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1. 发明授权

US08628790B2 Coating system and method for drug elution management 有权
标题翻译：涂药系统及药物洗脱管理方法
公开(公告)号：US08628790B2
公开(公告)日：2014-01-14
申请号：US12901426
申请日：2010-10-08
申请人： John Thao To , Charles M. Blaha
发明人： John Thao To , Charles M. Blaha
IPC分类号： A61F13/00 , A61F2/00 , A61F2/04
CPC分类号： A61L31/10 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61K31/16 , A61K31/192 , A61K31/337 , A61K31/436 , A61K31/565 , A61K31/60 , A61K31/727 , A61K38/1825 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2420/08 , C08L67/04
摘要： The teachings are directed to a medical device having a drug-retaining coating that at least substantially delays the initial elution of a drug for a time effective at forming a functional endothelium over a surface of the medical device.
摘要翻译：该教导涉及具有药物保持涂层的医疗装置，该药物保持涂层至少基本上延迟药物的初始洗脱，以在医疗装置的表面上形成功能性内皮的时间有效。

2. 发明申请

US20100119578A1 EXTRACELLULAR MATRIX MODULATING COATINGS FOR MEDICAL DEVICES 审中-公开
标题翻译：用于医疗器械的细胞基质调节涂层
公开(公告)号：US20100119578A1
公开(公告)日：2010-05-13
申请号：US12613477
申请日：2009-11-05
申请人： John Thao To , Charles M. Blaha , Loc Xuan Phan
发明人： John Thao To , Charles M. Blaha , Loc Xuan Phan
IPC分类号： A61F2/82 , A61K31/70 , A61K31/47 , A61K31/4965
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/608 , C08L67/04
摘要： A unique method and coatings are provided to promote/allow early stage tissue encapsulation/endothelization of medical devices while effectively controlling excessive tissue buildup by eluting antiproliferative therapeutic agent within a body of a patient. The method involves using a therapeutic agent that suppresses excessive extracellular matrix proliferation and allows/promotes thin tissue healing/encapsulation/endothelization of the device. Optimized timing of onset of elution to match onset of excessive extracellular matrix proliferation for maximum effectiveness is achieved by delay barrier with biochemical switch.
摘要翻译：提供独特的方法和涂层以促进/允许医疗装置的早期组织包封/内皮化，同时通过在患者体内洗脱抗增殖治疗剂来有效地控制过量的组织积聚。该方法包括使用抑制过度的细胞外基质增殖的治疗剂，并允许/促进该组织的细胞愈合/包封/内皮化装置。优化的洗脱开始时间与过度的细胞外基质增殖的发生匹配以获得最大的有效性是通过生化开关的延迟屏障实现的。

3. 发明申请

US20110086081A1 COATING SYSTEM AND METHOD FOR DRUG ELUTION MANAGEMENT 有权
标题翻译：涂药系统和药物治疗方法
公开(公告)号：US20110086081A1
公开(公告)日：2011-04-14
申请号：US12901426
申请日：2010-10-08
申请人： John Thao To , Charles M. Blaha
发明人： John Thao To , Charles M. Blaha
IPC分类号： A61F2/00 , A61K31/436 , B05D3/10
CPC分类号： A61L31/10 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61K31/16 , A61K31/192 , A61K31/337 , A61K31/436 , A61K31/565 , A61K31/60 , A61K31/727 , A61K38/1825 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2420/08 , C08L67/04
摘要： The teachings are directed to a medical device having a drug-retaining coating that at least substantially delays the initial elution of a drug for a time effective at forming a functional endothelium over a surface of the medical device.
摘要翻译：该教导涉及具有药物保持涂层的医疗装置，该药物保持涂层至少基本上延迟药物的初始洗脱，以在医疗装置的表面上形成功能性内皮的时间有效。

4. 发明授权

US07899237B2 Method, apparatus and system for detecting anomalies in mixed signal devices 有权
标题翻译：用于检测混合信号装置异常的方法，装置和系统
公开(公告)号：US07899237B2
公开(公告)日：2011-03-01
申请号：US11683548
申请日：2007-03-08
申请人： Dat T. Nguyen , Thao To , David Maxwell , Naweed Anjum
发明人： Dat T. Nguyen , Thao To , David Maxwell , Naweed Anjum
IPC分类号： G06K9/00
CPC分类号： G01R31/3167 , G01R31/311
摘要： An embodiment relates generally to a method of testing a mixed signal device. The method includes monitoring multiple parameters of the mixed signal device and scanning the mixed signal device with an optical source. The method also includes forming multiple windows, where each window is assigned to a respective parameter. The method further includes comparing an image from a respective image to a reference image to determine an existence of an anomaly.
摘要翻译：实施例一般涉及测试混合信号装置的方法。该方法包括监视混合信号装置的多个参数并用光源扫描混合信号装置。该方法还包括形成多个窗口，其中每个窗口被分配给相应的参数。该方法还包括将来自相应图像的图像与参考图像进行比较，以确定异常的存在。

5. 发明申请

US20090043330A1 Embolic protection devices and methods 审中-公开
标题翻译：栓塞保护装置及方法
公开(公告)号：US20090043330A1
公开(公告)日：2009-02-12
申请号：US12189538
申请日：2008-08-11
申请人： John Thao To
发明人： John Thao To
IPC分类号： A61M29/02 , A61M29/00
CPC分类号： A61F2/07 , A61F2/885 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/072 , A61F2250/0039
摘要： The present invention provides a PreStent comprising a sheath and frame designed for preparing a vessel passageway for the subsequent delivery of a stent. The PreStent can be self-expanding or balloon-expandable. Also provided is a supporting system for delivering the PreStent safely. The supporting system includes a delivery catheter, one or more occlusion balloon, optionally one or more dilation balloon, and a retention sheath for the self-expanding type of PreStent. The PreStent of the present invention is flexible for use with a variety of stent and guidewire models such that it can easily be incorporated with existing devices to improve stenting procedures.
摘要翻译：本发明提供了一种包括设计用于制备用于随后输送支架的血管通道的护套和框架的预备件。 PreStent可以自扩展或气球扩张。还提供了用于安全地递送PreStent的支持系统。支撑系统包括输送导管，一个或多个闭塞气囊，可选地一个或多个扩张气囊，以及用于自膨胀型PreStent的保持护套。本发明的前提是灵活地用于各种支架和导丝模型，使得其可以容易地与现有装置结合以改善支架置入程序。

6. 发明申请

US20080219546A1 METHOD, APPARATUS AND SYSTEM FOR DETECTING ANOMALIES IN MIXED SIGNAL DEVICES 有权
标题翻译：用于检测混合信号装置中异常的方法，装置和系统
公开(公告)号：US20080219546A1
公开(公告)日：2008-09-11
申请号：US11683548
申请日：2007-03-08
申请人： Dat T. Nguyen , Thao To , David Maxwell , Naweed Anjum
发明人： Dat T. Nguyen , Thao To , David Maxwell , Naweed Anjum
IPC分类号： G06K9/80
CPC分类号： G01R31/3167 , G01R31/311
摘要： An embodiment relates generally to a method of testing a mixed signal device. The method includes monitoring multiple parameters of the mixed signal device and scanning the mixed signal device with an optical source. The method also includes forming multiple windows, where each window is assigned to a respective parameter. The method further includes comparing an image from a respective image to a reference image to determine an existence of an anomaly.
摘要翻译：实施例一般涉及测试混合信号装置的方法。该方法包括监视混合信号装置的多个参数并用光源扫描混合信号装置。该方法还包括形成多个窗口，其中每个窗口被分配给相应的参数。该方法还包括将来自相应图像的图像与参考图像进行比较以确定异常的存在。

7. 发明申请

US20090112239A1 Sticky dilatation balloon and methods of using 审中-公开
标题翻译：粘性膨胀气球及使用方法
公开(公告)号：US20090112239A1
公开(公告)日：2009-04-30
申请号：US12262409
申请日：2008-10-31
申请人： John Thao To
发明人： John Thao To
IPC分类号： A61B17/221 , A61B17/22
CPC分类号： A61M25/104 , A61B17/22032 , A61B2017/00858 , A61B2017/00951 , A61B2017/00982 , A61B2017/22034 , A61B2017/22061 , A61B2017/22079 , A61M25/1027 , A61M2025/1081 , A61M2025/1086 , A61M2025/1088 , A61M2025/109
摘要： The present invention involves an expandable element with an outer sticky surface. The expandable element may be in the form of a balloon with deflated and inflated configurations. The expandable element serves to both dilate a lumen in a blood vessel thereby opening it and to exert force upon the sticky surface in order to press it into apposition against a vessel wall. The outer sticky surface may be provided directly upon the expandable element or on a separate outer sheath that conforms to and follows the contours of the expandable element. The sticky surface may take the form of a biochemical composition and/or a mechanically abrasive structure such as microhooks, hairs, mesh netting, etc. Optionally, additional expandable elements may be provided proximal and distal to the main element to occlude blood flow on either side of a lesion in order to better trap emboli for collection.
摘要翻译：本发明涉及具有外部粘性表面的可膨胀元件。可膨胀元件可以是具有放气和膨胀构型的气囊的形式。可膨胀元件用于扩张血管中的内腔，从而将其打开并施加在粘性表面上的力，以将其按压到血管壁上。外部粘性表面可以直接设置在可膨胀元件上或者在与可膨胀元件的轮廓相符并且跟随可扩张元件的轮廓的分开的外护套上。粘性表面可以采取生物化学组合物和/或机械研磨结构（例如微钩，毛发，网状网等）的形式。任选地，可以在主要元件的近端和远端设置附加的可扩张元件，以阻塞侧面的病变为了更好地收集栓塞栓塞。

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