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1. 发明申请

US20070003927A1 Mapk7 as modifier of branching morphogenesis and methods of use 审中-公开
标题翻译： Mapk7作为分支形态发生的调节剂和使用方法
公开(公告)号：US20070003927A1
公开(公告)日：2007-01-04
申请号：US10532406
申请日：2003-10-22
申请人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Heinrich , Jochen Scheel , Torsten Will , Yisheng Jin , Joanne Adamkewicz
发明人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Heinrich , Jochen Scheel , Torsten Will , Yisheng Jin , Joanne Adamkewicz
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/5088 , A01K2217/05 , C12N9/1205 , C12Q1/485 , G01N33/5011 , G01N33/57438 , G01N33/57496
摘要： Human MAPK7 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MAPK7 are provided.
摘要翻译：人MAPK7基因被鉴定为分支形态发生的调节剂，因此是与缺陷支链形态发生功能相关的病症的治疗靶点。提供了用于鉴定分支形态发生调节剂的方法，包括筛选调节MAPK7活性的试剂。

2. 发明申请

US20070269378A1 Nadks as Modifiers of Branching Morphogenesis and Methods of Use 审中-公开
标题翻译： Nadks作为分支形态发生的修饰剂和使用方法
公开(公告)号：US20070269378A1
公开(公告)日：2007-11-22
申请号：US10556440
申请日：2004-06-18
申请人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Odenthal , Jochen Scheel , Torsten Will , Yinsheng Jin , Lynn Bjerke , Timothy Heuer
发明人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Odenthal , Jochen Scheel , Torsten Will , Yinsheng Jin , Lynn Bjerke , Timothy Heuer
IPC分类号： A61K49/00 , A61P43/00 , C12N5/06 , C12Q1/48 , C12Q1/68
CPC分类号： G01N33/574 , A01K67/0275 , A01K2217/058 , A01K2227/40 , A01K2267/03 , A61K49/0008 , C12N9/1205 , C12Q1/485 , G01N33/5008 , G01N33/5011 , G01N33/5041
摘要： Human NADK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morpho-genesis, comprising screening for agents that modulate the activity of NADK are provided.
摘要翻译：人NADK基因被鉴定为分支形态发生的调节剂，因此是与缺陷支链形态发生功能相关的病症的治疗靶点。提供用于鉴定分支形态发生的调节剂的方法，包括筛选调节NADK活性的试剂。

3. 发明申请

US20130230895A1 METHOD AND DEVICE FOR UNIFORMLY TREATING ADHERENT CELLS 有权
标题翻译：用于均匀处理附着细胞的方法和装置
公开(公告)号：US20130230895A1
公开(公告)日：2013-09-05
申请号：US13806395
申请日：2011-06-21
申请人： Thomas Koblizek , Andreas Heinze , Timo Gleissner , Herbert Mueller-Hartmann , Andreas Wirth
发明人： Thomas Koblizek , Andreas Heinze , Timo Gleissner , Herbert Mueller-Hartmann , Andreas Wirth
IPC分类号： C12N13/00
CPC分类号： C12N13/00 , A61N1/327 , C12M23/12 , C12M35/02 , C12N15/87
摘要： The invention relates to a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least two active electrodes 63, wherein at least three electrodes 63, 64 are provided, and wherein at least two electrodes 63, 64 are active electrodes 63 when the voltage is applied in order to generate a first electric field, and in which at least one second electric field is generated, wherein at least one of the two previously active electrodes 63 is a potential-free electrode 64 when the voltage is applied. The invention further relates to a device 58 comprising at least three electrodes 63, 64, which are connected to at least one voltage source by means of at least one switching device 59, 60, 61, 62, wherein at least five electrodes 63, 64 are connected to the at least one voltage source by means of four switching devices 59, 60, 61, 62, wherein at least two electrodes 63, 64 are connected to the voltage source by means of a common switching device 59, 60, 61, 62. In conjunction with the method described above, the device according to the invention allows the efficient and uniform treatment of adherent cells using an electric field, wherein the switch between active and potential-free electrodes can be carried out quickly and safely using a lower number of switching devices.
摘要翻译：本发明涉及一种使贴壁细胞经受至少一个电场的方法，其中通过向至少两个有效电极63施加电压而产生电场，其中至少提供三个电极63,64，其中在当施加电压以产生第一电场时，至少两个电极63,64是有效电极63，并且其中产生至少一个第二电场，其中两个先前有效电极63中的至少一个是电位 - 当施加电压时，电极64。本发明还涉及包括至少三个电极63,64的装置58，这些电极通过至少一个开关装置59,60,61,62连接到至少一个电压源，其中至少五个电极63,64 通过四个开关装置59,60,61,62连接到至少一个电压源，其中至少两个电极63,64通过公共开关装置59,60,61连接到电压源，结合上述方法，根据本发明的装置允许使用电场对粘附细胞进行有效和均匀的处理，其中有效和无电极之间的开关可以使用较低的开关器件数量。

4. 发明授权

US09701954B2 Method and device for uniformly treating adherent cells 有权
公开(公告)号：US09701954B2
公开(公告)日：2017-07-11
申请号：US13806395
申请日：2011-06-21
申请人： Thomas Koblizek , Andreas Heinze , Timo Gleissner , Herbert Mueller-Hartmann , Andreas Wirth
发明人： Thomas Koblizek , Andreas Heinze , Timo Gleissner , Herbert Mueller-Hartmann , Andreas Wirth
IPC分类号： C12M1/42 , C12N13/00 , C12M1/32 , C12N15/87 , A61N1/32
CPC分类号： C12N13/00 , A61N1/327 , C12M23/12 , C12M35/02 , C12N15/87
摘要： The invention relates to a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least two active electrodes 63, wherein at least three electrodes 63, 64 are provided, and wherein at least two electrodes 63, 64 are active electrodes 63 when the voltage is applied in order to generate a first electric field, and in which at least one second electric field is generated, wherein at least one of the two previously active electrodes 63 is a potential-free electrode 64 when the voltage is applied. The invention further relates to a device 58 comprising at least three electrodes 63, 64, which are connected to at least one voltage source by means of at least one switching device 59, 60, 61, 62, wherein at least five electrodes 63, 64 are connected to the at least one voltage source by means of four switching devices 59, 60, 61, 62, wherein at least two electrodes 63, 64 are connected to the voltage source by means of a common switching device 59, 60, 61, 62. In conjunction with the method described above, the device according to the invention allows the efficient and uniform treatment of adherent cells using an electric field, wherein the switch between active and potential-free electrodes can be carried out quickly and safely using a lower number of switching devices.

5. 发明申请

US20060257870A1 Cdkl 1 as modifier of branching morphogenesis and methods of use 审中-公开
标题翻译： Cdkl 1作为分支形态发生的调节剂和使用方法
公开(公告)号：US20060257870A1
公开(公告)日：2006-11-16
申请号：US10532405
申请日：2003-10-22
申请人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Odenthal , Jochen Scheel , Torsten Will , Yisheng Jin , Bing Hai
发明人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Odenthal , Jochen Scheel , Torsten Will , Yisheng Jin , Bing Hai
IPC分类号： C12Q1/68 , G01N33/574 , C12Q1/48
CPC分类号： G01N33/57438 , C12Q1/485 , G01N33/57446 , G01N2500/00
摘要： Human CDKL1 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CDKL1 are provided.
摘要翻译：人CDKL1基因被鉴定为分支形态发生的调节剂，因此是与缺陷支链形态发生功能相关的病症的治疗靶点。提供用于鉴定分支形态发生调节剂的方法，包括筛选调节CDKL1活性的试剂。

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