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    • 6. 发明授权
    • Adsorbent for adsorbing organic compounds adsorbed on proteins
    • 用于吸附吸附在蛋白质上的有机化合物的吸附剂
    • US4202775A
    • 1980-05-13
    • US917828
    • 1978-06-22
    • Tsutomu AbeAkihiko IkedaTokio Sakurai
    • Tsutomu AbeAkihiko IkedaTokio Sakurai
    • A61K35/14A61M1/36B01J20/22C08J9/28B01D15/04
    • C08J9/286A61M1/3679B01J20/22C07K1/20C08J2357/00
    • An adsorbent comprising a porous copolymer produced by copolymerizing a cross-linkable monomer and a mono-ethylenically unsaturated monomer, said copolymer having pores of an average pore diameter (d) of 500 A to 6,000 A and having such a broad pore diameter distribution that the pore volume having a pore diameter in the range of from 0.5 d to 2 d is not more than 60% of the total pore volume in the copolymer. By the use of such a porous copolymer having a specific composition and pore characteristics, organic compounds (e.g. toxic compounds) adsorbed on the proteins (e.g. plasma proteins) present in intercellular and/or extracellular liquids (e.g. blood) can be effectively adsorption-removed. Especially when the present adsorbent is used for purification of blood, it is advantageously subjected to such a pretreatment that plasma proteins are adsorbed on the adsorbent and then crosslinked with a crosslinking agent. The pretreated adsorbent can prevent unfavorable adsorption of blood platelets and leukocytes thereon. The present adsorbent is quite suitable for use in a column type purifier apparatus.
    • 一种吸附剂,其包含通过使可交联单体和单烯键式不饱和单体共聚制备的多孔共聚物,所述共聚物具有平均孔径(d)为500至6,000的孔,并且具有如此宽的孔径分布, 孔径在0.5d至2d范围内的孔体积不大于共聚物中总孔体积的60%。 通过使用具有特定组成和孔特性的这种多孔共聚物,吸附在细胞间和/或细胞外液体(例如血液)中的蛋白质(例如血浆蛋白质)上的有机化合物(例如有毒化合物)可以被有效吸附去除 。 特别是当本发明的吸附剂用于血液净化时,有利地进行这样的预处理,使血浆蛋白质吸附在吸附剂上,然后与交联剂交联。 预处理的吸附剂可以防止血小板和白细胞在其上的不利吸附。 本发明的吸附剂非常适用于柱式净化装置。
    • 7. 发明授权
    • Method for producing a polyphenylene ether
    • 聚苯醚的制造方法
    • US4788277A
    • 1988-11-29
    • US127842
    • 1987-12-02
    • Sadao IbeTokio SakuraiKazuhiro TakahashiYoshiro Unno
    • Sadao IbeTokio SakuraiKazuhiro TakahashiYoshiro Unno
    • C08G65/44
    • C08G65/44
    • There is disclosed a novel method for producing a polyphenylene ether, in which a phenol compound is reacted with an oxidizing agent in a reaction medium in the presence of a highly active catalyst comprising at least one copper compound, at least one 1,3-diamine compound selected from N,N,N',N'-tetramethyl-1,3-diaminopropanes and at least one halogen compound selected from a bromine compound and a chlorine compound, wherein the reaction medium contains at least one alcohol selected from the group consisting of methanol and ethanol. The novel method can be advantageously employed for efficiently producing a polyphenylene ether which has a desirable color and gives a composition improved with respect to Izod impact strength in combination with a rubber-reinforced polystyrene and the like. Major application of such a composition is found in the field of generally known engineering plastics.
    • 公开了一种生产聚苯醚的新方法,其中在含有至少一种铜化合物,至少一种1,3-二胺的高活性催化剂存在下,使酚化合物与氧化剂在反应介质中反应 选自N,N,N',N'-四甲基-1,3-二氨基丙烷和至少一种选自溴化合物和氯化合物的卤素化合物的化合物,其中反应介质含有至少一种选自以下的醇: 的甲醇和乙醇。 该方法可以有利地用于有效地制备具有所需颜色的聚苯醚,并且与橡胶增强聚苯乙烯等组合使得相对于艾佐德冲击强度得到改善的组合物。 这种组合物的主要应用在普通已知的工程塑料领域中得到应用。