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1. 发明授权

EP2802337B1 PEPTIDE-BASED COMPOUNDS AS INHIBITORS OF NEUROTRANSMITTER SECRETION 有权
标题翻译：作为神经递质分泌抑制剂的以肽为基础的化合物
公开(公告)号：EP2802337B1
公开(公告)日：2018-03-21
申请号：EP12848736.0
申请日：2012-11-07
申请人： Tian, Feng , Zou, Daniel Liang , Ji, Lingyun
发明人： Tian, Feng , Zou, Daniel Liang , Ji, Lingyun
IPC分类号： A61K38/00 , A61K8/64 , A61Q19/08
CPC分类号： A61K8/64 , A61K38/00 , A61Q19/08 , C07K7/06
摘要： The present disclosure is directed to peptide-based compounds, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and compositions of the present disclosure may inhibit neurotransmitter release and muscle contraction as a treatment for wrinkles. The compounds of the disclosure may be used for pathological neuronal exocytosis-mediated cosmetic and/or therapeutic purposes.

2. 发明公开

EP2802337A4 PEPTIDE-BASED COMPOUNDS AS INHIBITORS OF NEUROTRANSMITTER SECRETION 有权
标题翻译： PEPTIDVERBINDUNGEN ALS HEMMER EINER NEUROTRANSMITTERSEKRETION
公开(公告)号：EP2802337A4
公开(公告)日：2015-10-28
申请号：EP12848736
申请日：2012-11-07
申请人： TIAN FENG , ZOU DANIEL LIANG , JI LINGYUN
发明人： TIAN FENG , ZOU DANIEL LIANG , JI LINGYUN
IPC分类号： A61K38/00 , A61K8/64 , A61Q19/08
CPC分类号： A61K8/64 , A61K38/00 , A61Q19/08 , C07K7/06
摘要： The present disclosure is directed to peptide-based compounds, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and compositions of the present disclosure may inhibit neurotransmitter release and muscle contraction as a treatment for wrinkles. The compounds of the disclosure may be used for pathological neuronal exocytosis-mediated cosmetic and/or therapeutic purposes.
摘要翻译：本公开涉及基于肽的化合物，其衍生物，药学上可接受的盐，溶剂合物和水合物。本公开的化合物和组合物可以抑制作为皱纹治疗的神经递质释放和肌肉收缩。本公开的化合物可用于病理性神经元胞吐作用介导的化妆品和/或治疗目的。

3. 发明公开

EP2802337A1 PEPTIDE-BASED COMPOUNDS AS INHIBITORS OF NEUROTRANSMITTER SECRETION 有权
标题翻译：肽类化合物作为抑制剂的神经递质
公开(公告)号：EP2802337A1
公开(公告)日：2014-11-19
申请号：EP12848736.0
申请日：2012-11-07
申请人： Tian, Feng , Zou, Daniel Liang , Ji, Lingyun
发明人： Tian, Feng , Zou, Daniel Liang , Ji, Lingyun
IPC分类号： A61K38/00
CPC分类号： A61K8/64 , A61K38/00 , A61Q19/08 , C07K7/06
摘要： Peptide-based compound according to Formula I. The peptide-based compounds administered to inhibit neurotransmitter release and muscle contraction as a treatment for facial wrinkles and facial asymmetry.

4. 发明申请

WO2013070808A1 PEPTIDE-BASED COMPOUNDS AS INHIBITORS OF NEUROTRANSMITTER SECRETION 审中-公开
标题翻译：基于肽的化合物作为神经递质分泌物的抑制剂
公开(公告)号：WO2013070808A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/064001
申请日：2012-11-07
申请人： TIAN, Feng , ZOU, Daniel Liang , JI, Lingyun
发明人： TIAN, Feng , ZOU, Daniel Liang , JI, Lingyun
IPC分类号： A61K38/00
CPC分类号： A61K8/64 , A61K38/00 , A61Q19/08 , C07K7/06
摘要： Peptide-based compound according to Formula I. The peptide-based compounds administered to inhibit neurotransmitter release and muscle contraction as a treatment for facial wrinkles and facial asymmetry.
摘要翻译：基于式I的肽类化合物。用于抑制神经递质释放和肌肉收缩的基于肽的化合物作为面部皱纹和面部不对称的治疗。

5. 发明申请

WO2009099486A1 RADIO FREQUENCY POWER DELIVERY SYSTEM 审中-公开
标题翻译：无线电频率供电系统
公开(公告)号：WO2009099486A1
公开(公告)日：2009-08-13
申请号：PCT/US2008/087921
申请日：2008-12-22
申请人： MKS INSTRUMENTS, INC. , NAGARKATTI, Siddharth, P. , BARSKIY, Yevgeniy , TIAN, Feng , BYSTRYAK, Ilya
发明人： NAGARKATTI, Siddharth, P. , BARSKIY, Yevgeniy , TIAN, Feng , BYSTRYAK, Ilya
IPC分类号： H03F3/191 , H01J37/32 , H03H7/40
CPC分类号： H03F3/20 , H01J37/32082 , H01J37/32183 , H03F1/565 , H03F3/195 , H03F2200/321 , H03F2200/387 , H03F2200/391 , H03F2200/393 , H03F2200/451 , H03H7/40 , Y10T307/305
摘要： A system and method are provided for delivering power to a dynamic load (260). The system includes a power supply (210) providing DC power having a substantially constant power open loop response, a power amplifier (220) for converting the DC power to RF power, a sensor (240) for measuring voltage, current and phase angle between voltage and current vectors associated with the RF power, an electrically controllable impedance matching system (250) to modify the impedance of the power amplifier (220) to at least a substantially matched impedance of a dynamic load (260), and a controller (252) for controlling the electrically controllable impedance matching system. The system further includes a sensor calibration measuring module for determining power delivered by the power amplifier, an electronic matching system calibration module for determining power delivered to a dynamic load, and a power dissipation module for calculating power dissipated in the electrically controllable impedance matching system.
摘要翻译：提供了一种将功率传递给动态负载（260）的系统和方法。该系统包括提供具有基本上恒定的功率开环响应的DC电力的电源（210），用于将DC功率转换成RF功率的功率放大器（220），用于测量DC功率的电压，电流和相位角的传感器（240）与RF功率相关联的电压和电流矢量，将电力可控阻抗匹配系统（250）修改为功率放大器（220）的阻抗至少为动态负载（260）的基本上匹配的阻抗;以及控制器（252）），用于控制电可控阻抗匹配系统。该系统还包括用于确定由功率放大器输出的功率的传感器校准测量模块，用于确定输送到动态负载的功率的电子匹配系统校准模块，以及用于计算在电气可控阻抗匹配系统中消耗的功率的功率耗散模块。

6. 发明申请

WO2009023718A2 NOVEL ACTIVATORS OF GLUCOKINASE 审中-公开
标题翻译：新型葡萄糖激酶激活剂
公开(公告)号：WO2009023718A2
公开(公告)日：2009-02-19
申请号：PCT/US2008073026
申请日：2008-08-13
申请人： METABASIS THERAPEUTICS INC , TIAN FENG , DANG QUN , PRASAD G SRIDHAR , LI WENYU , BOOKSER BRETT C , RAFFAELE NICHOLAS BRIAN , ERION MARK D
发明人： TIAN FENG , DANG QUN , PRASAD G SRIDHAR , LI WENYU , BOOKSER BRETT C , RAFFAELE NICHOLAS BRIAN , ERION MARK D
IPC分类号： C07F9/02
CPC分类号： C07F9/65586 , C07C233/11 , C07F9/3834 , C07F9/4021 , C07F9/582 , C07F9/587 , C07F9/65033 , C07F9/650952 , C07F9/650964 , C07F9/65122 , C07F9/653 , C07F9/6539 , C07F9/65392 , C07F9/65395 , C07F9/65397 , C07F9/6541 , C07F9/655345 , C07F9/65583 , C07F9/6561 , C07F9/65616 , C07F9/657181
摘要： The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinsae activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistence and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.
摘要翻译：本发明提供了具有葡糖激酶活化剂活性的式I和II的新型化合物及其药学上可接受的盐和共晶体。本发明进一步提供了包含其的药物组合物以及治疗，预防，延缓发作或降低发展或进展一种或多种葡糖激酶活化剂的疾病或病症的风险的方法，包括： 1型和2型糖尿病，葡萄糖耐量降低，胰岛素抵抗和高血糖。本发明还提供了制备式I和II化合物（包括其盐和共晶体）的方法以及包含其的药物组合物。

7. 发明申请

WO2007056448A3 ACCELERANTS FOR THE MODIFICATION OF NON-NATURAL AMINO ACIDS AND NON-NATURAL AMINO ACID POLYPEPTIDES 审中-公开
公开(公告)号：WO2007056448A3
公开(公告)日：2007-05-18
申请号：PCT/US2006/043472
申请日：2006-11-08
申请人： AMBRX, INC. , TIAN, Feng , MIAO, Zhenwei
发明人： TIAN, Feng , MIAO, Zhenwei
IPC分类号： C07C249/08 , C07C249/14 , C07C251/54
摘要： Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.

8. 发明申请

WO2012057801A1 APPARATUS FOR PROCESSING BIOLOGICAL SAMPLES AND METHOD THEREOF 审中-公开
标题翻译：用于处理生物样品的装置及其方法
公开(公告)号：WO2012057801A1
公开(公告)日：2012-05-03
申请号：PCT/US2010/054876
申请日：2010-10-29
申请人： TIAN, Feng , ZOU, Daniel Liang , JI, Lingyun
发明人： TIAN, Feng , ZOU, Daniel Liang , JI, Lingyun
IPC分类号： G01N35/00
CPC分类号： G01N1/31 , B01L3/5025 , B01L9/52 , B01L2300/021 , C12Q1/68 , G01N35/00 , G01N35/0099 , G01N35/04 , G01N2035/0477
摘要： The present invention provides devices, apparatuses and methods for automated processing of biological samples. This invention provides automated devices and automated methods of sequentially treating a biological sample with processing fluids in more than one washing basin. In some embodiments, the invention provides automated devices and automated methods of western blot processing. In some embodiments, the invention provides automated devices and automated methods of Southern blot processing. In some embodiments, the invention provides automated devices and automated methods of northern blot processing. In some embodiments, the invention provides automated devices and automated methods of staining biomolecules on solid supports. In some embodiments, the invention provides automated devices and automated methods of nucleic acid separation and isolation.
摘要翻译：本发明提供用于生物样品的自动处理的装置，装置和方法。本发明提供了在多于一个洗涤盆中用处理流体顺序处理生物样品的自动化装置和自动化方法。在一些实施方案中，本发明提供了自动化装置和蛋白质印迹法的自动化方法。在一些实施方案中，本发明提供了Southern印迹处理的自动化装置和自动化方法。在一些实施方案中，本发明提供了自动化装置和Northern印迹法的自动化方法。在一些实施方案中，本发明提供了在固体支持物上染色生物分子的自动化装置和自动化方法。在一些实施方案中，本发明提供自动化装置和核酸分离和分离的自动化方法。

9. 发明申请

WO2011087451A1 METHOD, DEVICE, AND COMPUTER READABLE MEDIUM FOR GENERATING A DIGITAL PICTURE 审中-公开
标题翻译：用于产生数字图像的方法，设备和计算机可读介质
公开(公告)号：WO2011087451A1
公开(公告)日：2011-07-21
申请号：PCT/SG2010/000003
申请日：2010-01-12
申请人： NANYANG TECHNOLOGICAL UNIVERSITY , SEAH, Hock Soon , TIAN, Feng , XIE, Xuexiang , HE, Ying
发明人： SEAH, Hock Soon , TIAN, Feng , XIE, Xuexiang , HE, Ying
IPC分类号： G06T15/00 , G06T17/00
CPC分类号： G06T15/50
摘要： A method is provided for generating a digital picture, the method comprising receiving a three-dimensional representation for each of a plurality of curves, wherein each curve represents at least partially a shape of a three-dimensional object; grouping the plurality of curves into at least one curve group based on the three-dimensional representations of the curves using three-dimensional information given by the three-dimensional representations; associating each curve group with a picture element based on the curves of the curve group; and forming the digital picture using the picture element.
摘要翻译：提供了一种用于生成数字图像的方法，所述方法包括接收多个曲线中的每一个的三维表示，其中每条曲线至少部分地表示三维物体的形状; 基于使用由三维表示给出的三维信息的曲线的三维表示，将多条曲线分组成至少一条曲线组; 基于曲线组的曲线将每个曲线组与图像元素相关联; 以及使用图像元素形成数字图像。

10. 发明申请

WO2010037062A1 NON-NATURAL AMINO ACID REPLICATION-DEPENDENT MICROORGANISMS AND VACCINES 审中-公开
标题翻译：非天然氨基酸复制相关微生物和疫苗
公开(公告)号：WO2010037062A1
公开(公告)日：2010-04-01
申请号：PCT/US2009/058668
申请日：2009-09-28
申请人： AMBRX, INC. , TIAN, Feng , HEHLI, Brad
发明人： TIAN, Feng , HEHLI, Brad
IPC分类号： C12N1/36 , C12P21/00
CPC分类号： C12N15/70 , A61K39/0258 , C12N1/36 , C12N9/93
摘要： Compositions and methods of producing vaccines, including methods wherein whole organism vaccines are provided with limited replication abilities, thereby increasing vaccine safety and efficacy, through the use of non-natural, unnatural, or non-naturally encoded amino acids.
摘要翻译：制备疫苗的组合物和方法，包括通过使用非天然的，非天然的或非天然编码的氨基酸使整个生物体疫苗具有有限的复制能力，从而增加疫苗安全性和功效的方法。

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