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1. 发明申请

US20110118312A1 BENZYLPIPERIZINE COMPOUND 失效
标题翻译：苄基化合物
公开(公告)号：US20110118312A1
公开(公告)日：2011-05-19
申请号：US13010194
申请日：2011-01-20
申请人： Tomohiro TOYODA , Hidefumi YOSHINAGA
发明人： Tomohiro TOYODA , Hidefumi YOSHINAGA
IPC分类号： A61K31/453 , C07D405/10 , C07D211/32 , A61K31/445 , A61P25/24 , A61P25/22
CPC分类号： C07C309/73 , C07D211/22 , C07D211/32 , C07D311/22 , C07D313/08 , C07D405/06
摘要： Disclosed is a benzylpiperizine compound represented by formula (1) or a pharmaceutically acceptable salt thereof, which is useful as a medicinal agent such as an antidepressant agent. (In the formula (1), R1 represents a hydrogen atom or a methyl group; R2 is a group bound in a p- or m-position relative to a methylene group and represents a chlorine atom bound in a p-position, a bromine atom bound in a p-position, a methyl group bound in a p-position, a chlorine atom bound in a m-position or a bromine atom bound to in a m-position; X represents a methylene or an oxygen atom; and n represents an integer of 1 to 3.)
摘要翻译：公开了由式（1）表示的苄基哌啶化合物或其药学上可接受的盐，其可用作药物如抗抑郁剂。（式（1）中，R 1表示氢原子或甲基，R 2表示相对于亚甲基的p位或m位的基团，表示在p位结合的氯原子，溴在p位上键合的原子，在p位上键合的甲基，与m位相连的m位或与溴原子结合的氯原子; X表示亚甲基或氧原子; n表示表示1〜3的整数。）

2. 发明申请

US20070256759A1 Method of Making a Magnetic Core Part 有权
标题翻译：制造磁芯部分的方法
公开(公告)号：US20070256759A1
公开(公告)日：2007-11-08
申请号：US11660702
申请日：2005-08-23
申请人： Kiyotaka Matsukawa , Kozo Ishihara , Kazuo Ishikawa , Tomohiro Toyoda , Toshikazu Tanaka
发明人： Kiyotaka Matsukawa , Kozo Ishihara , Kazuo Ishikawa , Tomohiro Toyoda , Toshikazu Tanaka
IPC分类号： H01F41/02
CPC分类号： H01F41/0206 , B22F3/225 , B29C45/14778 , B29K2995/0008 , C22C2202/02 , H01F1/083 , H01F1/24 , H01F1/26 , H01F17/045 , H01F17/062 , H01F27/027 , H01F27/255 , H01F41/005 , H01F2017/048
摘要： Magnetic powder contained in a resin composition for use in injection molding is coated with an insulating material, and a soft magnetic green compact or a hard magnetic green compact is insert molded into the resin composition.
摘要翻译：用于注射成型的树脂组合物中所含的磁性粉末涂覆有绝缘材料，并将软磁性生坯或硬磁性压坯嵌入成型到树脂组合物中。

3. 发明授权

US08778970B2 Benzyl piperidine compound 失效
标题翻译：苄基哌啶化合物
公开(公告)号：US08778970B2
公开(公告)日：2014-07-15
申请号：US13388623
申请日：2010-08-04
申请人： Tomohiro Toyoda , Tomoaki Nishida , Hidefumi Yoshinaga
发明人： Tomohiro Toyoda , Tomoaki Nishida , Hidefumi Yoshinaga
IPC分类号： A61K31/453 , C07D405/10
CPC分类号： C07D405/06
摘要： Provided is a new serotonin-reuptake inhibitor that exhibits affinity for serotonin-1A receptors. Said serotonin-reuptake inhibitor is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. In the formula, R1 represents a hydrogen atom, a 2-hydroxyethyl group, or a 2-methoxyethyl group. R2 represents one of the following bonded to a methylene group which is bonded to a piperidine ring: a chlorine atom bonded in a p-position; a bromine atom bonded in a p-position; a methyl group bonded in a p-position; a chlorine atom bonded in an m-position; or a bromine atom bonded in an m-position. Either Y1 represents a hydrogen atom and Y2 represents a hydrogen atom or a hydroxyl group, or Y1 and Y2 together represent an oxo group. Z represents a group represented by one of the following formulas: formula (3-1-1), formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2). However, if R1 represents a 2-hydroxyethyl group or a 2-methoxyethyl group and Y1 and Y2 both simultaneously represent hydrogen atoms, then Z represents a group represented by one of the following formulas: formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2).
摘要翻译：提供了对血清素-1A受体具有亲和性的新的5-羟色胺再摄取抑制剂。所述5-羟色胺再摄取抑制剂是由式（1）表示的化合物或其药理学上可接受的盐。在该式中，R 1表示氢原子，2-羟乙基或2-甲氧基乙基。 R 2表示与键合到哌啶环的亚甲基键合的下列之一：键合在对位的氯原子; 键合在p位的溴原子; 在p位上键合的甲基; 键合在m位的氯原子; 或结合在m位的溴原子。 Y1表示氢原子，Y2表示氢原子或羟基，Y1或Y2表示氧代基。 Z表示由下式表示的基团：式（3-1-1），式（3-1-2），式（3-2-1），式（3-2-2），式（ 3-3-1），式（3-3-2），式（3-4-1）或式（3-4-2）。然而，如果R1表示2-羟乙基或2-甲氧基乙基，Y1和Y2同时表示氢原子，则Z表示由下式表示的基团：式（3-1-2），式（ 3-2-1），式（3-2-2），式（3-3-1），式（3-3-2），式（3-4-1）或式（3-4- 2）。

4. 发明授权

US08557998B2 Benzylpiperizine compound 失效
标题翻译：苄基哌嗪化合物
公开(公告)号：US08557998B2
公开(公告)日：2013-10-15
申请号：US13527612
申请日：2012-06-20
申请人： Tomohiro Toyoda
发明人： Tomohiro Toyoda
IPC分类号： C07D211/22
CPC分类号： C07C309/73 , C07D211/22 , C07D211/32 , C07D311/22 , C07D313/08 , C07D405/06
摘要： Disclosed is a benzylpiperizine compound represented by formula (1) or a pharmaceutically acceptable salt thereof, which is useful as a medicinal agent such as an antidepressant agent. (In the formula (1), R1 represents a hydrogen atom or a methyl group; R2 is a group bound in a p- or m-position relative to a methylene group and represents a chlorine atom bound in a p-position, a bromine atom bound in a p-position, a methyl group bound in a p-position, a chlorine atom bound in a m-position or a bromine atom bound to in a m-position; X represents a methylene or an oxygen atom; and n represents an integer of 1 to 3.)
摘要翻译：公开了由式（1）表示的苄基哌啶化合物或其药学上可接受的盐，其可用作药物如抗抑郁剂。（式（1）中，R 1表示氢原子或甲基，R 2表示相对于亚甲基的p位或m位的基团，表示在p位结合的氯原子，溴在p位上键合的原子，在p位上键合的甲基，与m位相连的m位或与溴原子结合的氯原子; X表示亚甲基或氧原子; n表示表示1〜3的整数。）

5. 发明申请

US20130116296A1 PYRAZOLE COMPOUND 有权
标题翻译：吡唑化合物
公开(公告)号：US20130116296A1
公开(公告)日：2013-05-09
申请号：US13810030
申请日：2011-07-14
申请人： Izumi Sasaki , Tomohiro Toyoda , Hidefumi Yoshinaga , Itaru Natsutani , Yoko Takahashi
发明人： Izumi Sasaki , Tomohiro Toyoda , Hidefumi Yoshinaga , Itaru Natsutani , Yoko Takahashi
IPC分类号： C07D405/06 , C07D231/20 , C07D231/22
CPC分类号： C07D231/20 , C07D231/18 , C07D231/22 , C07D231/38 , C07D231/44 , C07D405/06 , C07D493/08
摘要： The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT2C antagonistic action (antidepressive and anxiolytic effects), in particular, 5-HT2C inverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereof wherein R1, R2, R3 and R4 are independently hydrogen or C1-6 alkyl etc.; R5 is C4-7 alkyl or —(CR8R9)r-E; R6, R7, R8 and R9 are independently hydrogen, fluorine or C1-6 alkyl; A is C6-10 aryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is C3-8 cycloalkyl or C6-10 aryl etc.; L is oxygen, sulfur or —NR10—; n is 1, 2 or 3; R10 is hydrogen or C1-6 alkyl etc.; and X is hydrogen or halogen etc.
摘要翻译：本发明涉及还显示5-HT 2C拮抗作用（抗抑郁和抗焦虑作用）的5-羟色胺再摄取抑制剂，特别是包含化合物（1）：或其药学上可接受的盐的5-HT 2C反向激动作用其中R1，R2 ，R3和R4独立地是氢或C1-6烷基等; R5是C4-7烷基或 - （CR8R9）r-E; R6，R7，R8和R9独立地是氢，氟或C1-6烷基; A为C6-10芳基或杂芳基等; r为1,2,3或4; E为C3-8环烷基或C6-10芳基等; L是氧，硫或-NR10-; n为1,2或3; R 10是氢或C 1-6烷基等; X为氢或卤素等。

6. 发明申请

US20120130077A1 BENZYL PIPERIDINE COMPOUND 失效
标题翻译：苄基哌啶化合物
公开(公告)号：US20120130077A1
公开(公告)日：2012-05-24
申请号：US13388623
申请日：2010-08-04
申请人： Tomohiro Toyoda , Tomoaki Nishida , Hidefumi Yoshinaga
发明人： Tomohiro Toyoda , Tomoaki Nishida , Hidefumi Yoshinaga
IPC分类号： C07D405/10
CPC分类号： C07D405/06
摘要： Provided is a new serotonin-reuptake inhibitor that exhibits affinity for serotonin-1A receptors. Said serotonin-reuptake inhibitor is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. In the formula, R1 represents a hydrogen atom, a 2-hydroxyethyl group, or a 2-methoxyethyl group. R2 represents one of the following bonded to a methylene group which is bonded to a piperidine ring: a chlorine atom bonded in a p-position; a bromine atom bonded in a p-position; a methyl group bonded in a p-position; a chlorine atom bonded in an m-position; or a bromine atom bonded in an m-position. Either Y1 represents a hydrogen atom and Y2 represents a hydrogen atom or a hydroxyl group, or Y1 and Y2 together represent an oxo group. Z represents a group represented by one of the following formulas: formula (3-1-1), formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2). However, if R1 represents a 2-hydroxyethyl group or a 2-methoxyethyl group and Y1 and Y2 both simultaneously represent hydrogen atoms, then Z represents a group represented by one of the following formulas: formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2).
摘要翻译：提供了对血清素-1A受体具有亲和性的新的5-羟色胺再摄取抑制剂。所述5-羟色胺再摄取抑制剂是由式（1）表示的化合物或其药理学上可接受的盐。在该式中，R 1表示氢原子，2-羟乙基或2-甲氧基乙基。 R 2表示与键合到哌啶环的亚甲基键合的下列之一：键合在对位的氯原子; 键合在p位的溴原子; 在p位上键合的甲基; 键合在m位的氯原子; 或结合在m位的溴原子。 Y1表示氢原子，Y2表示氢原子或羟基，Y1或Y2表示氧代基。 Z表示由下式表示的基团：式（3-1-1），式（3-1-2），式（3-2-1），式（3-2-2），式（ 3-3-1），式（3-3-2），式（3-4-1）或式（3-4-2）。然而，如果R1表示2-羟乙基或2-甲氧基乙基，Y1和Y2同时表示氢原子，则Z表示由下式表示的基团：式（3-1-2），式（ 3-2-1），式（3-2-2），式（3-3-1），式（3-3-2），式（3-4-1）或式（3-4- 2）。

7. 发明授权

US08232405B2 Benzylpiperizine compound 失效
标题翻译：苄基哌嗪化合物
公开(公告)号：US08232405B2
公开(公告)日：2012-07-31
申请号：US13010194
申请日：2011-01-20
申请人： Tomohiro Toyoda , Hidefumi Yoshinaga
发明人： Tomohiro Toyoda , Hidefumi Yoshinaga
IPC分类号： C07D401/00 , A61K31/445
CPC分类号： C07C309/73 , C07D211/22 , C07D211/32 , C07D311/22 , C07D313/08 , C07D405/06
摘要： Disclosed is a benzylpiperizine compound represented by formula (1) or a pharmaceutically acceptable salt thereof, which is useful as a medicinal agent such as an antidepressant agent. (In the formula (1), R1 represents a hydrogen atom or a methyl group; R2 is a group bound in a p- or m-position relative to a methylene group and represents a chlorine atom bound in a p-position, a bromine atom bound in a p-position, a methyl group bound in a p-position, a chlorine atom bound in a m-position or a bromine atom bound to in a m-position; X represents a methylene or an oxygen atom; and n represents an integer of 1 to 3.)
摘要翻译：公开了由式（1）表示的苄基哌啶化合物或其药学上可接受的盐，其可用作药物如抗抑郁剂。（式（1）中，R 1表示氢原子或甲基，R 2表示相对于亚甲基的p位或m位的基团，表示在p位结合的氯原子，溴在p位上键合的原子，在p位上键合的甲基，与m位相连的m位或与溴原子结合的氯原子; X表示亚甲基或氧原子; n表示表示1〜3的整数。）

8. 发明授权

US07785424B2 Method of making a magnetic core part 有权
标题翻译：制造磁芯部件的方法
公开(公告)号：US07785424B2
公开(公告)日：2010-08-31
申请号：US11660702
申请日：2005-08-23
申请人： Kiyotaka Matsukawa , Kozo Ishihara , Kazuo Ishikawa , Tomohiro Toyoda , Toshikazu Tanaka
发明人： Kiyotaka Matsukawa , Kozo Ishihara , Kazuo Ishikawa , Tomohiro Toyoda , Toshikazu Tanaka
IPC分类号： H01F1/14
CPC分类号： H01F41/0206 , B22F3/225 , B29C45/14778 , B29K2995/0008 , C22C2202/02 , H01F1/083 , H01F1/24 , H01F1/26 , H01F17/045 , H01F17/062 , H01F27/027 , H01F27/255 , H01F41/005 , H01F2017/048
摘要： Magnetic powder contained in a resin composition for use in injection molding is coated with an insulating material, and a soft magnetic green compact or a hard magnetic green compact is insert molded into the resin composition. Increased magnetic flux destiny, reduced size, a simplified shape, and/or increased filling density can be achieved in a core part of an electric instrument.
摘要翻译：用于注射成型的树脂组合物中所含的磁性粉末涂覆有绝缘材料，并将软磁性生坯或硬磁性压坯嵌入成型到树脂组合物中。在电气仪器的核心部分可以实现增加的磁通量命运，减小的尺寸，简化的形状和/或增加的填充密度。

9. 发明申请

US20120259122A1 BENZYLPIPERIZINE COMPOUND 失效
标题翻译：苄基化合物
公开(公告)号：US20120259122A1
公开(公告)日：2012-10-11
申请号：US13527612
申请日：2012-06-20
申请人： Tomohiro TOYODA , Hidefumi YOSHINAGA
发明人： Tomohiro TOYODA , Hidefumi YOSHINAGA
IPC分类号： C07D211/22 , C07C309/73 , C07D313/08 , C07D311/22
CPC分类号： C07C309/73 , C07D211/22 , C07D211/32 , C07D311/22 , C07D313/08 , C07D405/06
摘要： Disclosed is a benzylpiperizine compound represented by formula (1) or a pharmaceutically acceptable salt thereof, which is useful as a medicinal agent such as an antidepressant agent. (In the formula (1), R1 represents a hydrogen atom or a methyl group; R2 is a group bound in a p- or m-position relative to a methylene group and represents a chlorine atom bound in a p-position, a bromine atom bound in a p-position, a methyl group bound in a p-position, a chlorine atom bound in a m-position or a bromine atom bound to in a m-position; X represents a methylene or an oxygen atom; and n represents an integer of 1 to 3.)
摘要翻译：公开了由式（1）表示的苄基哌啶化合物或其药学上可接受的盐，其可用作药物如抗抑郁剂。（式（1）中，R 1表示氢原子或甲基，R 2表示相对于亚甲基的p位或m位的基团，表示在p位结合的氯原子，溴在p位上键合的原子，在p位上键合的甲基，与m位相连的m位或与溴原子结合的氯原子; X表示亚甲基或氧原子; n表示表示1〜3的整数。）

10. 发明授权

US08569353B2 Pyrazole compound 有权
标题翻译：吡唑化合物
公开(公告)号：US08569353B2
公开(公告)日：2013-10-29
申请号：US13810030
申请日：2011-07-14
申请人： Izumi Sasaki , Tomohiro Toyoda , Hidefumi Yoshinaga , Itaru Natsutani , Yoko Takahashi
发明人： Izumi Sasaki , Tomohiro Toyoda , Hidefumi Yoshinaga , Itaru Natsutani , Yoko Takahashi
IPC分类号： A61K31/415 , C07D405/06 , C07D231/22
CPC分类号： C07D231/20 , C07D231/18 , C07D231/22 , C07D231/38 , C07D231/44 , C07D405/06 , C07D493/08
摘要： The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT2C antagonistic action (antidepressive and anxiolytic effects), in particular, 5-HT2C inverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereof wherein R1, R2, R3 and R4 are independently hydrogen or C1-6 alkyl etc.; R5 is C4-7 alkyl or —(CR8R9)r-E; R6, R7, R8 and R9 are independently hydrogen, fluorine or C1-6 alkyl; A is C6-10 aryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is C3-8 cycloalkyl or C6-10 aryl etc.; L is oxygen, sulfur or —NR10—; n is 1, 2 or 3; R10 is hydrogen or C1-6 alkyl etc.; and X is hydrogen or halogen etc.
摘要翻译：本发明涉及还显示5-HT 2C拮抗作用（抗抑郁和抗焦虑作用）的5-羟色胺再摄取抑制剂，特别是包含化合物（1）：或其药学上可接受的盐的5-HT 2C反向激动作用其中R1，R2 ，R3和R4独立地是氢或C1-6烷基等; R5是C4-7烷基或 - （CR8R9）r-E; R6，R7，R8和R9独立地是氢，氟或C1-6烷基; A为C6-10芳基或杂芳基等; r为1,2,3或4; E为C3-8环烷基或C6-10芳基等; L是氧，硫或-NR10-; n为1,2或3; R 10是氢或C 1-6烷基等; X为氢或卤素等。

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