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1. 发明申请

US20090017427A1 Intelligent Math Problem Generation 审中-公开
标题翻译：智能数学问题生成
公开(公告)号：US20090017427A1
公开(公告)日：2009-01-15
申请号：US11776564
申请日：2007-07-12
申请人： William B. Kunz , Timothy J. Hoffman , Luke Kelly , Jinsong Yu , Larry J. Israel
发明人： William B. Kunz , Timothy J. Hoffman , Luke Kelly , Jinsong Yu , Larry J. Israel
IPC分类号： G09B19/02
CPC分类号： G09B7/00 , G09B19/025
摘要： A problem generator that takes an input as a math problem, analyzes the math problem, and intelligently spawns similar example problem types. The output is a set of math problems based on the conditions set during analysis and customization. For example, if the original problem deals with linear equations, this will be detected during analysis and used to spawn other linear equations as problems. Moreover, if the answer to the original problem is in integer format, so will the answers to the spawned problems. A customizable UI is designed to allow further customization of problem conditions to generate an accurate set of problems based on the initial input. Problem generator templates can be created, shared and modified for distribution and/or future use. Additionally, problem generation APIs can be extended for external code to automate and consume generated math problems.
摘要翻译：将输入作为数学问题的问题生成器，分析数学问题，并智能地生成类似的示例问题类型。输出是基于分析和定制期间设置的条件的一组数学问题。例如，如果原始问题涉及线性方程，则在分析过程中会检测到这一点，并将其用作产生其他线性方程作为问题。此外，如果原始问题的答案是整数格式，那么对于产生的问题的答案也是如此。可定制的UI被设计为允许进一步定制问题条件以基于初始输入生成准确的问题集。可以创建，共享和修改问题生成器模板，以便分发和/或将来使用。此外，问题生成API可以扩展为外部代码，以自动化并消耗生成的数学问题。

2. 发明授权

US07147838B2 Gastrin receptor-avid peptide conjugates 失效
公开(公告)号：US07147838B2
公开(公告)日：2006-12-12
申请号：US11025636
申请日：2004-12-29
申请人： Timothy J. Hoffman , Wynn A. Volkert , Ning Li , Gary Sieckman , Chrys-Ann Higginbotham
发明人： Timothy J. Hoffman , Wynn A. Volkert , Ning Li , Gary Sieckman , Chrys-Ann Higginbotham
IPC分类号： A61K49/00
CPC分类号： A61K51/088 , A61K38/00 , C07F5/003 , C07F15/008 , C07K7/086 , C07K14/57572
摘要： A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.

3. 发明授权

US06200546B1 Gastrin receptor-avid peptide conjugates 失效
标题翻译：胃泌素受体 - 狂犬病肽缀合物
公开(公告)号：US06200546B1
公开(公告)日：2001-03-13
申请号：US09064499
申请日：1998-04-22
申请人： Timothy J. Hoffman , Wynn A. Volkert , Ning Li , Gary Sieckman , C. A. Higginbotham
发明人： Timothy J. Hoffman , Wynn A. Volkert , Ning Li , Gary Sieckman , C. A. Higginbotham
IPC分类号： A61K4900
CPC分类号： A61K51/088 , A61K38/00 , C07F5/003 , C07F15/008 , C07K7/086 , C07K14/57572
摘要： A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.
摘要翻译：用作治疗或诊断性放射性药物的化合物包括能够使与能够结合胃泌素释放肽受体的部分连接的医学上有用的金属络合的基团。用于治疗患有肿瘤疾病的受试者的方法包括向受试者施用有效量的具有与螯合基螯合的金属的放射性药物，所述螯合基团连接到能够结合肿瘤细胞上表达的胃泌素释放肽受体的部分，随后内化的细胞。形成治疗或诊断化合物的方法包括使金属合成酶与能够结合胃泌素释放肽受体的部分共价连接的螯合基团反应。

4. 发明授权

US5082637A Removal of potassium from ammonium molybdate 失效
标题翻译：从钼酸铵中去除钾
公开(公告)号：US5082637A
公开(公告)日：1992-01-21
申请号：US608447
申请日：1990-11-02
申请人： Michael J. Cheresnowsky , Timothy J. Hoffman
发明人： Michael J. Cheresnowsky , Timothy J. Hoffman
IPC分类号： C01G39/02
CPC分类号： C01G39/02 , C01P2006/80
摘要： Potassium impurity is removed from ammonium molybdate by dissolving the ammonium molybdate in hot acid, allowing the acid solution to cool whereby the ammonium molybdate precipitates out of the solution as molybdenum trioxide and then separating, washing and drying the molybdenum trioxide.
摘要翻译：通过将钼酸铵溶解在热酸中将钼酸铵从钼酸铵中除去，使酸溶液冷却，由此钼酸铵从三氧化钼中沉淀出溶液，然后分离，洗涤和干燥三氧化钼。

5. 发明授权

US5045121A Method for removing carbon from cemented tungsten carbide articles 失效
标题翻译：从硬质合金制品中除去碳的方法
公开(公告)号：US5045121A
公开(公告)日：1991-09-03
申请号：US649328
申请日：1991-02-04
申请人： Timothy J. Hoffman , Robert G. Mendenhall , Michael J. Cheresnowsky
发明人： Timothy J. Hoffman , Robert G. Mendenhall , Michael J. Cheresnowsky
IPC分类号： B22F3/24 , C04B41/53 , C04B41/91 , C09K13/00 , C22C1/05 , C22C29/08
CPC分类号： C04B41/009 , B22F3/24 , C04B41/5353 , C04B41/91 , C09K13/00 , C22C1/051 , C22C29/08
摘要： A method is disclosed for removing carbon from the surface of a cemented tungsten carbide article which comprises contacting a cemented tungsten carbide article with an aqueous solution of hydrogen peroxide having a concentration of at least about 5% by volume hydrogen perioxide for a sufficient length of time to remove the major portion of the carbon from the surfaces of the article.
摘要翻译：公开了一种从粘结碳化钨制品的表面去除碳的方法，该方法包括将硬质合金碳化物制品与浓度为至少约5体积％二氧化硫的过氧化氢水溶液接触足够长的时间以从制品的表面去除碳的主要部分。

6. 发明授权

US5015458A Method for purifying sulfuric acid solutions 失效
标题翻译：硫酸溶液的纯化方法
公开(公告)号：US5015458A
公开(公告)日：1991-05-14
申请号：US504479
申请日：1990-04-04
申请人： Clarence D. Vanderpool , Timothy J. Hoffman
发明人： Clarence D. Vanderpool , Timothy J. Hoffman
IPC分类号： B01D61/52 , C01B17/90
CPC分类号： C01B17/902 , B01D61/52 , Y10S210/912 , Y10S423/02
摘要： A method is disclosed for removing iron from iron-contaminated sulfuric acid to render the sulfuric acid suitable for ion membrane processing which comprises contacting the iron-contaminated sulfuric acid with an oxidizing agent to oxidize essentially all of the iron to the +3 oxidation state, contacting the resulting iron-contaminated sulfuric acid containing oxidized iron with a complexing agent which can be citric acid, oxalic acid, and tartaric acid, with the amount of the complexing agent being sufficient to complex essentially all of the oxidized iron, and contacting the resulting iron-contaminated sulfuric acid containing the complexed iron with activated carbon to remove essentially all of the iron and produce a purified sulfuric acid solution.
摘要翻译：公开了一种用于从铁污染的硫酸中除去铁以使硫酸适合于离子膜处理的方法，其包括将铁污染的硫酸与氧化剂接触以将基本上所有的铁氧化为+3氧化态，使所得到的含铁氧化铁的硫酸与可以是柠檬酸，草酸和酒石酸的络合剂接触，其中络合剂的量足以使基本上所有的氧化铁络合，并使所得的铁络合的硫酸含有复合铁与活性炭，以去除基本上所有的铁，并产生纯化的硫酸溶液。

7. 发明授权

US06921526B2 Gastrin receptor-avid peptide conjugates 失效
标题翻译：胃泌素受体 - 狂犬病肽缀合物
公开(公告)号：US06921526B2
公开(公告)日：2005-07-26
申请号：US10122611
申请日：2002-04-12
申请人： Timothy J. Hoffman , Wynn A. Volkert , Ning Li , Gary Sieckman , Chrys-Ann Higginbotham
发明人： Timothy J. Hoffman , Wynn A. Volkert , Ning Li , Gary Sieckman , Chrys-Ann Higginbotham
IPC分类号： G01N33/566 , A61K38/00 , A61K51/00 , A61K51/08 , A61P35/00 , C07F5/00 , C07F15/00 , C07K7/06 , C07K7/08 , C07K14/575 , A61M36/14
CPC分类号： A61K51/088 , A61K38/00 , C07F5/003 , C07F15/008 , C07K7/086 , C07K14/57572
摘要： A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.
摘要翻译：用作治疗或诊断性放射性药物的化合物包括能够使与能够结合胃泌素释放肽受体的部分连接的医学上有用的金属络合的基团。用于治疗患有肿瘤疾病的受试者的方法包括向受试者施用有效量的具有与螯合基螯合的金属的放射性药物，所述螯合基团连接到能够结合肿瘤细胞上表达的胃泌素释放肽受体的部分，随后内化的细胞。形成治疗或诊断化合物的方法包括使金属合成酶与能够结合胃泌素释放肽受体的部分共价连接的螯合基团反应。

8. 发明授权

US07060247B2 Gastrin receptor-avid peptide conjugates 失效
公开(公告)号：US07060247B2
公开(公告)日：2006-06-13
申请号：US09847134
申请日：2001-05-02
申请人： Timothy J. Hoffman , Wynn A. Volkert , Gary Sieckman , Charles J. Smith , Hariprasad Gali
发明人： Timothy J. Hoffman , Wynn A. Volkert , Gary Sieckman , Charles J. Smith , Hariprasad Gali
IPC分类号： A61K49/00
CPC分类号： A61K51/088 , A61K38/00 , C07F5/003 , C07F15/008 , C07K7/086 , C07K14/57572
摘要： A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a-moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.

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