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1. 发明授权

US07767819B2 Thiazolylimidazole derivatives and their use as inhibitors of microsomal triglyceride transfer protein 失效
标题翻译：噻唑咪唑衍生物及其作为微粒体甘油三酯转移蛋白的抑制剂
公开(公告)号：US07767819B2
公开(公告)日：2010-08-03
申请号：US10587975
申请日：2005-01-17
申请人： Philippe Guedat , Olivier Chevreuil , Thierry Convard
发明人： Philippe Guedat , Olivier Chevreuil , Thierry Convard
IPC分类号： C07D417/04 , A61K31/4535
CPC分类号： C07D417/14
摘要： The present invention relates to thiazolylimidazole derivatives of the general formula (I) in which: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3; and R1, R2, R3, R4, R5, R6, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
摘要翻译：本发明涉及通式（I）的噻唑咪唑衍生物，其中：G表示选自基团g1，g2和g3的键或二价基团; 并且R1，R2，R3，R4，R5，R6，Y和Z如说明书中所定义。式（I）化合物用于治疗高甘油三酯血症，高胆固醇血症和血脂异常。

2. 发明申请

US20120252721A1 METHODS FOR TREATING DRUG-RESISTANT HEPATITIS C VIRUS INFECTION WITH A 5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITOR 审中-公开
标题翻译：用5,5-FUSY ARYLENE或异丙肾上腺素C病毒抑制剂治疗耐药性丙型肝炎病毒感染的方法
公开(公告)号：US20120252721A1
公开(公告)日：2012-10-04
申请号：US13434503
申请日：2012-03-29
申请人： Cyril B. Dousson , David Dukhan , John P. Billelo , Christophe Claude Parsy , Claire Pierra , Francois-Rene Alexandre , Guillaume Brandt , Daniel Da Costa , Houcine Rahali , Jean-Laurent Paparin , Michel Derock , Thierry Convard , Dominique Surleraux
发明人： Cyril B. Dousson , David Dukhan , John P. Billelo , Christophe Claude Parsy , Claire Pierra , Francois-Rene Alexandre , Guillaume Brandt , Daniel Da Costa , Houcine Rahali , Jean-Laurent Paparin , Michel Derock , Thierry Convard , Dominique Surleraux
IPC分类号： A61K31/4178 , A61K31/5377 , A61P31/14 , A61K31/4184 , A61P1/16 , A61K38/05 , A61K31/429
CPC分类号： A61K31/424 , A61K31/381 , A61K31/407 , A61K31/4188 , A61K31/429
摘要： Provided herein are methods for treating or preventing drug-resistant hepatitis C virus infection in a subject, which comprises administering to the subject a 5,5-fused heteroarylene hepatitis C virus inhibitor compound, for example, of Formula I, IA, or IB.
摘要翻译：本文提供了治疗或预防受试者中耐药性丙型肝炎病毒感染的方法，其包括向受试者施用例如式I，IA或IB的5,5-稠合亚麻丙基丙型肝炎病毒抑制剂化合物。

3. 发明授权

US07829721B2 Specific caspase-10 inhibitors 有权
标题翻译：特异性半胱天冬酶-10抑制剂
公开(公告)号：US07829721B2
公开(公告)日：2010-11-09
申请号：US11791922
申请日：2005-11-02
申请人： Claude Lardy , Marc Lecomte , Catherine Vidal , Thierry Convard , Stéphane Yvon , Marie Noelle Denuault , Denis Descours
发明人： Claude Lardy , Marc Lecomte , Catherine Vidal , Thierry Convard , Stéphane Yvon , Marie Noelle Denuault , Denis Descours
IPC分类号： A61K31/44 , A61K31/192 , C07C57/38 , C07D213/55 , A61P27/02
CPC分类号： A61K31/192 , A61K31/44 , A61K31/50 , A61K31/505 , A61K31/53 , C07C57/38 , C07C57/58 , C07C59/64
摘要： The invention relates to compounds of the general formula (I), and to their use as caspase-10 inhibitors, especially for the treatment of diabetic retinopathy.
摘要翻译：本发明涉及通式（I）的化合物及其作为半胱天冬酶-10抑制剂的用途，特别是用于治疗糖尿病性视网膜病变。

4. 发明申请

US20100260710A1 MACROCYCLIC SERINE PROTEASE INHIBITORS 有权
标题翻译：大肠杆菌丝氨酸蛋白酶抑制剂
公开(公告)号：US20100260710A1
公开(公告)日：2010-10-14
申请号：US12756082
申请日：2010-04-07
申请人： Christophe Claude Parsy , Francois-Rene Alexandre , Michel Derock , Frederic Leroy , Jean-Christophe Meillon , Thierry Convard , Dominique Surleraux
发明人： Christophe Claude Parsy , Francois-Rene Alexandre , Michel Derock , Frederic Leroy , Jean-Christophe Meillon , Thierry Convard , Dominique Surleraux
IPC分类号： A61K38/20 , A61K38/21 , C12N9/99 , C12N7/06 , C12N5/02 , A61K31/7056 , A61K31/7105 , A61K31/506 , A61K31/4353 , C07D471/04 , A61P31/14
CPC分类号： A61K38/005 , A61K31/444 , A61K31/4709 , A61K31/506 , A61K45/06 , C07D471/04
摘要： Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula Ia or Ib, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
摘要翻译：本文提供的是大环丝氨酸蛋白酶抑制剂化合物，例如式Ia或Ib，包含该化合物的药物组合物及其制备方法。还提供了它们用于在有需要的宿主中治疗HCV感染的方法。

5. 发明授权

US08362068B2 5,5-fused arylene or heteroarylene hepatitis C virus inhibitors 有权
公开(公告)号：US08362068B2
公开(公告)日：2013-01-29
申请号：US12972254
申请日：2010-12-17
申请人： Cyril B. Dousson , David Dukhan , Christophe Claude Parsy , Claire Pierra , Francois-Rene Alexandre , Guillaume Brandt , Daniel Da Costa , Houcine Rahali , Jean-Laurent Paparin , Michel Derock , Thierry Convard , Dominique Surleraux
发明人： Cyril B. Dousson , David Dukhan , Christophe Claude Parsy , Claire Pierra , Francois-Rene Alexandre , Guillaume Brandt , Daniel Da Costa , Houcine Rahali , Jean-Laurent Paparin , Michel Derock , Thierry Convard , Dominique Surleraux
IPC分类号： A61K31/4184 , A61K31/4178 , A61K31/4025 , A61K31/381 , C07D235/04 , C07D409/14 , C07D495/04
CPC分类号： C07D513/04 , A61K31/4178 , A61K31/4184 , A61K31/429 , A61K31/5377 , A61K31/7056 , A61K38/05 , A61K38/20 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/217 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07K5/06165
摘要： Provided herein are 5,5-fused heteroarylene hepatitis C virus inhibitor compounds, for example, of Formula I, IA, or IB, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

6. 发明申请

US20100137601A1 THIAZOLYLIMIDAZOLE DERIVATIVES AN THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN 审中-公开
标题翻译：它们作为微量TRIGLYCERIDE转移蛋白的抑制剂使用的三唑基咪唑衍生物
公开(公告)号：US20100137601A1
公开(公告)日：2010-06-03
申请号：US12700441
申请日：2010-02-04
申请人： Philippe GUEDAT , Olivier Chevreuil , Thierry Convard
发明人： Philippe GUEDAT , Olivier Chevreuil , Thierry Convard
IPC分类号： C07D401/14
CPC分类号： C07D417/14
摘要： The present invention relates to thiazolylimidazole derivatives of the general formula (I) in which: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3; and R1, R2, R3, R4, R5, R6, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
摘要翻译：本发明涉及通式（I）的噻唑咪唑衍生物，其中：G表示选自基团g1，g2和g3的键或二价基团; 并且R1，R2，R3，R4，R5，R6，Y和Z如说明书中所定义。式（I）化合物用于治疗高甘油三酯血症，高胆固醇血症和血脂异常。

7. 发明申请

US20080182906A1 Novel Specific Caspase-10 Inhibitors 失效
标题翻译：新型特异性Caspase-10抑制剂
公开(公告)号：US20080182906A1
公开(公告)日：2008-07-31
申请号：US11912461
申请日：2006-04-06
申请人： Claude Lardy , Marc Lecomte , Thierry Convard , Catherine Vidal
发明人： Claude Lardy , Marc Lecomte , Thierry Convard , Catherine Vidal
IPC分类号： A61K31/18 , C07C311/17 , A61P27/02
CPC分类号： C07C311/17 , A61K31/18 , C07C311/16 , C07C311/29 , C07C317/28 , C07C323/49 , C07C2601/02 , C07C2601/14 , C07D213/64
摘要： The invention relates to compounds of the general formula (I) wherein R1, R2, R3, R4, R5, R6, i and j have the meanings given in claim 1, and to the use thereof as caspase-10 inhibitors, especially for the treatment of diabetic retinopathy.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，i和j具有权利要求1中给出的含义，以及其作为胱天蛋白酶-10抑制剂的用途，治疗糖尿病性视网膜病变。

8. 发明授权

US07159012B2 Computational data processing system and computational process implemented by means of such a system 失效
标题翻译：通过这种系统实现的计算数据处理系统和计算过程
公开(公告)号：US07159012B2
公开(公告)日：2007-01-02
申请号：US09808005
申请日：2001-03-15
申请人： Edouard Viollet , Thierry Convard , Jacques Barbanton
发明人： Edouard Viollet , Thierry Convard , Jacques Barbanton
IPC分类号： G06F15/16 , G06F9/50
CPC分类号： G06F9/505 , G06F2209/503 , G06F2209/509
摘要： This computational data processing system comprises an assembly of networked computers (12, . . . 22) in each of which is stored at least one computational application, and a machine (10) for storing computational data which is linked to the network and in communication with the computers, at least one of the computers (12) operating as master computer and at least some of the other computers (14, . . . 22) operating as slave computer. At least one of the computers comprises, stored in memory an algorithm for configuring the other computers of the network as slave computers and an executable master application for managing the tasks of each slave computer (14, . . . 22) as a function of their availability for the assignment, to each of them, of computational tasks and of corresponding computational data which are stored in the storage machine (10).
摘要翻译：该计算数据处理系统包括每个存储至少一个计算应用的网络计算机（12 ... 22）的组合，以及用于存储连接到网络和通信的计算数据的机器（10）与计算机一起运行的计算机（12）中的至少一个作为主计算机运行，以及作为从计算机运行的至少一些其他计算机（14 ... 22）。计算机中的至少一个包括存储在存储器中的用于将网络的其他计算机配置为从属计算机的算法和用于根据它们的功能来管理每个从属计算机（14 ... 22）的任务的可执行主应用程序分配给每个计算任务的可用性以及存储在存储机器（10）中的对应的计算数据。

9. 发明授权

US09284307B2 Macrocyclic serine protease inhibitors 有权
公开(公告)号：US09284307B2
公开(公告)日：2016-03-15
申请号：US12850534
申请日：2010-08-04
申请人： Christophe Claude Parsy , Francois-Rene Alexandre , Frederic Leroy , Thierry Convard , Dominique Surleraux
发明人： Christophe Claude Parsy , Francois-Rene Alexandre , Frederic Leroy , Thierry Convard , Dominique Surleraux
IPC分类号： A61K31/4709 , A61K38/21 , A61P31/14 , C07D417/14 , C12N5/00 , C12N7/06 , C12N9/99 , A61K31/403
CPC分类号： C07D417/14 , A61K31/403 , A61K31/4709
摘要： Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula Ia or Ib, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

10. 发明申请

US20120207703A1 MACROCYCLIC SERINE PROTEASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE FOR TREATING HCV INFECTIONS 有权
标题翻译：大肠杆菌丝氨酸蛋白酶抑制剂，其药物组合物及其用于治疗HCV感染的用途
公开(公告)号：US20120207703A1
公开(公告)日：2012-08-16
申请号：US13370198
申请日：2012-02-09
申请人： Christophe Claude PARSY , Francois-Rene ALEXANDRE , Thierry CONVARD , Dominique SURLERAUX
发明人： Christophe Claude PARSY , Francois-Rene ALEXANDRE , Thierry CONVARD , Dominique SURLERAUX
IPC分类号： A61K38/20 , C12N9/99 , C12N5/02 , A61K31/7088 , A61K31/506 , C07D403/12 , A61K31/427 , C07D245/04 , A61P31/12 , C07D401/12 , C07D417/14 , A61K38/21 , A61K31/4709
CPC分类号： C07D417/14 , C07D417/12
摘要： Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, and pharmaceutical compositions and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
摘要翻译：本文提供了大环丝氨酸蛋白酶抑制剂化合物，例如式I，以及药物组合物及其制备方法。还提供了它们用于在有需要的宿主中治疗HCV感染的方法。

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