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1. 发明授权

US08309083B2 Polypeptides involved in immune response 有权
标题翻译：涉及免疫应答的多肽
公开(公告)号：US08309083B2
公开(公告)日：2012-11-13
申请号：US12753819
申请日：2010-04-02
申请人： Steven K. Yoshinaga , Tak W. Mak , Arda Shahinian , Anna Tafuri Bladt , Giorgio Senaldi
发明人： Steven K. Yoshinaga , Tak W. Mak , Arda Shahinian , Anna Tafuri Bladt , Giorgio Senaldi
IPC分类号： A61K39/395
CPC分类号： C07K14/47 , C07K14/705 , C07K16/2818 , C07K16/2827 , C07K2317/73 , C07K2319/30
摘要： Polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding the polypeptides, and vectors and host cells for expressing the polypeptides are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
摘要翻译：公开了包含参与T细胞活化的受体 - 配体对的多肽。还公开了编码多肽的核酸分子，以及用于表达多肽的载体和宿主细胞。多肽或其激动剂和拮抗剂用于治疗T细胞介导的病症。

2. 发明授权

US5625122A Mouse having a disrupted lck gene 失效
标题翻译：具有破坏的lck基因的小鼠
公开(公告)号：US5625122A
公开(公告)日：1997-04-29
申请号：US145043
申请日：1993-11-03
申请人： Tak W. Mak
发明人： Tak W. Mak
IPC分类号： C12N15/85 , C12N5/00 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0381
摘要： A mutant non-human mammal lacking expression of the lymphocyte-specific tyrosine kinase p56.sup.lck. Lck deficient mice possess few peripheral T lymphocytes and a pronounced thymic atrophy. The remaining thymus contains immature thymocytes surrounded by a perturbed thymic microenvironment. p56.sup.lck appears to play a crucial role in early thymocyte differentiation.
摘要翻译：缺乏淋巴细胞特异性酪氨酸激酶p56lck表达的突变非人哺乳动物。 Lck缺陷小鼠具有很少的外周T淋巴细胞和明显的胸腺萎缩。剩余的胸腺含有由扰动的胸腺微环境包围的未成熟胸腺细胞。 p56lck似乎在早期胸腺细胞分化中起关键作用。

3. 发明授权

US5616491A Knockout mice 失效
标题翻译：淘汰小鼠
公开(公告)号：US5616491A
公开(公告)日：1997-04-01
申请号：US528363
申请日：1995-09-14
申请人： Tak W. Mak , Craig B. Thompson
发明人： Tak W. Mak , Craig B. Thompson
IPC分类号： A01K67/027 , A61K38/00 , C07K14/705 , C12N15/12 , C12N15/85 , C12N5/00 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , C07K14/70503 , C07K14/70521 , C07K14/70589 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0381 , A61K38/00
摘要： Mice lacking expression of CD28 or particular CD45 isoforms in certain cells of the immune system are provided. Also provided are methods of using these mice.
摘要翻译：提供了在免疫系统的某些细胞中缺少CD28或特定CD45同种型表达的小鼠。还提供了使用这些小鼠的方法。

4. 发明授权

US5532158A Interleukin-2 receptor deficient mammals 失效
标题翻译：白细胞介素-2受体缺陷型哺乳动物
公开(公告)号：US5532158A
公开(公告)日：1996-07-02
申请号：US326896
申请日：1994-10-21
申请人： Haruhiko Suzuki , Tak W. Mak
发明人： Haruhiko Suzuki , Tak W. Mak
IPC分类号： C07K14/715 , C12N15/85 , C12N5/00 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0276 , C07K14/7155 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03
摘要： A mouse lacking expression of a subunit of the IL-2 receptor in certain cells of the immune system is provided. Also provided are methods of using such mice.
摘要翻译：提供了在免疫系统的某些细胞中缺乏IL-2受体亚单位表达的小鼠。还提供了使用这种小鼠的方法。

5. 发明授权

US4923799A T cell specific cDNA clone 失效
标题翻译： T细胞特异性cDNA克隆
公开(公告)号：US4923799A
公开(公告)日：1990-05-08
申请号：US100286
申请日：1987-11-09
申请人： Tak W. Mak
发明人： Tak W. Mak
IPC分类号： C07K14/725 , C07K14/82 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6881 , C07K14/7051 , C07K14/82 , G01N33/566 , C12Q2600/158
摘要： The invention provides a nucleic acid having a sequence which encodes a polypeptide that is at least part of a T cell antigen receptor. This encoded sequence is about 936 nucleotides in length and preferably is a human T cell antigen receptor. The nucleic acid sequence of one embodiment of the invention is shown in FIG. 3.The nucleic acid sequence may be used as a probe to determine whether an unknown cell, e.g., a tumor cell, is a T cell.Polypeptides encoded by the nucleic acid sequence include about 312 amino acids and are at least part of a T cell antigen receptor. They include at least one sequence which over 21 contiguous amino acids has greater than about 35% homology with mouse and human immunoglobin .lambda. light chains.Antibody to the polypeptide may be prepared and used to identify T cell antigen receptor and to determine whether an unknown cell, e.g., a tumor cell, is a T cell.
摘要翻译：本发明提供了具有编码至少部分T细胞抗原受体的多肽的序列的核酸。该编码序列的长度约为936个核苷酸，优选为人T细胞抗原受体。本发明的一个实施方案的核酸序列示于图1。核酸序列可以用作探针以确定未知细胞，例如肿瘤细胞是否是T细胞。由核酸序列编码的多肽包括约312个氨基酸，并且是T细胞抗原受体的至少一部分。它们包括至少一个21个连续氨基酸与小鼠和人免疫球蛋白λ轻链具有大于约35％同源性的序列。可以制备多肽的抗体并用于鉴定T细胞抗原受体并确定未知细胞，例如肿瘤细胞是否为T细胞。

6. 发明授权

US5907079A MSH2 disrupted mice develop lymphomas 失效
标题翻译： MSH2破坏小鼠发展淋巴瘤
公开(公告)号：US5907079A
公开(公告)日：1999-05-25
申请号：US588521
申请日：1996-01-18
申请人： Tak W. Mak , Armin Reitmair
发明人： Tak W. Mak , Armin Reitmair
IPC分类号： A61K49/00 , C07K14/82 , C12N15/85 , C12N5/00 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0276 , A61K49/0008 , C07K14/82 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , A01K2267/0381
摘要： Non-human mammals comprising a disrupted MSH2 gene are disclosed. More particularly, animals having a disruption in one or both alleles of the MSH2 gene or a homolog of the MSH2 gene are disclosed. Animals homozygous for the disruption are viable past the embryonic stage of development but show an increased incidence of lymphoma, intestinal adenomas and carcinomas, and squamous cell tumors of the skin. Specifically disclosed are mice whose genome comprises a disrupted MSH2 gene such that the mice exhibits an increase in the incidence of spontaneous lymphoma over the incidence of spontaneous lymphoma in wild type mice.
摘要翻译：公开了包含破坏的MSH2基因的非人哺乳动物。更具体地，公开了在MSH2基因的一个或两个等位基因或MSH2基因的同源物中具有破坏性的动物。对于破坏纯合的动物在胚胎发育阶段是可行的，但是表现出淋巴瘤，肠腺瘤和癌症以及皮肤鳞状细胞肿瘤的发病率增加。具体公开的是其基因组包含破坏的MSH2基因的小鼠，使得小鼠表现出自发性淋巴瘤发生率在野生型小鼠中自发性淋巴瘤发生率的增加。

7. 发明授权

US5731490A Mutant mouse lacking the expression of interferon regulatory factor 1 (IRF-1) 失效
标题翻译：缺乏干扰素调节因子1（IRF-1）表达的突变体小鼠
公开(公告)号：US5731490A
公开(公告)日：1998-03-24
申请号：US392292
申请日：1995-02-21
申请人： Tak W. Mak , Tadatsugu Taniguchi
发明人： Tak W. Mak , Tadatsugu Taniguchi
IPC分类号： C07K14/47 , C12N15/85 , C12N15/00 , C12N5/10 , C12N15/87 , C12N15/90
CPC分类号： C12N15/8509 , A01K67/0276 , C07K14/4702 , A01K2217/075 , A01K2227/105 , A01K2267/03
摘要： Interferon regulatory factor-1 (IRF-1) is implicated in the regulation of type I interferons (IFN) and cell growth. The invention is a mutant mouse lacking expression of the IRF-1 gene. Mice lacking IRF-1 did not differ from normal mice in size, behaviour, or reproductive ability. With fibroblasts derived from these mutant mice, it was shown that type I IFN induction is dramatically reduced when cells are induced by poly(I):poly(C). In contrast, no differences were found when cells are induced by New Castle Disease Virus (NDV), or induced by poly(I):poly(C) with prior treatment of IFN-.beta.. On the other hand, the induction levels of IFN-inducible genes such as MHC class I and 2'-5' oligoadenylate synthetase (2'5'OAS) were not affected. Collectively, these results illustrate an IRF-1 independent mechanism of gene induction for type I IFN and these IFN-inducible genes. The critical role of IRF-1 in the immune system has been documented for the first time by the observation that the number of TcR.alpha..beta..sup.+ CD4.sup.- CD8.sup.+ T cells were dramatically reduced in IRF-1 deficient mice. This phenotype may be ascribed to a thymocyte developmental defect between the double positive and single positive stages during CD8.sup.+ T cell ontogeny.
摘要翻译：干扰素调节因子-1（IRF-1）涉及I型干扰素（IFN）和细胞生长的调节。本发明是缺少IRF-1基因表达的突变体小鼠。缺乏IRF-1的小鼠与正常小鼠的大小，行为或生殖能力没有差异。使用衍生自这些突变小鼠的成纤维细胞，显示当通过聚（I）：聚（C）诱导细胞时，I型IFN诱导显着降低。相比之下，当新城堡病毒（NDV）诱导细胞或由poly（I）：poly（C））诱导IFN-β之前没有发现差异。另一方面，IFN-诱导型基因如MHC I类和2'-5'寡腺苷酸合成酶（2'5'OAS）的诱导水平不受影响。总而言之，这些结果说明了I型IFN和这些IFN诱导型基因的基因诱导的IRF-1独立机制。 IRF-1在免疫系统中的关键作用已经首次记录在IRF-1缺陷小鼠中，TcRαβ+ CD4-CD8 + T细胞数量急剧减少。这种表型可能归因于CD8 + T细胞个体发育期间双阳性和单阳性阶段之间的胸腺细胞发育缺陷。

8. 发明授权

US5557032A Knockout mice 失效
标题翻译：淘汰小鼠
公开(公告)号：US5557032A
公开(公告)日：1996-09-17
申请号：US451691
申请日：1995-05-26
申请人： Tak W. Mak
发明人： Tak W. Mak
IPC分类号： A01K67/027 , A61K38/00 , C07K14/705 , C12N15/12 , C12N15/85 , C12N15/00 , A61K49/00 , C12N5/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , C07K14/70503 , C07K14/70521 , C07K14/70589 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0381 , A61K38/00
摘要： Mice lacking expression of CD28 or particular CD45 isoforms in certain cells of the immune system are provided. Also provided are methods of using these mice.
摘要翻译：提供了在免疫系统的某些细胞中缺少CD28或特定CD45同种型表达的小鼠。还提供了使用这些小鼠的方法。

9. 发明授权

US4713332A T cell specific CDNA clone 失效
标题翻译： T细胞特异性CDNA克隆
公开(公告)号：US4713332A
公开(公告)日：1987-12-15
申请号：US577526
申请日：1984-02-06
申请人： Tak W. Mak
发明人： Tak W. Mak
IPC分类号： C07K14/705 , A61K35/14 , A61K35/74 , A61K38/00 , C07H21/04 , C07K14/435 , C07K14/725 , C07K14/82 , C07K16/00 , C07K16/28 , C12N1/20 , C12N1/21 , C12N15/00 , C12N15/09 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/04 , C12Q1/68 , C12R1/19 , G01N33/53 , G01N33/566 , G01N33/577 , C07H15/12 , C12P19/34
CPC分类号： G01N33/566 , C07K14/7051 , C07K14/82 , C12Q1/6881 , C12Q2600/158 , Y10S930/30
摘要： The invention provides a nucleic acid having a sequence which encodes a polypeptide that is at least part of a T cell antigen receptor. This encoded sequence is about 936 nucleotides in length and preferably is a human T cell antigen receptor. The nucleic acid sequence of one embodiment of the invention is shown in FIG. 3.The nucleic acid sequence may be used as a probe to determine whether an unknown cell, e.g., a tumor cell, is a T cell.Polypeptides encoded by the nucleic acid sequence include about 312 amino acids and are at least part of a T cell antigen receptor. They include at least one sequence which over 21 contiguous amino acids has greater than about 35% homology with mouse and human immunoglobin .lambda. light chains.Antibody to the polypeptide may be prepared and used to identify T cell antigen receptor and to determine whether an unknown cell, e.g., a tumor cell, is a T cell.
摘要翻译：本发明提供了具有编码至少部分T细胞抗原受体的多肽的序列的核酸。该编码序列的长度约为936个核苷酸，优选为人T细胞抗原受体。本发明的一个实施方案的核酸序列示于图1。核酸序列可以用作探针以确定未知细胞，例如肿瘤细胞是否是T细胞。由核酸序列编码的多肽包括约312个氨基酸，并且是T细胞抗原受体的至少一部分。它们包括至少一个21个连续氨基酸与小鼠和人免疫球蛋白λ轻链具有大于约35％同源性的序列。可以制备多肽的抗体并用于鉴定T细胞抗原受体并确定未知细胞，例如肿瘤细胞是否为T细胞。

10. 发明授权

US07708993B2 Polypeptides involved in immune response 有权
标题翻译：涉及免疫应答的多肽
公开(公告)号：US07708993B2
公开(公告)日：2010-05-04
申请号：US11359254
申请日：2006-02-21
申请人： Steven K. Yoshinaga , Tak W. Mak , Arda Shahinian , Anna Tafuri Bladt , Giorgio Senaldi
发明人： Steven K. Yoshinaga , Tak W. Mak , Arda Shahinian , Anna Tafuri Bladt , Giorgio Senaldi
IPC分类号： A61K39/395
CPC分类号： C07K14/47 , C07K14/705 , C07K16/2818 , C07K16/2827 , C07K2317/73 , C07K2319/30
摘要： Polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding the polypeptides, and vectors and host cells for expressing the polypeptides are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
摘要翻译：公开了包含参与T细胞活化的受体 - 配体对的多肽。还公开了编码多肽的核酸分子，以及用于表达多肽的载体和宿主细胞。多肽或其激动剂和拮抗剂用于治疗T细胞介导的病症。

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