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    • 6. 发明申请
    • DOSAGE INHALATOR WITH INDICATING/INTERRUPTING MEANS
    • 具有指示/中断手段的剂量吸入器
    • WO1993021980A1
    • 1993-11-11
    • PCT/SE1993000389
    • 1993-05-04
    • AKTIEBOLAGET ASTRATROFAST, Eva, Ann-ChristinWETTERLIN, Kjell, Ingvar, LeopoldVIRTANEN, Risto
    • AKTIEBOLAGET ASTRA
    • A61M15/00
    • A61M15/0068A61M15/0066A61M2202/064
    • The invention relates to a dosage inhalator for dispensing to a patient a pharmacologically active compound or substance suspended in a fluid comprising a nozzle (2), a conduit (3) connected to said nozzle, a storage means (4) adjacent said conduit (3) containing multiple doses of said active compound to be dispensed, a carrying means (5) having portions (6) for carrying predetermined and reproducible unit doses of said active compound, said carrying means being mounted for movement between said conduit (3) and said storage means (4) to position one of said portions (6) in said conduit (3) whereby said unit dose of said active compound located at said portion (6) can be dispensed into the conduit, said carrying means being actuated by means of a maneuvering means (10, 110). The inhalator further comprises means (20) for disrupting the movement of said maneuvering means (10, 110) directly or indirectly upon exhaustion of said active compound in said storage means (4). In an alternative embodiment the inhalator comprises means for indicating either the number of doses remaining in said storage means or the number of doses used, said indicating means comprising a screw and nut mechanism being rotated by said intermittent movement of said carrying means, the relative movement between the screw (16) and the nut (17) in said mechanism being caused by said rotation being used for actuating said indicating means.
    • 本发明涉及一种用于向患者分配悬浮在流体中的药理活性化合物或物质的剂量吸入器,其包括喷嘴(2),连接到所述喷嘴的导管(3),与所述导管(3)相邻的存储装置(4) ),包含多个剂量的待分配的所述活性化合物的载体装置(5),其具有用于承载预定和可再现的单位剂量的所述活性化合物的部分(6),所述携带装置安装成在所述导管(3)和所述 存储装置(4)将所述部分(6)中的一个定位在所述导管(3)中,由此位于所述部分(6)处的所述活性化合物的单位剂量可以被分配到导管中,所述携带装置通过 操纵装置(10,110)。 吸入器还包括用于在所述存储装置(4)中排出所述活性化合物时直接或间接地中断所述操纵装置(10,110)运动的装置(20)。 在替代实施例中,吸入器包括用于指示所述存储装置中剩余的剂量数量或使用的剂量数量的装置,所述指示装置包括通过所述携带装置的所述间歇运动而旋转的螺钉和螺母机构,所述相对运动 在所述机构中的螺钉(16)和螺母(17)之间由所述旋转引起的用于致动所述指示装置。
    • 9. 发明申请
    • PROCESS II
    • 程序二
    • WO1995009616A1
    • 1995-04-13
    • PCT/SE1994000897
    • 1994-09-29
    • ASTRA AKTIEBOLAGTROFAST, EvaOLSSON, MagnusAHLNECK, Claes
    • ASTRA AKTIEBOLAG
    • A61K09/16
    • A61K9/1688B01J2/20Y10T428/2982
    • According to the invention there is provided a method of treatment of a finely divided powdered medicament having a particle size smaller than 10 mu m and poor flowing properties to form, in a controlled manner, agglomerates or pellets which are free flowing and which are capable of breaking down to provide the finely divided medicament, comprising the steps of agglomerating the powdered medicament having a particle size being smaller than 10 mu m by feeding the material to a sieve, causing the finely divided powdered medicament to pass through the apertures of the sieve thereby obtaining agglomerates, spheronizing the resulting agglomerates in order to provide agglomerates which are more spherical, more dense and more compact than the agglomerates resulting from the agglomeration process in the sieve, and sizing the agglomerates to obtain a uniform size of the final product. According to the invention there is also provided an apparatus for carrying out the method.
    • 根据本发明,提供了一种处理粒度小于10μm的细碎粉末状药物的方法,并且流动性差,以可控方式形成自由流动的凝聚体或丸粒,并且能够 破碎以提供细碎的药物,包括通过将材料进料到筛上而使具有小于10μm的粒度的粉末状药物附聚的步骤,使细碎的粉末药物通过筛子的孔,由此 获得附聚物,使所得附聚物成球,以提供比由筛子中的附聚过程产生的附聚物更球形,更致密和更致密的附聚物,以及对附聚物进行定型以获得最终产品的均匀尺寸。 根据本发明,还提供了一种用于执行该方法的装置。