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1. 发明授权

US08329739B2 Phenylimidazole compounds 有权
标题翻译：苯并咪唑化合物
公开(公告)号：US08329739B2
公开(公告)日：2012-12-11
申请号：US13145041
申请日：2010-02-03
申请人： Tadao Shibutani , Koushi Iwata , Satoshi Kido
发明人： Tadao Shibutani , Koushi Iwata , Satoshi Kido
IPC分类号： A61K31/4174 , C07D233/64
CPC分类号： C07D233/64 , C07D233/54 , C07D405/04 , C07D409/04
摘要： [Object] To provide a pharmaceutical product (chemotherapeutic agent) effective in the prevention and treatment of hyperlipidemia, obesity, etc.[Solving Means] A phenylimidazole compound represented by the following General Formula (1): wherein, R1 represents a hydrogen atom, a phenyl lower alkyl group optionally having a substituent, or a pyridyl lower alkyl group optionally having a substituent, and the benzene ring and the pyridine ring are optionally substituted with 1 or 2 substituents selected from the group consisting of halogen atoms, cyano group and halogen-substituted lower alkyl groups. One of R2 and R3 represents a hydrogen atom and the other represents a lower alkoxy group. R4 represents a phenyl group optionally having a substituent. R5 and R6 are the same or different, and represent a hydrogen atom or a lower alkyl group. R7 and R8 are the same or different, and represent a hydrogen atom or a lower alkoxy group. However, when R1 represents an unsubstituted phenyl lower alkyl group, R2 represents a lower alkoxy group, R3 represents a hydrogen atom, R4 represents a phenyl group optionally having a substituent, and R5 represents a hydrogen atom, R6 is not a hydrogen atom.
摘要翻译：提供有效预防和治疗高脂血症，肥胖症等的药物（化学治疗剂）。[解决方案]由以下通式（1）表示的苯基咪唑化合物：其中，R1表示氢原子，任选具有取代基的苯基低级烷基或任选具有取代基的吡啶基低级烷基，苯环和吡啶环任选被1或2个选自卤素原子，氰基和卤素的取代基取代取代的低级烷基。 R2和R3之一表示氢原子，另一个表示低级烷氧基。 R4表示任选具有取代基的苯基。 R5和R6相同或不同，表示氢原子或低级烷基。 R 7和R 8相同或不同，表示氢原子或低级烷氧基。然而，当R1表示未取代的苯基低级烷基时，R2表示低级烷氧基，R3表示氢原子，R4表示任选具有取代基的苯基，R5表示氢原子，R6不是氢原子。

2. 发明申请

US20130296342A1 LIPOPROTEIN LIPASE-ACTIVATING COMPOSITIONS COMPRISING BENZENE DERIVATES 审中-公开
标题翻译：含有苯甲酸衍生物的脂蛋白脂酶活化组合物
公开(公告)号：US20130296342A1
公开(公告)日：2013-11-07
申请号：US13931196
申请日：2013-06-28
申请人： Irina NEAGU , Michael OHLMEYER , Vidyadhar M. PARADKAR , Kurt W. SAIONZ , Koushi IWATA , Takashi OKAMURA , Tadao SHIBUTANI
发明人： Irina NEAGU , Michael OHLMEYER , Vidyadhar M. PARADKAR , Kurt W. SAIONZ , Koushi IWATA , Takashi OKAMURA , Tadao SHIBUTANI
IPC分类号： A61K31/519 , A61K31/4164 , A61K31/4184 , A61K31/428 , A61K31/437 , A61K31/429
CPC分类号： A61K31/519 , A61K31/4164 , A61K31/4184 , A61K31/4188 , A61K31/428 , A61K31/429 , A61K31/437 , A61K31/4745 , C07D233/56 , C07D233/58 , C07D235/18 , C07D277/66 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides pharmaceutical compositions containing benzene compound(s) represented by General Formula (1) below and, particularly, LPL-activating compositions for use in hyperlipidemia therapeutic and preventive agents, anti-obesity agents, and the like: wherein R1, R2, R3 and R4 are as defined in the specification.
摘要翻译：本发明提供了含有下述通式（1）表示的苯化合物的药物组合物，特别是用于高脂血症治疗和预防剂，抗肥胖剂等的LPL活化组合物，其中R1，R2 ，R3和R4如说明书中所定义。

3. 发明授权

US07071187B2 Naphthyridine derivatives 失效
标题翻译：萘啶衍生物
公开(公告)号：US07071187B2
公开(公告)日：2006-07-04
申请号：US10487209
申请日：2002-02-21
申请人： Tadao Shibutani
发明人： Tadao Shibutani
IPC分类号： A61K31/535 , C07D417/00 , C07D471/02
CPC分类号： C07D471/04 , A61K31/4375
摘要： The present invention provides a novel naphthyridine derivative that is effective for relieving pain, less toxic, and also is effective for treating diabetic neuropathy, the derivative being represented by the general formula (1): wherein R1, R2, R3 and R4 are as described in the description.
摘要翻译：本发明提供一种新颖的萘啶衍生物，其有效缓解疼痛，毒性小，对治疗糖尿病性神经病有效，该衍生物由通式（1）表示：其中R 1， R 2，R 3和R 4如描述中所述。

4. 发明授权

US06372749B1 Pyrazolo[1,5-a]pyrimidine derivatives 失效
标题翻译：吡唑并[1,5-a]嘧啶衍生物
公开(公告)号：US06372749B1
公开(公告)日：2002-04-16
申请号：US09700764
申请日：2000-11-20
申请人： Takashi Okumura , Yasuo Shoji , Tadao Shibutani , Tsuneo Yasuda , Takeshi Iwamoto
发明人： Takashi Okumura , Yasuo Shoji , Tadao Shibutani , Tsuneo Yasuda , Takeshi Iwamoto
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： The present invention provides pyrazolo[1,5-a]pyrimidine derivatives represented by the formula (1) wherein R1 represents lower alkyl or the like; one of R2 and R3 represents hydrogen and the other represents phenyl having lower alkoxy or the like, and R4 is hydrogen, carboxyl, lower alkoxy-carbonyl or the like. The derivatives of the invention have pharmacological effects such as analgesic action, inhibitory effect on nitrogen monoxide synthetase and the like and are useful as analgesics. The derivatives of the invention are also useful as therapeutic or prophylactic agents for septicemia, endotoxin shock, chronic articular rheumatism, etc.
摘要翻译：本发明提供由式（1）表示的吡唑并[1,5-a]嘧啶衍生物，其中R 1表示低级烷基等; R2和R3之一表示氢，另一个表示具有低级烷氧基等的苯基，R4表示氢，羧基，低级烷氧基 - 羰基等。本发明的衍生物具有镇痛作用，对一氧化氮合成酶等的抑制作用等药理作用，可用作止痛剂。本发明的衍生物还可用作败血症，内毒素休克，慢性关节风湿病等的治疗或预防剂。

5. 发明申请

US20110275823A1 PHENYLIMIDAZOLE COMPOUNDS 有权
标题翻译：苯并咪唑化合物
公开(公告)号：US20110275823A1
公开(公告)日：2011-11-10
申请号：US13145041
申请日：2010-02-03
申请人： Tadao Shibutani , Koushi Iwata , Satoshi Kido
发明人： Tadao Shibutani , Koushi Iwata , Satoshi Kido
IPC分类号： C07D401/12 , C07D409/04 , C07D407/04 , C07D233/56
CPC分类号： C07D233/64 , C07D233/54 , C07D405/04 , C07D409/04
摘要： [Object] To provide a pharmaceutical product (chemotherapeutic agent) effective in the prevention and treatment of hyperlipidemia, obesity, etc.[Solving Means] A phenylimidazole compound represented by the following General Formula (1): wherein, R1 represents a hydrogen atom, a phenyl lower alkyl group optionally having a substituent, or a pyridyl lower alkyl group optionally having a substituent, and the benzene ring and the pyridine ring are optionally substituted with 1 or 2 substituents selected from the group consisting of halogen atoms, cyano group and halogen-substituted lower alkyl groups. One of R2 and R3 represents a hydrogen atom and the other represents a lower alkoxy group. R4 represents a phenyl group optionally having a substituent. R5 and R6 are the same or different, and represent a hydrogen atom or a lower alkyl group. R7 and R8 are the same or different, and represent a hydrogen atom or a lower alkoxy group. However, when R1 represents an unsubstituted phenyl lower alkyl group, R2 represents a lower alkoxy group, R3 represents a hydrogen atom, R4 represents a phenyl group optionally having a substituent, and R5 represents a hydrogen atom, R6 is not a hydrogen atom.
摘要翻译：提供有效预防和治疗高脂血症，肥胖症等的药物（化学治疗剂）。[解决方案]由以下通式（1）表示的苯基咪唑化合物：其中，R1表示氢原子，任选具有取代基的苯基低级烷基或任选具有取代基的吡啶基低级烷基，苯环和吡啶环任选被1或2个选自卤素原子，氰基和卤素的取代基取代取代的低级烷基。 R2和R3之一表示氢原子，另一个表示低级烷氧基。 R4表示任选具有取代基的苯基。 R5和R6相同或不同，表示氢原子或低级烷基。 R 7和R 8相同或不同，表示氢原子或低级烷氧基。然而，当R1表示未取代的苯基低级烷基时，R2表示低级烷氧基，R3表示氢原子，R4表示任选具有取代基的苯基，R5表示氢原子，R6不是氢原子。

6. 发明申请

US20110065728A1 LIPOPROTEIN LIPASE-ACTIVATING COMPOSITIONS COMPRISING BENZENE DERIVATIVES 审中-公开
标题翻译： LIPOPROTEIN脂肪酶活化组合物，包含苯并噻唑衍生物
公开(公告)号：US20110065728A1
公开(公告)日：2011-03-17
申请号：US12992394
申请日：2008-05-14
申请人： Irina Neagu , Michael Ohlmeyer , Vidyadhar M. Paradkar , Kurt W. Saionz , Koushi Iwata , Takashi Okamura , Tadao Shibutani
发明人： Irina Neagu , Michael Ohlmeyer , Vidyadhar M. Paradkar , Kurt W. Saionz , Koushi Iwata , Takashi Okamura , Tadao Shibutani
IPC分类号： A61K31/519 , A61K31/437 , C07D471/04 , A61K31/429 , C07D513/04 , C07D487/04 , A61K31/4184 , C07D235/18 , A61K31/4164 , C07D233/64 , A61K31/428 , C07D277/66 , A61P3/04 , A61P3/06
CPC分类号： A61K31/519 , A61K31/4164 , A61K31/4184 , A61K31/4188 , A61K31/428 , A61K31/429 , A61K31/437 , A61K31/4745 , C07D233/56 , C07D233/58 , C07D235/18 , C07D277/66 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides pharmaceutical compositions containing benzene compound(s) represented by General Formula (1) below and, particularly, LPL-activating compositions for use in hyperlipidemia therapeutic and preventive agents, anti-obesity agents, and the like: wherein R1, R2, R3 and R4 are as defined in the specification.
摘要翻译：本发明提供了含有下述通式（1）表示的苯化合物的药物组合物，特别是用于高脂血症治疗和预防剂，抗肥胖剂等的LPL活化组合物，其中R1，R2 ，R3和R4如说明书中所定义。

7. 发明授权

US06245779B1 Naphthyridine derivatives 失效
标题翻译：萘啶衍生物
公开(公告)号：US06245779B1
公开(公告)日：2001-06-12
申请号：US09445564
申请日：1999-12-09
申请人： Tadao Shibutani , Yasuo Shoji , Takashi Okamura , Tsuneo Yasuda , Takeshi Iwamoto
发明人： Tadao Shibutani , Yasuo Shoji , Takashi Okamura , Tsuneo Yasuda , Takeshi Iwamoto
IPC分类号： A61K314375
CPC分类号： C07D471/04
摘要： The present invention provides a naphthyridine derivative represented by the formula (1) wherein A is lower alkylene; R1 is H or an electron pair “-”; R2 is optionally substituted phenyl; when R1 is an electron pair “-”, R3 is a group represented by (wherein R4 and R5 each represent lower alkyl, etc.); when R1 is H, R3 is a group —S—R6 (wherein R6 is lower alkyl, etc.); and R7 is H or lower alkyl; and also provides an analgesic composition containing the above derivative as an active ingredient.
摘要翻译：本发明提供由式（1）表示的萘啶衍生物，其中A为低级亚烷基; R1是H或电子对“ - ”; R2是任选取代的苯基;当R 1是电子对“ - ”时，R 3是由（其中R 4和R 5各自表示低级烷基等）表示的基团; 当R 1为H时，R 3为基团-S-R 6（其中R 6为低级烷基等）; 并且R 7为H或低级烷基; 并且还提供含有上述衍生物作为活性成分的镇痛组合物。

8. 发明授权

US6166016A Amide derivatives 失效
标题翻译：酰胺衍生物
公开(公告)号：US6166016A
公开(公告)日：2000-12-26
申请号：US194727
申请日：1998-12-02
申请人： Takashi Okamura , Yasuo Shoji , Tadao Shibutani , Tsuneo Yasuda , Takeshi Iwamoto
发明人： Takashi Okamura , Yasuo Shoji , Tadao Shibutani , Tsuneo Yasuda , Takeshi Iwamoto
IPC分类号： C07D473/00 , A61K31/505 , C07D473/34 , C07D487/04 , C07D495/04 , C07C233/64 , A61K31/166 , A61K31/52
CPC分类号： C07D487/04 , C07D473/34 , C07D495/04
摘要： The invention provides amide derivatives which are useful as analgesics, anti-inflammatory agents, antimicrobial drugs, hypoglycemic agents, hypolipidemic agents, antihypertensive agents, anti-cancer agents, etc., the derivatives being represented by the formula ##STR1## wherein ring A represents a benzene ring, a naphthalene ring, a pyridine ring or a furan ring; R.sup.4 represents a heterocyclic group selected from the group consisting of a lower alkyl-substituted thieno[3,2-d]pyrimidin-4-yl group, an optionally substituted pyrazolo[1,5-a]-1,3,5-triazin-4-yl group, a pyrazolo[3,4-d]pyrimidin-4-yl group substituted at the 6-position and a purin-6-yl group substituted at the 2-position; and R.sup.5 represents a hydrogen atom or a group represented by ##STR2##
摘要翻译： PCT No.PCT / JP97 / 01875 Sec。 371日期1998年12月2日第 102（e）日期1998年12月2日PCT提交1997年6月2日PCT公布。公开号WO97 / 46560 PCT 日期1997年11月12日本发明提供可用作止痛剂，抗炎剂，抗微生物药物，降血糖药，降血脂药，降压药，抗癌剂等的酰胺衍生物，其衍生物由下式表示：其中环 A表示苯环，萘环，吡啶环或呋喃环; R 4表示选自低级烷基取代的噻吩并[3,2-d]嘧啶-4-基，任选取代的吡唑并[1,5-a] -1,3,5-三嗪 -4-基，在6位被取代的吡唑并[3,4-d]嘧啶-4-基和在2位被取代的嘌呤-6-基; 并且R 5表示氢原子或由其表示的基团

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