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1. 发明申请

US20110206711A1 METHOD FOR INDUCING CYTOTOXIC T-CELLS, CYTOTOXIC T-CELL INDUCER, AND PHARMACEUTICAL COMPOSITION AND VACCINE EMPLOYING SAME 审中-公开
标题翻译：诱导细胞毒T细胞，CYTOTOXIC T细胞诱导剂和药物组合物的方法及其使用的疫苗
公开(公告)号：US20110206711A1
公开(公告)日：2011-08-25
申请号：US12279556
申请日：2007-02-16
申请人： Tomoya Miyakawa , Keiko Udaka , Morikazu Onji
发明人： Tomoya Miyakawa , Keiko Udaka , Morikazu Onji
IPC分类号： A61K39/29 , C07K7/06 , C12N5/00 , A61K38/08 , A61P31/14
CPC分类号： A61K39/29 , A61K38/162 , A61K39/12 , A61K2039/53 , A61K2039/55594 , A61K2039/57 , C07K14/005 , C12N2770/24222 , C12N2770/24234 , G16B20/00 , G16B40/00
摘要： A method for inducing cytotoxic T-cells that includes binding to an HLA molecule on the surface of a cell that is a target of a cytotoxic T-cell a peptide containing one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 13 and consisting of not less than 8 and not more than 11 amino acid residues, or a peptide derived from a precursor thereof.
摘要翻译：一种诱导细胞毒性T细胞的方法，其包括与作为细胞毒性T细胞靶标的细胞表面上的HLA分子结合，所述肽含有一种或多种类型的氨基酸序列，所述氨基酸序列选自SEQ ID NO： NOS：1至13并且由不少于8个且不超过11个氨基酸残基组成，或由其前体衍生的肽。

2. 发明申请

US20090144209A1 SEQUENCE PREDICTION SYSTEM 审中-公开
标题翻译：序列预测系统
公开(公告)号：US20090144209A1
公开(公告)日：2009-06-04
申请号：US11571822
申请日：2005-07-07
申请人： Tomoya Miyakawa
发明人： Tomoya Miyakawa
IPC分类号： G06F15/18 , G06F7/06 , G06F17/30
CPC分类号： G16B40/00 , G16B15/00 , G16B30/00
摘要： The system includes a storage device 126 as a database having biopolymer attributes which contain sequences of a biopolymer, and add values owned by the biopolymer having the sequences; a data control section 128 as a selection section selecting N data sets from the storage device 126; a generation section 102 generating a different plurality of data subsets from the data sets; and a learning section 104 generating a hypothesis for each of the individual data subsets, applying the hypotheses respectively to second data sets composed of biopolymer sequences independent of the data sets, to thereby derive add values of the biopolymer sequences relevant to the second data sets.
摘要翻译：该系统包括作为具有包含生物聚合物序列的生物聚合物属性的数据库的存储装置126，以及由具有序列的生物聚合物所拥有的值; 数据控制部分128作为选择部分，从存储装置126选择N个数据集; 生成部分102，从数据集中生成不同的多个数据子集; 以及学习部分104，为每个单独的数据子集生成假设，将假设分别应用于独立于数据集的生物聚合物序列组成的第二数据集，从而导出与第二数据集相关的生物聚合物序列的附加值。

3. 发明申请

US20150087809A1 HLA-BINDING PEPTIDES, PRECURSORS THEREOF, DNA FRAGMENTS AND RECOMBINANT VECTORS THAT CODE FOR THOSE PEPTIDE SEQUENCES 审中-公开
标题翻译： HLA-BINDING PEPTIDES，其前身，DNA片段和重组载体，用于这些肽序列的代码
公开(公告)号：US20150087809A1
公开(公告)日：2015-03-26
申请号：US14563502
申请日：2014-12-08
申请人： Tomoya MIYAKAWA , Keiko UDAKA
发明人： Tomoya MIYAKAWA , Keiko UDAKA
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , C07K14/005 , C12N2770/24222
摘要： An HLA-binding peptide binding to an HLA-A type molecule, said HLA-binding peptide comprising at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 183, and not less than 8 and not more than 11 amino acid residues is provided. Any of the amino acid sequence is predicted to have the binding property to a human HLA-A type molecule by a predicting program using an active learning experiment method as illustrated in FIG. 1.
摘要翻译：与HLA-A型分子结合的HLA结合肽，所述HLA结合肽包含至少一种选自SEQ ID NO：1至183，不小于8且不小于8的氨基酸序列提供了11个氨基酸残基。通过使用如图1所示的主动学习实验方法的预测程序，预测任何氨基酸序列具有与HLA-A型分子的结合特性。 1。

4. 发明申请

US20110060124A1 HLA-BINDING PEPTIDES, PRECURSORS THEREOF, DNA FRAGMENTS AND RECOMBINANT VECTORS THAT CODE FOR THOSE PEPTIDE SEQUENCES 审中-公开
标题翻译： HLA-BINDING PEPTIDES，其前身，DNA片段和重组载体，用于这些肽序列的代码
公开(公告)号：US20110060124A1
公开(公告)日：2011-03-10
申请号：US12903000
申请日：2010-10-12
申请人： Tomoya MIYAKAWA , Keiko UDAKA
发明人： Tomoya MIYAKAWA , Keiko UDAKA
IPC分类号： C07K7/06 , C12N15/63 , C07H21/04
CPC分类号： C07K14/47 , C07K14/005 , C12N2770/24222
摘要： An HLA-binding peptide binding to an HLA-A type molecule, said HLA-binding peptide comprising at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 183, and not less than 8 and not more than 11 amino acid residues is provided. Any of the amino acid sequences is predicted to have the binding property to a human HLA-A type molecule by a predicting program using an active learning experiment method as illustrated in FIG. 1.
摘要翻译：与HLA-A型分子结合的HLA结合肽，所述HLA结合肽包含至少一种选自SEQ ID NO：1至183，不小于8且不小于8的氨基酸序列提供了11个氨基酸残基。通过使用如图1所示的主动学习实验方法的预测程序，预测任何氨基酸序列具有与HLA-A型分子的结合特性。 1。

5. 发明申请

US20110087005A1 HLA-BINDING PEPTIDE, PRECURSOR THEREOF, AND DNA FRAGMENT AND RECOMBINANT VECTOR CODING FOR SAID HLA-BINDING PEPTIDE 审中-公开
标题翻译： HLA-BINDING PEPTIDE，其前体和DNA片段和重组载体编码用于HLA HLA-BINDING PEPTIDE
公开(公告)号：US20110087005A1
公开(公告)日：2011-04-14
申请号：US12947624
申请日：2010-11-16
申请人： Tomoya MIYAKAWA , Keiko UDAKA
发明人： Tomoya MIYAKAWA , Keiko UDAKA
IPC分类号： C07K7/06
CPC分类号： C07K14/005 , A61K38/00 , A61K38/08 , A61K39/00 , A61K39/12 , A61K39/145 , C07K7/06 , C12N2760/16022 , C12N2760/16034
摘要： An HLA-binding peptide binding to an HLA-A type molecule is provided that includes one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 52, and not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences are amino acid sequences predicted to bind to a human HLA-A molecule using a prediction program employing an active learning experiment method shown in FIG. 1.
摘要翻译：提供了与HLA-A型分子结合的HLA结合肽，其包括一种或多种选自SEQ ID NO：1至52和不少于8个且不超过11个氨基酸的氨基酸序列酸残留。所有这些氨基酸序列是使用图1所示的主动学习实验方法的预测程序预测结合人HLA-A分子的氨基酸序列。 1。

6. 发明申请

US20100255020A1 METHOD FOR INDUCING CYTOTOXIC T-CELLS, CYTOTOXIC T-CELL INDUCERS, AND PHARMACEUTICAL COMPOSITIONS AND VACCINES EMPLOYING THEM 审中-公开
标题翻译：诱导细胞毒性T细胞，细胞毒性T细胞诱导剂和药物组合物的方法及使用它们的疫苗
公开(公告)号：US20100255020A1
公开(公告)日：2010-10-07
申请号：US12743733
申请日：2008-11-20
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
IPC分类号： A61K39/00 , C12N5/0783 , C07K7/06 , A61K38/08 , A61P35/00
CPC分类号： A61K38/08 , A61K39/0011
摘要： A method for inducing cytotoxic T-cells is provided that includes binding to an HLA molecule on the surface of a cell that is a target of a cytotoxic T-cell, a peptide containing one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1, 2, and 3 and composed of not less than 8 and not more than 11 amino acid residues, or a peptide derived from a precursor thereof.
摘要翻译：提供了诱导细胞毒性T细胞的方法，其包括与作为细胞毒性T细胞靶标的细胞表面上的HLA分子的结合，含有一种或多种类型的氨基酸序列的肽，所述氨基酸序列选自 SEQ ID NO：1,2和3，并且由不少于8个且不超过11个氨基酸残基组成，或由其前体衍生的肽。

7. 发明申请

US20090023895A1 HLA-BINDING PEPTIDE, PRECURSOR THEREOF, AND DNA FRAGMENT AND RECOMBINANT VECTOR CODING FOR SAID HLA-BINDING PEPTIDE 审中-公开
标题翻译： HLA-BINDING PEPTIDE，其前体和DNA片段和重组载体编码用于HLA HLA-BINDING PEPTIDE
公开(公告)号：US20090023895A1
公开(公告)日：2009-01-22
申请号：US12278348
申请日：2007-02-06
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
IPC分类号： C07K7/06 , C07H21/04 , C12N15/63
CPC分类号： C07K14/005 , A61K38/00 , A61K38/08 , A61K39/00 , A61K39/12 , A61K39/145 , C07K7/06 , C12N2760/16022 , C12N2760/16034
摘要： An HLA-binding peptide binding to an HLA-A type molecule is provided that includes one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 52, and not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences are amino acid sequences predicted to bind to a human HLA-A molecule using a prediction program employing an active learning experiment method shown in FIG. 1.
摘要翻译：提供了与HLA-A型分子结合的HLA结合肽，其包括一种或多种选自SEQ ID NO：1至52和不少于8个且不超过11个氨基酸的氨基酸序列酸残留。所有这些氨基酸序列是使用图1所示的主动学习实验方法的预测程序预测结合人HLA-A分子的氨基酸序列。 1。

8. 发明授权

US08487076B1 HLA-binding peptide, and DNA fragment and recombinant vector coding for said HLA-binding peptide 有权
标题翻译： HLA结合肽和编码所述HLA结合肽的DNA片段和重组载体
公开(公告)号：US08487076B1
公开(公告)日：2013-07-16
申请号：US11814709
申请日：2005-12-06
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
IPC分类号： A61K38/04
CPC分类号： C07K7/06 , A61K38/00 , C07K14/4738
摘要： There is provided an HLA-binding peptide binding to a HLA-A type molecule, the HLA-binding peptide comprising at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 80, and consisting of not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences herein mentioned are the predicted amino acid sequences binding to a human HLA-A type molecule with the prediction program using the certain active learning method.
摘要翻译：提供了与HLA-A型分子结合的HLA结合肽，HLA结合肽包含至少一种选自SEQ ID NO：1至80的氨基酸序列，并且不少于超过8个，不超过11个氨基酸残基。本文提及的所有这些氨基酸序列是使用某些主动学习方法的预测程序与人HLA-A型分子结合的预测氨基酸序列。

9. 发明授权

US08324345B2 HLA-binding peptide, precursor thereof, DNA fragment and recombinant vector encoding the same 有权
标题翻译： HLA结合肽，其前体，DNA片段和编码其的重组载体
公开(公告)号：US08324345B2
公开(公告)日：2012-12-04
申请号：US12444988
申请日：2007-10-03
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
IPC分类号： A61K39/12 , C07K7/06
CPC分类号： C07K14/70539 , A61K38/00 , Y02A50/385
摘要： There is provided an HLA-binding peptide being excellent in binding affinity to an HLA-A type molecule. An HLA-binding peptide capable of binding to an HLA-A type molecule, including one or more amino acid sequences selected from the group consisting of SEQ ID NOs: 1 to 50, and being composed of 8 or more and 11 or less amino acid residues, is provided. All of the amino acid sequences are the amino acid sequences that are predicted to be capable of binding to an HLA-A molecule by using a prediction program utilizing an active learning method shown in FIG. 1.
摘要翻译：提供了对HLA-A型分子的结合亲和性优异的HLA结合肽。能够结合HLA-A型分子的HLA结合肽，包括一个或多个选自SEQ ID NO：1至50的氨基酸序列，并且由8个或更多个和11个或更少的氨基酸组成残留物。所有氨基酸序列是通过使用利用图1所示的主动学习方法的预测程序预测能够结合HLA-A分子的氨基酸序列。 1。

10. 发明申请

US20100144025A1 HLA-BINDING PEPTIDE, PRECURSOR THEREOF, DNA FRAGMENT AND RECOMBINANT VECTOR ENCODING THE SAME 有权
标题翻译： HLA结合肽，其前体，DNA片段和编码其的重组载体
公开(公告)号：US20100144025A1
公开(公告)日：2010-06-10
申请号：US12444988
申请日：2007-10-03
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
IPC分类号： C07K7/06 , C12N15/12 , C12N15/63
CPC分类号： C07K14/70539 , A61K38/00 , Y02A50/385
摘要： There is provided an HLA-binding peptide being excellent in binding affinity to an HLA-A type molecule. An HLA-binding peptide capable of binding to an HLA-A type molecule, including one or more amino acid sequences selected from the group consisting of SEQ ID NOs: 1 to 50, and being composed of 8 or more and 11 or less amino acid residues, is provided. All of the amino acid sequences are the amino acid sequences that are predicted to be capable of binding to an HLA-A molecule by using a prediction program utilizing an active learning method shown in FIG. 1.
摘要翻译：提供了对HLA-A型分子的结合亲和性优异的HLA结合肽。能够结合HLA-A型分子的HLA结合肽，包括一个或多个选自SEQ ID NO：1至50的氨基酸序列，并且由8个或更多个和11个或更少的氨基酸组成残留物。所有氨基酸序列是通过使用利用图1所示的主动学习方法的预测程序预测能够结合HLA-A分子的氨基酸序列。 1。

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