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1. 发明申请

WO2010127317A1 QUANTITATIVELY MEASURING THE DEGREE OF CONCORDANCE BETWEEN OR AMONG MICROARRAY PROBE LEVEL DATA SETS 审中-公开
标题翻译：量化测量微波探测水平数据集之间的相似度
公开(公告)号：WO2010127317A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/033297
申请日：2010-04-30
申请人： HELICON THERAPEUTICS, INC. , CHEUNG, Philip , TULLY, Timothy, P. , ZUAZAGA, Humberto, Ortiz , MORENO, Oscar
发明人： CHEUNG, Philip , TULLY, Timothy, P. , ZUAZAGA, Humberto, Ortiz , MORENO, Oscar
IPC分类号： G06F17/15
CPC分类号： G06F19/24 , G06F19/20
摘要： Methods, systems and products are provided to quantitatively measure the degree of concordance between or among microarray probe level data sets. These can include the steps of evaluating outlier probe values, determine gene expression scores, evaluating the significant treatment effect for each gene expression score, and determining concordance between replicate data sets
摘要翻译：提供了方法，系统和产品来定量测量微阵列探针级数据集之间或之间的一致性程度。这些可以包括评估异常值探针值，确定基因表达得分，评估每个基因表达得分的显着治疗效果以及确定复制数据集之间的一致性的步骤

2. 发明申请

WO0060078A3 LATHEO ENCODES A SUBUNIT OF THE ORIGIN OF RECOGNITION COMPLEX 审中-公开
标题翻译： LATHEO编码识别复合体的子集
公开(公告)号：WO0060078A3
公开(公告)日：2001-01-18
申请号：PCT/US0008844
申请日：2000-04-03
申请人： COLD SPRING HARBOR LAB , BRIGHAM AND WOMEN S HOSPITALS , UNIV UTAH , TULLY TIMOTHY , DUTTA ANINDYA , BROADIE KENDAL
发明人： TULLY TIMOTHY , DUTTA ANINDYA , BROADIE KENDAL
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , A61K38/17 , C07K16/18 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention relates to isolated nucleic acid which encodes mammalian latheo protein (e.g., human). The present invention also relates to an isolated mammalian latheo protein (e.g., human). Also encompassed by the present invention are nucleic acid constructs, host cells, fusion proteins, antibodies and antisense nucleic acid. The present invention also relates to a method of producing a mammalian latheo protein. Also encompassed by the present invention are methods of identifying an agent that modulates (enhances, inhibits) interaction of latheo with a member of the origin recognition complex (e.g., ORC2, ORC4, ORC5, ORC6), a method of identifying an agent that modulates cell proliferation which results from latheo activity, a method of identifying sequence variants of latheo, a method of identifying an agent for use in the treatment of cancer, a method of identifying an agent to treat defects in synaptic function associated with a defective latheo and a method of identifying an agent to treat a cognitive dysfunction associated with latheo. Agents identified by the methods are also encompassed. The present invention also relates to methods of treating cancer, a defect in synaptic plasticity associated with a defective latheo and cognitive dysfunction associated with a defective latheo.
摘要翻译：本发明涉及编码哺乳动物车床蛋白（例如人）的分离的核酸。本发明还涉及分离的哺乳动物latheo蛋白（例如人）。本发明还包括核酸构建体，宿主细胞，融合蛋白，抗体和反义核酸。本发明还涉及一种哺乳动物车床蛋白的生产方法。本发明还包括鉴定调节（增强，抑制）车床与起始识别复合物成员（例如ORC2，ORC4，ORC5，ORC6）的相互作用的试剂的方法，一种鉴定调节剂的方法由车床活动产生的细胞增殖，识别车床的序列变体的方法，鉴定用于治疗癌症的药剂的方法，鉴定用于治疗与故障车床有关的突触功能缺陷的药剂的方法和识别治疗与车床相关的认知功能障碍的药物的方法。通过方法识别的药剂也包括在内。本发明还涉及治疗癌症的方法，与有缺陷的车床相关的突触可塑性的缺陷和与有缺陷的车床相关的认知功能障碍。

3. 发明申请

WO2007137181A2 PHOSPHODIESTERASE 4 INHIBITORS FOR COGNITIVE AND MOTOR REHABILITATION 审中-公开
标题翻译：磷酸二酯酶4抑制剂用于认知和电机康复
公开(公告)号：WO2007137181A2
公开(公告)日：2007-11-29
申请号：PCT/US2007069279
申请日：2007-05-18
申请人： HELICON THERAPEUTICS INC , HALLAM THOMAS M , BOURTCHOULADZE RUSIKO , TULLY TIMOTHY
发明人： HALLAM THOMAS M , BOURTCHOULADZE RUSIKO , TULLY TIMOTHY
CPC分类号： A61K31/4015 , A61K31/00 , A61K31/4412
摘要： The present invention provides methods of improving cognitive and motor deficits associated with central nervous system (CNS) disorder or condition in an animal. The methods comprise a general administration of phosphodiesterase 4 inhibitors and optionally training the animal under conditions sufficient to produce an improvement in performance.
摘要翻译：本发明提供了改善与动物中枢神经系统（CNS）病症或病症相关的认知和运动障碍的方法。所述方法包括一般施用磷酸二酯酶4抑制剂，并且任选地在足以产生性能改善的条件下培养动物。

4. 发明申请

WO2004092929A2 METHODS FOR CONTROLLING APPARATUSES HAVING AN EMERGENCY ALERT FUNCTION 审中-公开
标题翻译：用于控制具有紧急警报功能的装置的方法
公开(公告)号：WO2004092929A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/009712
申请日：2004-03-30
申请人： THOMSON LICENSING S.A. , KENDALL, Scott, Allan , MERRELL, John Douglas , LINEBERRY, Roger, Lee , TULLY, Timothy, Joseph , SCHAFFER, Bruce, Wayne , JOHNSTON, Gavin, Lee , SAHASRABUDHE, Rajeev, Madhukar
发明人： KENDALL, Scott, Allan , MERRELL, John Douglas , LINEBERRY, Roger, Lee , TULLY, Timothy, Joseph , SCHAFFER, Bruce, Wayne , JOHNSTON, Gavin, Lee , SAHASRABUDHE, Rajeev, Madhukar
IPC分类号： G06F
CPC分类号： G08B27/008 , H04H20/59 , H04H40/27 , H04N7/08 , H04N7/088 , H04N21/478
摘要： An apparatus (20) such as a television signal receiver, radio or other device provides an emergency alert function. According to an exemplary embodiment, the apparatus (20) includes a processor (27) operative to detect a first condition wherein signal strength on a selected channel frequency associated with the emergency alert function exceeds a predetermined threshold, and to detect a second condition wherein a broadcast test associated with said emergency alert function is passed. A visual indicator (30) is operative to provide a predetermined output if the first and second conditions are detected.
摘要翻译：诸如电视信号接收机，无线电设备或其他设备的装置（20）提供紧急警报功能。根据示例性实施例，装置（20）包括处理器（27），其可操作以检测第一状态，其中与紧急警报功能相关联的所选择的信道频率上的信号强度超过预定阈值，并且检测第二状态，其中，通过与所述紧急警报功能相关联的广播测试。如果检测到第一和第二条件，则视觉指示器（30）可操作以提供预定的输出。

5. 发明申请

WO2003053058A1 SYSTEM AND METHOD FOR AUTOMATIC SWITCHING TO INTERACTIVE APPLICATION DURING TELEVISION PROGRAM BREAKS 审中-公开
标题翻译：在电视节目破坏期间自动切换到互动应用的系统和方法
公开(公告)号：WO2003053058A1
公开(公告)日：2003-06-26
申请号：PCT/US2002/039401
申请日：2002-12-10
申请人： THOMSON LICENSING S.A. , STEVENS, John, Herbert , TULLY, Timothy, Joseph
发明人： STEVENS, John, Herbert , TULLY, Timothy, Joseph
IPC分类号： H04N7/16
CPC分类号： H04N21/4316 , H04N7/163 , H04N7/165 , H04N21/4331 , H04N21/4333 , H04N21/44008 , H04N21/472 , H04N21/6125 , H04N21/812
摘要： A system and method for automatically switching a primary image of a display module from a television program to an interactive application upon detecting the beginning of a commercial break and optionally switching the primary image back to the television program upon detecting or determining the end of the commercial break; wherein the user's progress in executing the interactive application is automatically saved upon return to the television program so that the user can progressively execute the interactive application program during consecutive commercial breaks.
摘要翻译：一种检测商业休息开始时自动将显示模块的主要图像从电视节目切换到交互式应用的系统和方法，并且在检测或确定商业广告的结束时可选地将主图像切换回电视节目打破; 其中，所述用户在执行所述交互式应用程序时的进度在返回所述电视节目时被自动保存，使得所述用户可以在连续商业广告期间逐渐执行所述交互式应用程序。

6. 发明申请

WO2008144453A9 METHODS OF TREATING COGNITIVE DISORDERS BY INHIBITION OF GPR12 审中-公开
标题翻译：通过抑制GPR12治疗认知障碍的方法
公开(公告)号：WO2008144453A9
公开(公告)日：2010-03-18
申请号：PCT/US2008063804
申请日：2008-05-15
申请人： HELICON THERAPEUTICS INC , PETERS MARCO , SCOTT RODERICK E M , TULLY TIMOTHY P
发明人： PETERS MARCO , SCOTT RODERICK E M , TULLY TIMOTHY P
IPC分类号： A61K31/70
CPC分类号： C12N15/1138 , C12N2310/14
摘要： The present invention provides methods for screening a pharmaceutical agent for its ability to modulate long term memory formation, performance of a hippocampal-dependent cognitive task or Gpr12 function. The present invention also provides methods for modulating long term memory formation or performance of a hippocampal-dependent cognitive task by modulating Gpr12-dependent protein expression. The present invention further provides methods for treating a defect in long term memory formation by inhibiting Gpr12 function and methods for treating a defect in performance of a hippocampal-dependent cognitive task by inhibiting Gpr12 function.
摘要翻译：本发明提供了用于筛选药剂以调节长期记忆形成，海马依赖性认知任务或Gpr12功能的表现的能力的方法。本发明还提供了通过调节Gpr12依赖性蛋白质表达来调节长期记忆形成或海马依赖性认知任务的表现的方法。本发明还提供通过抑制Gpr12功能来治疗长期记忆形成缺陷的方法以及通过抑制Gpr12功能治疗海马依赖性认知任务的缺陷的方法。

7. 发明申请

WO2008144455A1 METHODS OF IDENTIFYING GENES INVOLVED IN MEMORY FORMATION USING SMALL INTERFERING RNA(SIRNA) 审中-公开
标题翻译：使用小干扰RNA（SIRNA）识别记忆形成所涉及的基因的方法
公开(公告)号：WO2008144455A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/063806
申请日：2008-05-15
申请人： HELICON THERAPEUTICS, INC. , SCOTT, Roderick E.m. , BOURTCHOULADZE, Rusiko , PETERS, Marco , TULLY, Timothy P.
发明人： SCOTT, Roderick E.m. , BOURTCHOULADZE, Rusiko , PETERS, Marco , TULLY, Timothy P.
IPC分类号： A61K31/70
CPC分类号： C12N15/111 , C12N2320/12
摘要： The present invention relates to a method of identifying a gene or gene product associated with transcription dependent memory formation in an animal comprising the steps of: (a) administering to said animal sufficient small interfering RNA (siRNA) specific for the gene to inhibit gene function; (b) training said animal under conditions sufficient to induce transcription dependent memory formation in a normal untreated animal; and (c) determining the level of transcription dependent memory formation induced by the training of the treated animal. The present invention provides methods of using small interfering RNAs (siRNA) in hippocampus to identify genes and gene product whose inhibition affects contextual and temporal long-term (LTM) memory, but not short-term memory (STM).
摘要翻译：本发明涉及鉴定与动物中与转录依赖记忆形成有关的基因或基因产物的方法，包括以下步骤：（a）向所述动物施用足够的基因特异性的小干扰RNA（siRNA）以抑制基因功能 ; （b）在足以在正常未处理的动物中诱导转录依赖记忆形成的条件下训练所述动物; 和（c）确定由经过处理的动物训练引起的转录依赖记忆形成的水平。本发明提供在海马中使用小干扰RNA（siRNA）的方法来鉴定其抑制影响上下文和时间长期（LTM）记忆而不是短期记忆（STM）的基因和基因产物。

8. 发明申请

WO2004092929A3 METHODS FOR CONTROLLING APPARATUSES HAVING AN EMERGENCY ALERT FUNCTION 审中-公开
标题翻译：用于控制具有紧急警报功能的装置的方法
公开(公告)号：WO2004092929A3
公开(公告)日：2005-06-30
申请号：PCT/US2004009712
申请日：2004-03-30
申请人： THOMSON LICENSING SA , KENDALL SCOTT ALLAN , MERRELL JOHN DOUGLAS , LINEBERRY ROGER LEE , TULLY TIMOTHY JOSEPH , SCHAFFER BRUCE WAYNE , JOHNSTON GAVIN LEE , SAHASRABUDHE RAJEEV MADHUKAR
发明人： KENDALL SCOTT ALLAN , MERRELL JOHN DOUGLAS , LINEBERRY ROGER LEE , TULLY TIMOTHY JOSEPH , SCHAFFER BRUCE WAYNE , JOHNSTON GAVIN LEE , SAHASRABUDHE RAJEEV MADHUKAR
IPC分类号： G08B27/00 , H04H20/59 , H04H40/27 , H04N7/025 , H04N7/10
CPC分类号： G08B27/008 , H04H20/59 , H04H40/27 , H04N7/08 , H04N7/088 , H04N21/478
摘要： An apparatus (20) such as a television signal receiver, radio or other device provides an emergency alert function. According to an exemplary embodiment, the apparatus (20) includes a processor (27) operative to detect a first condition wherein signal strength on a selected channel frequency associated with the emergency alert function exceeds a predetermined threshold, and to detect a second condition wherein a broadcast test associated with said emergency alert function is passed. A visual indicator (30) is operative to provide a predetermined output if the first and second conditions are detected.
摘要翻译：诸如电视信号接收机，无线电设备或其他设备的装置（20）提供紧急警报功能。根据示例性实施例，装置（20）包括处理器（27），其可操作以检测第一状态，其中与紧急警报功能相关联的所选择的信道频率上的信号强度超过预定阈值，并且检测第二状态，其中，通过与所述紧急警报功能相关联的广播测试。如果检测到第一和第二条件，则视觉指示器（30）可操作以提供预定的输出。

9. 发明申请

WO2004016227A3 SCREENING METHODS FOR COGNITIVE ENHANCERS 审中-公开
标题翻译：认知强化的筛选方法
公开(公告)号：WO2004016227A3
公开(公告)日：2004-06-24
申请号：PCT/US0325942
申请日：2003-08-19
申请人： HELICON THERAPEUTICS INC , TULLY TIMOTHY P , SCOTT RODERICK E M , BOURTCHOULADZE RUSIKO
发明人： TULLY TIMOTHY P , SCOTT RODERICK E M , BOURTCHOULADZE RUSIKO
IPC分类号： A61K20060101 , C12N15/85 , C12N15/86 , C12Q1/66 , G01N33/00 , G01N33/50 , G01N33/53
CPC分类号： G01N33/5041 , C12Q1/66 , C12Q1/6811 , C12Q1/6888 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/5058 , G01N33/5085 , G01N33/5088 , G01N33/6896
摘要： The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in rehabilitating an animal with cognitive dysfunctions and for enhancing memory or normal cognitive performance (ability or function) in a normal animal.
摘要翻译：本发明提供了用于鉴定能够增强CREB途径功能的认知增强剂的方法。根据本发明鉴定的认知增强剂可用于恢复患有认知功能障碍的动物并用于增强正常动物的记忆或正常认知表现（能力或功能）。

10. 发明申请

WO2004025945A2 PERSONAL VIDEO MESSAGE SYSTEM 审中-公开
标题翻译：个人视频消息系统
公开(公告)号：WO2004025945A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/028211
申请日：2003-09-09
申请人： THOMSON LICENSING S.A. , MERRELL, John, Douglas , TULLY, Timothy, Joseph, Jr.
发明人： MERRELL, John, Douglas , TULLY, Timothy, Joseph, Jr.
IPC分类号： H04N
CPC分类号： H04N21/4223 , G06Q10/107 , H04N5/76 , H04N5/781 , H04N5/85 , H04N7/142 , H04N7/147 , H04N9/8042 , H04N21/4147 , H04N21/4307 , H04N21/4325 , H04N21/4334 , H04N21/4335 , H04N21/478 , H04N21/4788 , H04N21/4882
摘要： There is provided a video message system that includes a video display (115), a frame (105), and at least one video camera (110). The video display (115), which has a fixed position, plays back a video portion of a video message from a user. The frame (105) frames the video display. The at least one video camera (110) is disposed on the frame, and is oriented in the same direction as the video display (115), for capturing video data of the user for inclusion in the video portion of the video message.
摘要翻译：提供了一种视频消息系统，其包括视频显示器（115），框架（105）和至少一个摄像机（110）。具有固定位置的视频显示器（115）回放来自用户的视频消息的视频部分。帧（105）构成视频显示。所述至少一个摄像机（110）设置在所述框架上，并且与所述视频显示器（115）的方向相同，用于捕获所述用户的视频数据以包含在所述视频消息的所述视频部分中。 p>

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