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1. 发明申请

US20110223596A1 Multiplex Detection Compositions, Methods, and Kits 审中-公开
标题翻译：多重检测组合，方法和试剂盒
公开(公告)号：US20110223596A1
公开(公告)日：2011-09-15
申请号：US13030622
申请日：2011-02-18
申请人： Timothy M. WOUDENBERG , Dar Bahatt , Muhammad A. Sharaf , Timothy Z. Liu , Serguei Ermakov , Charles R. Connell , Jens J. Hyldig-Nielsen
发明人： Timothy M. WOUDENBERG , Dar Bahatt , Muhammad A. Sharaf , Timothy Z. Liu , Serguei Ermakov , Charles R. Connell , Jens J. Hyldig-Nielsen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6858 , C12Q2565/1025 , C12Q2563/185 , C12Q2535/131 , C12Q2563/107
摘要： The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention also relates to methods for determining the presence of at least one analyte in a sample, the methods employing employ single molecule detection techniques to individually detect at least one molecular complex or at least part of a molecular complex.
摘要翻译：本发明一般涉及检测分析物，特别是样品中的生物分子。本发明还涉及通常以多重检测形式检测分析物的存在的组合物，方法和试剂盒。本发明还涉及用于确定样品中至少一种分析物的存在的方法，采用单分子检测技术单独检测至少一种分子复合物或至少部分分子复合物的方法。

2. 发明授权

US07357852B2 Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices 失效
标题翻译：用于电泳和电渗设备的无气泡和压力产生电极
公开(公告)号：US07357852B2
公开(公告)日：2008-04-15
申请号：US10984239
申请日：2004-11-09
申请人： Timothy M. Woudenberg , Zbigniew T. Bryning , Reid B. Kowallis
发明人： Timothy M. Woudenberg , Zbigniew T. Bryning , Reid B. Kowallis
IPC分类号： G01N27/453 , C12Q1/68 , B01L3/00
CPC分类号： G01N27/44704 , C02F1/46109 , C02F1/469
摘要： Bubble-free electrodes, electrochemical cells including bubble-free electrodes, analytical devices, and methods for preparing and using them are provided. The analytical devices each include at least one bubble-free electrode. Analytical devices that include an electrochemical cell and a sample containment device are also provided, wherein the electrochemical cell includes an anodic reservoir, a cathodic reservoir, an electrical connection between the anodic reservoir and the cathodic reservoir, and a first bubble-free electrode disposed within one of the anodic reservoir and the cathodic reservoir. A second electrode is disposed within the other reservoir and a power source is provided having a positive terminal that is normally in electrical contact with the first electrode, and a negative terminal that is normally in electrical contact with the second electrode. The analytical device further includes a power source polarity-inverting device for switching the contacts between the terminals of the power source and the first and second electrodes. The sample containment device includes a sample containment chamber having an opening for introducing a sample into the chamber and being positioned with respect to the electrochemical cell such that an electrical field generated by the electrochemical cell can influence a property of a component of a sample disposed in the sample containment chamber. Pressure-generating cells are also provided.
摘要翻译：提供无气泡电极，包括无气泡电极的电化学电池，分析装置及其制备和使用方法。分析装置各自包括至少一个无气泡电极。还提供了包括电化学电池和样品容纳装置的分析装置，其中电化学电池包括阳极储存器，阴极储存器，阳极储存器和阴极储存器之间的电连接以及设置在阴极储存器内的第一无气泡电极一个阳极储层和阴极储层。第二电极设置在另一储存器内，并且提供具有通常与第一电极电接触的正端子的电源，以及通常与第二电极电接触的负极端子。分析装置还包括用于切换电源的端子与第一和第二电极之间的触点的电源极性反转装置。样品容纳装置包括样品容纳室，其具有用于将样品引入室中并且相对于电化学电池定位的开口，使得由电化学电池产生的电场可以影响设置在电化学电池中的样品的组分的性质样品容纳室。还提供了压力发生电池。

3. 发明授权

US5720923A Nucleic acid amplification reaction apparatus 失效
公开(公告)号：US5720923A
公开(公告)日：1998-02-24
申请号：US299033
申请日：1994-08-31
申请人： Lawrence A. Haff , Enrico Picozza , Will Bloch , Robert Ragusa , Joseph DiCesare , David Tracy , Paul Saviano , Timothy M. Woudenberg
发明人： Lawrence A. Haff , Enrico Picozza , Will Bloch , Robert Ragusa , Joseph DiCesare , David Tracy , Paul Saviano , Timothy M. Woudenberg
IPC分类号： C12N15/09 , B01J19/00 , B01L7/00 , C12M1/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N35/00 , C12M1/40 , C12P19/34
CPC分类号： B01L7/525 , B01J19/0046 , B01L7/52 , B01L9/065 , B01J2219/00495 , B01J2219/00722 , B01L2300/1883 , C12Q1/686 , C40B40/06 , C40B60/14 , G01N2035/00237 , Y10T436/116664
摘要： Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.

4. 发明申请

US20090325184A1 Compositions and Methods for Clonal Amplification and Analysis of Polynucleotides 审中-公开
标题翻译：多核苷酸克隆扩增和分析的组合物和方法
公开(公告)号：US20090325184A1
公开(公告)日：2009-12-31
申请号：US12555730
申请日：2009-09-08
申请人： Timothy M. Woudenberg , Cheryl Heiner , Eric S. Nordman
发明人： Timothy M. Woudenberg , Cheryl Heiner , Eric S. Nordman
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6846 , C12Q1/6844 , C12Q2565/501 , C12Q2537/143 , C12Q2527/125
摘要： Compositions and methods of use are disclosed for clonally amplifying and analyzing one or more polynucleotides.
摘要翻译：公开了用于克隆扩增和分析一种或多种多核苷酸的组合物和使用方法。

5. 发明申请

US20090317824A1 Fluid Processing Device Comprising Radial Channels 审中-公开
标题翻译：包括径向通道的流体处理装置
公开(公告)号：US20090317824A1
公开(公告)日：2009-12-24
申请号：US12548409
申请日：2009-08-26
申请人： Timothy M. Woudenberg , Reid B. Kowallis
发明人： Timothy M. Woudenberg , Reid B. Kowallis
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： B01L3/502753 , B01L3/5025 , B01L3/502707 , B01L3/502723 , B01L3/50273 , B01L7/52 , B01L2200/0684 , B01L2300/044 , B01L2300/0645 , B01L2300/0803 , B01L2300/087 , B01L2300/0887 , B01L2300/12 , B01L2400/0409 , B01L2400/0421 , C12Q1/686 , G01N27/44721 , G01N27/44782 , G01N27/44791 , G01N35/00069 , C12Q2565/629
摘要： The present invention provides, in one aspect, an apparatus that comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) a proximal end which is linked to the reservoir region, and (ii) a distal end, and preferably (3) for each channel, at least one chamber, and preferably three chambers, linked by a passageway in fluid communication with the distal end of that channel. Preferably, each passageway leads from each chamber in a direction that is initially away from the central reservoir region, whereby centrifugation of the substrate about a central axis that is perpendicular to the channels is effective to disperse liquid from the central reservoir region into the channels and chambers, such that any air bubbles in the chambers, channels, and passageways are forced towards the axis of rotation, when such liquid is present in the central reservoir region.
摘要翻译：在一个方面，本发明提供了一种装置，其包括盘形基底，其限定（1）中央储存区域，（2）多个通道，其与中央储存区域基本上径向流体连通并且基本上径向离开，所述通道彼此共面，并且每个通道具有（i）连接到储存器区域的近端，以及（ii）用于每个通道的远端，优选（3）至少一个室，并且优选地三个腔室通过与该通道的远端流体连通的通道连接。优选地，每个通道从最初远离中心储存器区域的方向引导每个室，由此衬底围绕垂直于通道的中心轴的离心有效地将液体从中央储存器区域分散到通道中，并且当这种液体存在于中央储存区域中时，腔室，通道和通道中的任何气泡被迫朝向旋转轴线。

6. 发明申请

US20080299651A1 Thermal cycle for automatic performance of the polymerase chain reaction with close temperature control 审中-公开
标题翻译：热循环用于自动执行聚合酶链反应与温度控制
公开(公告)号：US20080299651A1
公开(公告)日：2008-12-04
申请号：US11999179
申请日：2007-12-04
申请人： John Girdner Atwood , Albert Carmelo Mossa , Lisa May Goven , Fenton Williams , Timothy M. Woudenberg , Marcel Margulies , Robert P. Ragusa , Richard Leath , Clive Miles
发明人： John Girdner Atwood , Albert Carmelo Mossa , Lisa May Goven , Fenton Williams , Timothy M. Woudenberg , Marcel Margulies , Robert P. Ragusa , Richard Leath , Clive Miles
IPC分类号： C12M1/00
CPC分类号： B01L3/50851 , B01L3/50853 , B01L7/00 , B01L7/52 , B01L2200/147 , B01L2300/042 , B01L2300/046 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , G05D23/1917 , Y10S435/809
摘要： A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.
摘要翻译：提供了用于自动执行聚合酶链式反应的热循环仪。热循环仪包括提供对反应的温度控制的加热器控制。

7. 发明授权

US07381569B2 Device and method for multiple analyte detection 有权
标题翻译：多分析物检测的装置和方法
公开(公告)号：US07381569B2
公开(公告)日：2008-06-03
申请号：US11341732
申请日：2006-01-27
申请人： Timothy M. Woudenberg , Michael Albin , Reid B. Kowallis , Yefim Raysberg , Robert P. Raqusa , Emily S. Winn-Deen
发明人： Timothy M. Woudenberg , Michael Albin , Reid B. Kowallis , Yefim Raysberg , Robert P. Raqusa , Emily S. Winn-Deen
IPC分类号： G01N33/543 , G01N15/06 , G01N33/53 , G01N33/566 , G01N21/00 , C12Q1/68 , B32B5/02 , B32B27/12 , B01L3/00 , C12M1/34
CPC分类号： C12Q1/6816 , B01J2219/00317 , B01J2219/00599 , B01J2219/00722 , B01L3/5027 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L2200/027 , B01L2200/0642 , B01L2300/0816 , B01L2300/0864 , B01L2300/1827 , B01L2400/049 , C12Q1/08 , C40B40/06 , C40B50/08 , C40B60/14 , G01N21/6452 , G01N2035/00148 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , C12Q2565/631
摘要： The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.
摘要翻译：本发明涉及一种用于同时测试样品中多种所选分析物中一种或多种的存在，不存在和/或量的方法和装置。本发明在一个方面包括用于检测或定量液体样品中的多种不同分析物的装置。每个室可以包括有效地与可能存在于样品中的选定分析物反应的分析物特异性试剂和用于检测信号的检测装置。还公开了利用该装置的方法。

8. 发明申请

US20080066549A1 METHODS, SYSTEMS AND APPARATUS FOR LIGHT CONCENTRATING MECHANISMS 审中-公开
标题翻译：用于光浓缩机制的方法，系统和装置
公开(公告)号：US20080066549A1
公开(公告)日：2008-03-20
申请号：US11857419
申请日：2007-09-18
申请人： Mark F. OLDHAM , Eric S. Nordman , Charles R. Connell , Timothy M. Woudenberg
发明人： Mark F. OLDHAM , Eric S. Nordman , Charles R. Connell , Timothy M. Woudenberg
IPC分类号： G01N33/00
CPC分类号： G01N21/648 , G01N2021/6432
摘要： An embodiment relates generally to a method for analysis of a nucleic acid. The method includes providing for a resonant structure configured to couple with one or more fluorescently labeled nucleic acids and directing an excitation light from a source on the resonant structure. The method also includes generating plasmons on the surface of the resonant structure where the analyte is fixed at a point of energy concentration of the resonant structure.
摘要翻译：实施方案一般涉及核酸分析方法。该方法包括提供构造成与一个或多个荧光标记的核酸耦合并将来自源的激发光引导到谐振结构上的谐振结构。该方法还包括在谐振结构的表面上产生等离子体激元，其中分析物固定在谐振结构的能量集中点处。

9. 发明授权

US07211443B2 Device and method for multiple analyte detection 有权
公开(公告)号：US07211443B2
公开(公告)日：2007-05-01
申请号：US10373450
申请日：2003-02-24
申请人： Timothy M. Woudenberg , Michael Albin , Reid B. Kowalis , Yefim Raysberg , Robert P. Ragusa , Emily S. Winn-Deen
发明人： Timothy M. Woudenberg , Michael Albin , Reid B. Kowalis , Yefim Raysberg , Robert P. Ragusa , Emily S. Winn-Deen
IPC分类号： G01N33/543 , G01N15/06 , G01N33/53 , G01N33/533 , G01N33/542 , G01N33/566 , G01N21/00 , C12Q1/68 , B32B5/02 , B32B27/12 , B01L3/00 , C12M1/34
CPC分类号： B01L3/5027 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/049 , C12Q1/08 , G01N35/08 , G01N35/10 , G01N2035/00148 , G01N2035/00356 , G01N2035/1032 , G01N2035/1034 , Y10S436/807
摘要： The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. The device includes a substrate which defines a sample-distribution network having (i) a sample inlet, (ii) one or more detection chambers, and (iii) channel means providing a dead-end fluid connection between each of the chambers and the inlet. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.

10. 发明授权

US5282543A Cover for array of reaction tubes 失效
标题翻译：盖子用于反应管阵列
公开(公告)号：US5282543A
公开(公告)日：1994-02-01
申请号：US2559
申请日：1993-01-11
申请人： Enrico Picozza , Timothy M. Woudenberg , Robert Ragusa , Ralph Keese
发明人： Enrico Picozza , Timothy M. Woudenberg , Robert Ragusa , Ralph Keese
IPC分类号： G01N35/02 , B01L3/00 , B01L3/14 , B01L7/00 , G05D23/19 , B65D51/18
CPC分类号： B01L3/50853 , B01L3/50825 , B01L3/5085 , B01L3/50851 , B01L7/00 , B01L7/52 , G05D23/1917 , G05D23/1919 , B01L2200/147 , B01L2300/042 , B01L2300/046 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , B01L2300/185
摘要： An array of reaction tube covers adapted to seal a plurality of reaction tubes comprises a unitary body of flexible material having a plurality of flexible plastic nodules. Each nodule is adapted to seal one of the reaction tubes. Each of the nodules is flexible held in a predetermined planar spaced relationship from each other in rows, preferably in rows and columns, by an integral web having a plurality of apertures therethrough. Each of the nodules has a downwardly convex, generally hemispherical lower portion extending from the web, an upwardly convex upper portion extending from the web over the lower portion, and a centrally domed nipple extending upwardly from the upper portion.
摘要翻译：适于密封多个反应管的反应管盖阵列包括具有多个柔性塑料结节的柔性材料的整体。每个结节适于密封反应管中的一个。每个结节通过具有穿过其中的多个孔的整体腹板而以行，优选地以行和列彼此以预定的平面间隔关系灵活地保持。每个结节具有从腹板延伸的向下凸出的，大致半球形的下部，从腹板延伸穿过下部的向上凸起的上部，以及从上部向上延伸的中心圆顶的乳头。

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