor system 有权
公开(公告)号：US20060224353A1
公开(公告)日：2006-10-05
申请号：US11384416
申请日：2006-03-21
申请人： Yusuke Iida , Yuichi Inoue , Nobuharu Ishikawa , Toru Hosoda
发明人： Yusuke Iida , Yuichi Inoue , Nobuharu Ishikawa , Toru Hosoda
IPC分类号： G01B7/00
CPC分类号： G01B11/245 , G01B11/14 , G01S17/48
摘要： An extension unit provided adjacent to an amp unit comprises a measurement data accumulation memory, a measurement data acquiring part for acquiring measurement data coming through a transmission line and accumulating it in the above memory, a data analyzing part for analyzing an accumulated series of measurement data according to predetermined algorithm, a determining part for determining a data analyzed result, and an output part for outputting a control signal corresponding to a determined result to the outside. A plurality of process programs in which measurement algorithm is segmentalized are incorporated in the extension unit and a process program is selected according to a command from a personal computer and the selected process program is performed in a predetermined order.

5. 发明授权

US3956942A Mechanism producing a linear reciprocating output motion with a low speed interval near the center of the stroke 失效
标题翻译：在行程中心附近以低速间隔产生线性往复输出运动的机构
公开(公告)号：US3956942A
公开(公告)日：1976-05-18
申请号：US452521
申请日：1974-03-19
申请人： Mitsuru Seki , Toru Hosoda
发明人： Mitsuru Seki , Toru Hosoda
IPC分类号： B21D43/02 , B23Q39/04 , F16H21/18 , F16H21/30 , F16H37/12
CPC分类号： F16H21/18 , F16H37/124 , Y10T74/18176 , Y10T74/18184 , Y10T74/18272 , Y10T74/18888
摘要： A gear is oscillatingly rolled on a fixed gear so that a pin fixed thereto describes epitrochoidal movement. The pin rocks a sector gear to reciprocate a rack meshing therewith. A low speed interval is produced when the pin position corresponds to a cusp of the epicycloid.
摘要翻译：齿轮在固定齿轮上摇摆，使得固定在其上的销描述外旋运动。销钉将扇形齿轮摇动以使与其啮合的齿条往复运动。当针位置对应于外摆线的尖点时，产生低速间隔。

6. 发明授权

US07520432B2 Sensor system 有权
标题翻译：传感器系统
公开(公告)号：US07520432B2
公开(公告)日：2009-04-21
申请号：US11215124
申请日：2005-08-31
申请人： Hiroyuki Inoue , Hitoshi Oba , Koji Shimada , Toru Hosoda , Naoya Nakashita , Hajime Takegawa , Kenji Horie , Takeshi Yoshiura , Mai Miyawaki
发明人： Hiroyuki Inoue , Hitoshi Oba , Koji Shimada , Toru Hosoda , Naoya Nakashita , Hajime Takegawa , Kenji Horie , Takeshi Yoshiura , Mai Miyawaki
IPC分类号： G06K7/00
CPC分类号： G06T1/0007
摘要： To enables realization of an image data collection function, a bank switch function and the like at low cost in a juxtaposedly placed type sensor system for handling an image, such as a visual sensor or a displacement sensor, by introduction of the minimum required number of new units into an existing system.A first operation of storing image data acquired by a sensor controller from a sensor head and/or measurement data obtained by processing the image data, into a non-volatile record medium of a data storage unit, and/or a second operation of writing the setting data having been stored into the non-volatile record medium of the data storage unit, on a bank memory inside the sensor controller unit, are made possible.
摘要翻译：为了实现图像数据收集功能，以并行放置的类型传感器系统中低成本地实现图像数据收集功能，银行开关功能等，用于通过引入最小所需数量的诸如视觉传感器或位移传感器来处理图像新单位进入现有系统。将由传感器控制器从传感器头获取的图像数据和/或通过处理图像数据获得的测量数据存储到数据存储单元的非易失性记录介质中的第一操作和/或写入数据的第二操作已经存储在数据存储单元的非易失性记录介质中的设置数据在传感器控制器单元内的存储体存储器上成为可能。

7. 发明申请

US20060224354A1 Multiple sensor system 有权
公开(公告)号：US20060224354A1
公开(公告)日：2006-10-05
申请号：US11384439
申请日：2006-03-21
申请人： Yusuke Iida , Yuichi Inoue , Nobuharu Ishikawa , Toru Hosoda
发明人： Yusuke Iida , Yuichi Inoue , Nobuharu Ishikawa , Toru Hosoda
IPC分类号： G01B7/00
CPC分类号： G01B11/245 , G01B11/14 , G01S17/48
摘要： An extension unit provided adjacent to an amp unit comprises a measurement data accumulation memory, a measurement data acquiring part for acquiring measurement data coming through a transmission line and accumulating it in the above memory, a data analyzing part for analyzing an accumulated series of measurement data according to predetermined algorithm, a determining part for determining a data analyzed result, and an output part for outputting a control signal corresponding to a determined result to the outside. A plurality of process programs in which measurement algorithm is segmentalized are incorporated in the extension unit and a process program is selected according to a command from a personal computer and the selected process program is performed in a predetermined order.

8. 发明授权

US06819100B2 Method of creating conversion table for distance detection and displacement sensor 有权
公开(公告)号：US06819100B2
公开(公告)日：2004-11-16
申请号：US10734576
申请日：2003-12-15
申请人： Yusuke Iida , Hidetomo Ohtsuki , Toru Hosoda
发明人： Yusuke Iida , Hidetomo Ohtsuki , Toru Hosoda
IPC分类号： G01B714
CPC分类号： G01D3/022
摘要： A source table showing a standard relation between a detection object and a detection distance is stored in a memory (4). A CPU (3) receives inputs regarding distances to three measurement points from an input portion (5) and recognizes an amplitude voltage corresponding to the input, as a measured value at the measurement point. Furthermore, the CPU (3) extracts a range which corresponds to a difference between the farthest distance and the shortest distance, in which a ratio between voltages corresponding to measurement points closely resembles a ratio between the actually measured values, from the source table as a usage range, and creates a conversion table by correcting voltages in this extracted range.

9. 发明申请

US20130017176A1 COMPOSITIONS COMPRISING CARDIAC STEM CELLS OVEREXPRESSING SPECIFIC MICRORNAS AND METHODS OF THEIR USE IN REPAIRING DAMAGED MYOCARDIUM 有权
公开(公告)号：US20130017176A1
公开(公告)日：2013-01-17
申请号：US13487974
申请日：2012-06-04
申请人： Toru Hosoda , Piero Anversa , Annarosa Leri , Jan Kajstura
发明人： Toru Hosoda , Piero Anversa , Annarosa Leri , Jan Kajstura
IPC分类号： A61K35/34 , A61P9/10
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0657 , C12N5/0662 , C12N2501/42 , C12N2501/998 , Y10S977/913
摘要： The invention provides compositions comprising modified stem cells containing a transgene that affects the expression of at least one gene that inhibits or promotes cardiomyogenesis. In particular, the invention discloses compositions comprising cardiac stem cells, wherein said cardiac stem cells comprise a transgene encoding a microRNA. The compositions of the invention find use in the treatment of cardiovascular disorders, such as myocardial infarction. Methods of repairing damaged myocardium in a subject using the modified stem cells are also disclosed.

10. 发明申请

US20050110000A1 Multiple sensor system 有权
标题翻译：多传感器系统
公开(公告)号：US20050110000A1
公开(公告)日：2005-05-26
申请号：US10942083
申请日：2004-09-16
申请人： Yusuke Iida , Yuichi Inoue , Nobuharu Ishikawa , Toru Hosoda
发明人： Yusuke Iida , Yuichi Inoue , Nobuharu Ishikawa , Toru Hosoda
IPC分类号： G01B11/00 , G06F17/00 , G06F17/40 , H01L29/00
CPC分类号： G01B11/245 , G01B11/14 , G01S17/48
摘要： An extension unit provided adjacent to an amp unit comprises a measurement data accumulation memory, a measurement data acquiring part for acquiring measurement data coming through a transmission line and accumulating it in the above memory, a data analyzing part for analyzing an accumulated series of measurement data according to predetermined algorithm, a determining part for determining a data analyzed result, and an output part for outputting a control signal corresponding to a determined result to the outside. A plurality of process programs in which measurement algorithm is segmentalized are incorporated in the extension unit and a process program is selected according to a command from a personal computer and the selected process program is performed in a predetermined order.
摘要翻译：与放大器单元相邻设置的扩展单元包括测量数据累积存储器，测量数据获取部分，用于获取通过传输线路进行的测量数据并将其累加在上述存储器中;数据分析部件，用于分析累积的一系列测量数据根据预定算法，确定数据分析结果的确定部分和用于将对应于确定结果的控制信号输出到外部的输出部分。将分割测量算法的多个处理程序结合在扩展单元中，并且根据来自个人计算机的命令选择处理程序，并且以预定顺序执行所选择的处理程序。

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