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1. 发明授权

US08319390B2 Generator with ferromagnetic teeth 有权
标题翻译：发电机铁磁齿
公开(公告)号：US08319390B2
公开(公告)日：2012-11-27
申请号：US13164023
申请日：2011-06-20
申请人： Gregory L. Snitchler , Timothy MacDonald
发明人： Gregory L. Snitchler , Timothy MacDonald
IPC分类号： H02K3/04
CPC分类号： H02K1/165 , H02K7/1838 , H02K55/04 , H02K2213/03 , Y02E10/725 , Y02E40/625
摘要： A stator assembly for use in a superconducting generator operated at frequencies up to 10 Hz is disclosed. The stator assembly includes a ferromagnetic stator winding support having a plurality of teeth defining slots, the slots configured to receive and support stator windings. The stator winding support is formed so that the ratio of the sum of the widths of the slots to the sum of the widths of the teeth and slots is in the range of 0.65 to 0.90.
摘要翻译：公开了用于在高达10Hz的频率下运行的超导发电机的定子组件。定子组件包括铁磁定子绕组支撑件，其具有限定槽的多个齿，所述槽配置成接收和支撑定子绕组。定子绕组支撑件形成为使得槽的宽度之和与齿和槽的宽度之和的比率在0.65至0.90的范围内。

2. 发明授权

US06531457B2 Methods and compositions for treating inflammatory response 有权
标题翻译：用于治疗炎症反应的方法和组合物
公开(公告)号：US06531457B2
公开(公告)日：2003-03-11
申请号：US09827083
申请日：2001-04-05
申请人： Joel M. Linden , Gail W. Sullivan , Ian J. Sarembock , Timothy MacDonald , Mark Okusa , Irving L. Kron , W. Michael Scheld
发明人： Joel M. Linden , Gail W. Sullivan , Ian J. Sarembock , Timothy MacDonald , Mark Okusa , Irving L. Kron , W. Michael Scheld
IPC分类号： A61K3170
CPC分类号： C07H19/06
摘要： Compounds and methods are provided to treat inflammatory conditions with certain A2A adenosine receptor antagonists.
摘要翻译：提供化合物和方法以用某些A2A腺苷受体拮抗剂治疗炎性病症。

3. 发明授权

US5686310A Method for determination of the amount of either phosphotyrosine or phosphoserine in a protein 失效
标题翻译：测定蛋白质中磷酸酪氨酸或磷酸丝氨酸量的方法
公开(公告)号：US5686310A
公开(公告)日：1997-11-11
申请号：US467717
申请日：1995-06-06
申请人： Timothy A.J. Haystead , Timothy MacDonald , R. Patrick Fadden
发明人： Timothy A.J. Haystead , Timothy MacDonald , R. Patrick Fadden
IPC分类号： C07K1/00 , C07K1/107 , C07K1/13
CPC分类号： C07K1/003 , C07K1/1077 , Y10T436/16
摘要： Traditional methods for measuring the phosphorylation state of cellular proteins have relied on .sup.32 P-orthophosphate labeling of cells in culture. The problems associated with radioactive isotopes have therefor prohibited phosphorylation studies on whole animals and humans. The present invention provides a unique technique that allows quantitative attachment of probes (e.g. fluorophors or biotin) to phospho-proteins and peptides by activating phospho-amino acids. the phosphorylation state of cellular proteins derived from human tissues can now be measured. This method can be used for early detection of cancer and diabetes and also for the identification of pharmaceutical agents.
摘要翻译：用于测量细胞蛋白磷酸化状态的传统方法依赖于32P-正磷酸盐对培养细胞的标记。与放射性同位素相关的问题因此禁止对整个动物和人类进行磷酸化研究。本发明提供了一种独特的技术，其允许通过激活磷酸 - 氨基酸使探针（例如荧光体或生物素）与磷酸蛋白质和肽的定量连接。现在可以测量源于人组织的细胞蛋白的磷酸化状态。该方法可用于癌症和糖尿病的早期检测，也可用于鉴定药剂。

4. 发明授权

US4215006A 2-and 3-Cyclotetradecen-1-one to augment or enhance the aroma of solid or liquid detergents 失效
标题翻译： 2-和3-环十四碳烯-1-酮，以增强或增强固体或液体洗涤剂的香气
公开(公告)号：US4215006A
公开(公告)日：1980-07-29
申请号：US52830
申请日：1979-06-27
申请人： Braja D. Mookherjee , Robert W. Trenkle , Manfred H. Vock , Domenick Luccarelli, Jr. , Frederick L. Schmitt , Gilbert Stork , Timothy Macdonald , Arthur L. Liberman
发明人： Braja D. Mookherjee , Robert W. Trenkle , Manfred H. Vock , Domenick Luccarelli, Jr. , Frederick L. Schmitt , Gilbert Stork , Timothy Macdonald , Arthur L. Liberman
IPC分类号： C11B9/00 , C11D3/50 , C11D9/44
CPC分类号： C11B9/0038 , C11D3/50
摘要： Processes and compositions are described for use in solid and liquid anionic, cationic or nonionic detergent aroma augmenting, modifying, altering and enhancing compositions and as solid or liquid anionic, cationic and nonionic detergent aroma imparting materials of a specific isomer and isomer mixtures of 2- and 3-cyclotetradecen-1-ones having the structures: ##STR1## or mixtures of same or mixtures of such 2- and 3-cyclotetradecen-1-ones with cyclotetradecanone having the structure: ##STR2## or cyclododecanone having the structure: ##STR3## Addition of said 2- and 3-cyclotetradecen-1-ones or mixtures produces in such detergents a sweet, musk aroma and exaltone-like, scorched linen, waxy and rooty nuances.
摘要翻译：描述了用于固体和液体阴离子，阳离子或非离子洗涤剂香气的方法和组合物，其增强，改变，改变和增强组合物以及作为固体或液体阴离子，阳离子和非离子洗涤剂香气赋予材料的特定异构体和2-异构体异构体混合物，和具有以下结构的3-环十四碳烯-1-酮或其混合物或这些2-和3-环十四碳烯-1-酮与具有以下结构的环十四烷酮的混合物：具有以下结构的结构：所述2-和3-环十四碳烯-1-酮或混合物的添加物在这种洗涤剂中产生甜味，麝香香气和异黄酮样的烧焦亚麻，蜡质和粗糙的细微差别。

5. 发明申请

US20110248509A1 GENERATOR WITH FERROMAGNETIC TEETH 有权
标题翻译：发电机与非磁性材料
公开(公告)号：US20110248509A1
公开(公告)日：2011-10-13
申请号：US13164023
申请日：2011-06-20
申请人： Gregory L. Snitchler , Timothy MacDonald
发明人： Gregory L. Snitchler , Timothy MacDonald
IPC分类号： F03D9/00 , H02K1/16
CPC分类号： H02K1/165 , H02K7/1838 , H02K55/04 , H02K2213/03 , Y02E10/725 , Y02E40/625
摘要： A stator assembly for use in a superconducting generator operated at frequencies up to 10 Hz is disclosed. The stator assembly includes a ferromagnetic stator winding support having a plurality of teeth defining slots, the slots configured to receive and support stator windings. The stator winding support is formed so that the ratio of the sum of the widths of the slots to the sum of the widths of the teeth and slots is in the range of 0.65 to 0.90.
摘要翻译：公开了用于在高达10Hz的频率下运行的超导发电机的定子组件。定子组件包括铁磁定子绕组支撑件，其具有限定槽的多个齿，所述槽配置成接收和支撑定子绕组。定子绕组支撑件形成为使得槽的宽度之和与齿和槽的宽度之和的比率在0.65至0.90的范围内。

6. 发明申请

US20060040888A1 2-propynyl adenosine analogs with modifed 5'-ribose groups having A2A agonist activity 有权
标题翻译：具有修饰的具有A2A激动剂活性的5'-核糖基团的2-丙炔基腺苷类似物
公开(公告)号：US20060040888A1
公开(公告)日：2006-02-23
申请号：US11196529
申请日：2005-08-02
申请人： Jayson Rieger , Joel Linden , Timothy Macdonald , Gail Sullivan , Lauren Murphree , Robert Figler
发明人： Jayson Rieger , Joel Linden , Timothy Macdonald , Gail Sullivan , Lauren Murphree , Robert Figler
IPC分类号： A61K31/7076 , C07H19/16
CPC分类号： C07H19/167 , A61K31/7076 , A61K45/06 , C07H19/16 , A61K2300/00
摘要： The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
摘要翻译：本发明提供具有以下通式（I）的化合物：其中X，R 1，R 2，R 7和Z如上所述这里。

7. 发明申请

US20050222422A1 Compounds active in spinigosine 1-phosphate signaling 有权
标题翻译：在igigosine 1-磷酸信号传导中活跃的化合物
公开(公告)号：US20050222422A1
公开(公告)日：2005-10-06
申请号：US10523337
申请日：2003-07-30
申请人： Kevin Lynch , Timothy Macdonald
发明人： Kevin Lynch , Timothy Macdonald
IPC分类号： C07D233/54 , C07F9/09 , C07F9/6506 , C07F9/28
CPC分类号： C07F9/65068 , C07F9/091 , C07F9/094 , C07F9/6506
摘要： The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure of Formula (I) wherein R11 is C5-C18 alkyl or C5-C18 alkenyl; Q is selected from the group consisting of C3-C6 optionally substituted cycloalkyl, C3-C6 optionally substituted heterocyclic, C3-C6 optionally substituted aryl C3-C6 optionally substituted heteroaryl and —NH(CO)—; R2 is selected from the group consisting of H, C1-C4 alkyl, (C1-C4 alkyl)OH and (C1-C4 alkyl)NH2; R23 is H or C1-C4 alkyl, and R15 is selected from the group consisting of hydroxy, phosphonate, and of Formula (II) wherein X and R15 is selected from the group consisting of O and S; or a pharmaceutically acceptable salt or tautomer thereof.
摘要翻译：本发明涉及具有作为S1P受体调节剂的活性的S1P类似物以及这些化合物用于治疗与不适当S1P受体活性相关的疾病的用途。这些化合物具有式（I）的通式结构，其中R 11是C 5 -C 18烷基或C 5 - C 1 -C 18链烯基; Q选自C 3 -C 6任选取代的环烷基，C 3 -C 6亚烷基，C 3 -C 6 - 任选取代的杂环，C 3 -C 6任选取代的芳基C 3 -C 6 -C 6任选取代的杂芳基和 - NH（CO） - ; R 2选自H，C 1 -C 4烷基，（C 1〜 C 4烷基）OH和（C 1 -C 4烷基）NH 2; R 23是H或C 1 -C 4烷基，R 15选自由以下组成的组：羟基，膦酸酯和式（II）的化合物，其中X和R 15选自O和S; 或其药学上可接受的盐或互变异构体。

8. 发明授权

US5854006A Gamma-glutamyl transpeptidase-specific antibody, prodrugs for the treatment of gamma-glutamyl transpeptidase-expressing tumors, and methods of administration thereof 失效
标题翻译： γ-谷氨酰转肽酶特异性抗体，用于治疗表达γ-谷氨酰转肽酶的肿瘤的前药及其施用方法
公开(公告)号：US5854006A
公开(公告)日：1998-12-29
申请号：US825349
申请日：1997-03-28
申请人： Marie Hanigan , Timothy MacDonald
发明人： Marie Hanigan , Timothy MacDonald
IPC分类号： C07K16/40 , C12N9/10 , G01N33/573 , G01N33/53 , C07K16/00
CPC分类号： C12N9/104 , C07K16/40 , G01N33/573
摘要： An antibody is provided which binds to active GGT, and can identify tissues which express GGT on their surface. Many solid tumors express GGT on their surface. Individuals identified with such tumors may be treated with inactivated prodrugs of chemotherapeutic agents at local dosage levels substantially above the maximum dosage levels currently permitted due to side effect limitations. The prodrugs are comprised of chemotherapeutic agents rendered inactive by the attachment of a gamma-glutamyl group thereto. The gamma-glutamyl group is cleaved by GGT on the surface of solid tumor cells expressing GGT, and thus active only locally against the tumor. Side effects are suppressed. The antibody is used to identify solid tumors that are candidates for this treatment, as well as to identify tissues which express GGT and which must therefore be the basis of selection criteria of various available chemotherapeutic agents.
摘要翻译：提供与活性GGT结合的抗体，并且可以鉴定表达GGT的组织。许多实体瘤在其表面表达GGT。用这些肿瘤鉴定的个体可以用局部剂量水平的化学治疗剂的灭活前药进行治疗，其实质上高于由于副作用限制而允许的最大剂量水平。前药由通过连接γ-谷氨酰基而变得无活性的化学治疗剂组成。 γ-谷氨酰基在表达GGT的实体肿瘤细胞表面被GGT切割，因此仅在局部对抗肿瘤。副作用被抑制。该抗体用于鉴定作为该治疗的候选物的实体瘤，以及鉴定表达GGT的组织，因此必须是各种可用的化学治疗剂的选择标准的基础。

9. 发明授权

US4224352A Pear flavoring containing a mixture of 2- and 3-cyclotetradecen-1-ones 失效
标题翻译：含有2-和3-环十四碳烯-1-酮的混合物的梨调味剂
公开(公告)号：US4224352A
公开(公告)日：1980-09-23
申请号：US52829
申请日：1979-06-27
申请人： Braja D. Mookherjee , Robert W. Trenkle , Manfred H. Vock , Domenick Luccarelli, Jr. , Frederick L. Schmitt , Gilbert Stork , Timothy MacDonald , Arthur L. Liberman
发明人： Braja D. Mookherjee , Robert W. Trenkle , Manfred H. Vock , Domenick Luccarelli, Jr. , Frederick L. Schmitt , Gilbert Stork , Timothy MacDonald , Arthur L. Liberman
IPC分类号： A23L27/20 , A23L27/29 , C07C45/56 , C07C49/587 , C11B9/00 , A23L1/235
CPC分类号： C11B9/0038 , A23L27/203 , A23L27/29 , C07C45/562 , C07C49/587
摘要： Described is a pear flavoring containing isomer mixtures of 2- and 3-cyclotetradecen-1-ones having the structures: ##STR1##
摘要翻译：描述了含有具有以下结构的2-和3-环十四碳烯-1-酮的异构体混合物的梨调味剂：

10. 发明授权

US4183965A 2- and 3-Cyclotetradecen-1-ones as bitterness depressants 失效
标题翻译： 2-和3-环十四碳烯-1-酮作为苦味抑制剂
公开(公告)号：US4183965A
公开(公告)日：1980-01-15
申请号：US973093
申请日：1978-12-26
申请人： Braja D. Mookherjee , Robert W. Trenkle , Manfred H. Vock , Domenick Luccarelli, Jr. , Frederick L. Schmitt , Gilbert Stork , Timothy MacDonald , Arthur L. Liberman
发明人： Braja D. Mookherjee , Robert W. Trenkle , Manfred H. Vock , Domenick Luccarelli, Jr. , Frederick L. Schmitt , Gilbert Stork , Timothy MacDonald , Arthur L. Liberman
IPC分类号： A23F5/46 , A23G3/00 , A23G3/36 , A23L27/20 , A23L27/30 , C07C45/56 , C07C49/587 , C11B9/00 , A23F1/04 , A23L1/22 , A23L1/226 , C12C3/00
CPC分类号： A23G3/36 , A23F5/465 , A23L27/203 , A23L27/30 , C07C45/562 , C07C49/587 , C11B9/0038
摘要： Processes and compositions are described for the use in foodstuff flavor and aroma and perfume and perfumed article aroma augmenting, modifying, altering and enhancing compositions and as foodstuffs, chewing gum, toothpaste, medicinal product, perfume and perfumed article aroma imparting materials of specific isomer and isomer mixtures of 2- and 3-cyclotetradecen-1-ones having the structures: ##STR1## or mixtures of same or mixtures of such 2- and 3-cyclotetradecen-1-ones with cyclotetradecanone having the structure: ##STR2## or cyclododecanone having the structure: ##STR3## Addition of said 2- and 3-cyclotetradecen-1-ones or mixtures is indicated to produce:(a) In food flavorings, a sweet, brown sugar and musky aroma and sweet and musky flavor characteristics (useful for flavor augmentation or enhancement in pear, blackberry, apricot and peach flavors and as a bitterness depressant for such foodstuffs, flavor adjuvants and beverages as black coffee; and(b) In perfumes and perfumed articles, a sweet, musk aroma and exaltone-like, scorched linen, waxy and rooty nuances.
摘要翻译：描述了用于食品香料和香料和香料和香料制品香气增强，改性，改变和增强组合物以及作为食品，口香糖，牙膏，药用产品，香料和香料赋予特定异构体的芳香赋予材料的方法和组合物，具有以下结构的2-和3-环十四碳烯-1-酮的异构体混合物：或其混合物或这些2-和3-环十四碳烯-1-酮与环十四烷酮的混合物，其具有以下结构：具有以下结构：结构：所述2-和3-环十四碳烯-1-酮或其混合物的添加表明产生：（a）在食品香料中，甜味，红糖和麝香的香气和甜味和麝香风味特征（可用于梨，黑莓，杏子和桃子香味的香味增强或增强，以及作为黑咖啡的这类食品，风味佐剂和饮料的苦味抑制剂;和（b）在香水和香料中一种甜美的麝香，麝香香气和高雅的香味，烧焦的亚麻，蜡质和根深蒂固的细微差别。

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