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1. 发明授权

US06317207B2 Frequency-domain light detection device 失效
公开(公告)号：US06317207B2
公开(公告)日：2001-11-13
申请号：US09767579
申请日：2001-01-22
申请人： Todd E. French , David P. Stumbo , Douglas N. Modlin
发明人： Todd E. French , David P. Stumbo , Douglas N. Modlin
IPC分类号： G01N2164
CPC分类号： G01N21/6408
摘要： Apparatus and methods for determining temporal properties of photoluminescent samples using frequency-domain photoluminescence measurements, where the measurements may include photon counting and/or the separation of measured luminescence into potentially overlapping time bins.

2. 发明授权

US06992761B2 Broad range light detection system 有权
标题翻译：宽范围光检测系统
公开(公告)号：US06992761B2
公开(公告)日：2006-01-31
申请号：US10445292
申请日：2003-05-22
申请人： Douglas N. Modlin , David P. Stumbo , Rick V. Stellmacher , Jonathan F. Petersen , Todd E. French
发明人： Douglas N. Modlin , David P. Stumbo , Rick V. Stellmacher , Jonathan F. Petersen , Todd E. French
IPC分类号： G01J3/30 , G01N21/54
CPC分类号： G01N21/6452 , G01N21/6428 , G01N21/76
摘要： Broad-range light-detection systems, including components and methods of use thereof. These systems may include apparatus and methods for detecting light with increased speed and/or detection efficiency, particularly in applications involving repeated analysis of the same sample and/or successive analysis of different samples, and particularly when the sample or samples have a wide range of light intensities. These systems also may include apparatus and methods for detecting light with increased accuracy over a broad range of intensities. These systems also may include vapparatus and methods for automatically scaling detection range to improve detection based on the intensity of the detected light.
摘要翻译：宽范围光检测系统，包括组件及其使用方法。这些系统可以包括用于以增加的速度和/或检测效率检测光的装置和方法，特别是在涉及重复分析不同样品的相同样品和/或连续分析的应用中，特别是当样品或样品具有宽范围光强度。这些系统还可以包括用于在宽范围的强度下以更高精度检测光的装置和方法。这些系统还可以包括用于自动缩放检测范围的装置和方法，以根据检测到的光的强度改进检测。

3. 发明授权

US06503719B2 Methods and apparatus for detecting polynucleotide hybridization 失效
标题翻译：检测多核苷酸杂交的方法和装置
公开(公告)号：US06503719B2
公开(公告)日：2003-01-07
申请号：US09767316
申请日：2001-01-22
申请人： Douglas N. Modlin , Todd E. French , Jon F. Petersen , John C. Owicki
发明人： Douglas N. Modlin , Todd E. French , Jon F. Petersen , John C. Owicki
IPC分类号： C12Q168
CPC分类号： G01N35/028 , B01J2219/00317 , B01J2219/00529 , B01L3/50853 , C12Q1/6816 , C12Q1/6827 , C40B60/14 , G01N35/1011 , G01N35/1074 , G01N2035/00237 , G01N2035/0405 , G01N2035/0425 , G01N2035/0462 , Y10T436/143333 , C12Q2565/107 , C12Q2563/103 , C12Q2561/119
摘要： Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) contacting a sample polynucleotide with a reference polynucleotide at an assay site, where at least one of the polynucleotides is capable of emitting luminescence, (2) illuminating the assay site with light capable of stimulating such luminescence, (3) detecting light transmitted from the assay site, and (4) deriving information relating to the extent of hybridization between the sample and reference polynucleotides based on the detected light. The methods may further include (1) illuminating with and/or detecting polarized light, (2) deriving information relating to the sequence of the sample polynucleotide from the extent of hybridization, and (3) converting the light to a signal and distinguishing between a portion of the signal attributable to luminescence and a portion attributable to background.
摘要翻译：用于在基于发光的测定中检测多核苷酸杂交的方法和装置。方法可以包括（1）在测定位点使样品多核苷酸与参考多核苷酸接触，其中至少一个多核苷酸能够发射发光，（2）用能够刺激这种发光的光照射测定位点，（3 ）检测从测定位点传输的光，以及（4）基于检测到的光导出与样品和参考多核苷酸之间的杂交程度相关的信息。所述方法还可以包括（1）用偏振光进行照射和/或检测偏振光，（2）从杂交程度导出与样品多核苷酸序列相关的信息，和（3）将光转换成信号并区分可归因于发光的信号的一部分和归因于背景的部分。

4. 发明授权

US06483582B2 Apparatus and methods for time-resolved spectroscopic measurements 失效
标题翻译：用于时间分辨光谱测量的装置和方法
公开(公告)号：US06483582B2
公开(公告)日：2002-11-19
申请号：US09765874
申请日：2001-01-19
申请人： Douglas N. Modlin , Todd E. French , John C. Owicki
发明人： Douglas N. Modlin , Todd E. French , John C. Owicki
IPC分类号： G01J330
CPC分类号： G01N21/6452 , B82Y15/00 , G01N21/51 , G01N21/6408 , G01N21/6445 , G01N21/645 , G01N2021/6471
摘要： Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a plurality of sample wells. The apparatus may be configured to take frequency-domain time-resolved measurements of one or more of luminescence lifetimes and reorientational correlation times of a luminescent analyte in the sample.
摘要翻译：用于测量从样品透射的光的装置和方法。该装置可以包括舞台，光源和检测器。该台可以被配置成容纳具有多个样品孔的微孔板。该装置可以被配置为进行样品中发光分析物的发光寿命和重新定向相关时间中的一个或多个的频域时间分辨测量。

5. 发明授权

US07714301B2 Instrument excitation source and calibration method 有权
标题翻译：仪器励磁源和校准方法
公开(公告)号：US07714301B2
公开(公告)日：2010-05-11
申请号：US11100320
申请日：2005-04-05
申请人： Joseph H. Jackson , Robert M. Gavin, III , Richard C. Tighe , Steve McNerney , Wu Jiang , Todd E. French , Reginald Tobias
发明人： Joseph H. Jackson , Robert M. Gavin, III , Richard C. Tighe , Steve McNerney , Wu Jiang , Todd E. French , Reginald Tobias
IPC分类号： G01N21/64
CPC分类号： G01N21/6456
摘要： An apparatus including an LED excitation source and module useful for full plate imaging fluorescence instruments as well as methods for calibrating such instruments. The apparatus may include a light source operative to provide simultaneous illumination of a first wavelength selected to a plurality of samples to excite the fluorescent emission of light of a second wavelength by said plurality of samples wherein the light source is an LED array; and an optical sensor, responsive to light at said second wavelength.
摘要翻译：一种包括用于全板成像荧光仪器的LED激发源和模块的装置以及用于校准这种仪器的方法。该装置可以包括光源，其可操作以提供对多个样本的所选择的第一波长的同时照明，以激发所述多个样本的荧光发射第二波长的光，其中所述光源是LED阵列; 以及响应于所述第二波长的光的光学传感器。

6. 发明授权

US07265829B2 Reflective optic system for imaging microplate readers 有权
标题翻译：用于成像酶标仪的反光光学系统
公开(公告)号：US07265829B2
公开(公告)日：2007-09-04
申请号：US10738438
申请日：2003-12-17
申请人： Wu Jiang , Todd E. French , David P. Stumbo
发明人： Wu Jiang , Todd E. French , David P. Stumbo
IPC分类号： G01J3/28
CPC分类号： G01N21/6452 , G01N21/6428 , G02B17/061 , G02B27/0025
摘要： A reflective light imaging system for use in high-throughput screening of samples disposed in multiple-well plates. The system can include a set of mirrors and lenses. The first mirror has a central aperture through which light from the object passes. The first mirror has a concave reflective surface that faces the image plane. The next element is a second mirror with a convex reflective surface. The system can include an aberration corrective system positioned between the second mirror and the image plane, and an optical sensor near the image plane. Light from an object passes through the central aperture of the first mirror and is reflected off the convex surface of the second mirror. The light then strikes the reflective surface of the first mirror. The light from the first mirror is then collected by the aberration correction system and transmitted toward the image plane.
摘要翻译：一种用于高通量筛选多孔板样品的反射光成像系统。该系统可以包括一组镜子和镜头。第一个镜子有一个中心光阑，通过这个中心孔光从物体通过。第一反射镜具有面向图像平面的凹面反射面。下一个元件是具有凸反射表面的第二镜。该系统可以包括位于第二反射镜和图像平面之间的像差校正系统，以及靠近图像平面的光学传感器。来自物体的光穿过第一反射镜的中心孔并从第二反射镜的凸表面反射。光然后撞击第一反射镜的反射表面。来自第一反射镜的光然后被像差校正系统收集并且朝向图像平面传送。

7. 发明授权

US06930314B2 Light detection device 失效
标题翻译：光检测装置
公开(公告)号：US06930314B2
公开(公告)日：2005-08-16
申请号：US10003030
申请日：2001-10-29
申请人： Joseph H. Jackson, III , Dean G. Hafeman , Todd E. French
发明人： Joseph H. Jackson, III , Dean G. Hafeman , Todd E. French
IPC分类号： G01J1/58 , G01J3/30 , G01N21/64 , G02B20060101 , H01L29/22
CPC分类号： G01N21/6456
摘要： Apparatus and methods for optical illumination and/or detection with improved flexibility and/or read speed. The apparatus and methods may include mechanisms for selecting and switching between multiple excitation wavelengths and/or simultaneously reading from a plurality of sample sites. The apparatus and methods may be used with microplates, PCR plates, cell culture plates, biochips, chromatography plates, microscope slides, and other substrates for high-throughput screening, genomics, SNPs analysis, pharmaceutical research and development, life sciences research, and other applications.
摘要翻译：具有改善的灵活性和/或读取速度的用于光学照明和/或检测的装置和方法。装置和方法可以包括用于在多个激发波长之间选择和切换和/或同时从多个采样点读取的机构。该设备和方法可以与微孔板，PCR板，细胞培养板，生物芯片，色谱板，显微镜载玻片和其它底物一起使用，用于高通量筛选，基因组学，SNP分析，药物研究和开发，生命科学研究等应用程序。

8. 发明授权

US06825921B1 Multi-mode light detection system 有权
标题翻译：多模光检测系统
公开(公告)号：US06825921B1
公开(公告)日：2004-11-30
申请号：US09710061
申请日：2000-11-10
申请人： Douglas N. Modlin , John C. Owicki , Jon F. Petersen , Todd E. French , Carl L. Wright , Jeanne A. Ruiz , Lorne E. Bechtel
发明人： Douglas N. Modlin , John C. Owicki , Jon F. Petersen , Todd E. French , Carl L. Wright , Jeanne A. Ruiz , Lorne E. Bechtel
IPC分类号： G01N2100
CPC分类号： G01N21/76 , G01N21/255 , G01N21/31 , G01N21/474 , G01N21/6445 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6476 , G01N2021/6484
摘要： Apparatus and methods for combining multiple modes and methods of optical detection, postprocessing, and/or feedback loops in bioanalytical measurements. The methods may include (1) positioning a composition at an examination site in a multi-mode instrument; (2) detecting light transmitted form the composition using the multi-mode instrument in a first optical measurement mode; (3) detecting light transmitted from the composition using the multi-mode instrument in a second optical measurement mode, the second mode being different than the first mode; and (4) computing a quantity related to a property of the composition using the light detected in at least one of the optical measurement modes. These steps may be performed on one or more samples, simultaneously and/or sequentially. The quantity may relate to photoluminescence, chemiluminescence, absorption, and/or scattering, among others.
摘要翻译：用于组合生物分析测量中的多种模式和光学检测，后处理和/或反馈回路的方法的装置和方法。所述方法可以包括（1）将组合物定位在多模式仪器的检查部位; （2）以第一光学测量模式使用多模式仪器检测从组合物透射的光; （3）在第二光学测量模式中使用所述多模式仪器检测从所述组合物发射的光，所述第二模式不同于所述第一模式; 以及（4）使用在所述光学测量模式中的至少一个中检测到的光来计算与所述构图的属性有关的量。这些步骤可以同时和/或顺序地在一个或多个样品上进行。该量可以涉及光致发光，化学发光，吸收和/或散射等。

9. 发明授权

US06297018B1 Methods and apparatus for detecting nucleic acid polymorphisms 有权
公开(公告)号：US06297018B1
公开(公告)日：2001-10-02
申请号：US09494407
申请日：2000-01-28
申请人： Todd E. French , Douglas N. Modlin , John C. Owicki , James S. Richey , Lev J. Leytes , Enal S. Razvi
发明人： Todd E. French , Douglas N. Modlin , John C. Owicki , James S. Richey , Lev J. Leytes , Enal S. Razvi
IPC分类号： C02Q168
CPC分类号： G01N21/6445 , B01J2219/00315 , B01J2219/00317 , B01J2219/00529 , B01J2219/00605 , B01J2219/00659 , B01J2219/00686 , B01J2219/00691 , B01J2219/00707 , B01L3/50853 , B01L9/523 , B01L2300/0829 , B82Y15/00 , C07K7/06 , C07K7/08 , C12Q1/485 , C12Q1/6816 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6858 , C40B60/14 , G01N21/76 , G01N35/028 , G01N35/1011 , G01N35/1074 , G01N2035/00237 , G01N2035/0405 , G01N2035/0425 , G01N2035/0462 , G01N2333/9121 , C12Q2565/107 , C12Q2561/119
摘要： Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance energy transfer (FRET) detection, and (3) allele-specific nucleotide incorporation, using primer extension with luminescence polarization (FP) detection. More specifically, the methods may include (1) locating a sample containing a nucleic acid material at an examination site, (2) illuminating the sample, (3) detecting light transmitted from the sample, and (4) determining the presence, absence, and/or identity of a nucleic acid target in the sample using the light transmitted from the sample.

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