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    • 1. 发明授权
    • 8-oxodihydropurine derivative
    • 8-氧代二氢嘌呤衍生物
    • US08735406B2
    • 2014-05-27
    • US13395429
    • 2010-09-08
    • Keiji AdachiYoko NakaiTomoyuki FurutaYuki Fujii
    • Keiji AdachiYoko NakaiTomoyuki FurutaYuki Fujii
    • A61K31/522C07D473/40
    • A61K31/52A61K31/5377A61K31/55C07D473/00
    • The present invention provides a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof (wherein W represents a hydrogen atom, a halogen atom, or the others; A represents an alkyl group optionally substituted by aryl group or the others, an aryl group, or the others; and one of X and Y represents a di-substituted alkylaminocarbonyl group, or the others, and the other represents a hydrogen atom, an alkyl group, an alkylcarbonyl group, or the others); a medicament or a pharmaceutical composition for treatment or prophylaxis of FAAH-related diseases such as depression, anxiety disorder or pains, comprising the compound or the like as an active ingredient; a use of the compound or the like; and a method for treatment or prophylaxis using the compound or the like.
    • 本发明提供由式(1)表示的化合物或其药学上可接受的盐(其中W表示氢原子,卤素原子等),A表示任选被芳基取代的烷基等, 芳基或其它基团; X和Y之一表示二取代的烷基氨基羰基等,另一个表示氢原子,烷基,烷基羰基等)。 用于治疗或预防FAAH相关疾病如抑郁症,焦虑症或疼痛的药物或药物组合物,其包含化合物等作为活性成分; 化合物等的用途; 以及使用该化合物等进行治疗或预防的方法。
    • 10. 发明申请
    • ELECTRIC DISCHARGE MACHINE
    • 电动排料机
    • US20120228270A1
    • 2012-09-13
    • US13282872
    • 2011-10-27
    • Masao MURAIYasuo ARAKAWATomoyuki FURUTA
    • Masao MURAIYasuo ARAKAWATomoyuki FURUTA
    • B23H1/00B23H1/02
    • B23H1/022B23H1/024B23H7/04
    • An electric discharge machine includes a machining power supply for applying a voltage to a machining gap between a machining electrode and its opposite workpiece and detecting a contact between the machining electrode and the workpiece. The machining power supply includes a first power supply circuit whose output voltage is equal to or less than an arc voltage, a second power supply circuit for supplying a pulse current to the machining gap, and a control unit. When the first power supply circuit detects a contact between the machining electrode and the workpiece, the control unit operates to supply a pulse current from the second power supply circuit to the machining gap while the machining electrode and the workpiece are in contact with each other.
    • 放电加工机包括:加工电源,用于向加工电极与其相对的工件之间的加工间隙施加电压,并检测加工电极与工件之间的接触。 加工电源包括输出电压等于或小于电弧电压的第一电源电路,用于向加工间隙提供脉冲电流的第二电源电路和控制单元。 当第一电源电路检测到加工电极和工件之间的接触时,控制单元操作以在加工电极和工件彼此接触的同时将来自第二电源电路的脉冲电流提供给加工间隙。