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1. 发明授权

US09429579B2 Blood analysis apparatus 有权
标题翻译：血液分析仪
公开(公告)号：US09429579B2
公开(公告)日：2016-08-30
申请号：US12311175
申请日：2007-09-20
申请人： Koji Sugiyama , Tatsuo Kamata , Takeshi Takagi
发明人： Koji Sugiyama , Tatsuo Kamata , Takeshi Takagi
IPC分类号： G01N33/00 , G01N35/00 , G01N33/66 , G01N33/72 , G01N35/02 , A61B5/145 , G01N30/88
CPC分类号： G01N33/66 , A61B5/14532 , G01N33/723 , G01N35/026 , G01N2030/8822 , G01N2800/042
摘要： The present invention relates to a blood analysis apparatus X for measuring concentrations of glucose and glycohemoglobin in blood. The blood analysis apparatus X is configured to perform the concentration measurement of the glucose and the glycohemoglobin by one sampling of blood 13. The blood analysis apparatus X is preferably configured to simultaneously carry out sample preparations for concentration measurement of the glucose and the glycohemoglobin by one sample preparation. The blood analysis apparatus X may be configured to perform dilution of a blood sample for measuring the glycohemoglobin and dilution of a blood sample for measuring the glucose using the same diluent.
摘要翻译：血液分析装置技术领域本发明涉及用于测定血液中葡萄糖和糖血红蛋白浓度的血液分析装置X. 血液分析装置X构成为通过血液13的一次取样来进行葡萄糖和糖血红蛋白的浓度测定。血液分析装置X优选同时进行葡萄糖和糖血红蛋白的浓度测定用样品制剂1 样品制备。血液分析装置X可以被配置为执行用于测量糖血红蛋白的血液样品的稀释和用于使用相同的稀释剂测量葡萄糖的血液样品的稀释。

2. 发明申请

US20080014610A1 Container for Nucleic Acid Extraction, Method of Cleaning Solid Matrix and Relevant Cleaning Mechanism, and Method of Purifying Nucleic Acid 审中-公开
标题翻译：用于核酸提取的容器，固体基质的清洗方法和相关的清洁机理以及纯化核酸的方法
公开(公告)号：US20080014610A1
公开(公告)日：2008-01-17
申请号：US11597970
申请日：2005-06-01
申请人： Tatsuo Kamata , Shinichi Ohta , Kouji Egawa
发明人： Tatsuo Kamata , Shinichi Ohta , Kouji Egawa
IPC分类号： C12N15/09 , C12M1/00 , G01N1/34 , C12M1/34
CPC分类号： B01L3/5085 , B01L3/502 , B01L2200/0631 , B01L2300/0609 , G01N1/34 , G01N1/405
摘要： The present invention relates to a nucleic acid extraction container (2) which includes a nucleic acid extraction element (20) for extracting a target nucleic acid from a sample and supporting the extracted nucleic acid, and a container main body formed as a separate member from the nucleic acid extraction element and having a having a housing vessel (27) for storing the nucleic acid extraction element (20). The nucleic acid extraction element (20) includes, for example, a solid matrix (23) for supporting the target nucleic acid, and a holding member (20) for holding the solid matrix (23). Preferably, the solid matrix (23) is held as tilted with respect to a vertical axis of the holding member (20).
摘要翻译：本发明涉及一种核酸提取容器（2），其包括用于从样品中提取目标核酸并支持所提取的核酸的核酸提取元件（20），以及形成为独立构件的容器主体所述核酸提取元件具有用于储存所述核酸提取元件（20）的容纳容器（27）。核酸提取元件（20）包括例如用于支撑靶核酸的固体基质（23）和用于保持固体基质（23）的保持构件（20）。优选地，固体基质（23）相对于保持构件（20）的垂直轴线保持倾斜。

3. 发明授权

US07935483B2 Method of effecting lysis of acid-fast bacteria and method of performing gene amplification or detection therewith 有权
标题翻译：实施耐酸细菌裂解的方法及其进行基因扩增或检测的方法
公开(公告)号：US07935483B2
公开(公告)日：2011-05-03
申请号：US11656575
申请日：2007-01-23
申请人： Tatsuo Kamata , Yuji Izumizawa
发明人： Tatsuo Kamata , Yuji Izumizawa
IPC分类号： C12Q1/68
CPC分类号： C12N15/1003 , C12Q1/6806
摘要： A method of effecting lysis of acid-fast bacteria, comprising heating acid-fast bacteria in a liquid containing a non-ionic surfactant at a temperature of below the boiling point of the liquid. This method enables accomplishing secure lysis of acid-fast bacteria in a simple manner within a short period of time without the use of special apparatus and agent and enables extracting genes. The heating is preferably conducted at 96° C. for 10 min. As the nonionic surfactant, use can be made of a d-sorbitol fatty acid ester, a polyoxyethylene glycol sorbitan alkyl ester, a polyoxyethylene glycol p-t-octylphenyl ether or the like. The pH value of the liquid is preferably 8, and the liquid preferably contains EDTA. It is also preferred that before the heating, the acid-fast bacteria be treated with lipase.
摘要翻译：一种实现耐酸菌细菌裂解的方法，包括在低于液体沸点的温度下，将含有非离子表面活性剂的液体中的耐酸细菌加热。该方法能够在短时间内以简单的方式实现耐酸菌的安全裂解，而无需使用专门的装置和试剂，能够提取基因。加热优选在96℃进行10分钟。作为非离子表面活性剂，可以使用d-山梨糖醇脂肪酸酯，聚氧乙烯二醇脱水山梨醇烷基酯，聚氧乙烯二醇对叔辛基苯基醚等。液体的pH值优选为8，液体优选含有EDTA。还优选在加热之前，用脂肪酶处理耐酸细菌。

4. 发明申请

US20070178508A1 Method of effecting lysis of acid-fast bacteria and method of performing gene amplification or detection therewith 有权
标题翻译：实施耐酸细菌裂解的方法及其进行基因扩增或检测的方法
公开(公告)号：US20070178508A1
公开(公告)日：2007-08-02
申请号：US11656575
申请日：2007-01-23
申请人： Tatsuo Kamata , Yuji Izumizawa
发明人： Tatsuo Kamata , Yuji Izumizawa
IPC分类号： C12Q1/68 , C12N1/08 , C12P19/34
CPC分类号： C12N15/1003 , C12Q1/6806
摘要： A method of effecting lysis of acid-fast bacteria, comprising heating acid-fast bacteria in a liquid containing a non-ionic surfactant at a temperature of below the boiling point of the liquid. This method enables accomplishing secure lysis of acid-fast bacteria in a simple manner within a short period of time without the use of special apparatus and agent and enables extracting genes. The heating is preferably conducted at 96° C. for 10 min. As the nonionic surfactant, use can be made of a d-sorbitol fatty acid ester, a polyoxyethylene glycol sorbitan alkyl ester, a polyoxyethylene glycol p-t-octylphenyl ether or the like. The pH value of the liquid is preferably 8, and the liquid preferably contains EDTA. It is also preferred that before the heating, the acid-fast bacteria be treated with lipase.
摘要翻译：一种实现耐酸菌细菌裂解的方法，包括在低于液体沸点的温度下，将含有非离子表面活性剂的液体中的耐酸细菌加热。该方法能够在短时间内以简单的方式实现耐酸菌的安全裂解，而无需使用专门的装置和试剂，能够提取基因。加热优选在96℃进行10分钟。作为非离子表面活性剂，可以使用d-山梨糖醇脂肪酸酯，聚氧乙烯二醇脱水山梨醇烷基酯，聚氧乙烯二醇对叔辛基苯基醚等。液体的pH值优选为8，液体优选含有EDTA。还优选在加热之前，用脂肪酶处理耐酸细菌。

5. 发明授权

US08712702B2 Measuring apparatus for measuring a physical property of a sample 有权
标题翻译：用于测量样品的物理性质的测量装置
公开(公告)号：US08712702B2
公开(公告)日：2014-04-29
申请号：US13167585
申请日：2011-06-23
申请人： Takeshi Takagi , Koji Okumura , Tatsuo Kamata
发明人： Takeshi Takagi , Koji Okumura , Tatsuo Kamata
IPC分类号： G06F19/00 , G01N1/10
CPC分类号： G01N1/38 , B01L3/502715 , B01L2200/10 , B01L2300/0654 , B01L2300/0816 , B01L2300/087 , B01L2300/0877 , B01L2300/0883 , B01L2300/0887 , B01L2400/0406 , G01N27/3271 , G01N2021/054 , G01N2035/1018
摘要： A measuring apparatus for measuring a predetermined physical property of a liquid measuring sample comprises a preparing unit in which a plurality of materials including at least a liquid material are mixed; a supply route which supplies the liquid material to the preparing unit; a withdrawing unit which withdraws the measuring sample from the preparing unit into the supply route, the measuring sample being prepared to contain the liquid material supplied to the preparing unit via the supply route; and a measuring unit which measures the predetermined physical property of the measuring sample withdrawn into the supply route by the withdrawing unit.
摘要翻译：用于测量液体测量样品的预定物理性能的测量装置包括其中混合至少包含液体材料的多种材料的制备单元; 将液体材料供给到制备单元的供给路径; 所述取出单元将所述测量样品从所述准备单元抽出到所述供给路径中，所述测量样品准备容纳经由所述供给路径供给到所述准备单元的液体材料; 以及测量单元，其测量由所述抽出单元抽出到所述供给路径中的所述测量样本的预定物理属性。

6. 发明申请

US20100200432A1 METHOD AND APPARATUS FOR DETERMINING SUBSTRATE CONCENTRATION AND REAGENT FOR DETERMINING SUBSTRATE CONCENTRATION 审中-公开
标题翻译：用于确定底物浓度和测定底物浓度的试剂的方法和装置
公开(公告)号：US20100200432A1
公开(公告)日：2010-08-12
申请号：US12449732
申请日：2008-02-24
申请人： Tatsuo Kamata , Takeshi Takagi
发明人： Tatsuo Kamata , Takeshi Takagi
IPC分类号： G01N27/26 , C01B21/08
CPC分类号： C12Q1/006 , C12Q1/28
摘要： The present invention relates to a method, a reagent and an apparatus for determining a substrate concentration based on an amount of hydrogen peroxide generated from a substrate. In the present invention, a suppressing agent for suppressing a reaction between the hydrogen peroxide and an inhibitor is added. As the suppressing agent, an azide compound such as sodium azide or a nitrite compound such as sodium nitrite is used. In the invention, a supporting electrolyte, such as sodium chloride or potassium chloride may be further added.
摘要翻译：本发明涉及一种基于从基底产生的过氧化氢量来确定底物浓度的方法，试剂和装置。在本发明中，添加抑制过氧化氢与抑制剂的反应的抑制剂。作为抑制剂，可以使用叠氮化钠等叠氮化合物，亚硝酸钠等亚硝酸酯化合物。在本发明中，可以进一步添加氯化钠或氯化钾等担载电解质。

7. 发明授权

US08535510B2 Method for measuring substrate concentration and apparatus for measuring substrate concentration 有权
标题翻译：测量底物浓度的方法和测量底物浓度的装置
公开(公告)号：US08535510B2
公开(公告)日：2013-09-17
申请号：US12450775
申请日：2008-04-15
申请人： Tatsuo Kamata , Takeshi Takagi , Yuki Ito
发明人： Tatsuo Kamata , Takeshi Takagi , Yuki Ito
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61B2560/0223
摘要： This invention provides a substrate concentration measuring method for measuring a concentration of a substrate included in a specimen based on an output for measurement from an enzyme electrode when the enzyme electrode and the substrate are reacted with each other, the substrate concentration is calculated using an output for correction from the enzyme electrode obtained when a reference solution whose substrate concentration is known and the enzyme electrode are reacted with each other before or after the enzyme electrode and the substrate are reacted with each other. For example, the output for correction is measured by each specimen. In this method, the substrate concentration may be calculated using the output for correction for the specimen to be measured and an output for correction corresponding to the at least one other specimen and measured prior to the output for correction.
摘要翻译：本发明提供一种基板浓度测量方法，用于当酶电极和基板彼此反应时，基于酶电极的测量输出测量样品中包含的基板的浓度，基板浓度使用输出用于当酶底物浓度已知的参比溶液和酶电极在酶电极和底物之间彼此反应之前彼此反应的酶电极获得的酶电极校正。例如，用于校正的输出由每个样本测量。在该方法中，可以使用待测试样本的校正输出和与至少一个其他样本相对应的校正输出并在校正输出之前测量来计算衬底浓度。

8. 发明申请

US20120158314A1 MEASURING APPARATUS FOR MEASURING A PHYSICAL PROPERTY OF A SAMPLE 有权
标题翻译：测量样品物理性能的测量装置
公开(公告)号：US20120158314A1
公开(公告)日：2012-06-21
申请号：US13167585
申请日：2011-06-23
申请人： Takeshi TAKAGI , Koji OKUMURA , Tatsuo KAMATA
发明人： Takeshi TAKAGI , Koji OKUMURA , Tatsuo KAMATA
IPC分类号： G06F19/00 , G01N1/10
CPC分类号： G01N1/38 , B01L3/502715 , B01L2200/10 , B01L2300/0654 , B01L2300/0816 , B01L2300/087 , B01L2300/0877 , B01L2300/0883 , B01L2300/0887 , B01L2400/0406 , G01N27/3271 , G01N2021/054 , G01N2035/1018
摘要： A measuring apparatus for measuring a predetermined physical property of a liquid measuring sample comprises a preparing unit in which a plurality of materials including at least a liquid material are mixed; a supply route which supplies the liquid material to the preparing unit; a withdrawing unit which withdraws the measuring sample from the preparing unit into the supply route, the measuring sample being prepared to contain the liquid material supplied to the preparing unit via the supply route; and a measuring unit which measures the predetermined physical property of the measuring sample withdrawn into the supply route by the withdrawing unit.
摘要翻译：用于测量液体测量样品的预定物理性能的测量装置包括其中混合至少包含液体材料的多种材料的制备单元; 将液体材料供给到制备单元的供给路径; 所述取出单元将所述测量样品从所述准备单元抽出到所述供给路径中，所述测量样品准备容纳经由所述供给路径供给到所述准备单元的液体材料; 以及测量单元，其测量由所述抽出单元抽出到所述供给路径中的所述测量样本的预定物理属性。

9. 发明申请

US20100299072A1 SUBSTRATE CONCENTRATION MEASUREMENT METHOD AND SUBSTRATE CONCENTRATION MEASUREMENT APPARATUS 审中-公开
标题翻译：基板浓度测量方法和基板浓度测量装置
公开(公告)号：US20100299072A1
公开(公告)日：2010-11-25
申请号：US12451085
申请日：2008-04-25
申请人： Tatsuo Kamata , Takeshi Takagi , Yuki Ito
发明人： Tatsuo Kamata , Takeshi Takagi , Yuki Ito
IPC分类号： G06F19/00 , G01N33/50
CPC分类号： G01N27/3274 , G01N30/8606 , G01N33/5438 , G01N33/721 , G01N33/96 , G01N2030/146 , G01N2030/8411 , G01N2030/8822
摘要： This invention is a method for a substrate concentration measurement method including measuring a concentration of a substrate in a blood specimen containing hemoglobin. In the method, the substrate concentration is calculated by using a measurement value correlating with a substrate concentration influenced by hemoglobin, and a hemoglobin concentration or a value correlating with the hemoglobin concentration. A substrate concentration is calculated by correcting the measurement value Re correlating with the substrate concentration based on the following Formulae 1 and 2: [Formula 1] Corrected value=100×Re/V (%), wherein V (%) represents a value with respect to plasma (a ratio of a measurement value influenced by hemoglobin with respect to a measurement value obtained by measuring plasma), and Re represents the measurement value correlating with the substrate concentration influenced by hemoglobin; [Formula 2] Value with respect to plasma V (%)=(Vmax×Re)/(Km+Re)+B, wherein Vmax represents a value obtained by subtracting an intercept (B) from the value (V) with respect to plasma which is maintained constant even when the measurement value influenced by hemoglobin increases, Km represents a value of Re at which the value V (%) with respect to plasma becomes Vmax/2, and B represents a value (constant) of V (%) with respect to plasma when Re is 0.
摘要翻译：本发明是一种测定含有血红蛋白的血液标本中的基质浓度的基板浓度测定方法。在该方法中，通过使用与受血红蛋白影响的底物浓度相关的测定值和血红蛋白浓度或与血红蛋白浓度相关的值来计算底物浓度。通过基于以下公式1和2校正与底物浓度相关的测量值Re来计算底物浓度：[式1]校正值= 100×Re / V（％），其中V（％）表示与对血浆的影响（由血红蛋白影响的测定值相对于通过测定血浆得到的测定值的比例），Re表示与由血红蛋白影响的底物浓度相关的测定值; [式2]相对于等离子体V（％）=（Vmax×Re）/（Km + Re）+ B的值，其中Vmax表示通过从相对于（V）的值（V）减去截距（B）即使当受血红蛋白影响的测量值增加时，也保持恒定的等离子体，Km表示相对于等离子体的值V（％）为Vmax / 2的Re值，B表示V（％）的值（常数））相对于等离子体。

10. 发明申请

US20120094367A1 Blood analysis apparatus 有权
标题翻译：血液分析仪
公开(公告)号：US20120094367A1
公开(公告)日：2012-04-19
申请号：US12311175
申请日：2007-09-20
申请人： Koji Sugiyama , Tatsuo Kamata , Takeshi Takagi
发明人： Koji Sugiyama , Tatsuo Kamata , Takeshi Takagi
IPC分类号： C12M1/40
CPC分类号： G01N33/66 , A61B5/14532 , G01N33/723 , G01N35/026 , G01N2030/8822 , G01N2800/042
摘要： The present invention relates to a blood analysis apparatus X for measuring concentrations of glucose and glycohemoglobin in blood. The blood analysis apparatus X is configured to perform the concentration measurement of the glucose and the glycohemoglobin by one sampling of blood 13. The blood analysis apparatus X is preferably configured to simultaneously carry out sample preparations for concentration measurement of the glucose and the glycohemoglobin by one sample preparation. The blood analysis apparatus X may be configured to perform dilution of a blood sample for measuring the glycohemoglobin and dilution of a blood sample for measuring the glucose using the same diluent.
摘要翻译：血液分析装置技术领域本发明涉及用于测定血液中葡萄糖和糖血红蛋白浓度的血液分析装置X. 血液分析装置X构成为通过血液13的一次取样来进行葡萄糖和糖血红蛋白的浓度测定。血液分析装置X优选同时进行葡萄糖和糖血红蛋白的浓度测定用样品制剂1 样品制备。血液分析装置X可以被配置为执行用于测量糖血红蛋白的血液样品的稀释和用于使用相同的稀释剂测量葡萄糖的血液样品的稀释。

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