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1. 发明授权

US07335350B2 Chemokines mutants having improved oral bioavailability 失效
标题翻译：具有改善的口服生物利用度的趋化因子突变体
公开(公告)号：US07335350B2
公开(公告)日：2008-02-26
申请号：US10510014
申请日：2003-03-31
申请人： Amanda Proudfoot , Marie Kosco-Vilbois , Timothy Wells
发明人： Amanda Proudfoot , Marie Kosco-Vilbois , Timothy Wells
IPC分类号： A61K45/00 , A61K39/00 , A01N37/18
CPC分类号： A61K38/195
摘要： The oral efficacy of C—C chemokines containing a dibasic site in the 40's conserved cationic sequence, such as RANTES and MIP-1β, is improved by substituting at least one of the residues in the dibasic site in a non-conservative manner.
摘要翻译：通过以非保守的方式代替二元位点中的至少一个残基，改善了含有二十一位点在40位保守阳离子序列（如RANTES和MIP-1beta）中的C-C趋化因子的口服功效。

2. 发明申请

US20060201992A1 Surgical stapling device 有权
公开(公告)号：US20060201992A1
公开(公告)日：2006-09-14
申请号：US11436282
申请日：2006-05-18
申请人： David Racenet , Timothy Wells
发明人： David Racenet , Timothy Wells
IPC分类号： A61B17/04
CPC分类号： A61B17/068 , A61B17/072 , A61B2017/00367 , A61B2017/0038 , A61B2017/07214 , A61B2017/07264 , A61B2017/2925 , A61B2017/2945 , A61B2017/320052 , A61B2090/0811
摘要： A surgical stapling device for applying an array of surgical staples to tissue is provided. The stapling device includes an approximation mechanism for moving a cartridge assembly and an anvil assembly between spaced and approximated positions and a firing mechanism for ejecting the array of staples from the cartridge assembly. A single trigger is operable to effect approximation and firing of the device. The device also includes an alignment pin assembly which can be selectively manually or automatically advanced. The anvil assembly includes a stiffener plate which allows the device to have a reduced head portion profile.

3. 发明申请

US20060046462A1 Circuitized substrate, method of making same and information handling system using same 失效
标题翻译：电路化基板，制造方法以及使用其的信息处理系统
公开(公告)号：US20060046462A1
公开(公告)日：2006-03-02
申请号：US11259043
申请日：2005-10-27
申请人： Timothy Antesberger , James Fuller , John Konrad , John Kresge , Stephen Krasniak , Timothy Wells
发明人： Timothy Antesberger , James Fuller , John Konrad , John Kresge , Stephen Krasniak , Timothy Wells
IPC分类号： H01L21/4763 , H01L21/44
CPC分类号： H01L21/4846 , H01L23/49838 , H01L24/48 , H01L2224/16 , H01L2224/48227 , H01L2924/00014 , H01L2924/01078 , H01L2924/01322 , H01L2924/12042 , H01L2924/14 , H01L2924/181 , H05K3/0035 , H05K3/0038 , H05K3/242 , H05K3/28 , H05K2203/107 , H05K2203/175 , H01L2924/00 , H01L2924/00012 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： A method of making a circuitized substrate in which a commoning bar, used during the plating of the circuitry on the substrate and coupled to a second set of conductors which in turn are coupled to a first set of conductors, is terminated from the second set of conductors.
摘要翻译：一种制造电路化基板的方法，其中在基板上的电路的电镀过程中使用并耦合到第二组导体的公共条被连接到第一组导体，该第二组导体被连接到第二组导体导体

4. 发明申请

US20050014695A1 Uses of a chemokine receptor able to bind to MCP-1, MIP-1 alpha and/or rantes 失效
标题翻译：使用能够结合MCP-1，MIP-1α和/或细胞的趋化因子受体
公开(公告)号：US20050014695A1
公开(公告)日：2005-01-20
申请号：US10933356
申请日：2004-09-03
申请人： Timothy Wells , Christine Power
发明人： Timothy Wells , Christine Power
IPC分类号： G01N33/53 , A61K38/00 , A61K45/00 , A61K48/00 , A61P7/00 , A61P9/10 , A61P11/06 , A61P17/00 , A61P27/02 , A61P27/14 , A61P27/16 , A61P31/12 , A61P31/18 , A61P37/00 , A61P37/08 , A61P43/00 , C07K14/52 , C07K14/715 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12R1/91 , G01N33/566 , A61K38/17
CPC分类号： C07K14/7158
摘要： A chemokine receptor binds to MCP-1, MIP-1α and/or RANTES. It can be used in screening for agents which act as antagonists to MCP-1, MIP-1α and/or RANTES. Such agents may be useful in treating various disorders, including allergies, atheromas and diseases mediated by viruses. They may also be useful in preventing graft rejection and in protecting stem cells from potentially damaging effects of chemotherapy.
摘要翻译：趋化因子受体结合MCP-1，MIP-1α和/或RANTES。它可用于筛选作为MCP-1，MIP-1α和/或RANTES拮抗剂的药剂。这样的药剂可用于治疗各种疾病，包括过敏，动脉粥样化和由病毒介导的疾病。它们也可用于预防移植物排斥和保护干细胞免受化学疗法的潜在破坏性影响。

5. 发明申请

US20090018169A1 Sulfonamide Derivatives for the Treatment of Bacterial Infections 审中-公开
标题翻译：用于治疗细菌感染的磺酰胺衍生物
公开(公告)号：US20090018169A1
公开(公告)日：2009-01-15
申请号：US12278831
申请日：2007-02-09
申请人： Jerome Gonzalez , Dominique Swinnen , Agnes Bombrun , Rob Hooft Van Huijsduijnen , Timothy Wells
发明人： Jerome Gonzalez , Dominique Swinnen , Agnes Bombrun , Rob Hooft Van Huijsduijnen , Timothy Wells
IPC分类号： A61K31/381 , C07D409/12 , A61K31/4436 , A61P31/04 , C07D333/04
CPC分类号： A61K31/381 , A61K31/4436
摘要： This present invention is related to sulfonamide derivatives of Formula (I), pharmaceutical composition thereof, methods of preparation thereof and to their use for the treatment and/or prophylaxis of bacterial infections such as tuberculosis.
摘要翻译：本发明涉及式（I）的磺酰胺衍生物，其药物组合物，其制备方法及其用于治疗和/或预防细菌感染如结核病的用途。

6. 发明申请

US20070169269A1 Ambulance cot with improved drop frame 审中-公开
标题翻译：救护床与改进的落架
公开(公告)号：US20070169269A1
公开(公告)日：2007-07-26
申请号：US11340165
申请日：2006-01-26
申请人： Timothy Wells
发明人： Timothy Wells
IPC分类号： A61G7/015
CPC分类号： A61G1/0262 , A61G1/0212 , A61G1/0237 , A61G1/0567
摘要： A multiple level elevating cot adapted to be rolled into emergency vehicles, the cot having a wheeled undercarriage supporting a cot frame having a leading end and a trailing end, and adapted to selectively secure the cot frame in a plurality of elevational positions. The cot frame includes an improved drop frame having a wider range of motion to a cot construction. The cot frame is also provided with patient support features, such as positionable back, leg, and side arm supports.
摘要翻译：一种适用于紧急车辆的多级升降床，该婴儿床具有一个轮式起落架，支撑着一个具有前端和后端的婴儿床框架，并且适于将婴儿床框架选择性地固定在多个高度位置。婴儿床框架包括具有相对于婴儿床构造的较宽运动范围的改进的落架框架。婴儿床框架还设置有患者支撑特征，例如可定位的背部，腿部和侧臂支撑件。

7. 发明申请

US20060255009A1 Plating method for circuitized substrates 失效
标题翻译：电路化基板的电镀方法
公开(公告)号：US20060255009A1
公开(公告)日：2006-11-16
申请号：US11128272
申请日：2005-05-13
申请人： Norman Card , Robert Edwards , John Konrad , Roy Magnuson , Timothy Wells , Michael Wozniak
发明人： Norman Card , Robert Edwards , John Konrad , Roy Magnuson , Timothy Wells , Michael Wozniak
IPC分类号： H01B13/00
CPC分类号： H05K3/427 , H05K3/108 , H05K3/382 , H05K3/429 , H05K2203/0353 , H05K2203/1476 , Y10T29/49156 , Y10T29/49165
摘要： A method of plating a circuit pattern on a substrate to produce a circuitized substrate (e.g., a printed circuit board) in which a dual step metallurgy application process is used in combination with a dual step photo-resist removal process. Thru-holes are also possible, albeit not required.
摘要翻译：将电路图案电镀在基板上以制造其中双步骤冶金施加工艺与双步骤光刻胶去除工艺结合使用的电路化基板（例如印刷电路板）的方法。通孔也是可以的，尽管不是必需的。

8. 发明申请

US20060040426A1 Circuitized substrate, method of making same and information handling system using same 失效
标题翻译：电路化基板，制造方法以及使用其的信息处理系统
公开(公告)号：US20060040426A1
公开(公告)日：2006-02-23
申请号：US11258092
申请日：2005-10-26
申请人： Timothy Antesberger , James Fuller , John Konrad , John Kresge , Stephen Krasniak , Timothy Wells
发明人： Timothy Antesberger , James Fuller , John Konrad , John Kresge , Stephen Krasniak , Timothy Wells
IPC分类号： H01L21/48
CPC分类号： H01L21/4846 , H01L23/49838 , H01L24/48 , H01L2224/16 , H01L2224/48227 , H01L2924/00014 , H01L2924/01078 , H01L2924/01322 , H01L2924/12042 , H01L2924/14 , H01L2924/181 , H05K3/0035 , H05K3/0038 , H05K3/242 , H05K3/28 , H05K2203/107 , H05K2203/175 , H01L2924/00 , H01L2924/00012 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： A method of making a circuitized substrate in which the substrate's commoning bar, used during the plating of the circuitry on the substrate, is terminated from the various conductors using a laser. In a preferred embodiment, the laser acts through a dielectric layer (soldermask) which is applied over the circuitry, including the commoning bar and connected parts. The laser may also be used to expose selected ones of the circuit's other parts, including various pads used to accommodate a wirebond (from a chip) and also solder balls for eventual placement of the substrate on a larger circuit board.
摘要翻译：制造电路化基板的方法，其中在基板上的电路的电镀期间使用的基板的共用条，使用激光从各种导体终止。在优选实施例中，激光器通过介电层（焊接掩模）进行作用，该电介质层被施加在电路上，包括共用条和连接部分。激光器还可以用于暴露电路的其他部分中的选定的部分，包括用于容纳引线键（来自芯片）的各种焊盘以及用于最终将衬底放置在较大电路板上的焊球。

9. 发明申请

US20080023523A1 Surgical stapling device 有权
公开(公告)号：US20080023523A1
公开(公告)日：2008-01-31
申请号：US11904566
申请日：2007-09-27
申请人： David Racenet , Timothy Wells
发明人： David Racenet , Timothy Wells
IPC分类号： A61B17/068
CPC分类号： A61B17/068 , A61B17/072 , A61B2017/00367 , A61B2017/0038 , A61B2017/07214 , A61B2017/07264 , A61B2017/2925 , A61B2017/2945 , A61B2017/320052 , A61B2090/0811
摘要： A surgical stapling device for applying an array of surgical staples to tissue is provided. The stapling device includes an approximation mechanism for moving a cartridge assembly and an anvil assembly between spaced and approximated positions and a firing mechanism for ejecting the array of staples from the cartridge assembly. A single trigger is operable to effect approximation and firing of the device. The device also includes an alignment pin assembly which can be selectively manually or automatically advanced. The anvil assembly includes a stiffener plate which allows the device to have a reduced head portion profile.

10. 发明申请

US20080000777A1 SELECTIVE SHIELD/MATERIAL FLOW MECHANISM 有权
标题翻译：选择性屏蔽/材料流动机制
公开(公告)号：US20080000777A1
公开(公告)日：2008-01-03
申请号：US11855507
申请日：2007-09-14
申请人： Ralph Barrese , Gary Gajdorus , Allen Hopkins , John Konrad , Robert Schaffer , Timothy Wells
发明人： Ralph Barrese , Gary Gajdorus , Allen Hopkins , John Konrad , Robert Schaffer , Timothy Wells
IPC分类号： C25D5/00
CPC分类号： C25D17/008 , C25D5/00 , C25D5/003 , C25D17/12 , C25D21/12 , Y10S204/07
摘要： An apparatus and method for plating a workpiece. The apparatus comprises, generally, an anode, a cathode, and a selective anode shield/material flow assembly. In use, both the anode and the cathode are immersed in a solution, and the cathode is used to support the workpiece. During an electroplating process, the anode and the cathode generate an electric field emanating from the anode towards the cathode, to generate a corresponding current to deposit an electroplating material on the workpiece. The selective shield/material flow assembly is located between the anode and the cathode, and forms a multitude of adjustable openings. These opening have sizes that are adjustable during the electroplating process for selectively and controllably adjusting the amount of electric flux passing through the selective shield/material flow assembly and the distribution of the electroplating material on the workpiece. The selective shield/material flow assembly can also be used with an electroless plating system. At least one selective shield material flow mechanism is used in a selective shield material flow assembly.
摘要翻译：一种用于电镀工件的装置和方法。该装置通常包括阳极，阴极和选择性阳极屏蔽/材料流组件。在使用中，将阳极和阴极两者浸入溶液中，阴极用于支撑工件。在电镀过程中，阳极和阴极产生从阳极向阴极发出的电场，以产生相应的电流，以将电镀材料沉积在工件上。选择性屏蔽/材料流动组件位于阳极和阴极之间，并形成多个可调开口。这些开口具有在电镀过程中可调节的尺寸，用于选择性地和可控地调节通过选择性屏蔽/材料流组件的电流量以及电镀材料在工件上的分布。选择性屏蔽/材料流动组件也可以与无电镀系统一起使用。在选择性屏蔽材料流动组件中使用至少一种选择性屏蔽材料流动机构。

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