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1. 发明申请

US20090279739A1 POINT SUBSELECTION FOR FAST DEFORMABLE POINT-BASED IMAGING 有权
标题翻译：基于快速基于点的成像的点选择
公开(公告)号：US20090279739A1
公开(公告)日：2009-11-12
申请号：US11915752
申请日：2006-05-31
申请人： Michael Kaus , Todd McNutt , Vladimir Pekar
发明人： Michael Kaus , Todd McNutt , Vladimir Pekar
IPC分类号： G06T7/60
CPC分类号： G06T7/30
摘要： A method for selecting vertices for performing deformable registration of imaged objects is provided. The selected vertices form corresponding pairs, each pair including a vertex from a first imaged object and a vertex from a second imaged object. The corresponding vertex pairs are sorted in order of distance between the vertices making up the corresponding vertex pair. The corresponding vertex pair with the greatest distance is given top priority. Corresponding vertex pairs that lie within a selected distance from the selected corresponding vertex pair are discarded. In this manner, the number of vertex pairs used for deformable registration of the imaged objects is reduced and therefore allows for processing times that are clinically acceptable.
摘要翻译：提供了一种用于选择用于执行成像对象的变形登记的顶点的方法。所选择的顶点形成对应的对，每对包括来自第一成像对象的顶点和来自第二成像对象的顶点。对应的顶点对按照构成相应顶点对的顶点之间的距离的顺序进行排序。具有最大距离的相应顶点对被赋予最高优先级。位于距所选择的对应顶点对的选定距离内的相应顶点对被丢弃。以这种方式，用于成像对象的可变形登记的顶点对的数量减少，因此允许临床可接受的处理时间。

2. 发明申请

US20070049785A1 Method and device for planning a radiation therapy 有权
标题翻译：辐射治疗方法和装置
公开(公告)号：US20070049785A1
公开(公告)日：2007-03-01
申请号：US10573730
申请日：2004-09-10
申请人： Vladimir Pekar , Michael Kaus , Todd McNutt
发明人： Vladimir Pekar , Michael Kaus , Todd McNutt
IPC分类号： A61N5/00
CPC分类号： A61N5/103 , A61N5/1049 , A61N5/1065 , A61N2005/1055 , A61N2005/1061 , G06F19/00 , G06F19/3481
摘要： A method and apparatus for planning a radiation therapy are disclosed. A radiation dose distribution is adapted on the basis of shape and position variations of the organs of interest determined from a comparison of a first image and a second image which were taken at different points of time during the radiation treatment process.
摘要翻译：公开了一种用于规划放射治疗的方法和装置。基于在放射治疗过程中从不同时间点拍摄的第一图像和第二图像的比较确定的感兴趣器官的形状和位置变化来调整辐射剂量分布。

3. 发明申请

US20110103551A1 Radiotherapeutic Treatment Plan Adaptation 有权
标题翻译：放射治疗计划适应
公开(公告)号：US20110103551A1
公开(公告)日：2011-05-05
申请号：US11573564
申请日：2005-07-28
申请人： Matthieu Bal , Lothar Spies , Todd McNutt
发明人： Matthieu Bal , Lothar Spies , Todd McNutt
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1031 , A61N2005/1061 , G06F19/00 , G06F19/3481
摘要： In a radiation therapy method, one or more planning images are acquired (102) of a subject. Features of at least malignant tissue are contoured in the one or more planning images to produce one or more initial feature contours. One or more treatment images of the subject are acquired (114). The one or more initial feature contours are updated (122) based on the one or more treatment images. Radiation treatment parameters are optimized (126) based upon the updated one or more feature contours. Radiation treatment of the subject is performed (130) using the optimized parameters.
摘要翻译：在放射治疗方法中，获取对象的一个或多个规划图像（102）。至少恶性组织的特征在一个或多个规划图像中具有轮廓，以产生一个或多个初始特征轮廓。获取对象的一个或多个处理图像（114）。一个或多个初始特征轮廓基于一个或多个治疗图像被更新（122）。基于更新的一个或多个特征轮廓对辐射处理参数进行优化（126）。使用优化的参数进行受试者的放射治疗（130）。

4. 发明申请

US20080219406A1 Method of Accounting for Tumor Motion in Radiotherapy Treatment 有权
标题翻译：放射治疗肿瘤运动会计方法
公开(公告)号：US20080219406A1
公开(公告)日：2008-09-11
申请号：US11995337
申请日：2006-07-10
申请人： Michael Kaus , Vladimir Pekar , Todd Mcnutt
发明人： Michael Kaus , Vladimir Pekar , Todd Mcnutt
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1037 , A61N5/1038 , A61N5/1065 , A61N2005/1061
摘要： A method and apparatus accounting for tumor motion during radiation therapy is provided. The method allows for radiation therapy treatments based on updated radiation therapy plans. For each fractionate radiation treatment that results in an updated radiation treatment, radiation treatment images are acquired, automatically segmented, and then subject to deformable registration to develop updated contours and an updated radiation therapy plan.
摘要翻译：提供了放射治疗期间肿瘤移动的方法和装置。该方法允许基于更新的放射治疗计划的放射治疗治疗。对于导致更新的辐射治疗的每个分级放射治疗，获取放射治疗图像，自动分割，然后进行变形注册以开发更新的轮廓和更新的放射治疗计划。

5. 发明申请

US20070133848A1 Manual tools for model based image segmentation 有权
标题翻译：用于基于模型的图像分割的手动工具
公开(公告)号：US20070133848A1
公开(公告)日：2007-06-14
申请号：US10595357
申请日：2004-10-06
申请人： Todd McNutt , Michael Kaus , Vladimir Pekar
发明人： Todd McNutt , Michael Kaus , Vladimir Pekar
IPC分类号： G06K9/00
CPC分类号： G06T19/00 , G06K9/209 , G06K9/34 , G06K2009/366 , G06K2209/05 , G06T7/11 , G06T7/12 , G06T7/149 , G06T2200/24 , G06T2207/10081 , G06T2207/30004 , G06T2219/2021
摘要： A scanner (18) acquires images of a subject. A 3D model (52) of an organ is selected from an organ model database (50) and dropped over an image of an actual organ. A best fitting means (62) globally scales, translates and/or rotates the model (52) to best fit the actual organ represented by the image. A user uses a mouse (38) to use a set of manual tools (68) to segment and manipulate the model (52)1:o match the image data. The set of tools (68) includes: a Gaussian tool (72) for deforming a surface portion of the model along a Gaussian curve, a spherical push tool (80) for deforming the surface portion along a spherical surface segment, and a pencil tool (90) for manually drawing a line to which the surface portion is redefined.
摘要翻译：扫描器（18）获取被摄体的图像。从器官模型数据库（50）中选择器官的3D模型（52）并且落在实际器官的图像上。最佳拟合装置（62）在全局范围内缩放，平移和/或旋转模型（52）以最佳地适合由图像表示的实际器官。用户使用鼠标（38）使用一组手动工具（68）来分割和操纵模型（52）1：o匹配图像数据。所述工具集（68）包括：用于使模型的表面部分沿着高斯曲线变形的高斯工具（72），用于使表面部分沿着球形表面段变形的球形推动工具（80）和铅笔工具（90），用于手动绘制重新定义表面部分的线。

6. 发明申请

US20060210158A1 Object-specific segmentation 审中-公开
标题翻译：对象特定的分割
公开(公告)号：US20060210158A1
公开(公告)日：2006-09-21
申请号：US10564657
申请日：2004-07-13
申请人： Vladimir Pekar , Michael Kaus , Todd McNutt
发明人： Vladimir Pekar , Michael Kaus , Todd McNutt
IPC分类号： G06K9/34 , G06K9/00
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/149 , G06T2207/10072 , G06T2207/20104 , G06T2207/30004
摘要： The invention relates to the field of efficient segmentation of collections of anatomical structures in medical imaging. For example, in radiotherapy planning, the segmentation of a collection of several anatomical structures, which represent the target volume in risk organs is required. When using model based segmentation, organ models represented by flexible surfaces are adapted to the boundaries of the object of interest. According to an aspect of the present invention, object-specific a priori information is incorporated in the segmentation process, which allows to provide for an improved segmentation. Furthermore, the segmentation process according to the present invention, may have an improved robustness, also the time required for the segmentation maybe reduced.
摘要翻译：本发明涉及医学成像中解剖结构集合的有效分割领域。例如，在放射治疗计划中，需要分割几个解剖结构的集合，其代表风险器官中的目标体积。当使用基于模型的分割时，由柔性表面表示的器官模型适应于感兴趣对象的边界。根据本发明的一个方面，将特定于对象的先验信息并入分割过程中，这允许提供改进的分割。此外，根据本发明的分割处理可以具有改进的鲁棒性，也可以减少分割所需的时间。

7. 发明授权

US08325878B2 Real-time dose computation for radiation therapy using graphics processing unit acceleration of the convolution/superposition dose computation method 有权
标题翻译：使用图形处理单元加速的卷积/叠加剂量计算方法的放射治疗的实时剂量计算
公开(公告)号：US08325878B2
公开(公告)日：2012-12-04
申请号：US12934513
申请日：2009-05-08
申请人： Todd McNutt , Robert Allan Jacques
发明人： Todd McNutt , Robert Allan Jacques
IPC分类号： A61B5/05
CPC分类号： A61N5/1031 , A61N2005/1034
摘要： A system for radiation therapy including a radiation planning system, wherein the radiation planning system comprises a parallel processor adapted to receive input information concerning a body having an intended radiation treatment region and to output information for providing radiation treatment to the intended radiation treatment region of the body, wherein the parallel processor is adapted to perform a plurality of reverse ray tracing calculations based on the input information concerning the body in determining the output information for providing radiation treatment, each of the plurality of reverse ray tracing calculations comprising: calculating a first physical property corresponding to a first sub-region of the intended radiation treatment region of the body that is intersected by a ray traced between a source position and the intended radiation treatment region; and calculating, subsequent to the first-mentioned calculating, a second physical property corresponding to a second sub-region of the intended radiation treatment region that is intersected by the ray at a location closer to the source position than is the first sub-region.
摘要翻译：一种用于包括辐射计划系统的放射治疗系统，其中所述辐射计划系统包括并行处理器，其适于接收关于具有预期辐射治疗区域的身体的输入信息，并输出用于向所述辐射治疗区域的预期辐射治疗区域提供辐射治疗的信息其中所述并行处理器适于在确定用于提供放射治疗的输出信息时，基于关于身体的输入信息执行多个反射光线跟踪计算，所述多个反射光线跟踪计算中的每一个包括：计算第一物理对应于由源位置和预期辐射处理区域之间的轨迹相交的身体的预期辐射治疗区域的第一子区域; 以及在所述第一次计算之后，计算与所述预期辐射处理区域的第二子区域相对应的第二物理特性，所述第二子区域在与所述第一子区域相比更靠近所述源位置的位置与所述射线相交。

8. 发明授权

US08094895B2 Point subselection for fast deformable point-based imaging 有权
标题翻译：点选择快速可变形点基成像
公开(公告)号：US08094895B2
公开(公告)日：2012-01-10
申请号：US11915752
申请日：2006-05-31
申请人： Michael Kaus , Todd McNutt , Vladimir Pekar
发明人： Michael Kaus , Todd McNutt , Vladimir Pekar
IPC分类号： G06K9/00 , G06K9/62 , G06K9/32
CPC分类号： G06T7/30
摘要： A method for selecting vertices for performing deformable registration of imaged objects is provided. The selected vertices form corresponding pairs, each pair including a vertex from a first imaged object and a vertex from a second imaged object. The corresponding vertex pairs are sorted in order of distance between the vertices making up the corresponding vertex pair. The corresponding vertex pair with the greatest distance is given top priority. Corresponding vertex pairs that lie within a selected distance from the selected corresponding vertex pair are discarded. In this manner, the number of vertex pairs used for deformable registration of the imaged objects is reduced and therefore allows for processing times that are clinically acceptable.
摘要翻译：提供了一种用于选择用于执行成像对象的变形登记的顶点的方法。所选择的顶点形成对应的对，每对包括来自第一成像对象的顶点和来自第二成像对象的顶点。对应的顶点对按照构成相应顶点对的顶点之间的距离的顺序进行排序。具有最大距离的相应顶点对被赋予最高优先级。位于距所选择的对应顶点对的选定距离内的相应顶点对被丢弃。以这种方式，用于成像对象的可变形登记的顶点对的数量减少，因此允许临床可接受的处理时间。

9. 发明申请

US20110153547A1 SYSTEM AND METHOD FOR SHAPE BASED RETRIEVAL OF PRIOR PATIENTS FOR AUTOMATION AND QUALITY CONTROL OF RADIATION THERAPY TREATMENT PLANS 有权
标题翻译：用于自动化和辐射治疗治疗计划质量控制的前期患者形状回缩的系统和方法
公开(公告)号：US20110153547A1
公开(公告)日：2011-06-23
申请号：US12820852
申请日：2010-06-22
申请人： Todd McNutt , Russell H. Taylor , Michael Kazhdan , Binbin Wu , Patricio Simari
发明人： Todd McNutt , Russell H. Taylor , Michael Kazhdan , Binbin Wu , Patricio Simari
IPC分类号： G06N5/02
CPC分类号： G06N5/02 , A61N2005/1041 , G06F19/00 , G06F19/3481 , G16H50/70
摘要： A system and method for determining at least one new treatment plan for at least one new patient, comprising: providing at least one representation of the at least one new patient's at least one organ at risk relative to at least one target; searching for at least one prior treatment plan for at least one prior patient with at least one similar representation; and reviewing the at least one prior treatment plan for the at least one prior patient in order to determine whether the at least one new treatment plan can be improved based on information in the at least one prior treatment plan.
摘要翻译：一种用于确定至少一个新患者的至少一个新的治疗计划的系统和方法，包括：提供所述至少一个新患者至少一个相对于至少一个靶标的风险的器官的至少一个表示; 为至少一个具有至少一个类似表示的先前患者寻找至少一个先前的治疗计划; 以及审查所述至少一个先前患者的至少一个先前治疗计划，以便基于所述至少一个以前的治疗计划中的信息确定是否可以改善所述至少一个新的治疗计划。

10. 发明授权

US07636420B2 Radio-therapeutic treatment planning incorporating functional imaging information 有权
标题翻译：包括功能成像信息的放射治疗治疗计划
公开(公告)号：US07636420B2
公开(公告)日：2009-12-22
申请号：US11914765
申请日：2006-05-01
申请人： Lothar Spies , Matthieu Bal , Todd McNutt
发明人： Lothar Spies , Matthieu Bal , Todd McNutt
IPC分类号： A61N5/10 , H05G1/42
CPC分类号： A61N5/103 , A61B6/03 , A61N5/1039 , A61N5/1042
摘要： A radiation therapy planning procedure and device provides a model-based segmentation of co-registered anatomical and functional imaging information to provide a more precise radiation therapy plan. The biology-based segmentation models the imaging information to produce a parametric map, which is then clustered into regions of similar radiation sensitivity or other biological parameters relevant for treatment definition. Each clustered region is prescribed its own radiation prescription dose.
摘要翻译：辐射治疗计划程序和装置提供共同注册的解剖和功能成像信息的基于模型的分割，以提供更精确的放射治疗计划。基于生物学的分割模拟成像信息以产生参数图，然后将其聚类到具有相似辐射敏感性的区域或与治疗定义相关的其他生物参数。每个聚簇区域规定自己的辐射处方剂量。

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