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1. 发明专利

JP2004077077A Vacuum dryer 审中-公开
公开(公告)号：JP2004077077A
公开(公告)日：2004-03-11
申请号：JP2002240897
申请日：2002-08-21
申请人： Shoji Ikeda , Yukinori Kurahashi , Tadashi Nakajima , 中島正 , 倉橋幸徳 , 池田庄治
发明人： TAKADA SHIRO , UDA TOSHIMITSU , KAWAKAMI MINORU , ENDO MOTOTADA , HAYASHI ICHIO , IKEDA SHOJI , NAKAJIMA TADASHI , KURAHASHI YUKINORI
IPC分类号： F26B5/04 , B09B3/00 , F26B21/00
CPC分类号： Y02W30/824
摘要： PROBLEM TO BE SOLVED: To make the energy cost inexpensive and to effectively utilize an article to be dried as a resource of good quality after drying in a vacuum drier. SOLUTION: The vacuum drier is provided with a drying drum for storing the article to be dried; an exhaust means 4 for discharging a gas in the drying drum 1; a heating means 21 for heating the inside of the drying drum 1; a cooling means 3 for cooling the gas discharged from the drying drum 1; and a heat pump system 6 having a refrigerator compressor 9, a condenser 8, a pressure reduction device 19 and an evaporator 7. The heating means 21 is heated utilizing heat release of the condenser 8 and the cooling means 3 is cooled utilizing the heat absorption of the evaporator 7. COPYRIGHT: (C)2004,JPO

2. 发明申请

US20110263638A1 Therapeutic agent for glaucoma comprising rho kinase inhibitor and ß- blocker 审中-公开
标题翻译：包含rho激酶抑制剂和β受体阻滞剂的青光眼治疗剂
公开(公告)号：US20110263638A1
公开(公告)日：2011-10-27
申请号：US13135295
申请日：2011-06-30
申请人： Masakazu Hatano , Tadashi Nakajima , Takeshi Matsugi , Hideaki Hara
发明人： Masakazu Hatano , Tadashi Nakajima , Takeshi Matsugi , Hideaki Hara
IPC分类号： A61K31/437 , A61P27/06
CPC分类号： A61K45/06 , A61K31/138 , A61K31/343 , A61K31/353 , A61K31/437 , A61K31/4409 , A61K31/4412 , A61K31/496 , A61K31/5377 , A61K31/551 , Y10S514/913 , A61K2300/00
摘要： A therapeutic agent for glaucoma including a combination of pharmaceutically effective amounts of a Rho kinase inhibitor and a β-blocker, wherein the Rho kinase inhibitor is (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide and the β-blocker is befunolol, carteolol, nipradilol, betaxolol, levobunolol or metipranolol. A method of treating glaucoma including administering effective amounts of a Rho kinase inhibitor and a β-blocker to a patient, wherein the Rho kinase inhibitor is (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide and the β-blocker is befunolol, carteolol, nipradilol, betaxolol, levobunolol or metipranolol.
摘要翻译：一种用于青光眼的治疗剂，其包括药学有效量的Rho激酶抑制剂和抑制剂的组合，其中所述Rho激酶抑制剂是（R） - （+） - N-（1H-吡咯并[2,3-b 吡啶-4-基）-4-（1-氨基乙基）苯甲酰胺，并且β-阻滞剂是非芬洛尔，卡替洛尔，阿普拉洛尔，倍他洛尔，左布洛尔或美替洛尔。一种治疗青光眼的方法，包括向患者施用有效量的Rho激酶抑制剂和抑制剂，其中所述Rho激酶抑制剂是（R） - （+） - N-（1H-吡咯并[2,3-b 吡啶-4-基）-4-（1-氨基乙基）苯甲酰胺，并且β-阻滞剂是非芬洛尔，卡替洛尔，阿普拉洛尔，倍他洛尔，左布洛尔或美替洛尔。

3. 发明申请

US20100063060A1 Therapeutic agent for glaucoma comprising Rho Kinhase inhibitor and prostaglandin 审中-公开
标题翻译：包含Rho Kinhase抑制剂和前列腺素的青光眼治疗剂
公开(公告)号：US20100063060A1
公开(公告)日：2010-03-11
申请号：US12589004
申请日：2009-10-16
申请人： Tadashi Nakajima , Takeshi Matsugi , Hideaki Hara
发明人： Tadashi Nakajima , Takeshi Matsugi , Hideaki Hara
IPC分类号： A61K31/496 , A61K31/44 , A61K31/437 , A61P27/02
CPC分类号： A61K45/06 , A61K9/0048 , A61K31/437 , A61K31/4409 , A61K31/4725 , A61K31/5377 , A61K31/553 , A61K31/5575 , A61K2300/00
摘要： A combination of a Rho kinase inhibitor and a prostaglandin as a therapeutic agent for treating glaucoma. The actions of reducing intraocular pressure are complemented and/or enhanced by combining a Rho kinase inhibitor with a prostaglandin. Each of the Rho kinase inhibitor and the prostaglandin can be administered in combination or in a mixture.
摘要翻译：作为治疗青光眼的治疗剂的Rho激酶抑制剂和前列腺素的组合。通过组合Rho激酶抑制剂与前列腺素来补充和/或增强降低眼压的作用。 Rho激酶抑制剂和前列腺素中的每一种可以组合或混合施用。

4. 发明申请

US20070129404A1 Novel indazole derivatives 失效
标题翻译：新型吲唑衍生物
公开(公告)号：US20070129404A1
公开(公告)日：2007-06-07
申请号：US10575645
申请日：2004-10-15
申请人： Masahiko Hagihara , Ken-ichi Komori , Hidetoshi Sunamoto , Hiroshi Nishida , Takeshi Matsugi , Tadashi Nakajima , Masakazu Hatano , Kazutaka Kido , Hideaki Hara
发明人： Masahiko Hagihara , Ken-ichi Komori , Hidetoshi Sunamoto , Hiroshi Nishida , Takeshi Matsugi , Tadashi Nakajima , Masakazu Hatano , Kazutaka Kido , Hideaki Hara
IPC分类号： A61K31/4439 , A61K31/416 , C07D403/02 , C07D231/56
CPC分类号： C07D231/56 , C07D401/04 , C07D403/04 , C07D413/04
摘要： An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.
摘要翻译：本发明的目的是产生一种可用作药物的新型吲唑衍生物，并找到该衍生物的新药理作用。本发明的化合物由式[I]表示，具有优异的Rho激酶抑制作用。在该式中，环X为苯环或吡啶环; R 1和R 2均为H或烷基; R 3和R 4是卤素，H，OH，烷氧基，烯氧基，炔氧基，环烷氧基，环烯氧基，芳氧基，烷基，烯基，炔基，环烷基，环烯基，芳基，羧基，烃基，烷基羰基等; R 5是卤素原子，H，OH，烷氧基，芳氧基，烷基或芳基。每组可以替代。

5. 发明授权

US06814892B2 Ethylene propylene rubber foam and image formation equipment 失效
标题翻译：乙烯丙烯橡胶泡沫和成像设备
公开(公告)号：US06814892B2
公开(公告)日：2004-11-09
申请号：US10411317
申请日：2003-04-11
申请人： Chikara Yamada , Toshiyuki Osaki , Tadashi Nakajima , Takahiro Kawagoe
发明人： Chikara Yamada , Toshiyuki Osaki , Tadashi Nakajima , Takahiro Kawagoe
IPC分类号： C08L2300
CPC分类号： G03G15/1685 , C08L23/16 , G03G15/0233 , G03G2215/0861 , H01B1/20 , H01B1/24
摘要： An ethylene propylene rubber foam which comprises as the crude rubber, an ethylene propylene rubber having an iodine value of 35 to 45 and a Mooney viscosity ML1+4 at 100° C. of 20 to 50, and which has less compression set and is suitable as a material for a transfer member, a primary transfer member, a secondary transfer member, a cleaning member for image formation bodies, a bias member, a backup member, etc.; an electroconductive ethylene propylene rubber foam which comprises as the crude rubber, an ethylene propylene rubber having an iodine value of 35 to 45 and a Mooney viscosity ML1+4 at 100° C. of 20 to 50, and which electrifies an image formation body through direct charge injection by applying voltage, thus enabling to electrify at low voltage, substantially prevent ozone generation, noises and defective image; an electrifying member comprising the above electroconductive rubber foam; electrifying equipment equipped with the above member; and image formation equipment equipped with the above member or the above equipment.
摘要翻译：包含作为粗制橡胶的乙烯丙烯橡胶泡沫，乙烯丙烯橡胶的碘值为35〜45，门尼粘度ML1 + 4为100〜50，压缩永久变形较小，适合作为转印部件的材料，一次转印部件，二次转印部件，图像形成体的清洁部件，偏压部件，支撑部件等; 包含作为粗制橡胶的导电乙丙橡胶泡沫，乙烯丙烯橡胶的碘值为35〜45，门尼粘度ML1 + 4在100℃为20〜50，并且使图像形成体通过通过施加电压进行直接电荷注入，从而能够在低电压下通电，基本上防止臭氧产生，噪声和图像不良; 包含上述导电橡胶泡沫的带电构件; 配备上述会员的充电设备; 和配备上述成员或上述设备的成像设备。

6. 发明授权

US06572791B2 Electroconductive elastic member, elastic member and image formation equipment 失效
标题翻译：导电弹性件，弹性件和成像设备
公开(公告)号：US06572791B2
公开(公告)日：2003-06-03
申请号：US09730777
申请日：2000-12-07
申请人： Junji Sakata , Hirotaka Yamazaki , Tadashi Nakajima , Takahiro Kawagoe
发明人： Junji Sakata , Hirotaka Yamazaki , Tadashi Nakajima , Takahiro Kawagoe
IPC分类号： H01B100
CPC分类号： C08J9/0066 , C08G18/12 , C08G18/4072 , C08G18/4837 , C08G18/632 , C08G2101/0008 , C08G2101/0058 , C08G2101/0066 , C08J2375/04 , Y10S206/823 , Y10S493/96 , C08G18/302
摘要： There is disclosed an elastic member constituted of polyurethane foam obtained by agitationally mixing with water, a urethane prepolymer synthesized from a polyol and a polyisocyanate, characterized by simultaneously employing as polyols, a (A) polymer polyol synthesized from a polyether polyol as a basis, comprising at least 70% by weight of oxypropylene moiety; and a (B) hydrophilic polyether polyol comprising at least 50% by weight of oxyethylene moiety, or simultaneously employing as polyols, the component (A), the component (B) and a (C) polyether polyol comprising at least 70% by weight of oxypropylene moiety. The above elastic member is simultaneously imparted with excellent characteristics such as low hardness, fine cells, low residual compressive strain, high strength and the like. The polyurethane foam which constitutes the elastic member can be produced by free foaming. The electroconductive elastic member which is produced by using an aqueous dispersion of carbon instead of water is imparted with low electric resistance in addition to the above excellent characteristics.
摘要翻译：公开了一种弹性构件，其由通过与水搅拌混合得到的聚氨酯泡沫构成，由多元醇和多异氰酸酯合成的氨基甲酸酯预聚物，其特征在于同时使用作为多元醇的（A）聚合物多元醇合成的聚合物多元醇作为基础，包含至少70重量％的氧化丙烯部分; 和（B）亲水性聚醚多元醇，其包含至少50重量％的氧化乙烯部分，或同时使用作为多元醇的组分（A），组分（B）和（C）聚醚多元醇，其包含至少70重量％的氧亚丙基部分。上述弹性构件同时具有低硬度，细小电池，低残余压缩应变，高强度等优异的特性。构成弹性部件的聚氨酯泡沫体可以通过自由发泡而制造。通过使用碳水分散体代替水制造的导电弹性构件除了上述优异的特性外还具有低电阻。

7. 发明授权

US5911099A Electroconductiive member and electrophotogrpahic apparatus 失效
标题翻译：导电构件和电子照相装置
公开(公告)号：US5911099A
公开(公告)日：1999-06-08
申请号：US960313
申请日：1997-10-29
申请人： Tadashi Nakajima , Junji Sakata , Takahiro Kawagoe
发明人： Tadashi Nakajima , Junji Sakata , Takahiro Kawagoe
IPC分类号： C08K5/098 , C08K5/19 , C08L75/00 , C08L75/04 , G03G15/00 , G03G15/08 , G03G15/16 , H01B1/20 , G03G15/06 , G03G15/14
CPC分类号： G03G15/1685 , C08K5/19 , G03G15/0818 , G03G2215/0861
摘要： There are disclosed an electroconductive member comprising a high-molecular material, e.g. polyurethane as a matrix and a quaternary ammonium salt of an organic acid, e.g. bis-or-mono(quaternary ammonium) oxalate; and an electrophotographic apparatus which makes use of the electroconductive member, especially in the form of an electroconductive roller as a developing member, image transfer member, etc. The electroconductive member, when used in electrophotographic mechanism, minimizes an increase in electric resistance at the time of normal continuous passage of an electric current and also variation range in the electric resistance between the circumstances of low temperature/humidity and those of high temperature/humidity.
摘要翻译：公开了一种导电构件，其包含高分子材料，例如，作为基质的聚氨酯和有机酸的季铵盐，例如草酸二 - 或单（季铵）; 以及使用导电构件的电子照相设备，特别是以导电辊作为显影部件的形式，图像转印部件等。当用于电子照相机构时，导电部件使电流的增加最小化电流的正常连续通过以及低温/高湿环境下的电阻的变化范围。

8. 发明授权

US4084010A Glycosides having sweetness 失效
标题翻译：甜味糖苷
公开(公告)号：US4084010A
公开(公告)日：1978-04-11
申请号：US755425
申请日：1976-12-29
申请人： Tsunematsu Takemoto , Tadashi Nakajima , Shigenobu Arihara , Megumi Okuhira
发明人： Tsunematsu Takemoto , Tadashi Nakajima , Shigenobu Arihara , Megumi Okuhira
IPC分类号： A23L27/12 , A23L27/30 , C07J19/00 , A23L1/22 , C07J17/00
CPC分类号： C07J19/00 , A23L27/12 , A23L27/36
摘要： Glycosides having an excellent sweetness and hydrolysate thereof of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and are each hydrogen, a residue of .beta.-D-glucose, or a residue of an oligosaccharide comprising not more than four D-glucose having 1,2-, 1,4- and/or 1,6-bond, provided that the total number of D-glucose residue in R.sub.1 and R.sub.2 is not more than 6, which is isolated from a fruit of a plant of Cucurbitaceae, particularly Momordica grosvenori Swingle (e.g. Fructus Momordicae) and said hydrolysates are produced by hydrolyzing the glycosides with an enzyme.
摘要翻译：具有下列通式的优异甜味和水解产物的糖苷：其中R1和R2相同或不同，各自为氢，β-D-葡萄糖的残基或寡糖的残基，包含不超过4个D - 具有1,2-，1,4-和/或1,6-键的葡萄糖，条件是R1和R2中D-葡萄糖残基的总数不大于6，其从植物的果实中分离葫芦科，尤其是苦瓜（Thoordus Momordicae）和所说的水解产物是通过用酶水解糖苷来制备的。

9. 发明申请

US20110039891A1 Methods for treating a disease in which Rho kinase is involved 有权
标题翻译：治疗涉及Rho激酶的疾病的方法
公开(公告)号：US20110039891A1
公开(公告)日：2011-02-17
申请号：US12925367
申请日：2010-10-20
申请人： Masahiko Hagihara , Ken-ichi Komori , Hidetoshi Sunamoto , Hiroshi Nishida , Takeshi Matsugi , Tadashi Nakajima , Masakazu Hatano , Kazutaka Kido , Hideaki Hara
发明人： Masahiko Hagihara , Ken-ichi Komori , Hidetoshi Sunamoto , Hiroshi Nishida , Takeshi Matsugi , Tadashi Nakajima , Masakazu Hatano , Kazutaka Kido , Hideaki Hara
IPC分类号： A61K31/454 , A61K31/415 , A61K31/4439 , A61K31/422 , A61K31/42 , A61P27/02 , A61P27/06
CPC分类号： C07D231/56 , C07D401/04 , C07D403/04 , C07D413/04
摘要： A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: wherein the ring X is a benzene ring or a pyridine ring; R1 and R2 are hydrogen or alkyl or together form a cycloalkene ring; R3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5 is a halogen atom or a hydrogen atom.
摘要翻译：一种治疗涉及Rho激酶的疾病的方法。该方法通过向有需要的患者施用药学有效量的下式化合物或其药学上可接受的盐进行：其中环X是苯环或吡啶环; R1和R2是氢或烷基或一起形成环烯烃环; R 3是氢，取代的烷基，未取代的烯基，羧基或其酯或酰胺，氨基或氰基; R4是氢，羟基，取代或未取代的烷氧基，未取代的烯氧基，未取代的环烷基氧基取代或未取代的烷基，未取代的烯基，未取代的环烷基，氨基，取代或未取代的烷基氨基，硝基，氰基或单环杂环; R5为卤素原子或氢原子。

10. 发明授权

US07855222B2 Methods for treating a disease in which Rho kinase is involved 有权
标题翻译：治疗涉及Rho激酶的疾病的方法
公开(公告)号：US07855222B2
公开(公告)日：2010-12-21
申请号：US12456652
申请日：2009-06-19
申请人： Masahiko Hagihara , Ken-ichi Komori , Hidetoshi Sunamoto , Hiroshi Nishida , Takeshi Matsugi , Tadashi Nakajima , Masakazu Hatano , Kazutaka Kido , Hideaki Hara
发明人： Masahiko Hagihara , Ken-ichi Komori , Hidetoshi Sunamoto , Hiroshi Nishida , Takeshi Matsugi , Tadashi Nakajima , Masakazu Hatano , Kazutaka Kido , Hideaki Hara
IPC分类号： A01N43/56 , A61K31/40 , C07D231/00 , C07D233/56
CPC分类号： C07D231/56 , C07D401/04 , C07D403/04 , C07D413/04
摘要： A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: wherein the ring X is a benzene ring or a pyridine ring; R1 and R2 are hydrogen or alkyl or together form a cycloalkene ring; R3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy, substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5 is a halogen atom or a hydrogen atom.
摘要翻译：一种治疗涉及Rho激酶的疾病的方法。该方法通过向有需要的患者施用药学有效量的下式化合物或其药学上可接受的盐进行：其中环X是苯环或吡啶环; R1和R2是氢或烷基或一起形成环烯烃环; R 3是氢，取代的烷基，未取代的烯基，羧基或其酯或酰胺，氨基或氰基; R4是氢，羟基，取代或未取代的烷氧基，未取代的烯氧基，未取代的环烷基氧基，取代或未取代的烷基，未取代的烯基，未被取代的环烷基，氨基，取代或未取代的烷基氨基，硝基，氰基或单环杂环; R5为卤素原子或氢原子。

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