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1. 发明专利

IL234313A Nitrogen-containing aromatic heterocyclic compounds 未知
公开(公告)号：IL234313A
公开(公告)日：2017-03-30
申请号：IL23431314
申请日：2014-08-26
申请人： ASTELLAS PHARMA INC , KOTOBUKI PHARMACEUTICAL CO LTD , KAZUHIKO IIKUBO , HIROSHI TOMIYAMA , YOSHINORI IWAI , MINORU KAMEDA , IKUMI KURIWAKI , HIROYUKI HISAMICHI , YUICHIRO KAWAMOTO , HIROYUKI MORITOMO , TOMOYUKI SUZUKI , TAKASHI FUTAMI , ATSUSHI SUZUKI , KAZUHISA TSUNOYAMA , MAKOTO ASAUMI , ATSUSHI NODA , KAZUO TOKUZAKI , HARUKI OKADA , KOZO MIYASAKA
发明人： KAZUHIKO IIKUBO , HIROSHI TOMIYAMA , YOSHINORI IWAI , MINORU KAMEDA , IKUMI KURIWAKI , HIROYUKI HISAMICHI , YUICHIRO KAWAMOTO , HIROYUKI MORITOMO , TOMOYUKI SUZUKI , TAKASHI FUTAMI , ATSUSHI SUZUKI , KAZUHISA TSUNOYAMA , MAKOTO ASAUMI , ATSUSHI NODA , KAZUO TOKUZAKI , HARUKI OKADA , KOZO MIYASAKA
IPC分类号： A61K31/4545 , A61P35/00 , A61P43/00
摘要： Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.

2. 发明申请

US20130137111A1 DETECTION METHOD OF NOVEL RET FUSION 审中-公开
标题翻译：新型RET融合检测方法
公开(公告)号：US20130137111A1
公开(公告)日：2013-05-30
申请号：US13812356
申请日：2011-07-22
申请人： Nobuaki Shindo , Kouichi Nishimura , Yorikata Sano , Makoto Asaumi , Aya Yamanaka , Takashi Futami , Tatsuya Kawase
发明人： Nobuaki Shindo , Kouichi Nishimura , Yorikata Sano , Makoto Asaumi , Aya Yamanaka , Takashi Futami , Tatsuya Kawase
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2525/155 , C12Q2600/118 , G01N33/57484
摘要： It was found that a new fusion gene of a portion of the KIF5B gene and a portion of the RET gene, which is present in a portion of cancer patients, is a gene responsible for cancer. Based on this finding, detection methods of a polynucleotide as the gene and a polypeptide encoded by the polynucleotide were established. The detection methods involve detecting a fusion gene of a portion of the KIF5B gene and a portion of the RET gene, or a fusion protein encoded by such a fusion gene. The primer sets and the detection kits comprise sense primers designed from a portion encoding KIF5B and antisense primers designed from a portion encoding RET.
摘要翻译：发现KIF5B基因的一部分的新融合基因和存在于癌症患者的一部分中的RET基因的一部分是导致癌症的基因。基于该发现，建立了作为基因的多核苷酸的检测方法和由多核苷酸编码的多肽。检测方法包括检测KIF5B基因的一部分和RET基因的一部分的融合基因或由这种融合基因编码的融合蛋白。引物组和检测试剂盒包括从编码KIF5B的部分和从编码RET的部分设计的反义引物设计的有义引物。

3. 发明授权

US08256922B2 Lighting device 有权
标题翻译：照明设备
公开(公告)号：US08256922B2
公开(公告)日：2012-09-04
申请号：US12487627
申请日：2009-06-18
申请人： Takashi Futami
发明人： Takashi Futami
IPC分类号： F21V21/00
CPC分类号： F21V29/004 , F21S41/143 , F21S41/147 , F21S41/29 , F21S41/336 , F21S45/47 , F21S45/60 , F21V7/0008 , F21V7/0025 , F21V13/12 , F21V29/70 , F21V29/713 , F21V29/763 , F21V29/89 , F21V29/90 , F21Y2115/10
摘要： A lighting device with a stable high light intensity can effectively dissipate heat generated by an LED so that the light emission efficiency does not deteriorate while the inside temperature distribution can be maintained in an even state. The lighting device can also be configured to prevent snow from adhering onto an outer lens by allowing an outer surface temperature of the lighting device to rise during actuation of the device. The lighting device can also be configured to improve light utilization efficiency. The lighting device can include a semiconductor light emitting device as a light source and can include structure(s) that guides the emission light to a projection lens. The semiconductor light emitting device can be configured to emit light in a reverse or opposed direction with respect to an illumination direction for the lighting device. A projection lens can be disposed in front of the semiconductor light emitting device. An elliptic reflector can be configured to reflect light from the semiconductor light emitting device and to direct the light to the projection lens. A lens holder can be made of metal and the semiconductor light emitting device and the projection lens can be disposed on the lens holder.
摘要翻译：具有稳定的高光强度的照明装置可以有效地散发由LED产生的热量，使得在内部温度分布能够保持均匀的状态下，发光效率不劣化。照明装置还可以被配置为通过允许照明装置的外表面温度在装置致动期间升高来防止雪粘附到外部透镜上。照明装置还可以被配置为提高光利用效率。照明装置可以包括作为光源的半导体发光器件，并且可以包括将发射光引导到投影透镜的结构。半导体发光器件可以被配置为相对于照明器件的照明方向以相反或相反的方向发光。投影透镜可以设置在半导体发光器件的前面。椭圆反射器可以被配置为反射来自半导体发光器件的光并将光引导到投影透镜。透镜保持器可以由金属制成，并且半导体发光器件和投影透镜可以设置在透镜保持器上。

4. 发明申请

US20110122637A1 VEHICLE LIGHT 失效
标题翻译：车辆灯
公开(公告)号：US20110122637A1
公开(公告)日：2011-05-26
申请号：US12945830
申请日：2010-11-12
申请人： Takashi FUTAMI
发明人： Takashi FUTAMI
IPC分类号： F21S8/10
CPC分类号： F21S41/43 , F21S41/147 , F21S41/255 , F21S41/26 , F21S41/321 , F21S41/36 , F21S41/365 , F21S45/47 , F21W2102/00 , F21Y2115/10
摘要： A vehicle light can include an LED light source disposed such that the optical axis of the LED light source is directed downward, a first lens disposed forward of the LED light source, a second lens disposed below and forward of the first lens, and a first reflector extending from both sides of the LED light source to a position near the optical axis of the LED light source. The first reflector can be configured to reflect light beams from the LED light source toward the first lens so as to form a wide vertically converged and horizontally diffused light distribution pattern. The vehicle light can include a second reflector disposed at a position below and forward of the first reflector. The second reflector can be configured to reflect light beams from the LED light source toward the second lens so as to form a middle-area vertically converged and horizontally diffused light distribution pattern. The lens can be formed by a toroidal lens that is horizontally elongated and that is formed by horizontally extending an aspherical lens cross section having a focus near the LED light source in an arc shape, or by a cylindrical lens having a horizontal focus line. In particular, the lens can be formed by an upper-half lens portion of such a toroidal lens. The vehicle light can include a light shielding shutter having a first upper edge portion and a second upper edge portion lower than the first upper edge portion.
摘要翻译：车辆灯可以包括LED光源，其被设置为使得LED光源的光轴向下指向，设置在LED光源前方的第一透镜，设置在第一透镜的下方和前方的第二透镜，以及第一透镜反射器从LED光源的两侧延伸到靠近LED光源的光轴的位置。第一反射器可以被配置为将来自LED光源的光束朝向第一透镜反射，以形成宽的垂直会聚和水平扩散的光分布图案。车辆灯可以包括设置在第一反射器的下方和前方的位置处的第二反射器。第二反射器可以被配置为将来自LED光源的光束反射到第二透镜，以形成中间垂直会聚的水平扩散的光分布图案。透镜可以由水平伸长的环形透镜形成，并且通过水平延伸具有圆弧形状的LED光源附近的焦点的非球面透镜横截面或通过具有水平聚焦线的柱面透镜形成。特别地，透镜可以由这种环形透镜的上半透镜部分形成。车辆灯可以包括具有第一上边缘部分和比第一上边缘部分低的第二上边缘部分的遮光遮板。

5. 发明申请

US20090316423A1 LIGHTING DEVICE 有权
标题翻译：照明设备
公开(公告)号：US20090316423A1
公开(公告)日：2009-12-24
申请号：US12487627
申请日：2009-06-18
申请人： TAKASHI FUTAMI
发明人： TAKASHI FUTAMI
IPC分类号： F21V7/00 , F21V29/00
CPC分类号： F21V29/004 , F21S41/143 , F21S41/147 , F21S41/29 , F21S41/336 , F21S45/47 , F21S45/60 , F21V7/0008 , F21V7/0025 , F21V13/12 , F21V29/70 , F21V29/713 , F21V29/763 , F21V29/89 , F21V29/90 , F21Y2115/10
摘要： A lighting device with a stable high light intensity can effectively dissipate heat generated by an LED so that the light emission efficiency does not deteriorate while the inside temperature distribution can be maintained in an even state. The lighting device can also be configured to prevent snow from adhering onto an outer lens by allowing an outer surface temperature of the lighting device to rise during actuation of the device. The lighting device can also be configured to improve light utilization efficiency. The lighting device can include a semiconductor light emitting device as a light source and can include structure(s) that guides the emission light to a projection lens. The semiconductor light emitting device can be configured to emit light in a reverse or opposed direction with respect to an illumination direction for the lighting device. A projection lens can be disposed in front of the semiconductor light emitting device. An elliptic reflector can be configured to reflect light from the semiconductor light emitting device and to direct the light to the projection lens. A lens holder can be made of metal and the semiconductor light emitting device and the projection lens can be disposed on the lens holder.
摘要翻译：具有稳定的高光强度的照明装置可以有效地散发由LED产生的热量，使得在内部温度分布能够保持均匀的状态下，发光效率不劣化。照明装置还可以被配置为通过允许照明装置的外表面温度在装置的致动期间升高来防止雪粘附到外部透镜上。照明装置还可以被配置为提高光利用效率。照明装置可以包括作为光源的半导体发光器件，并且可以包括将发射光引导到投影透镜的结构。半导体发光器件可以被配置为相对于照明器件的照明方向以相反或相反的方向发光。投影透镜可以设置在半导体发光器件的前面。椭圆反射器可以被配置为反射来自半导体发光器件的光并将光引导到投影透镜。透镜保持器可以由金属制成，并且半导体发光器件和投影透镜可以设置在透镜保持器上。

6. 发明申请

US20090231875A1 VEHICLE LAMP 有权
标题翻译：车灯
公开(公告)号：US20090231875A1
公开(公告)日：2009-09-17
申请号：US12364513
申请日：2009-02-02
申请人： YASUSHI YATSUDA , Teruo Koike , Takuya Kushimoto , Takashi Futami , Ryotaro Owada
发明人： YASUSHI YATSUDA , Teruo Koike , Takuya Kushimoto , Takashi Futami , Ryotaro Owada
IPC分类号： B60Q1/04 , F21V15/01
CPC分类号： F21S41/43 , F21S41/143 , F21S41/147 , F21S41/155 , F21Y2115/10 , H01L33/483 , Y10S362/80
摘要： A vehicle lamp can include a plurality of light source modules each having an LED as a light source, and optical systems for distributing light from each of the light source modules frontward toward predetermined areas or predetermined patterns that are different from each other and which make up a light distribution pattern. Each of the optical systems can be optimized to emit light to a predetermined area, and each of the light source modules' LEDs can be optimally arranged for each of the corresponding optical systems.
摘要翻译：车灯可以包括多个光源模块，每个光源模块具有作为光源的LED，以及用于将来自每个光源模块的光向前分配给预定区域或彼此不同的预定图案的光学系统，配光模式。每个光学系统可以被优化以将光发射到预定区域，并且每个光源模块的LED可以针对每个对应的光学系统进行最佳布置。

7. 发明申请

US20080117646A1 LED LAMP FOR LIGHT SOURCE AND METHOD 有权
标题翻译： LED灯用于光源和方法
公开(公告)号：US20080117646A1
公开(公告)日：2008-05-22
申请号：US11964003
申请日：2007-12-24
申请人： YASUSHI YATSUDA , Takashi Ebisutani , Teruo Koike , Takuya Kushimoto , Ryotaro Owada , Masafumi Ohno , Takashi Futami
发明人： YASUSHI YATSUDA , Takashi Ebisutani , Teruo Koike , Takuya Kushimoto , Ryotaro Owada , Masafumi Ohno , Takashi Futami
IPC分类号： B60Q1/04
CPC分类号： H01L33/58 , F21K9/00 , F21S41/14 , F21S41/141 , F21S41/143 , F21S41/16 , F21S41/43 , F21Y2115/10 , H01L33/52 , H01L33/60 , H01L2224/45144 , H01L2224/48091 , H01L2224/48465 , H01L2924/181 , H01L2924/19107 , H01L2924/3025 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
摘要： Whereas incandescent light bulbs and other similar light sources known in the related art emit light in all directions, LED lamps can emit light in a single direction, and this is manifested in the problem of being unable to achieve light distribution characteristics satisfied by conventional headlamp designs. In accordance with an embodiment of the disclosed subject matter, an LED lamp for a light source of a headlamp can include an LED chip in the vicinity of the focus of a projection means and a shielding member covering a portion of the LED chip in a formation allowing a light distribution characteristic suitable for a vehicle front-illumination light to be obtained when light from the LED chip is magnified and projected in an illumination direction by a projection lens or the like constituting the projection means. Accordingly, accurate light distribution characteristics can be obtained in a simple manner by projecting in the illumination direction using the projection lens.
摘要翻译：虽然现有技术中已知的白炽灯泡和其他类似的光源在所有方向都发光，但是LED灯可以在单个方向上发光，并且这表现在不能实现常规前照灯设计所满足的光分布特性的问题。根据所公开的主题的实施例，用于前照灯的光源的LED灯可以包括在投影装置的焦点附近的LED芯片和覆盖LED芯片的一部分的屏蔽构件当通过构成投影装置的投影透镜等在来自LED芯片的光在照明方向上放大投影时，可以获得适用于车辆前照明光的配光特性。因此，通过使用投影透镜在照明方向投影，能够以简单的方式获得准确的配光特性。

8. 发明申请

US20070242463A1 Lighting Device 有权
标题翻译：照明装置
公开(公告)号：US20070242463A1
公开(公告)日：2007-10-18
申请号：US11736216
申请日：2007-04-17
申请人： Takashi Futami
发明人： Takashi Futami
IPC分类号： F21V7/00
CPC分类号： F21S43/14 , F21S41/143 , F21S41/663 , F21Y2115/10
摘要： A lighting device can include at least one LED light source having at least one LED chip, the LED light source being configured to impart a certain directivity to light emitted from the LED chip in a direction of the optical axis of the light source. A first reflector can be disposed in front of the LED light source and upwards with respect to the optical axis. The first reflector can also extend forward and above the optical axis in an inclined manner from a first side to a second side so as to reflect part of light emitted from an upper part of the LED light source with respect to the optical axis. A second reflector can be disposed substantially in parallel to, and below, the first reflector. The second reflector can be configured to reflect light from the first reflector. A third reflector can be disposed in front of the LED light source and downward with respect to the optical axis. The third reflector can extend forward and below the optical axis in an inclined manner from the second side to the first side so as to reflect part of light emitted from a lower part of the LED light source with respect to the optical axis. A fourth reflector can be disposed substantially in parallel to, and above, the third reflector. The fourth reflector can also be configured to reflect light from the third reflector.
摘要翻译：照明装置可以包括具有至少一个LED芯片的至少一个LED光源，所述LED光源被配置为沿着所述光源的光轴的方向对从所述LED芯片发射的光赋予一定的方向性。第一反射器可以设置在LED光源的前面并相对于光轴向上。第一反射器还可以从第一侧向第二侧以倾斜的方式向前和向上延伸，以便相对于光轴反射从LED光源的上部发射的光的一部分。第二反射器可以基本上平行于第一反射器并且在其下方布置。第二反射器可以被配置为反射来自第一反射器的光。第三反射器可以设置在LED光源的前面并相对于光轴向下。第三反射器可以从第二侧向第一侧以倾斜的方式向前和向下延伸，以便相对于光轴反射从LED光源的下部发射的光的一部分。第四反射器可以基本上平行于第三反射器并且上方设置。第四反射器还可以被配置为反射来自第三反射器的光。

9. 发明申请

US20070070642A1 VEHICLE LIGHT 有权
标题翻译：车辆灯
公开(公告)号：US20070070642A1
公开(公告)日：2007-03-29
申请号：US11535342
申请日：2006-09-26
申请人： Takashi Futami
发明人： Takashi Futami
IPC分类号： F21V7/00
CPC分类号： F21S41/43 , F21S41/162 , F21S41/17 , F21S41/25 , F21S41/255 , F21S41/321 , F21S41/338 , F21S41/36 , F21S41/365 , F21V7/05 , F21V7/08
摘要： A vehicle light with a bulb arranged sideway is provided which can reduce a length of the entire light without a deterioration in its brightness and with a simple configuration. The vehicle light can include a light source arranged sideway on an optical axis extending horizontally in the front-to-rear direction of a vehicle. First and second projection lenses can be arranged in front of the light source above and below the optical axis. First and second reflecting surfaces can be provided for reflecting light emitted from the light source to the respective first and second projection lenses. A third reflecting surface can be provided for reflecting light emitted upward from the light source toward the area below the light source. A plane mirror can also be provided and configured to direct light reflected from the third reflecting surface toward the rear focus of the second projection lens.
摘要翻译：提供了一种具有侧壁布置的灯泡的车辆灯，其可以减少整个光的长度而不会使其亮度劣化并且具有简单的配置。车辆灯可以包括在车辆的前后方向上水平延伸的光轴上侧向设置的光源。第一投影透镜和第二投影透镜可以布置在光轴的前方和下方的光轴的前方。可以提供第一和第二反射表面以将从光源发射的光反射到相应的第一和第二投影透镜。可以提供第三反射表面，用于将从光源向上发射的光反射到光源下方的区域。平面镜也可以被设置成将从第三反射面反射的光引导到第二投影透镜的后焦点。

10. 发明授权

US06578997B2 Multi-ocular light 有权
标题翻译：多眼睛光
公开(公告)号：US06578997B2
公开(公告)日：2003-06-17
申请号：US09759976
申请日：2001-01-12
申请人： Takashi Futami
发明人： Takashi Futami
IPC分类号： F21V500
CPC分类号： B60Q1/0041 , F21S41/28 , F21S41/334 , F21S41/692 , F21W2102/00 , F21W2103/20
摘要： A multi-ocular light composed by using a multi-ocular lens integrating a plurality of lenses and comprising one illumination light source for said multi-ocular lens, and a reflector mirror for distributing light from this single illumination light source to said respective lenses, wherein a signal light source is provided at the back of said multi-ocular lens to correspond to at least one lens of this multi-ocular lens, in order to assure the illumination function when said illumination light source is turned on, and the signal function when said signal light source is turned on.
摘要翻译：通过使用集成多个透镜并且包括用于所述多眼镜头的一个照明光源的多眼镜头以及用于将来自该单个照明光源的光分配到所述各个镜片的反射镜构成的多眼睛光，其中信号光源设置在所述多眼镜头的背面以对应于该多眼镜头的至少一个透镜，以便确保当所述照明光源被接通时的照明功能，并且该信号功能当所述信号光源被接通。

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