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1. 发明申请

US20080086205A1 Bioprosthetic Heart Valve With Polyphosphazene 失效
标题翻译：生物假体心脏瓣膜与聚磷腈
公开(公告)号：US20080086205A1
公开(公告)日：2008-04-10
申请号：US11869889
申请日：2007-10-10
申请人： Thomas Gordy , Neng Ung , Ulf Fritz , Roman Denk
发明人： Thomas Gordy , Neng Ung , Ulf Fritz , Roman Denk
IPC分类号： A61F2/24
CPC分类号： A61L27/3641 , A61L27/34 , A61L27/3604 , A61L27/3645 , A61L27/3683 , A61L27/40 , A61L27/507 , C08L85/02
摘要： This disclosure encompasses a bioprosthetic heart valve having a polyphosphazene polymer such as poly[bis(trifluoroethoxy)phosphazene], which exhibits improved antithrombogenic, biocompatibility, and hemocompatibility properties. A method of manufacturing a bioprosthetic heart valve having a polyphosphazene polymer is also described.
摘要翻译：该公开内容包括具有聚磷腈聚合物如聚[双（三氟乙氧基）磷腈]的生物假体心脏瓣膜，其表现出改善的抗血栓形成，生物相容性和血液相容性。还描述了制造具有聚磷腈聚合物的生物假体心脏瓣膜的方法。

2. 发明申请

US20080095816A1 Compositions and Devices Comprising Silicone and Specific Polyphosphazenes 审中-公开
标题翻译：包含硅氧烷和特定聚磷腈的组合物和装置
公开(公告)号：US20080095816A1
公开(公告)日：2008-04-24
申请号：US11869960
申请日：2007-10-10
申请人： Thomas Gordy , Neng Ung , Ulf Fritz , Olaf Fritz , Ronald Wojcik
发明人： Thomas Gordy , Neng Ung , Ulf Fritz , Olaf Fritz , Ronald Wojcik
IPC分类号： A61F2/00
CPC分类号： A61L27/26 , C08G77/045 , C08G77/12 , C08G77/14 , C08G77/16 , C08G77/18 , C08G77/20 , C08G77/24 , C08G77/26 , C08G77/28 , C08G77/30 , C08G77/32 , C08G77/70 , C08G77/80 , C08L83/04 , C08L85/02 , C08L83/00
摘要： The present invention relates to compositions and medical devices comprising both polyorganosiloxane and polyphosphazene compounds. When incorporated into or onto medical devices, these compositions reduce cell encrustation on the device and reduce the severity of thrombosis when the devices are in contact with body fluids, and impart anti-rejection properties to the device.
摘要翻译：本发明涉及包含聚有机硅氧烷和聚磷腈化合物的组合物和医疗装置。当结合到医疗装置中或其上时，这些组合物减少装置上的细胞结垢并且当装置与体液接触时降低血栓形成的严重性，并赋予装置抗拒性能。

3. 发明申请

US20080102029A1 Loadable Polymeric Particles For Enhanced Imaging In Clinical Applications And Methods Of Preparing And Using The Same 有权
标题翻译：可加载聚合物颗粒用于临床应用中的增强成像及其制备和使用方法
公开(公告)号：US20080102029A1
公开(公告)日：2008-05-01
申请号：US11877839
申请日：2007-10-24
申请人： Ulf Fritz , Olaf Fritz , Thomas Gordy , Ronald Wojcik
发明人： Ulf Fritz , Olaf Fritz , Thomas Gordy , Ronald Wojcik
IPC分类号： A61K51/00 , A61K49/04 , A61B5/055 , A61K49/00
CPC分类号： A61K51/1244 , A61K49/0419 , A61K49/1824 , A61K49/225
摘要： Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Microspheres of the present invention may further be provided with physical and/or chemical enhancements within the particles' cores to enhance visualization of the embolized tissue using a variety of medical imaging modalities, including conventional radiography, fluoroscopy, tomography, computerized tomography, ultrasound, scintillation, magnetic resonance, or other imaging technologies.
摘要翻译：颗粒被提供用于治疗和/或诊断过程。颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或颗粒的外涂层内。颗粒还可以包括具有由丙烯酸类聚合物形成的水凝胶的芯。这样的颗粒可以以特定的选定尺寸提供给使用者，以允许特定大小的血管的选择性栓塞或在特定临床应用中用活性成分剂局部治疗。本发明的微球可以进一步提供颗粒内核内的物理和/或化学增强，以使用各种医学成像方式来增强栓塞组织的可视化，包括常规放射成像，荧光透视，层析成像，计算机断层扫描，超声，闪烁，磁共振或其他成像技术。

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