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1. 发明授权

US08647515B2 Blood processing filter and method for priming the filter 有权
标题翻译：血液处理过滤器和灌注过滤器的方法
公开(公告)号：US08647515B2
公开(公告)日：2014-02-11
申请号：US13252288
申请日：2011-10-04
申请人： Tomohisa Yokomizo , Morikazu Miura
发明人： Tomohisa Yokomizo , Morikazu Miura
IPC分类号： B01D37/00 , B01D35/00
CPC分类号： A61M1/02 , A61M1/3636
摘要： This invention relates to a blood processing filter including a sheet-like filter element and a flexible container having an internal space divided by the filter element. The container includes first and second container-forming-parts. The first container-forming-part includes an interior filtration space-forming-part and an exterior surrounding space-forming-part that are separated by a first seal-part. The second container-forming-part includes an extension space-forming-part surrounded by the second seal-part and arranged opposite the filter element and the surrounding space-forming-part, without being divided by the first seal-part. A port of the first container-forming-part is provided in the filtration space-forming-part and communicates with an internal space on one side defined by the filter element. The port of the second container-forming-part is provided in the extension space-forming-part and communicates with an internal space on another side defined by the filter element, and protrudes further than an outer surface of the extension space-forming-part.
摘要翻译：本发明涉及一种血液处理过滤器，其包括片状过滤器元件和具有被过滤元件分隔的内部空间的柔性容器。容器包括第一和第二容器形成部件。第一容器形成部分包括由第一密封部分隔开的内部过滤空间形成部分和围绕空间形成部分的外部。第二容器形成部分包括由第二密封部分围绕并且与过滤元件和周围空间形成部分相对设置的延伸空间形成部分，而不被第一密封部分分隔。第一容器形成部件的端口设置在过滤空间形成部分中，并与由过滤元件限定的一侧的内部空间连通。第二容器形成部分的端口设置在延伸空间形成部分中，并与由过滤元件限定的另一侧上的内部空间连通，并且延伸到延伸空间形成部分的外表面。

2. 发明申请

US20130005557A1 CHEMICAL LIQUID ADDITION SYSTEM AND CHEMICAL LIQUID ADDITION METHOD 有权
标题翻译：化学液体添加系统和化学液体添加方法
公开(公告)号：US20130005557A1
公开(公告)日：2013-01-03
申请号：US13635074
申请日：2011-03-16
申请人： Tomohisa Yokomizo , Shuichiro Inadome
发明人： Tomohisa Yokomizo , Shuichiro Inadome
IPC分类号： B04B11/00 , B01D37/00
CPC分类号： A61M1/0272 , A61M1/0218 , B04B5/0428
摘要： The preservation liquid addition system of the present invention enables a chemical liquid to be added to a blood cell component both easily and in a short period of time. The preservation liquid addition system is able to be placed on a centrifugal separator. The preservation liquid addition system has a blood bag, a preservation liquid bag, a mixed liquid bag, a first flow path and a static mixer. A blood component in the blood bag and a preservation liquid in the preservation liquid bag are sent to the static mixer through the first flow path, and a mixed liquid mixed by the static mixer is sent to the mixed liquid bag by centrifugal force of the centrifugal separator.
摘要翻译：本发明的保存液添加系统能够容易地且在短时间内将化学液体添加到血细胞成分。保存液体添加系统能够放置在离心分离器上。保存液体添加系统具有血袋，保存液袋，混合液袋，第一流路和静态混合器。将血袋中的血液成分和保存液袋中的保存液通过第一流路送入静态混合器，将通过静态混合器混合的混合液通过离心力的离心力送入混合液袋分隔器。

3. 发明申请

US20120160782A1 BLOOD PROCESSING FILTER AND METHOD FOR PRIMING THE FILTER 有权
标题翻译：血液加工过滤器和用于引导过滤器的方法
公开(公告)号：US20120160782A1
公开(公告)日：2012-06-28
申请号：US13252288
申请日：2011-10-04
申请人： Tomohisa YOKOMIZO , Morikazu MIURA
发明人： Tomohisa YOKOMIZO , Morikazu MIURA
IPC分类号： B01D29/05 , B01D35/00
CPC分类号： A61M1/02 , A61M1/3636
摘要： This invention relates to a blood processing filter including a sheet-like filter element and a flexible container having an internal space divided by the filter element. The container includes first and second container-forming-parts. The first container-forming-part includes an interior filtration space-forming-part and an exterior surrounding space-forming-part that are separated by a first seal-part. The second container-forming-part includes an extension space-forming-part surrounded by the second seal-part and arranged opposite the filter element and the surrounding space-forming-part, without being divided by the first seal-part. A port of the first container-forming-part is provided in the filtration space-forming-part and communicates with an internal space on one side defined by the filter element. The port of the second container-forming-part is provided in the extension space-forming-part and communicates with an internal space on another side defined by the filter element, and protrudes further than an outer surface of the extension space-forming-part.
摘要翻译：本发明涉及一种血液处理过滤器，其包括片状过滤器元件和具有被过滤元件分隔的内部空间的柔性容器。容器包括第一和第二容器形成部件。第一容器形成部分包括由第一密封部分隔开的内部过滤空间形成部分和围绕空间形成部分的外部。第二容器形成部分包括由第二密封部分围绕并且与过滤元件和周围空间形成部分相对布置的延伸空间形成部分，而不被第一密封部分分割。第一容器形成部件的端口设置在过滤空间形成部分中，并与由过滤元件限定的一侧的内部空间连通。第二容器形成部分的端口设置在延伸空间形成部分中，并与由过滤元件限定的另一侧上的内部空间连通，并且延伸到延伸空间形成部分的外表面。

4. 发明申请

US20120067810A1 BLOOD PROCESSING FILTER AND THE METHOD FOR MANUFACTURING THE SAME 有权
标题翻译：血液加工过滤器及其制造方法
公开(公告)号：US20120067810A1
公开(公告)日：2012-03-22
申请号：US13237029
申请日：2011-09-20
申请人： Tomohisa YOKOMIZO , Morikazu MIURA
发明人： Tomohisa YOKOMIZO , Morikazu MIURA
IPC分类号： B01D29/05 , B23P11/00
CPC分类号： A61M1/38 , A61M1/0218 , A61M1/3633 , A61M1/3636 , A61M2202/0439 , B01D29/05 , Y10T29/49826 , Y10T156/10
摘要： This invention relates to a blood processing filter comprising a sheet-like filter element, an inlet-side flexible container and an outlet-side flexible container that sandwich the filter element and are sealed thereto, an inlet port provided in the inlet-side flexible container for accepting blood before being processed by the filter element, and an outlet port provided in the outlet-side flexible container for discharging blood after being processed by the filter element. The blood processing filter also includes a flow channel securing sheet arranged between the filter element and the outlet-side flexible container. A flow channel hole through which blood processed by the filter element passes is formed in the flow channel securing sheet. The outlet port is provided so as to be capable of communicating with the flow channel hole.
摘要翻译：本发明涉及一种血液处理过滤器，其包括片状过滤元件，入口侧柔性容器和夹着过滤元件并密封的出口侧柔性容器，设置在入口侧柔性容器中的入口用于在被过滤元件处理之前接受血液，以及设置在出口侧柔性容器中的用于在由过滤元件处理之后排出血液的出口。血液处理过滤器还包括布置在过滤元件和出口侧柔性容器之间的流动通道固定片。在流路固定片上形成有由过滤元件处理的血液经过的流路孔。出口设置成能够与流路孔连通。

5. 发明申请

US20100051533A1 BLOOD PROCESSING FILTER 有权
标题翻译：血液加工过滤器
公开(公告)号：US20100051533A1
公开(公告)日：2010-03-04
申请号：US12615730
申请日：2009-11-10
申请人： Shin-ichiroh OKA , Yoshimasa MATSUURA , Tomohisa YOKOMIZO
发明人： Shin-ichiroh OKA , Yoshimasa MATSUURA , Tomohisa YOKOMIZO
IPC分类号： B01D29/56
CPC分类号： A61M1/3633 , A61M1/3636 , A61M2202/0439 , A61M2202/0057
摘要： A flexible blood filter allowing smooth flow of a liquid and being excellent in separation resistance, pressure resistance and centrifugation resistance. The blood processing filter, comprising a first filter element for removing aggregates from blood, a second filter element for removing leukocytes provided in the downstream of the first filter element, and the third filter element having gas permeability of 3 to 40 cc/cm2/sec per thickness of 1 cm provided between the second filter element and the outlet port side container.
摘要翻译：柔性血液过滤器，使液体平滑流动，分离性，耐压性和耐离心性优异。血液处理过滤器，包括用于从血液中除去聚集体的第一过滤元件，用于去除设置在第一过滤器元件的下游的白细胞的第二过滤元件，以及具有3至40cc / cm 2 / sec的透气度的第三过滤元件每1cm设置在第二过滤元件和出口侧容器之间。

6. 发明授权

US08881914B2 Blood processing filter and the method for manufacturing the same 有权
标题翻译：血液处理过滤器及其制造方法
公开(公告)号：US08881914B2
公开(公告)日：2014-11-11
申请号：US13237029
申请日：2011-09-20
申请人： Tomohisa Yokomizo , Morikazu Miura
发明人： Tomohisa Yokomizo , Morikazu Miura
IPC分类号： B01D35/28 , B01D29/01 , A61M1/34 , A61M1/02 , A61M1/38 , B01D29/05 , A61M1/36
CPC分类号： A61M1/38 , A61M1/0218 , A61M1/3633 , A61M1/3636 , A61M2202/0439 , B01D29/05 , Y10T29/49826 , Y10T156/10
摘要： This invention relates to a blood processing filter comprising a sheet-like filter element, an inlet-side flexible container and an outlet-side flexible container that sandwich the filter element and are sealed thereto, an inlet port provided in the inlet-side flexible container for accepting blood before being processed by the filter element, and an outlet port provided in the outlet-side flexible container for discharging blood after being processed by the filter element. The blood processing filter also includes a flow channel securing sheet arranged between the filter element and the outlet-side flexible container. A flow channel hole through which blood processed by the filter element passes is formed in the flow channel securing sheet. The outlet port is provided so as to be capable of communicating with the flow channel hole.
摘要翻译：本发明涉及一种血液处理过滤器，其包括片状过滤元件，入口侧柔性容器和夹着过滤元件并密封的出口侧柔性容器，设置在入口侧柔性容器中的入口用于在被过滤元件处理之前接受血液，以及设置在出口侧柔性容器中的用于在由过滤元件处理之后排出血液的出口。血液处理过滤器还包括布置在过滤元件和出口侧柔性容器之间的流动通道固定片。在流路固定片上形成有由过滤元件处理的血液经过的流路孔。出口设置成能够与流路孔连通。

7. 发明授权

US08524090B2 Blood processing filter 有权
标题翻译：血液处理过滤器
公开(公告)号：US08524090B2
公开(公告)日：2013-09-03
申请号：US12615730
申请日：2009-11-10
申请人： Shin-ichiroh Oka , Yoshimasa Matsuura , Tomohisa Yokomizo
发明人： Shin-ichiroh Oka , Yoshimasa Matsuura , Tomohisa Yokomizo
IPC分类号： B01D37/00 , B01D29/56
CPC分类号： A61M1/3633 , A61M1/3636 , A61M2202/0439 , A61M2202/0057
摘要： A flexible blood filter allowing smooth flow of a liquid and being excellent in separation resistance, pressure resistance and centrifugation resistance. The blood processing filter, comprising a first filter element for removing aggregates from blood, a second filter element for removing leukocytes provided in the downstream of the first filter element, and the third filter element having gas permeability of 3 to 40 cc/cm2/sec per thickness of 1 cm provided between the second filter element and the outlet port side container.
摘要翻译：柔性血液过滤器，使液体平滑流动，分离性，耐压性和耐离心性优异。血液处理过滤器，包括用于从血液中除去聚集体的第一过滤元件，用于去除设置在第一过滤器元件的下游的白细胞的第二过滤元件，以及具有3至40cc / cm 2 / sec的透气度的第三过滤元件每1cm设置在第二过滤元件和出口侧容器之间。

8. 发明授权

US07438821B2 Liquid filtering method and filtering system 有权
标题翻译：液体过滤法和过滤系统
公开(公告)号：US07438821B2
公开(公告)日：2008-10-21
申请号：US10474805
申请日：2002-04-02
申请人： Tomohisa Yokomizo , Yukihiko Uchi
发明人： Tomohisa Yokomizo , Yukihiko Uchi
IPC分类号： B01D37/00 , B01D29/00 , A61M1/02 , A61M1/36
CPC分类号： A61M1/3636 , A61M1/0222 , A61M1/0231 , A61M1/3633
摘要： A filtering method which prevents adhesion between an outlet vessel and a filter element and which uses a flexible filter which allows smooth flow of liquid and is superior in filtering performance; and a filtering system. A filtering method which uses a flexible vessel having an inlet and an outlet for liquid, a sheet-like filter element, and a filter in which the inlet and outlet for liquid are separated by the filter element, wherein in filtering a liquid by the action of gravity or of a liquid feed pump, the pressure in the outlet of the filter is not less than 0 mmHg with respect to the atmospheric pressure; and a filtering system. Further, a filtering method in which a suitable combination of the filter and the hydrodynamic characteristics of the flow channel upstream or downstream of the filter is selected to make the pressure in the outlet of the filter not less than 0 mmHg with respect to the atmospheric pressure; and a filtering system.
摘要翻译：一种防止出口容器和过滤元件之间的粘合并且使用柔性过滤器的过滤方法，其允许液体流畅并且过滤性能优异; 和过滤系统。一种过滤方法，其使用具有用于液体的入口和出口的柔性容器，片状过滤元件和过滤器，其中用于液体的入口和出口由过滤器元件分离，其中通过动作过滤液体的重力或液体供给泵，过滤器的出口压力相对于大气压不小于0mmHg; 和过滤系统。此外，选择过滤器的过滤器和过滤器的上游或下游的流体流动特性的适当组合以使过滤器的出口中的压力相对于大气压力不小于0mmHg的过滤方法 ; 和过滤系统。

9. 发明授权

US09474845B2 Cell removal method, cell removal system, and white blood cell removal method 有权
标题翻译：细胞去除方法，细胞去除系统和白细胞去除方法
公开(公告)号：US09474845B2
公开(公告)日：2016-10-25
申请号：US13635194
申请日：2011-03-22
申请人： Shuichiro Inadome , Nobukazu Shimada , Tomohisa Yokomizo
发明人： Shuichiro Inadome , Nobukazu Shimada , Tomohisa Yokomizo
IPC分类号： A61M1/36 , A61M1/02 , A61M1/34
CPC分类号： A61M1/3696 , A61M1/0209 , A61M1/0218 , A61M1/34 , A61M1/341 , A61M1/3693 , A61M2202/0439 , B04B5/0442
摘要： In the removal of white blood cells from blood, the efficiency of white blood cell removal by a filter is improved. Centrifugal force is applied to blood placed in a blood bag by centrifugal separation to form a plurality of separation layers having a concentration gradient of white blood cells. The separation layers are passed through a filter in ascending order of white blood cell concentration to remove the white blood cells from the separation layers. The separation layers from which the white blood cells have been removed are received in a first blood component bag.
摘要翻译：在从血液中除去白血球时，通过过滤器去除白细胞的效率提高。通过离心分离将离心力施加到放置在血袋中的血液中，形成具有白细胞浓度梯度的多个分离层。分离层以白细胞浓度的升序通过过滤器，以从分离层去除白细胞。将白细胞从其中除去的分离层被接收在第一血液成分袋中。

10. 发明授权

US08857627B2 Blood processing filter 有权
标题翻译：血液处理过滤器
公开(公告)号：US08857627B2
公开(公告)日：2014-10-14
申请号：US13334226
申请日：2011-12-22
申请人： Tomohisa Yokomizo , Morikazu Miura
发明人： Tomohisa Yokomizo , Morikazu Miura
IPC分类号： A61M1/34 , B01D35/28 , B01D35/30 , A61M1/02 , A61M1/36
CPC分类号： A61M1/02 , A61M1/3636 , A61M2205/7563
摘要： A blood processing filter including a flexible container (having an inlet and an outlet and a sheet-like filter member that is assembled in the flexible container) has a seal part that seals the flexible container and the filter member to form an effective filtration portion of the filter member and a partition part that seals the flexible container and the filter member to partition the effective filtration portion into a plurality of areas. The seal part and the partition part cooperate with the filter member to divide inside of the flexible container into three or more internal spaces including an inlet space that communicates with the inlet, and an outlet space that communicates with the outlet, and also form, as a blood channel, a channel that passes through each of three or more of the internal spaces and also passes multiple times through the filter member.
摘要翻译：包括柔性容器（具有入口和出口以及组装在柔性容器中的片状过滤构件）的血液处理过滤器具有密封柔性容器和过滤构件的密封部分，以形成有效的过滤部分过滤构件和分隔部，其密封柔性容器和过滤构件，以将有效过滤部分分隔成多个区域。密封部分和分隔部分与过滤构件配合，以将柔性容器的内部分成三个或更多个内部空间，包括与入口连通的入口空间，以及与出口连通的出口空间，并形成为血液通道，通过三个或更多个内部空间中的每一个的通道，并且还通过过滤器构件多次。

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