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1. 发明授权

US09008765B2 System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings 有权
标题翻译：用于控制上瘾欲望的治疗剂的双相透皮离子电渗递送系统和方法
公开(公告)号：US09008765B2
公开(公告)日：2015-04-14
申请号：US13466116
申请日：2012-05-07
申请人： Mir Imran , Talat Imran , Mir Hashim
发明人： Mir Imran , Talat Imran , Mir Hashim
IPC分类号： A61N1/30 , A61K9/00 , A61N1/04 , A61N1/32 , A61K31/465
CPC分类号： A61N1/30 , A61K9/0009 , A61K9/0014 , A61K31/465 , A61N1/0432 , A61N1/0448 , A61N1/303 , A61N1/325
摘要： Embodiments of the invention provide methods for the transdermal delivery of therapeutic agents for the treatment of addictive cravings e.g., nicotine compounds for the treatment of nicotine cravings from tobacco use. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient.
摘要翻译：本发明的实施方案提供了用于治疗成瘾性渴望的治疗剂的透皮递送方法，例如用于治疗来自烟草使用的尼古丁渴望的尼古丁化合物。用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。组合件包括包含被动地扩散入皮肤的治疗剂的溶液。使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物输送到皮肤中，以将药剂排斥出组合体。在第二时段期间，使用具有吸引剂的特性的第二电流来将药剂保持在组合中，使得药剂递送到皮肤中最小化。可以根据患者的输入要求递送剂量。

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