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1. 发明申请

US20040005319A1 Connective tissue growth factor 失效
标题翻译：结缔组织生长因子
公开(公告)号：US20040005319A1
公开(公告)日：2004-01-08
申请号：US10338587
申请日：2003-01-07
申请人： THE UNIVERSITY OF SOUTH FLORIDA
发明人： Gary R. Grotendorst , Douglass M. Bradham JR.
IPC分类号： G01N033/53 , A61K039/395
CPC分类号： C07K14/475 , A61K31/7076 , A61K38/00 , A61K38/164 , C07K16/22 , G01N33/5023 , G01N33/574 , G01N2333/71
摘要： The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF and polynucleotides regulating CTGF expression. The invention also provides agents that modulate CTGF and therapeutic methods for using the agents. Also provided are diagnostic methods for using CTGF and assays for identifying agents which affect the expression of CTGF polynucleotide.
摘要翻译：本发明提供新型多肽，结缔组织生长因子（CTGF），编码CTGF的多核苷酸和调节CTGF表达的多核苷酸。本发明还提供调节CTGF的药剂和使用该药剂的治疗方法。还提供了使用CTGF和测定用于鉴定影响CTGF多核苷酸表达的试剂的诊断方法。

2. 发明授权

US08912006B2 Microfluidic device for generating neural cells to simulate post-stroke conditions 有权
标题翻译：用于产生神经细胞以模拟中风后条件的微流体装置
公开(公告)号：US08912006B2
公开(公告)日：2014-12-16
申请号：US13758572
申请日：2013-02-04
申请人： The Charles Stark Draper Laboratory, Inc. , The University of South Florida
发明人： Anilkumar Harapanahalli Achyuta , Javier Cuevas , Shivshankar Sundaram , Chris Katnik
IPC分类号： G01N33/50 , C12M1/34 , C12M3/06 , G01N21/64
CPC分类号： G01N33/5058 , C12M23/16 , C12M35/02 , C12M35/08 , C12M41/34 , G01N21/6486 , G01N33/5005 , G01N33/5023 , G01N33/5026 , G01N2333/525 , G01N2333/5428 , G01N2333/545 , G01N2500/10 , G01N2510/00
摘要： This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.
摘要翻译：该应用程序提供了用于建模缺血性卒中病症的装置。该装置可用于培养神经元，并将神经元的第一群体置于低氧条件下，将第二群神经元置于常氧条件下。神经元在多孔屏障上培养，并且在屏障的另一侧运行一个或多个流体填充的通道。通过流过具有不同氧水平的流体通过通道，可以将所需的氧浓度递送到最靠近这些通道的细胞。

3. 发明申请

US20130203086A1 MICROFLUIDIC DEVICE FOR GENERATING NEURAL CELLS TO SIMULATE POST-STROKE CONDITIONS 有权
公开(公告)号：US20130203086A1
公开(公告)日：2013-08-08
申请号：US13758572
申请日：2013-02-04
申请人： The Charles Stark Draper Laboratory, Inc. , The University Of South Florida
发明人： Anilkumar Harapanahalli Achyuta , Javier Cuevas , Shankar Sundaram , Chris Katnik
IPC分类号： G01N21/64
CPC分类号： G01N33/5058 , C12M23/16 , C12M35/02 , C12M35/08 , C12M41/34 , G01N21/6486 , G01N33/5005 , G01N33/5023 , G01N33/5026 , G01N2333/525 , G01N2333/5428 , G01N2333/545 , G01N2500/10 , G01N2510/00
摘要： This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.

4. 发明申请

US20150140581A1 MICROFLUIDIC DEVICE FOR GENERATING NEURAL CELLS TO SIMULATE POST-STROKE CONDITIONS 有权
标题翻译：用于产生神经细胞以模拟后冲击条件的微流体装置
公开(公告)号：US20150140581A1
公开(公告)日：2015-05-21
申请号：US14539544
申请日：2014-11-12
申请人： The Charles Stark Draper Laboratory, Inc. , The University of South Florida
发明人： Anilkumar Harapanahalli Achyuta , Javier Cuevas , Shivshankar Sundaram , Chris Katnik
IPC分类号： G01N33/50 , C12M1/34 , C12M1/42 , C12M3/06
CPC分类号： G01N33/5058 , C12M23/16 , C12M35/02 , C12M35/08 , C12M41/34 , G01N21/6486 , G01N33/5005 , G01N33/5023 , G01N33/5026 , G01N2333/525 , G01N2333/5428 , G01N2333/545 , G01N2500/10 , G01N2510/00
摘要： This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.
摘要翻译：该应用程序提供了用于建模缺血性卒中病症的装置。该装置可用于培养神经元，并将神经元的第一群体置于低氧条件下，将第二群神经元置于常氧条件下。神经元在多孔屏障上培养，并且在屏障的另一侧运行一个或多个流体填充的通道。通过流过具有不同氧水平的流体通过通道，可以将所需的氧浓度递送到最靠近这些通道的细胞。

5. 发明授权

US09632076B2 Microfluidic device for generating neural cells to simulate post-stroke conditions 有权
公开(公告)号：US09632076B2
公开(公告)日：2017-04-25
申请号：US14539544
申请日：2014-11-12
申请人： The Charles Stark Draper Laboratory, Inc. , The University of South Florida
发明人： Anilkumar Harapanahalli Achyuta , Javier Cuevas , Shivshankar Sundaram , Chris Katnik
IPC分类号： G01N33/50 , G01N21/64 , C12M3/06 , C12M1/34 , C12M1/42
CPC分类号： G01N33/5058 , C12M23/16 , C12M35/02 , C12M35/08 , C12M41/34 , G01N21/6486 , G01N33/5005 , G01N33/5023 , G01N33/5026 , G01N2333/525 , G01N2333/5428 , G01N2333/545 , G01N2500/10 , G01N2510/00
摘要： This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.

6. 发明申请

US20150368599A1 DESIGN AND HOT EMBOSSING OF MACRO AND MICRO FEATURES WITH HIGH RESOLUTION MICROSCOPY ACCESS 审中-公开
标题翻译：具有高分辨率显微镜访问的宏观和微观特征的设计和热切割
公开(公告)号：US20150368599A1
公开(公告)日：2015-12-24
申请号：US14743634
申请日：2015-06-18
申请人： The Charles Stark Draper Laboratory, Inc. , The University of South Florida
发明人： Steven Maher , Wajeeh M. Saadi , Amy Jane Taylor , Hoi-Cheong Steve Sun , Dennis Kyle , John Adams
IPC分类号： C12M1/32 , C08G65/40 , C12M1/00 , C09D175/04 , C09D163/00 , B29C39/02 , C08G77/04 , C08G73/10
CPC分类号： C12M23/12 , B29C39/026 , B29K2071/00 , B29L2031/752 , C08G65/4012 , C08G73/10 , C08G77/04 , C09D163/00 , C09D175/04 , C12M23/22
摘要： This disclosure provides micro-feature devices and methods for fabricating micro-feature devices. A micro-feature device can include a substantially rigid transparent substrate. The device can include a plurality of macrowells defined in the transparent substrate. Each macrowell can have a width in the range of about one millimeter to about 35 millimeters and a depth in the range of about two millimeters to about 12 millimeters. Each macrowell can include a respective plurality of microwells defined in a respective lower surface of the macrowell. Each microwell can have a width in the range of about 50 microns to about 500 microns and a depth in the range of about 50 microns to about 500 microns.
摘要翻译：本公开提供了用于制造微特征器件的微特征器件和方法。微特征装置可以包括基本刚性的透明基板。该装置可以包括限定在透明基板中的多个孔眼。每个大孔径可以具有在约1毫米至约35毫米范围内的宽度和在约2毫米至约12毫米范围内的深度。每个小孔可以包括限定在大圆盘的相应下表面中的相应的多个微孔。每个微孔可以具有在约50微米至约500微米范围内的宽度和约50微米至约500微米范围内的深度。

7. 发明申请

WO1991010427A2 THE EFFECT OF TRANSGLUTAMINASE INHIBITION ON MICROFILARIAE DEVELOPMENT AND MACROFILARIAE VIABILITY 审中-公开
标题翻译：谷氨酸过氧化物酶抑制剂对微丝蚴发展和巨噬细胞生活力的影响
公开(公告)号：WO1991010427A2
公开(公告)日：1991-07-25
申请号：PCT/US1990007697
申请日：1990-12-31
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS , THE UNIVERSITY OF SOUTH FLORIDA , MEHTA, Kapil , RAO, Undaru, R. , VICKERY, Ann, C.
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS , THE UNIVERSITY OF SOUTH FLORIDA
IPC分类号： A61K31/13
CPC分类号： A61K31/415 , A61K31/00 , A61K31/13 , A61K31/14 , A61K31/16 , A61K31/18 , Y02A50/421
摘要： A method is described for blocking maturation and production of microfilariae in adult filarial nematodes utilizing a transglutaminase inhibitor, such as monodansyl cadaverine (MDC). Experiments applying this method to several Brugia filarial infections, including Brugia malayi, were successful. Higher concentration of transglutaminase inhibitor proved to be filariacidal.
摘要翻译：本发明涉及一种用于抑制成熟和产量在成年阶段的丝类型的线虫微丝蚴，以及转谷氨酰胺酶或反馈的由转谷氨酰胺酶发送的抑制通过一种方法使用转谷氨酰胺酶抑制剂阻断成人生物体对微丝蚴成熟和产生并杀死成虫生物体。已经证明应用这种方法来治疗布鲁氏菌蠕虫感染的实验，包括Brugia malayi蠕虫，是有效的。较高浓度的转谷氨酰胺酶抑制剂证明了对独立于宿主或宿主生物体内的成年生物体具有上述的细丝作用。

8. 发明申请

WO2015195941A1 DESIGN AND HOT EMBOSSING OF MACRO AND MICRO FEATURES WITH HIGH RESOLUTION MICROSCOPY ACCESS 审中-公开
标题翻译：具有高分辨率显微镜访问的宏观和微观特征的设计和热切割
公开(公告)号：WO2015195941A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036471
申请日：2015-06-18
申请人： THE CHARLES STARK DRAPER LABORATORY, INC. , THE UNIVERSITY OF SOUTH FLORIDA
发明人： MAHER, Steven , SAADI, Wajeeh M. , TAYLOR, Amy Jane , SUN, Hoi-Cheong Steve , KYLE, Dennis , ADAMS, John
IPC分类号： C12M1/32
CPC分类号： C12M23/12 , B29C39/026 , B29K2071/00 , B29L2031/752 , C08G65/4012 , C08G73/10 , C08G77/04 , C09D163/00 , C09D175/04 , C12M23/22
摘要： This disclosure provides micro-feature devices and methods for fabricating micro-feature devices. A micro-feature device can include a substantially rigid transparent substrate. The device can include a plurality of macrowells defined in the transparent substrate. Each macrowell can have a width in the range of about one millimeter to about 35 millimeters and a depth in the range of about two millimeters to about 12 millimeters. Each macrowell can include a respective plurality of microwells defined in a respective lower surface of the macrowell. Each microwell can have a width in the range of about 50 microns to about 500 microns and a depth in the range of about 50 microns to about 500 microns.
摘要翻译：本公开提供了用于制造微特征器件的微特征器件和方法。微特征装置可以包括基本刚性的透明基板。该装置可以包括限定在透明基板中的多个孔眼。每个大孔径可以具有在约1毫米至约35毫米范围内的宽度和在约2毫米至约12毫米范围内的深度。每个小孔可以包括限定在大圆盘的相应下表面中的相应的多个微孔。每个微孔可以具有在约50微米至约500微米范围内的宽度和约50微米至约500微米范围内的深度。

9. 发明申请

WO2013116834A2 MICROFLUIDIC DEVICE FOR GENERATING NEURAL CELLS TO SIMULATE POST-STROKE CONDITIONS 审中-公开
标题翻译：用于产生神经细胞以模拟后冲击条件的微流体装置
公开(公告)号：WO2013116834A2
公开(公告)日：2013-08-08
申请号：PCT/US2013/024626
申请日：2013-02-04
申请人： THE CHARLES STARK DRAPER LABORATORY, INC. , THE UNIVERSITY OF SOUTH FLORIDA , ACHYUTA, Anilkumar Harapanahalli , CUEVAS, Javier , SUNDARAM, Shankar , KATNIK, Chris
发明人： ACHYUTA, Anilkumar Harapanahalli , CUEVAS, Javier , SUNDARAM, Shankar , KATNIK, Chris
IPC分类号： G01N33/50
CPC分类号： G01N33/5058 , C12M23/16 , C12M35/02 , C12M35/08 , C12M41/34 , G01N21/6486 , G01N33/5005 , G01N33/5023 , G01N33/5026 , G01N2333/525 , G01N2333/5428 , G01N2333/545 , G01N2500/10 , G01N2510/00
摘要： This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.
摘要翻译：该应用程序提供了用于建模缺血性卒中病症的装置。该装置可用于培养神经元，并将神经元的第一群体置于低氧条件下，将第二群神经元置于常氧条件下。神经元在多孔屏障上培养，并且在屏障的另一侧运行一个或多个流体填充的通道。通过流过具有不同氧水平的流体通过通道，可以将所需的氧浓度递送到最靠近这些通道的细胞。

10. 发明申请

WO2008011046A2 COMPUTER SYSTEMS AND METHODS FOR SELECTING SUBJECTS FOR CLINICAL TRIALS 审中-公开
标题翻译：计算机系统和选择临床试验对象的方法
公开(公告)号：WO2008011046A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/016239
申请日：2007-07-16
申请人： THE H.LEE MOFFITT CANCER AND RESEARCH INSTITUTE, INC. , THE UNIVERSITY OF SOUTH FLORIDA , YEATMAN, Timothy , DALTON, William, S.
发明人： YEATMAN, Timothy , DALTON, William, S.
IPC分类号： G06F19/00
CPC分类号： G06Q50/24 , G06F19/00 , G06Q50/22 , G16H10/20 , G16H10/60
摘要： Computers, computer program products, and methods for identifying a plurality of subjects for a clinical trial are provided. A candidate set of molecular profiles in a stored plurality of molecular profiles are identified. Each such profile has measurements for a discriminating set of cellular constituents that match the measurements of corresponding cellular constituents in a responder set of biological samples, thereby identifying the plurality of subjects for the trial from those subjects from which the candidate set of molecular profiles were derived. Each respective molecular profile in the stored plurality of profiles has measurements of a plurality of cellular constituents from a respective biological sample in a plurality of samples obtained from a first plurality of subjects. The discriminating set of cellular constituents is identified from those cellular constituents in the plurality of cellular constituents whose measurement values discriminates between the responder and nonresponder sets of biological samples.
摘要翻译：提供了用于识别临床试验的多个受试者的计算机，计算机程序产品和方法。识别存储的多个分子谱中的一组候选分子谱。每个这样的概况都具有用于识别一组细胞成分的测量结果，该组细胞成分匹配生物样本的响应组中的对应细胞成分的测量结果，从而从衍生出候选分子谱集的那些受试者识别用于试验的多个受试者。所存储的多个分布图中的每个相应的分子图谱具有对从第一多个受试者获得的多个样品中来自各个生物样品的多个细胞成分的测量结果。从其多个细胞成分中的那些细胞成分中鉴别出一组细胞成分，其测量值区分响应者组和无响应者组的生物样品。

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