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1. 发明授权

US5817509A Culture vessel assembly 失效
标题翻译：文化船舶装配
公开(公告)号：US5817509A
公开(公告)日：1998-10-06
申请号：US818648
申请日：1997-03-19
申请人： Timothy A. Stevens , Tadeusz A. Tyndorf , Susan L. Barker
发明人： Timothy A. Stevens , Tadeusz A. Tyndorf , Susan L. Barker
IPC分类号： C12M1/22 , C12M1/20 , C12M3/00 , C12M3/06 , C12N5/06
CPC分类号： C12M25/04 , C12M23/12 , C12M23/24 , C12M23/38 , C12M29/04
摘要： A multiwell tissue culture assembly for culturing cells comprising a plate and a lid. The plate includes a plurality of wells for receiving liquids therein and the lid includes means for varying the gas diffusion into and out of the assembly and for substantially minimizing biological contamination of the cells being cultured. The means for varying the gas diffusion is a gas permeable membrane provided in an opening in the lid and a removable thin impermeable film label is provided for selectively occluding passage of gases through the gas permeable membrane. The means for minimizing biological contamination of the cells being cultured is a sealing material located in the lid and means for removably securing the lid and the plate together whereby the sealing material is compressed between the lid and the plate.
摘要翻译：一种用于培养包含板和盖的细胞的多孔组织培养组件。板包括用于在其中接收液体的多个孔，并且盖包括用于改变进入和离开组件的气体扩散并且用于基本上最小化被培养的细胞的生物污染的装置。用于改变气体扩散的装置是设置在盖中的开口中的透气膜，并且提供可移除的薄不透水膜标签，用于选择性地封闭气体通过透气膜的通道。用于最小化正在培养的细胞的生物污染的装置是位于盖中的密封材料和用于将盖和板可拆卸地固定在一起的装置，由此密封材料在盖和板之间被压缩。

2. 发明授权

US5468638A Cell culture insert 失效
标题翻译：细胞培养插入物
公开(公告)号：US5468638A
公开(公告)日：1995-11-21
申请号：US952004
申请日：1992-09-28
申请人： Susan Barker , I-Hsi Chu , Oresta N. Fedun , Tadeusz A. Tyndorf
发明人： Susan Barker , I-Hsi Chu , Oresta N. Fedun , Tadeusz A. Tyndorf
IPC分类号： C12M1/20 , C12M1/12 , C12M3/00 , C12M3/04 , C12M3/06
CPC分类号： C12M25/04
摘要： Apparatus for growing tissue cultures in vitro, which permits a concentration gradient of nutrients to develop through a permeable membrane to which a sample of tissue is attached. The permeable membrane is attached to the bottom end of a cell culture insert that in turn is supported by a flange connected to its upper end on the top of a well containing the nutrients and is self centered in the well by the arrangement of the sidewalls of the cell culture insert. The self centering feature of the insert minimizes capillary action.
摘要翻译：用于在体外生长组织培养物的装置，其允许营养物的浓度梯度通过附着有组织样品的渗透膜发育。可渗透膜连接到细胞培养插入物的底端，细胞培养插入物的底端由与其营养物质的顶部上端连接的凸缘支撑，并且通过侧壁的排列细胞培养插入。插入件的自定心特征使毛细管作用最小化。

3. 外观设计

USD382063S Culture slide 失效
公开(公告)号：USD382063S
公开(公告)日：1997-08-05
申请号：US39860
申请日：1995-06-06
申请人： Timothy A. Stevens , Tadeusz A. Tyndorf
设计人： Timothy A. Stevens , Tadeusz A. Tyndorf

4. 发明授权

US5652142A Cell culture insert 失效
标题翻译：细胞培养插入物
公开(公告)号：US5652142A
公开(公告)日：1997-07-29
申请号：US535368
申请日：1995-09-28
申请人： Susan Barker , I-Hsi Chu , Oresta N. Fedun , Tadeusz A. Tyndorf
发明人： Susan Barker , I-Hsi Chu , Oresta N. Fedun , Tadeusz A. Tyndorf
IPC分类号： C12M1/20 , C12M1/12 , C12M3/00 , C12M3/04 , C12M3/06
CPC分类号： C12M25/04
摘要： Apparatus for growing cells or tissue in vitro, which permits a concentration gradient of nutrients to develop through a permeable membrane to which a sample of tissue is attached. The permeable membrane is attached to the bottom end of a cell culture insert that in turn is supported by a flange connected to its upper end on the top of a well containing the nutrients. Restricted movement of the cell culture insert in the well may be facilitated by projections extending off the outer wall surface of the insert so as to avoid capillary action in the space between the well and the insert.
摘要翻译：用于在体外生长细胞或组织的装置，其允许营养物的浓度梯度通过附着有组织样品的渗透膜显影。渗透膜连接到细胞培养插入物的底端，细胞培养插入物的底端又由连接到其含有营养物的孔的顶部上端的凸缘支撑。可以通过从插入件的外壁表面延伸的突起来促进细胞培养插入物在孔中的限制运动，以避免孔与插入物之间的空间中的毛细管作用。

5. 发明授权

US5780294A Culture vessel assembly 失效
标题翻译：文化船舶装配
公开(公告)号：US5780294A
公开(公告)日：1998-07-14
申请号：US820920
申请日：1997-03-19
申请人： Timothy A. Stevens , Tadeusz A. Tyndorf , Susan L. Barker
发明人： Timothy A. Stevens , Tadeusz A. Tyndorf , Susan L. Barker
IPC分类号： C12M1/22 , C12M1/20 , C12M3/00 , C12M3/06 , C12N5/06
CPC分类号： C12M25/04 , C12M23/12 , C12M23/24 , C12M23/38 , C12M29/04
摘要： A multiwell tissue culture assembly for culturing cells comprising a plate and a lid. The plate includes a plurality of wells for accommodating a cell culture insert and the lid includes means for varying the gas diffusion into and out of the assembly and for substantially minimizing biological contamination of the cells being cultured in the cell culture insert. The means for varying the gas diffusion is a gas permeable membrane provided in a plurality of openings in the lid and a plurality of removable thin impermeable film labels are provided for selectively occluding passage of gases through the gas permeable membranes.
摘要翻译：一种用于培养包含板和盖的细胞的多孔组织培养组件。板包括用于容纳细胞培养插入物的多个孔，并且盖包括用于改变进入和离开组件的气体扩散并且用于基本上最小化在细胞培养插入物中培养的细胞的生物污染的装置。用于改变气体扩散的装置是设置在盖中的多个开口中的透气膜，并且提供多个可移除的薄不透水膜标签，用于选择性地封闭通过透气膜的气体通道。

6. 发明授权

US5518925A Culture slide assembly 失效
标题翻译：文化滑梯组装
公开(公告)号：US5518925A
公开(公告)日：1996-05-21
申请号：US468782
申请日：1995-06-06
申请人： Tadeusz A. Tyndorf , Timothy A. Stevens
发明人： Tadeusz A. Tyndorf , Timothy A. Stevens
IPC分类号： G01N1/28 , C12M1/00 , C12M1/34 , C12M3/00 , G02B21/34 , G01N21/01
CPC分类号： G02B21/34 , C12M41/36
摘要： The present invention is a culture slide assembly having a base member, a cooperable receptacle removably attached to the base and means for separating the receptacle from the base. Preferably, the assembly may be used for carrying out biological reactions or growth therein, such as growing tissue or cell cultures.
摘要翻译：本发明是一种培养用滑动组件，其具有基部构件，可移除地附接到基部的可配合插座和用于将容器与基座分开的装置。优选地，组合物可以用于在其中进行生物反应或生长，例如生长组织或细胞培养物。

7. 外观设计

USD360698S Cell insert for a tissue culture plate 失效
公开(公告)号：USD360698S
公开(公告)日：1995-07-25
申请号：US11696
申请日：1993-08-12
申请人： Timothy A. Stevens , Edward F. Mussi , Douglas P. Henderson , Tadeusz A. Tyndorf
设计人： Timothy A. Stevens , Edward F. Mussi , Douglas P. Henderson , Tadeusz A. Tyndorf

8. 发明授权

US07854896B2 Closed system storage plates 有权
标题翻译：封闭系统存储板
公开(公告)号：US07854896B2
公开(公告)日：2010-12-21
申请号：US10241121
申请日：2002-09-11
申请人： Tadeusz A. Tyndorf , Richard Cannataro
发明人： Tadeusz A. Tyndorf , Richard Cannataro
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , B01L2300/042 , B01L2300/044 , B01L2300/123 , G01N35/1079
摘要： The present invention is a closed system storage plate that includes a specimen collection plate having a plurality of wells for storing specimens and a cover that is sealably secured to the specimen collection plate. The cover has a thermoplastic elastomer membrane that provides pierceable access by a probe to each well interior and self-seals upon removal of the probe.
摘要翻译：本发明是一种封闭系统存储板，其包括具有多个用于存储试样的孔的样本收集板和可密封地固定到样本收集板的盖。盖具有热塑性弹性体膜，其通过探针可刺穿进入每个孔内部并且在去除探针时自我密封。

9. 发明授权

US5882922A Culture vessel assembly 失效
标题翻译：文化船舶装配
公开(公告)号：US5882922A
公开(公告)日：1999-03-16
申请号：US818649
申请日：1997-03-19
申请人： Tadeusz A. Tyndorf , Timothy A. Stevens , Susan L. Barker
发明人： Tadeusz A. Tyndorf , Timothy A. Stevens , Susan L. Barker
IPC分类号： C12M1/22 , C12M1/20 , C12M3/00 , C12M3/06 , C12N5/06
CPC分类号： C12M23/24 , C12M23/12 , C12M23/38 , C12M25/04 , C12M29/04
摘要： A multiwell tissue culture assembly for culturing cells comprising a plate and a lid. The plate includes a plurality of wells for accommodating a cell culture insert and the lid includes means for varying the gas diffusion into and out of the assembly and for substantially minimizing biological contamination of the cells being cultured in the cell culture insert. The means for varying the gas diffusion is a gas permeable membrane provided in an opening in the lid and a removable thin impermeable film label is provided for selectively occluding passage of gases through the gas permeable membrane.
摘要翻译：一种用于培养包含板和盖的细胞的多孔组织培养组件。板包括用于容纳细胞培养插入物的多个孔，并且盖包括用于改变进入和离开组件的气体扩散并且用于基本上最小化在细胞培养插入物中培养的细胞的生物污染的装置。用于改变气体扩散的装置是设置在盖中的开口中的透气膜，并且提供可移除的薄不透水膜标签，用于选择性地封闭气体通过透气膜的通道。

10. 发明授权

US5863792A Culture vessel assembly 失效
标题翻译：文化船舶装配
公开(公告)号：US5863792A
公开(公告)日：1999-01-26
申请号：US820921
申请日：1997-03-19
申请人： Tadeusz A. Tyndorf , Timothy A. Stevens , Susan L. Barker
发明人： Tadeusz A. Tyndorf , Timothy A. Stevens , Susan L. Barker
IPC分类号： C12M3/00 , C12M1/20 , C12M3/06
CPC分类号： C12M23/24 , C12M23/12 , C12M23/38 , C12M25/04 , C12M29/04
摘要： A multiwell tissue culture assembly for culturing cells comprising a plate and a lid. The plate includes a plurality of wells for accommodating a cell culture insert and the lid includes means for varying the gas diffusion into and out of the assembly and for substantially minimizing biological contamination of the cells being cultured in the cell culture insert. The means for varying the gas diffusion is a gas permeable membrane provided in a plurality of openings in the lid and a plurality of removable thin impermeable film labels are provided for selectively occluding passage of gases through the gas permeable membranes. The means for minimizing biological contamination of the cells being cultured is a sealing material located in the lid and means for removably securing the lid and the plate together whereby the sealing material is compressed between the lid and the plate.
摘要翻译：一种用于培养包含板和盖的细胞的多孔组织培养组件。板包括用于容纳细胞培养插入物的多个孔，并且盖包括用于改变进入和离开组件的气体扩散并且用于基本上最小化在细胞培养插入物中培养的细胞的生物污染的装置。用于改变气体扩散的装置是设置在盖中的多个开口中的透气膜，并且提供多个可移除的薄不透水膜标签，用于选择性地封闭通过透气膜的气体通道。用于最小化正在培养的细胞的生物污染的装置是位于盖中的密封材料和用于将盖和板可拆卸地固定在一起的装置，由此密封材料在盖和板之间被压缩。

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