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1. 发明申请

US20130078234A1 ANTI B7-H3 ANTIBODY 有权
标题翻译：抗B7-H3抗体
公开(公告)号：US20130078234A1
公开(公告)日：2013-03-28
申请号：US13455021
申请日：2012-04-24
申请人： Shu Takahashi , Tatsuji Matsuoka , Kenji Murakami , Takeshi Takizawa , Kenji Hirotani , Atsushi Urano , Keisuke Fukuchi , Mitsuhiro Yazawa
发明人： Shu Takahashi , Tatsuji Matsuoka , Kenji Murakami , Takeshi Takizawa , Kenji Hirotani , Atsushi Urano , Keisuke Fukuchi , Mitsuhiro Yazawa
IPC分类号： C07K16/42
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K16/42 , C07K2317/24 , C07K2317/40 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody exhibiting antitumor activity that binds to B7-H3, a functional fragment of the antibody, a pharmaceutical composition that includes the antibody or the functional fragment, methods for making the antibody or the functional fragment, methods for treating a tumor using the antibody or the functional fragment, and polynucleotides encoding the antibody or the functional fragment.
摘要翻译：显示与B7-H3（抗体的功能片段）结合的抗肿瘤活性的抗体，包含抗体或功能片段的药物组合物，制备抗体或功能片段的方法，使用抗体治疗肿瘤的方法或功能片段和编码抗体或功能片段的多核苷酸。

2. 发明申请

US20100183618A1 ANTI-EPHA2 ANTIBODY 有权
标题翻译：抗EPHA2抗体
公开(公告)号：US20100183618A1
公开(公告)日：2010-07-22
申请号：US12713041
申请日：2010-02-25
申请人： Jun Hasegawa , Toshiaki Ohtsuka , Atsushi Urano , Junko Yamaguchi , Toshinori Agatsuma , Kaori Nakahara , Takeshi Takizawa
发明人： Jun Hasegawa , Toshiaki Ohtsuka , Atsushi Urano , Junko Yamaguchi , Toshinori Agatsuma , Kaori Nakahara , Takeshi Takizawa
IPC分类号： A61K39/395 , C12P21/02 , C12N5/18 , C12N5/10 , C12N1/21 , C12N1/19 , C07K16/00 , C07H21/04
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： Problem to Be SolvedIt is intended to provide an antibody having an inhibitory activity against cell malignant transformation and/or tumor cell growth, etc.SolutionThe present invention provides an antibody which recognizes an epitope recognized by an antibody produced by a hybridoma SH348-1 (FERM BP-10836) or a hybridoma SH357-1 (FERM BP-10837), an antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, an antibody obtained by humanizing the antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, a pharmaceutical agent comprising the antibody as an active ingredient, etc.
摘要翻译：要解决的问题旨在提供具有抑制细胞恶性转化和/或肿瘤细胞生长等的活性的抗体。溶液本发明提供一种抗体，其识别由杂交瘤SH348-1产生的抗体识别的表位（FERM BP-10836）或杂交瘤SH357-1（FERM BP-10837），由杂交瘤SH348-1或杂交瘤SH357-1产生的抗体，通过将由杂交瘤SH348-1产生的抗体人源化而获得的抗体或杂交瘤SH357-1是包含抗体作为活性成分的药剂等

3. 发明授权

US07320257B2 Load measuring device for rolling bearing unit and load measuring rolling bearing unit 有权
标题翻译：滚动轴承单元负载测量装置和负载测量滚动轴承单元
公开(公告)号：US07320257B2
公开(公告)日：2008-01-22
申请号：US10535936
申请日：2004-05-06
申请人： Takeshi Takizawa , Tomoyuki Yanagisawa , Koichiro Ono , Ikunori Sakatani
发明人： Takeshi Takizawa , Tomoyuki Yanagisawa , Koichiro Ono , Ikunori Sakatani
IPC分类号： G01L1/00
CPC分类号： G01M13/045 , B60B27/00 , F16C19/186 , F16C19/522 , F16C33/416 , F16C41/007 , F16C2326/02 , G01P3/443
摘要： Revolution speeds nca, nib of rolling elements 9a, 9b are sensed by a pair of revolution speed sensors 21a, 21b. Also, a rotational speed ni of a hub 2 is sensed by a rotational speed sensor 15b. A sum “nca+ncb” or a difference “nca−nib” the revolution speeds of rolling elements 9a, 9b in double rows is calculated based on sensed signals of the revolution speed sensors 21a, 21b, and then a ratio “nca+nib/ni” or “nca−ncb/ni” of this sum or difference to the rotational speed ni is calculated. Then, the radial load or the an axial load is calculated based on the ratio “nca+ncb/ni” or “ca−nib/ni”.
摘要翻译：一对转速传感器21a，21b检测出滚动元件9a，9b的转速，转速，nb，此外，轮毂2的旋转速度n 1 i由转速传感器15b感测。总和“n + n”cb“或差异”n 基于转速传感器21a，21b的感测信号来计算双列中的滚动元件9a，9b的速度，然后比较“n / SUB“b / ni”或“n”或“n”或“n”之间的差值与转速n < SUB> i 。然后，径向载荷或轴向载荷基于“n”/“n”或“ -n＆lt; ib＆gt; / ni“。

4. 发明申请

US20060259225A1 Stability control apparatus and load measuring instrument for wheel supporting rolling bearing unit 有权
标题翻译：车轮支承滚动轴承单元的稳定性控制装置和载荷测量仪
公开(公告)号：US20060259225A1
公开(公告)日：2006-11-16
申请号：US10570263
申请日：2004-09-03
申请人： Koichiro Ono , Takeshi Takizawa , Tomoyuki Yanagisawa
发明人： Koichiro Ono , Takeshi Takizawa , Tomoyuki Yanagisawa
IPC分类号： G06F19/00
CPC分类号： B60G17/0195 , B60G17/016 , B60G17/019 , B60G2204/115 , B60G2206/50 , B60G2400/0523 , B60G2400/208 , B60G2400/64 , B60G2400/822 , B60K28/16 , B60T8/1755 , B60T8/241 , B60T8/246 , B60T2230/02 , B60T2240/06 , B60T2260/06 , B60W40/064 , B60W40/068 , F16C19/186 , F16C19/522 , F16C41/007 , F16C2326/02 , F16C2326/05 , G01P3/446
摘要： A stability control apparatus, includes: a grip detector that changes an output based on a grip force applied in a direction hindering a slippage of a wheel, acting on a contact face between the wheel supported by a wheel supporting rolling bearing unit and the road surface, the wheel supporting rolling bearing unit for supporting freely rotatably the wheel to a vehicle body; and a controller that performs a control for keeping a running stability of the vehicle in response to an input of a detection signal of the grip detector.
摘要翻译：一种稳定性控制装置，其特征在于，包括：抓地力检测器，其基于在阻碍车轮滑动的方向上施加的夹持力而改变输出，作用在由车轮支承滚动轴承单元支撑的车轮与路面之间的接触面所述车轮支承滚动轴承单元用于将所述车轮自由旋转地支撑在车体上; 以及控制器，其执行用于响应于所述握持检测器的检测信号的输入来保持所述车辆的行驶稳定性的控制。

5. 发明申请

US20060110086A1 Sensor and rollling bearing apparatus with sensor 审中-公开
标题翻译：带传感器的传感器和滚动轴承装置
公开(公告)号：US20060110086A1
公开(公告)日：2006-05-25
申请号：US11330148
申请日：2006-01-12
申请人： Kouichi Morita , Hiromasa Fukuyama , Ikunori Sakatani , Takeshi Takizawa , Shigeru Endo , Toshio Takahashi
发明人： Kouichi Morita , Hiromasa Fukuyama , Ikunori Sakatani , Takeshi Takizawa , Shigeru Endo , Toshio Takahashi
IPC分类号： F16C41/04
CPC分类号： G01P3/487 , B61F15/20 , F16C19/386 , F16C19/52 , F16C19/525 , F16C33/723 , F16C35/063 , F16C41/007 , F16C2326/10 , G01M13/045 , G01P1/026 , G01P3/443
摘要： A rolling bearing apparatus with sensor includes a sensor unit retaining a plurality of types of sensors for detecting the status of a rolling bearing, in a single holder. The plurality of types of sensors are at least two types of sensors of a rotation speed sensor, a temperature sensor, and an acceleration sensor.
摘要翻译：具有传感器的滚动轴承装置包括在单个保持器中保持用于检测滚动轴承的状态的多种类型的传感器的传感器单元。多种类型的传感器是转速传感器，温度传感器和加速度传感器的至少两种传感器。

6. 发明申请

US20060070462A1 Load measuring device for rolling bearing unit and load measuring rolling bearing unit 有权
标题翻译：滚动轴承单元负载测量装置和负载测量滚动轴承单元
公开(公告)号：US20060070462A1
公开(公告)日：2006-04-06
申请号：US10535936
申请日：2004-05-06
申请人： Takeshi Takizawa , Tomoyuki Yanagisawa , Koichiro Ono , Ikunori Sakatani
发明人： Takeshi Takizawa , Tomoyuki Yanagisawa , Koichiro Ono , Ikunori Sakatani
IPC分类号： G01L1/00
CPC分类号： G01M13/045 , B60B27/00 , F16C19/186 , F16C19/522 , F16C33/416 , F16C41/007 , F16C2326/02 , G01P3/443
摘要： Revolution speeds nca, nib of rolling elements 9a, 9b are sensed by a pair of revolution speed sensors 21a, 21b. Also, a rotational speed ni of a hub 2 is sensed by a rotational speed sensor 15b. A sum “nca+ncb” or a difference “nca−nib” the revolution speeds of rolling elements 9a, 9b in double rows is calculated based on sensed signals of the revolution speed sensors 21a, 21b, and then a ratio “nca+nib/ni” or “nca−ncb/ni” of this sum or difference to the rotational speed ni is calculated. Then, the radial load or the an axial load is calculated based on the ratio “nca+ncb/ni” or “ca−nib/ni”.
摘要翻译：一对转速传感器21a，21b检测出滚动元件9a，9b的转速，转速，nb，此外，轮毂2的旋转速度n 1 i由转速传感器15b感测。总和“n + n”cb“或差异”n 基于转速传感器21a，21b的感测信号来计算双列中的滚动元件9a，9b的速度，然后比较“n / SUB“b / ni”或“n”或“n”或“n”之间的差值与转速n < SUB> i 。然后，径向载荷或轴向载荷基于“n”/“n”或“ -n＆lt; ib＆gt; / ni“。

7. 发明申请

US20050259903A1 Rolling bearing device and ring with sensor for the rolling bearing device 审中-公开
公开(公告)号：US20050259903A1
公开(公告)日：2005-11-24
申请号：US11192096
申请日：2005-07-29
申请人： Takeshi Takizawa , Shigeru Endo , Kouichi Morita , Yoshio Shoda , Hiromasa Fukuyama , Toshio Takahashi
发明人： Takeshi Takizawa , Shigeru Endo , Kouichi Morita , Yoshio Shoda , Hiromasa Fukuyama , Toshio Takahashi
IPC分类号： F16C19/52 , F16C33/58 , G01P3/44 , F16C41/04 , F16C32/00
CPC分类号： F16C41/004 , F16C19/06 , F16C19/525 , F16C19/527 , F16C33/586 , F16C41/007 , F16C41/008 , F16C43/04 , F16C2226/30 , F16C2300/02 , G01P3/443
摘要： A rolling bearing with sensor includes an inner ring, an outer ring, a plurality of rolling elements disposed between the inner and outer rings, and a sensor having a detecting part detecting a state of the rolling bearing and a circuit part connected to the detecting part. The detecting part and the circuit part are attached to the rolling bearing.

8. 发明申请

US20050140357A1 Wheel rotation detecting device 失效
标题翻译：车轮旋转检测装置
公开(公告)号：US20050140357A1
公开(公告)日：2005-06-30
申请号：US11059420
申请日：2005-02-17
申请人： Takeshi Takizawa , Shigeru Endo , Ikunori Sakatani , Tatsunobu Momono , Yasushi Mutoh
发明人： Takeshi Takizawa , Shigeru Endo , Ikunori Sakatani , Tatsunobu Momono , Yasushi Mutoh
IPC分类号： G01P3/488 , B60B35/18 , B60T8/171 , B60T8/32 , F16C19/18 , F16C19/52 , F16C41/00 , G01D21/02 , G01K1/14 , G01K13/08 , G01P3/44 , G01P3/48 , G01F15/06 , G01P3/54
CPC分类号： G01P3/446 , B60T8/171 , B60T8/329 , F16C19/186 , F16C19/525 , F16C19/527 , F16C41/007 , F16C2326/02 , G01D21/02 , G01M13/045
摘要： A sensor unit is supported on a stationary ring which does not rotate even when it is in use, and the rotation of the rotary ring can be detected by a rotation detecting sensor held within the sensor unit. Within the sensor unit, besides the rotation detecting sensor, there are disposed other sensors such as a temperature sensor and a vibration sensor, thereby being able to detect the rotation speed and the rotation number of the wheel supported on the rotary ring, and the other car driving conditions.
摘要翻译：传感器单元支撑在固定环上，即使在使用中也不会旋转，并且可以通过保持在传感器单元内的旋转检测传感器来检测旋转环的旋转。在传感器单元内，除了旋转检测传感器之外，还设置有诸如温度传感器和振动传感器的其它传感器，从而能够检测支撑在旋转环上的轮子的旋转速度和旋转数，而另一个汽车驾驶条件。

9. 发明授权

US06695483B2 Sensor and rolling bearing apparatus with sensor 有权
标题翻译：带传感器的传感器和滚动轴承装置
公开(公告)号：US06695483B2
公开(公告)日：2004-02-24
申请号：US09996593
申请日：2001-11-30
申请人： Ikunori Sakatani , Takeshi Takizawa , Shigeru Endo
发明人： Ikunori Sakatani , Takeshi Takizawa , Shigeru Endo
IPC分类号： F16C1900
CPC分类号： G01P3/487 , B61F15/20 , F16C19/386 , F16C19/52 , F16C19/525 , F16C33/723 , F16C35/063 , F16C41/007 , F16C2326/10 , G01M13/045 , G01P1/026 , G01P3/443
摘要： A rolling bearing apparatus with sensor includes a sensor unit retaining a plurality of types of sensors for detecting the status of a rolling bearing, in a single holder. The plurality of types of sensors are at least two types of sensors of a rotation speed sensor, a temperature sensor, and an acceleration sensor.
摘要翻译：具有传感器的滚动轴承装置包括在单个保持器中保持用于检测滚动轴承的状态的多种类型的传感器的传感器单元。多种类型的传感器是转速传感器，温度传感器和加速度传感器的至少两种传感器。

10. 发明授权

US06259179B1 Magnetic bearing system 失效
标题翻译：磁轴承系统
公开(公告)号：US06259179B1
公开(公告)日：2001-07-10
申请号：US09440115
申请日：1999-11-15
申请人： Hiromasa Fukuyama , Takeshi Takizawa
发明人： Hiromasa Fukuyama , Takeshi Takizawa
IPC分类号： H02K709
CPC分类号： F16C32/0451 , F16C32/0465 , F16C32/0489
摘要： A magnetic bearing system includes a rotor shaft 1, stationary electromagnetic pole, a radial displacement sensor 5 for detecting the position of the rotor shaft 1 with respect to the electromagnetic polarity, and a control circuit 220 which supplies a control current in accordance with an output from the radial displacement sensor 5. A permanent magnet 20 is disposed in the magnetic bearing so as to constitute a portion of a magnetic member 10 which forms a magnetic circuit between the rotor shaft 1 and the electromagnetic pole. The position where a balance exists between an attraction force developed in the permanent magnet 20 and static force, which acts on the rotor shaft 1 when no load is imposed on the rotor shaft 1, is set as a target position for the rotor shaft 1.
摘要翻译：磁轴承系统包括转子轴1，固定电磁极，用于检测转子轴1相对于电磁极性的位置的径向位移传感器5以及根据输出提供控制电流的控制电路220 永磁体20设置在磁性轴承中，以构成在转子轴1和电磁极之间形成磁路的磁性部件10的一部分。作为转子轴1的目标位置，在永磁体20中产生的吸引力与作用在转子轴1上的静力之间产生平衡的位置被设定为转子轴1的目标位置。

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