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    • 1. 发明申请
    • METHOD OF AND APPARATUS FOR DETERMINING A PROPERTY OF A SAMPLE
    • 测定样品性质的方法和装置
    • WO1994002846A1
    • 1994-02-03
    • PCT/GB1993001544
    • 1993-07-22
    • BRITISH TECHNOLOGY GROUP LTD.LIU, YingABEL, Eric, WilliamBELCH, Jill, Janette, FredaTWEEDIE, Richard, John
    • BRITISH TECHNOLOGY GROUP LTD.
    • G01N33/48
    • G01N15/12G01N15/1218G01N15/1227
    • The invention provides an apparatus and method for determining a property of a sample, derived from a response obtained from the sample after an electrical pulse has been applied to it. In a preferred embodiment blood cells (224) are subjected to an electrical pulse (figure 3c), a response (figure 3d) is obtained using data retrieval means and a Fourier Transform is applied to the response. As the pulse (202) applied is of very short duration (ideally a Dirac pulse) the Fourier Transform yields information across a very broad bandwidth, typically several MHz, and accordingly a wide range of frequency response data is obtained. Certain cellular defects can be deduced from the transformed data. In a preferred embodiment detection means (204, 206) is provided to precisely detect the presence of a cell (224) as it passes through a particular region of an orifice (220). This is then used to trigger the pulse at a precisely controlled instant. This reduces the effect of random dispersion and can be adapted to ignore noise peaks which inevitably occur. The invention may be operated continuously and provides information across a bandwidth which is wider than was previously possible.
    • 本发明提供了一种用于确定样品性质的装置和方法,该装置和方法源自在对其施加电脉冲之后从样品获得的响应。 在优选实施例中,血细胞(224)经受电脉冲(图3c),使用数据检索装置获得响应(图3d),并且对响应应用傅里叶变换。 当施加的脉冲(202)的持续时间非常短(理想地是狄拉克脉冲)时,傅立叶变换通过非常宽的带宽(通常为几MHz)产生信息,因此获得宽范围的频率响应数据。 某些细胞缺陷可以从转化的数据中推导出来。 在优选实施例中,检测装置(204,206)被提供用于在细胞通过孔口(220)的特定区域时精确地检测细胞(224)的存在。 然后将其用于在精确控制的瞬间触发脉冲。 这减少了随机色散的影响,并且可以适应于忽略不可避免地发生的噪声峰值。 本发明可以连续地操作,并且跨越比以前更宽的带宽提供信息。
    • 2. 发明申请
    • AN AMPLIFIER
    • 放大器
    • WO1995021487A1
    • 1995-08-10
    • PCT/GB1995000218
    • 1995-02-03
    • BRITISH TECHNOLOGY GROUP LIMITEDTWEEDIE, Richard, John
    • BRITISH TECHNOLOGY GROUP LIMITED
    • H03F03/45
    • H03F3/347H03F3/45479H03F2200/261
    • The invention relates to an amplifier which in a preferred embodiment has a common mode rejection ratio (CMRR) above 100 dB at or around 1 MHz. The amplifier is able to amplify signals within a wide dynamic range, typically from 10 mu V to 10 V and cope with extremely poor signal-to-noise ratios of typically 1, so as to provide a clean, amplified signal. The amplifier achieves these superior characteristics as a result of a cross-coupled transistor feedback arrangement. The amplifier effectively uses two input signals (each signal in effect consisting of an output signal from a differential amplifier) and isolates the input signals using a transistor array and feeds the signals back, in a cross-couple manner, to reduce noise and improve the quality of the output signal.
    • 本发明涉及一种放大器,在一个优选实施例中,其放大器的共模抑制比(CMRR)在1MHz附近或大约100dB处。 该放大器能够在宽动态范围内放大信号,通常为10 V至10 V,并可处理通常为1的极差信噪比,从而提供干净的放大信号。 由于交叉耦合的晶体管反馈装置,放大器实现了这些优异的特性。 放大器有效地使用两个输入信号(每个信号有效地由差分放大器的输出信号组成),并且使用晶体管阵列隔离输入信号,并以交叉耦合的方式将信号反馈给减少噪声并改善 输出信号的质量。