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1. 发明授权

US08772254B2 Method and constructs for delivering double stranded RNA to pest organisms 有权
标题翻译：将双链RNA递送给有害生物的方法和构建体
公开(公告)号：US08772254B2
公开(公告)日：2014-07-08
申请号：US11666017
申请日：2005-10-25
申请人： Thierry AndréOlivier Eddy Bogaert , Richard Zwaal , Geert Karel Maria Plaetinck , Jan Octaaf De Kerpel , Titus Jan Kaletta
发明人： Thierry AndréOlivier Eddy Bogaert , Richard Zwaal , Geert Karel Maria Plaetinck , Jan Octaaf De Kerpel , Titus Jan Kaletta
IPC分类号： C12N15/11 , C07H21/04
CPC分类号： C12N15/8279 , A01K2217/058 , A01K2227/703 , A61K48/0033 , C12N15/111 , C12N15/113 , C12N15/8216 , C12N15/8283 , C12N15/8285 , C12N15/8286 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , C12N2710/14143 , C12N2770/00011 , Y02A40/162 , Y02A40/164
摘要： The present invention relates in generally to RNAi and its use in gene silencing. In particular, the present invention relates to methods and constructs for delivering double stranded RNA (dsRNA) to pest organisms.
摘要翻译：本发明一般涉及RNAi及其在基因沉默中的用途。特别地，本发明涉及用于将双链RNA（dsRNA）递送给有害生物的方法和构建体。

2. 发明申请

US20080125432A1 5-Carboxamido Substituted Thiazole Derivatives that Interact With Ion Channels, In Particular With Ion Channels From the Kv Family 审中-公开
标题翻译：与离子通道相互作用的5-酰胺取代的噻唑衍生物，特别是与Kv族的离子通道
公开(公告)号：US20080125432A1
公开(公告)日：2008-05-29
申请号：US11792030
申请日：2005-12-01
申请人： Petra Blom , Jan Octaaf De Kerpel , Eric Pierre Paul Rene Fourmaintraux , Titus Jan Kaletta , Dirk Leysen
发明人： Petra Blom , Jan Octaaf De Kerpel , Eric Pierre Paul Rene Fourmaintraux , Titus Jan Kaletta , Dirk Leysen
IPC分类号： A61K31/53 , A61K31/4245 , A61K31/426 , A61K31/506 , A61K31/501 , C07D403/02 , C07D417/02
CPC分类号： C07D239/42 , C07D233/90 , C07D263/48 , C07D271/07 , C07D277/56 , C07D333/38 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula having the structural Formula I, II, III or IV, stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, wherein X, Y1, Y2, R1, n, R3, R8, R9, R10, L1, L2, Ar1 and Ar2 are defined in claim 1. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.
摘要翻译：本发明涉及与离子通道相互作用的化合物。特别地，本发明涉及具有结构式I，II，III或IV的立体异构体，互变异构体，外消旋学，前药，其代谢物或其药学上可接受的盐和/或溶剂合物的结构式的化合物，其中X，Y R 1，R 2，R 1，...，R 3，R 8， R 9，R 10，L 1，L 2，Ar 1，和Ar 2定义在权利要求1中。本发明还涉及制备所述化合物的方法，包含所述化合物的药物组合物以及所述化合物在治疗人和动物体的方法中的用途。

3. 发明授权

US08759306B2 RNAi for the control of insects and arachnids 有权
标题翻译：用于控制昆虫和蜘蛛的RNAi
公开(公告)号：US08759306B2
公开(公告)日：2014-06-24
申请号：US11921370
申请日：2006-05-31
申请人： Titus Jan Kaletta
发明人： Titus Jan Kaletta
IPC分类号： C12N15/11 , C07H21/04
CPC分类号： C12N15/113 , A01M1/103 , A01M1/20 , A01N25/34 , A01N57/16 , A01N63/00 , A01N63/02 , C07K14/435 , C12N2310/111 , C12N2310/14 , C12N2320/30 , C12P19/34
摘要： The present invention describes a new non-compound based approach for insect and/or arachnid control. The present inventors have identified for the first time novel targets for RNAi, which can effectively control insect and/or arachnid pest populations. Accordingly, the invention provides both nucleotide and amino acid sequences for the novel targets. Also provided are RNA constructs including double stranded RNA regions for mediating RNAi in insects, DNA constructs, expression vectors, host cells and compositions for controlling insects and/or arachnids using RNAi. Finally, the invention also provides for the use of the constructs, vectors, host cells and compositions in control of insects and/or arachnids populations and suitable kits for use in an RNAi based method of controlling insect and/or arachnid pests.
摘要翻译：本发明描述了用于昆虫和/或蜘蛛控制的新的基于非化合物的方法。本发明人首次确定了可有效控制昆虫和/或蛛形纲虫害群体的RNAi新靶标。因此，本发明提供新靶标的核苷酸和氨基酸序列。还提供了包括用于介导昆虫中RNAi的双链RNA区域的RNA构建体，DNA构建体，表达载体，宿主细胞和使用RNAi控制昆虫和/或蜘蛛的组合物。最后，本发明还提供构建体，载体，宿主细胞和组合物在昆虫和/或蜘蛛种群的控制中的应用以及用于控制昆虫和/或蜘蛛虫害的基于RNAi的方法中的合适的试剂盒。

4. 发明申请

US20100011654A1 RNAI FOR THE CONTROL OF INSECTS AND ARACHNIDS 有权
标题翻译：用于控制毒素和神经元的RNAI
公开(公告)号：US20100011654A1
公开(公告)日：2010-01-21
申请号：US11921370
申请日：2006-05-31
申请人： Titus Jan Kaletta
发明人： Titus Jan Kaletta
IPC分类号： A01M1/10 , A01N25/00 , A01N25/06 , A01N63/00 , C12N1/21 , C12N15/63 , A01N43/40 , C07H21/02 , C07H21/04
CPC分类号： C12N15/113 , A01M1/103 , A01M1/20 , A01N25/34 , A01N57/16 , A01N63/00 , A01N63/02 , C07K14/435 , C12N2310/111 , C12N2310/14 , C12N2320/30 , C12P19/34
摘要： The present invention describes a new non-compound based approach for insect and/or arachnid control. The present inventors have identified for the first time novel targets for RNAi, which can effectively control insect and/or arachnid pest populations. Accordingly, the invention provides both nucleotide and amino acid sequences for the novel targets. Also provided are RNA constructs including double stranded RNA regions for mediating RNAi in insects, DNA constructs, expression vectors, host cells and compositions for controlling insects and/or arachnids using RNAi. Finally, the invention also provides for the use of the constructs, vectors, host cells and compositions in control of insects and/or arachnids populations and suitable kits for use in an RNAi based method of controlling insect and/or arachnid pests.
摘要翻译：本发明描述了用于昆虫和/或蜘蛛控制的新的基于非化合物的方法。本发明人首次确定了可有效控制昆虫和/或蛛形纲虫害群体的RNAi新靶标。因此，本发明提供新靶标的核苷酸和氨基酸序列。还提供了包括用于介导昆虫中RNAi的双链RNA区域的RNA构建体，DNA构建体，表达载体，宿主细胞和使用RNAi控制昆虫和/或蜘蛛的组合物。最后，本发明还提供构建体，载体，宿主细胞和组合物在昆虫和/或蜘蛛种群的控制中的应用以及用于控制昆虫和/或蜘蛛虫害的基于RNAi的方法中的合适的试剂盒。

5. 发明申请

US20090263364A1 Method and constructs for delivering double stranded rna to pest organisms 有权
标题翻译：将双链rna递送给有害生物的方法和结构
公开(公告)号：US20090263364A1
公开(公告)日：2009-10-22
申请号：US11666017
申请日：2005-10-25
申请人： Thierry Andre Olivier Eddy Bogaert , Richard Zwaal , Geert Plaetinck , Jan Octaaf De Kerpel , Titus Jan Kaletta
发明人： Thierry Andre Olivier Eddy Bogaert , Richard Zwaal , Geert Plaetinck , Jan Octaaf De Kerpel , Titus Jan Kaletta
IPC分类号： A61K48/00 , A61K31/713 , C12N15/82 , C07H21/04 , C12N1/21 , C12P21/02 , A01H5/00 , C07H21/02 , C12N1/15 , C12N1/19 , C12N5/10 , A61K35/00
CPC分类号： C12N15/8279 , A01K2217/058 , A01K2227/703 , A61K48/0033 , C12N15/111 , C12N15/113 , C12N15/8216 , C12N15/8283 , C12N15/8285 , C12N15/8286 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , C12N2710/14143 , C12N2770/00011 , Y02A40/162 , Y02A40/164
摘要： The present invention relates in generally to RNAi and its use in gene silencing. In particular, the present invention relates to methods and constructs for delivering double stranded RNA (dsRNA) to pest organisms.
摘要翻译：本发明一般涉及RNAi及其在基因沉默中的用途。特别地，本发明涉及用于将双链RNA（dsRNA）递送给有害生物的方法和构建体。

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