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1. 发明申请

US20120059038A1 POLYKETIDE COMPOUND 审中-公开
标题翻译：聚合物化合物
公开(公告)号：US20120059038A1
公开(公告)日：2012-03-08
申请号：US13320347
申请日：2010-05-13
申请人： Keisuke Ohsumi , Teruhisa Masaki
发明人： Keisuke Ohsumi , Teruhisa Masaki
IPC分类号： A61K31/4433 , A61P31/10 , C12P17/16 , A61P33/02 , C07D405/04 , C12N1/14
CPC分类号： C07D405/04 , C12P17/16 , C12R1/645
摘要： [Problem]Provided is a compound which is useful as an agent for treating trichophytosis, protozoan infection and/or Pneumocystis pneumonia.[Means for Solution]Capnodiaceae strain No. 339855 was collected and a polyketide compound was isolated from the cultural solution thereof It was confirmed that the polyketide compound or a salt thereof has a potent anti-Trichophyton activity and is useful as a pharmaceutical, particularly as an agent for treating trichophytosis, thereby completing the present invention. A cyclic compound of the present invention or a salt thereof may be used as agent for preventing or treating trichophytosis, protozoan infection and/or Pneumocystis pneumonia (formerly: carinii pneumonia).
摘要翻译： [问题]提供可用作治疗头孢菌素，原生动物感染和/或肺孢子虫肺炎的药剂的化合物。 [解决方案]收集Capnodiaceae菌株339855，从其文化溶液中分离聚酮化合物。证实聚酮化合物或其盐具有有效的抗癣菌活性，并且可用作药物，特别是作为用于治疗头孢菌素的药剂，从而完成本发明。本发明的环状化合物或其盐可用作预防或治疗毛发病，原生动物感染和/或肺孢子虫肺炎（以前称为：卡里尼肺炎）的药剂。

2. 发明申请

US20110020872A1 MICROORGANISM PRODUCING CYCLIC COMPOUND 有权
标题翻译：微生物生产周期化合物
公开(公告)号：US20110020872A1
公开(公告)日：2011-01-27
申请号：US12922675
申请日：2009-03-13
申请人： Ikuko Nakamura , Koji Yoshikawa , Teruhisa Masaki , Ryuichi Kanasaki , Neelam Shahab
发明人： Ikuko Nakamura , Koji Yoshikawa , Teruhisa Masaki , Ryuichi Kanasaki , Neelam Shahab
IPC分类号： C12P21/04 , C12N1/14
CPC分类号： C12R1/645 , C07K7/64 , C12N1/14 , C12P21/02
摘要： A microorganism which produces compounds useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, such as mycotic sinusitis, is provided. The present inventors have conducted intensive studies on naturally-occurring microorganisms as a research for antifungal compounds, and found a fungus Acremonium persicinum which produces cyclic compounds having a potent antifungal activity and useful as a medicament, particularly an antifungal agent, and the present invention was completed.
摘要翻译：提供了产生用作抗真菌剂的化合物的微生物，特别是用于深层真菌病的治疗剂如真菌性鼻窦炎。本发明人对天然存在的微生物进行了深入研究，作为抗真菌化合物的研究，发现了一种产生具有有效抗真菌活性的环状化合物的真菌（Acremonium persicinum），可用作药物，特别是抗真菌剂，本发明是完成

3. 发明授权

US08241872B2 Microorganism producing cyclic compound 有权
标题翻译：微生物生产环状化合物
公开(公告)号：US08241872B2
公开(公告)日：2012-08-14
申请号：US12922675
申请日：2009-03-13
申请人： Ikuko Nakamura , Koji Yoshikawa , Teruhisa Masaki , Ryuichi Kanasaki , Neelam Shahab
发明人： Ikuko Nakamura , Koji Yoshikawa , Teruhisa Masaki , Ryuichi Kanasaki , Neelam Shahab
IPC分类号： C12N1/14 , C12P21/04 , C12P1/02
CPC分类号： C12R1/645 , C07K7/64 , C12N1/14 , C12P21/02
摘要： A microorganism which produces compounds useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, such as mycotic sinusitis, is provided. The present inventors have conducted intensive studies on naturally-occurring microorganisms as a research for antifungal compounds, and found a fungus Acremonium persicinum which produces cyclic compounds having a potent antifungal activity and useful as a medicament, particularly an antifungal agent, and the present invention was completed.
摘要翻译：提供了产生用作抗真菌剂的化合物的微生物，特别是用于深层真菌病的治疗剂如真菌性鼻窦炎。本发明人对天然存在的微生物进行了深入研究，作为抗真菌化合物的研究，并发现了一种产生具有有效抗真菌活性的环状化合物的真菌（Acremonium persicinum），可用作药物，特别是抗真菌剂，本发明是完成

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