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1. 发明授权

US10352864B2 Automatic analyzer for identifying a cause of abnormalities of measurement results 有权
公开(公告)号：US10352864B2
公开(公告)日：2019-07-16
申请号：US13808743
申请日：2011-07-04
申请人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
发明人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
IPC分类号： G01N35/00 , G01N21/75 , G16C20/10 , B01F15/00 , B01F11/02 , G01N21/27
摘要： An automatic analyzer includes sample vessels containing samples to be measured and; reaction vessels in which to mix a sample and a reagent. A sample dispenser 5 dispenses a sample from any of the sample vessels to any of the reaction vessels. A reagent dispenser dispenses a reagent from a reagent vessel to a reaction vessel, and a stirrer stirs the sample-reagent mix contained in the reaction vessel. A photometric measurement unit is provided for obtaining multiple measurement data points during the progress of reaction of a mixed solution. At least one approximation formula is performed and an approximation curve from the measurement data points is generated. A shape descriptor is calculated from the approximation curve and abnormalities based on the shape descriptor are determined. This not only allows abnormalities to be detected accurately from each measurement result, but also allows the causes of the abnormalities to be identified.

2. 发明授权

US09470570B2 Automatic analyzer and method for determining malfunction thereof 有权
标题翻译：自动分析仪及确定故障的方法
公开(公告)号：US09470570B2
公开(公告)日：2016-10-18
申请号：US14239958
申请日：2012-05-17
申请人： Masaharu Nishida , Hideto Tamezane , Isao Yamazaki , Kumiko Kamihara , Tomonori Mimura
发明人： Masaharu Nishida , Hideto Tamezane , Isao Yamazaki , Kumiko Kamihara , Tomonori Mimura
IPC分类号： G01F23/00 , G01N35/10 , G01F23/26 , G01L7/00 , G01N35/00
CPC分类号： G01F23/00 , G01F23/263 , G01L7/00 , G01N35/1011 , G01N2035/009 , G01N2035/1018 , G01N2035/1025
摘要： An automatic analyzer which performs a suction operation a plurality of times on a same sample has a sample dispensing unit 9, a liquid level sensor which detects the liquid level of the sample in a sample vessel 8, an arithmetic unit 5 which computes a liquid level height h1 at the end of a first suction operation of the two consecutive suction operations from a liquid level height h0 and a sample suction volume V1 detected at the start of the first suction operation, a storage unit 7 which stores the liquid level height h1 computed by the arithmetic unit 5, and a determination unit 18 which compares a liquid level height h2 detected at the start of a second suction operation following the first suction operation with the liquid level height h1 at the end of the first suction operation.
摘要翻译：在同一样品上进行多次抽吸操作的自动分析仪具有样品分注单元9，检测样品容器8中的样品的液位的液位传感器，计算液位的运算单元5 在从第一抽吸操作开始时检测到的液面高度h0和样品吸入容积V1进行两次连续抽吸操作的第一抽吸操作结束时的高度h1，存储单元7，其存储计算出的液位高度h1 以及确定单元18，其将在第一抽吸操作之后的第二抽吸操作开始时检测到的液位高度h2与在第一抽吸操作结束时的液位高度h1进行比较。

3. 发明授权

US08852511B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US08852511B2
公开(公告)日：2014-10-07
申请号：US13382316
申请日：2010-07-05
申请人： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
发明人： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
IPC分类号： G01N33/00 , G01N21/51
CPC分类号： G01N21/51 , G01N15/0205 , G01N21/253 , G01N2015/0065 , G01N2035/00396 , G01N2035/0453
摘要： To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
摘要翻译：适用于各种类型的用于检测散射光的乳胶试剂，从而以高灵敏度测量凝集反应，同时充分确保积分时间。为了适应于各种类型的不同粒度的胶乳颗粒，多个光接收器通过旋转细胞盘而布置在垂直于细胞移动方向的平面中。为了确保足够的积分时间，使得照射光的光轴与从电池单元的上方观察的散射光的多个光轴中的每一个之间的角度等于或小于包括安装误差的17.7°。

4. 发明申请

US20130266484A1 AUTOMATIC ANALYZER 审中-公开
标题翻译：自动分析仪
公开(公告)号：US20130266484A1
公开(公告)日：2013-10-10
申请号：US13988069
申请日：2011-10-17
申请人： Kumiko Kamihara , Tomonori Mimura
发明人： Kumiko Kamihara , Tomonori Mimura
IPC分类号： G01N21/59
CPC分类号： G01N21/59 , G01N35/00613 , G01N35/00663 , G01N35/00732 , G01N2035/00851
摘要： Realized is an automatic analyzer that allows appropriate setting of analytical parameters which incorporate batch-to-batch variations in characteristics of reagents. The analytical parameters 35, consisting of fixed parameters 37 and variable parameters 38, are stored into a storage unit of the automatic analyzer. The fixed parameters 37 include a reagent-dispensing quantity, a sample-dispensing quantity, measuring wavelength, and the like, each of which becomes a pivot for measurement of a sample, and parameters to be used are selected from an item code and bottle code assigned to a reagent bottle 36. The variable parameters 38 include a linearity check value, a prozone check value, reaction limit absorbance, technical limits, first standard solution absorbance, variation allowable absorbance, and the like, each of which is associated with sample-measurement result checks. The variable parameters 38 have a plurality of versions, and the automatic analyzer has a control unit, which reads bar code information from the reagent bottle and adopts variable parameters of a corresponding version with the item code, the bottle code, and batch information relating to the reagent, as a key.
摘要翻译：实现了一种自动分析仪，允许适当设置分析参数，这些分析参数包含试剂特性的批次间变化。由固定参数37和可变参数38组成的分析参数35被存储在自动分析器的存储单元中。固定参数37包括试剂分注量，样品分注量，测量波长等，其每一个都成为样品的测量的枢轴，并且要使用的参数从项目代码和瓶子代码中选择分配给试剂瓶36.可变参数38包括线性检验值，前区检验值，反应极限吸光度，技术限度，第一标准溶液吸光度，变化允许吸光度等，其中每一个与样品 - 测量结果检查。可变参数38具有多个版本，并且自动分析器具有控制单元，其从试剂瓶读取条形码信息，并且采用相应版本的可变参数与项目代码，瓶子代码以及与试剂，作为关键。

5. 发明授权

US08524153B2 Quality control system 有权
标题翻译：质量控制体系
公开(公告)号：US08524153B2
公开(公告)日：2013-09-03
申请号：US11710424
申请日：2007-02-26
申请人： Tomonori Mimura , Kazumitsu Kawase
发明人： Tomonori Mimura , Kazumitsu Kawase
IPC分类号： G01N21/00
CPC分类号： G01N35/00603 , G01N35/00613 , G01N35/00712 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/2575
摘要： In a clinical laboratory of a hospital, an enormous amount of effort has been required to maintain the quality of an analyzer, standard solution and control samples. An object of the present invention is to provide a control method for controlling a clinical laboratory with reduced cost, and a control apparatus using the same.In order to control data of an analyzer, standard solution, and a control sample, a support center is connected to each analyzer located in each hospital through a network line. Various kinds of analysis parameters and the result of measurements are exchanged so as to provide each clinical laboratory with a control situation in real time.
摘要翻译：在医院的临床实验室，需要大量的努力来保持分析仪，标准溶液和对照样品的质量。本发明的目的是提供一种用于以降低的成本控制临床实验室的控制方法和使用该控制方法的控制装置。为了控制分析仪，标准解决方案和控制样本的数据，支持中心通过网络线连接到位于每个医院的每个分析仪。交换各种分析参数和测量结果，以便为每个临床实验室提供实时的控制情况。

6. 发明申请

US20130046480A1 AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS METHOD 审中-公开
标题翻译：自动分析装置及自动分析方法
公开(公告)号：US20130046480A1
公开(公告)日：2013-02-21
申请号：US13641881
申请日：2011-04-05
申请人： Chihiro Manri , Satoshi Mitsuyama , Tomonori Mimura , Kumiko Kamihara
发明人： Chihiro Manri , Satoshi Mitsuyama , Tomonori Mimura , Kumiko Kamihara
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G01N21/272 , G01N21/78 , G01N35/00584 , G01N35/00693 , G01N2035/00465
摘要： There is provided a technique for automatically determining or predicting a line range specific to a sample that appears in a reaction curve in an automated analyzer for mixing a specimen and a reagent and measuring a change in a mixture of the specimen and the reagent with time. This invention approximates reaction curve data by a function and automatically determines a curve part at an early stage or a second stage of a reaction. The invention determines a line range not including a curve part for each sample and calculates a laboratory test value using absorbance data within the determined line range. This invention also automatically determines a start time of line at the early stage of the reaction on the basis of absorbance data obtained up to a point halfway through the reaction curve, predicts a line range on the basis of the end time of line and a planned end time of line, and calculates a predictive value on the basis of a result of the prediction.
摘要翻译：提供了一种用于自动确定或预测在自动分析器中出现在反应曲线中的样品特异性的线范围的技术，用于混合样品和试剂，并测量样品和试剂的混合物随时间的变化。本发明通过功能近似反应曲线数据，并在反应的早期阶段或第二阶段自动确定曲线部分。本发明确定不包括每个样品的曲线部分的线范围，并使用确定的线范围内的吸光度数据计算实验室测试值。本发明还根据通过反应曲线中途的一点获得的吸光度数据自动确定反应初期的起始时间，基于线的结束时间和计划的预测线范围并且基于预测结果来计算预测值。

7. 发明申请

US20120065898A1 AUTOMATIC ANALYZER 有权
标题翻译：自动分析仪
公开(公告)号：US20120065898A1
公开(公告)日：2012-03-15
申请号：US13318819
申请日：2010-04-12
申请人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
发明人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G01N35/00613 , G01N2035/0097
摘要： To change a photometric time for each item or to change a measurement time for each specimen so that time required for biochemical measurement can be reduced, an index that indicates an end of a reaction is required. Unfortunately, however, no methods have been available for determining the end of the reaction. In measuring a substance to be measured contained in a sample, a parameter in an approximate expression is calculated using a measured value that changes with time, a degree of convergence of a reaction is determined according to a degree of convergence of the parameter, and a measured value at the end of the reaction is calculated using the parameter at a point in time at which it is determined that the reaction has converged.
摘要翻译：要更改每个项目的光度时间或更改每个样品的测量时间，以便可以减少生物化学测量所需的时间，则需要指示反应结束的指标。然而，不幸的是，没有方法可用于确定反应的结束。在测定样品中含有的待测物质时，使用随时间变化的测定值来计算近似表达式中的参数，根据参数的收敛程度确定反应的收敛程度，使用在确定反应已经收敛的时间点的参数来计算反应结束时的测量值。

8. 发明申请

US20110301917A1 AUTOMATIC ANALYZER 有权
标题翻译：自动分析仪
公开(公告)号：US20110301917A1
公开(公告)日：2011-12-08
申请号：US13133655
申请日：2009-11-11
申请人： Kumiko Kamihara , Tomonori Mimura
发明人： Kumiko Kamihara , Tomonori Mimura
IPC分类号： G06F17/18
CPC分类号： G01N35/00693 , G01N35/00603 , G06F17/18
摘要： Abnormality causes are automatically identified during daily quality control, based on the focused consideration of complex uncertainty factors and, especially, of the causes of device-side abnormalities (i.e., abnormalities of the optical system and the dispenser mechanism), the latter of which are often difficult to identify.The analyzer performance that affects measurement results can be estimated from analysis parameters and calibration results. Thus, uncertainty estimates are automatically calculated for each analysis item during quality control, and the estimates are compared with uncertainties obtained during actual QC sample measurement, thereby monitoring and evaluating the analyzer performance. Also, measurements are performed on QC samples of multiple concentrations that contain substances known to subject to particular influences such as those of the optical system, sample dispenser, and reagent dispenser, so that the causes of abnormalities can be identified. Uncertainty estimates calculated from the parameters set for the analysis items are compared with uncertainties obtained from the QC sample measurements. The data sets that have value deviations are classified on an item-by-item basis, and the classification pattern is used to determine which analyzer component is abnormal.
摘要翻译：基于复杂不确定因素的重点考虑，特别是设备侧异常（即光学系统和分配器机构的异常）的原因，后者是在日常质量控制期间自动识别异常原因往往难以识别。影响测量结果的分析仪性能可以通过分析参数和校准结果进行估算。因此，在质量控制期间，为每个分析项目自动计算不确定性估计，并将估计与实际QC样品测量期间获得的不确定性进行比较，从而监测和评估分析仪性能。此外，对含有已知会受到光学系统，样品分配器和试剂分配器的特定影响的物质的多种浓度的QC样品进行测量，从而可以识别出异常的原因。将从分析项目设置的参数中计算出的不确定度估计与从QC样本测量获得的不确定性进行比较。具有价值偏差的数据集按逐项分类，分类模式用于确定哪个分析器组件异常。

9. 发明授权

US07887751B2 Reagent cassette and automatic analyzer using the same 有权
标题翻译：试剂盒和自动分析仪使用相同
公开(公告)号：US07887751B2
公开(公告)日：2011-02-15
申请号：US10963557
申请日：2004-10-14
申请人： Tomonori Mimura , Masaaki Hanawa , Masaharu Nishida , Yoshiaki Igarashi , Yoshimitsu Takagi
发明人： Tomonori Mimura , Masaaki Hanawa , Masaharu Nishida , Yoshiaki Igarashi , Yoshimitsu Takagi
IPC分类号： G01N35/00 , G01N21/00
CPC分类号： G01N35/00663 , G01N35/025 , G01N35/026 , G01N2035/00673 , Y10T436/11 , Y10T436/113332
摘要： A reagent cassette used in an automatic analyzer for a clinical examination room, which provides an analysis environment enabling an operator to select reagent bottles with proper capacities depending on the number of tests to be performed in each different type of facility and to properly set reagents with ease. In the automatic analyzer comprising a sample pipetting section, a reagent pipetting section, a reaction cuvette, etc., one component in a sample is analyzed by using the reagent cassette in which one or a plurality of reagent bottles containing two or more types of reagents are combined together. The reagent cassette is provided with a reagent identifier including information regarding the presence or absence of a reagent opening of the reagent bottle for each of a plurality of positions of the openings.
摘要翻译：一种用于临床检查室的自动分析仪中的试剂盒，其提供分析环境，使得操作者能够根据在每种不同类型的设施中进行的测试次数选择具有适当容量的试剂瓶，并且适当地将试剂与缓解。在包含样品移液部，试剂吸移部，反应池等的自动分析装置中，通过使用其中含有两种或更多种试剂的一种或多种试剂瓶的试剂盒来分析样品中的一种成分结合在一起试剂盒设置有试剂标识符，包括关于开口的多个位置中的每一个的试剂瓶的试剂开口的存在或不存在的信息。

10. 发明申请

US20090222213A1 AUTOMATIC ANALYZER 审中-公开
标题翻译：自动分析仪
公开(公告)号：US20090222213A1
公开(公告)日：2009-09-03
申请号：US12388845
申请日：2009-02-19
申请人： Yuko HAMAZUMI , Tomonori Mimura , Yuki Fukuyama
发明人： Yuko HAMAZUMI , Tomonori Mimura , Yuki Fukuyama
IPC分类号： G01N33/48 , G06F19/00
CPC分类号： G01N35/00663 , G01N2035/00673
摘要： The present invention provides an index that makes it possible to use, in an automatic analyzer, an approximate expression based on a theoretical chemical reaction formula derived from reaction process data, and automatically check for apparatus abnormalities, reagent deteriorations, and improper accuracy control during each continuous or individual inspection.Reaction process data, which is measured when the automatic analyzer determines the relationship between reaction absorbance and time, is approximated to ABS=A0+A1 (1−e−kt) by the least-squares method. The resulting reaction start point absorbance A0, final reaction absorbance A1, reaction rate constant k, and residual error, which is the aggregate sum of differences between approximate values and measured values, are then used as the index of reaction status.
摘要翻译：本发明提供一种能够在自动分析装置中使用基于从反应过程数据导出的理论化学反应式的近似表达式的指标，并且可以自动检查装置异常，试剂恶化和每次检测中的不正确的精度控制连续或个别检查。当自动分析仪确定反应吸光度和时间之间的关系时测量的反应过程数据通过最小二乘法近似为ABS = A0 + A1（1-e-kt）。然后将所得到的反应起点吸光度A0，最终反应吸光度A1，反应速率常数k和剩余误差（即近似值和测量值之间的差值的总和）用作反应状态的指标。

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