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1. 发明授权

US08173606B2 Sulfated oligosaccharide derivatives 有权
标题翻译：硫酸寡糖衍生物
公开(公告)号：US08173606B2
公开(公告)日：2012-05-08
申请号：US12960145
申请日：2010-12-03
申请人： Vito Ferro , Jon Krueger Fairweather , Tomislav Karoli , Ligong Liu
发明人： Vito Ferro , Jon Krueger Fairweather , Tomislav Karoli , Ligong Liu
IPC分类号： A61K31/7034 , A61K31/7028 , A61K31/7056 , C07H11/00 , C07H15/08 , C07H15/18
CPC分类号： C07H15/04 , C07H3/04 , C07H3/06 , C07H11/00
摘要： The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
摘要翻译：本发明涉及具有作为硫酸乙酰肝素结合蛋白的抑制剂和乙酰肝素酶的抑制剂的活性的多硫酸化寡糖衍生物的化合物; 化合物的制备方法; 包含该化合物的组合物，以及其用于抗血管生成，抗转移，抗炎，抗微生物，抗凝血和/或抗血栓形成治疗的化合物及其组合物的用途，降低血液甘油三酯水平和抑制哺乳动物受试者的心血管疾病。

2. 发明授权

US07875592B2 Sulfated oligosaccharide derivatives 有权
标题翻译：硫酸寡糖衍生物
公开(公告)号：US07875592B2
公开(公告)日：2011-01-25
申请号：US10591577
申请日：2005-03-04
申请人： Vito Ferro , Jon Krueger Fairweather , Tomislav Karoli , Ligong Liu
发明人： Vito Ferro , Jon Krueger Fairweather , Tomislav Karoli , Ligong Liu
IPC分类号： A61K31/702 , C07H3/06
CPC分类号： C07H15/04 , C07H3/04 , C07H3/06 , C07H11/00
摘要： The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
摘要翻译：本发明涉及具有作为硫酸乙酰肝素结合蛋白的抑制剂和乙酰肝素酶的抑制剂的活性的多硫酸化寡糖衍生物的化合物; 化合物的制备方法; 包含该化合物的组合物，以及其用于抗血管生成，抗转移，抗炎，抗微生物，抗凝血和/或抗血栓形成治疗的化合物及其组合物的用途，降低血液甘油三酯水平和抑制哺乳动物受试者的心血管疾病。

3. 发明申请

WO2013038259A1 BENZOTHIAZINONE DERIVATIVES AS ANTI -TUBERCULOSIS AGENTS 审中-公开
标题翻译：苯并噻嗪酮衍生物作为抗肿瘤药物
公开(公告)号：WO2013038259A1
公开(公告)日：2013-03-21
申请号：PCT/IB2012/001788
申请日：2012-09-14
申请人： THE UNIVERSITY OF QUEENSLAND , COOPER, Matthew , ZUEGG, Johannes , BECKER, Bernd , TOMISLAV, Karoli
发明人： COOPER, Matthew , ZUEGG, Johannes , BECKER, Bernd , TOMISLAV, Karoli
IPC分类号： C07D417/04 , A61K31/5415 , A61P31/06
CPC分类号： C07D417/04
摘要： Novel benzothiazinone derivatives of formula (I) or pharmaceutically acceptable salts or solvates thereof have been found to be effective against Mycobacterium tuberculosis strains and may thus be useful in the treatment of tuberculosis: wherein EWG (electron withdrawing group) = NO 2 , CN, CF 3 , F, Cl, Br, OCF 3 , OH, OR, OCHF 2 , COOR, wherein R is hydrogen or a straight or branched C 1 -C 4 alkyl group, X = a bond or a straight or branched C 1 -C 4 alkylene group which may be substituted with a group selected from F, Cl, Br, I or C 1 -C 4 alkoxy; Y = hydrogen, a straight or branched C 1 -C 4 alkyl group, OH or OR, wherein R is hydrogen or a straight or branched C 1 -C 4 alkyl group; n = 0, 1 or 2; R 1 , R 2 = hydrogen or substituent (s) which may be the same or different from each other and are selected from the group consisting of D, F, Cl, Br, CF 3 , a straight or branched C 1 -C 4 alkyl group, a phenyl group, OR, SR, NR 3 R 4 , wherein R, R 3 , R 4 may be the same or different from each other and are hydrogen or a straight or branched C 1 -C 4 alkyl group or a phenyl group.
摘要翻译：已经发现新的式（I）苯并噻嗪酮衍生物或其药学上可接受的盐或溶剂合物对结核分枝杆菌菌株有效，因此可用于治疗结核病：其中EWG（吸电子基团）= NO 2，CN，CF 3， F，Cl，Br，OCF 3，OH，OR，OCHF 2，COOR，其中R为氢或直链或支链C 1 -C 4烷基，X =可被直链或支链C 1 -C 4烷基取代的键或直链或支链C 1 -C 4亚烷基选自F，Cl，Br，I或C 1 -C 4烷氧基的基团; Y =氢，直链或支链C 1 -C 4烷基，OH或OR，其中R是氢或直链或支链C 1 -C 4烷基; n = 0,1或2; R 1，R 2 =氢或可以彼此相同或不同的取代基，并且选自D，F，Cl，Br，CF 3，直链或支链C 1 -C 4烷基，苯基基团，OR，SR，NR 3 R 4，其中R 3，R 3，R 4可以彼此相同或不同，并且是氢或直链或支链C 1 -C 4烷基或苯基。

4. 发明授权

US08828952B2 Sulfated oligosaccharide derivatives 有权
标题翻译：硫酸寡糖衍生物
公开(公告)号：US08828952B2
公开(公告)日：2014-09-09
申请号：US12738552
申请日：2008-10-16
申请人： Vito Ferro , Tomislav Karoli , Ligong Liu , Paul Newton Handley , Kenneth David Johnstone , Norbert Wimmer , Edward Timothy Hammond
发明人： Vito Ferro , Tomislav Karoli , Ligong Liu , Paul Newton Handley , Kenneth David Johnstone , Norbert Wimmer , Edward Timothy Hammond
IPC分类号： A61K31/70 , C07H15/00 , C07H17/02
CPC分类号： C07J43/003 , C07H3/04 , C07H3/06 , C07H5/02 , C07H5/04 , C07H5/06 , C07H11/00 , C07H15/04 , C07H15/207 , C07H15/24 , C07H15/26 , C07H17/02 , C07J17/005 , C07J31/006 , C07J41/0088 , C07J41/0094
摘要： The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian subject.
摘要翻译：本发明涉及可用作硫酸乙酰肝素结合蛋白的抑制剂的新型化合物; 包含该化合物的组合物，以及该化合物及其组合物用于哺乳动物受试者的抗血管生成，抗转移，抗炎，抗微血管和/或抗血栓形成治疗的用途。

5. 发明申请

US20110130354A1 SULFATED OLIGOSACCHARIDE DERIVATIVES 有权
标题翻译：硫化寡糖衍生物
公开(公告)号：US20110130354A1
公开(公告)日：2011-06-02
申请号：US12960145
申请日：2010-12-03
申请人： Vito Ferro , Jon Krueger Fairweather , Tomislav Karoli , Ligong Liu
发明人： Vito Ferro , Jon Krueger Fairweather , Tomislav Karoli , Ligong Liu
IPC分类号： A61K31/7034 , C07H11/00 , C07H15/08 , C07H15/18 , C07H15/26 , A61K31/7028 , A61K31/7056 , A61P35/00 , A61P35/04 , A61P29/00 , A61P7/02 , A61P3/00 , A61P31/00 , A61P9/00 , A61P19/02 , A61P25/00 , A61P11/06 , A61P9/10
CPC分类号： C07H15/04 , C07H3/04 , C07H3/06 , C07H11/00
摘要： The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
摘要翻译：本发明涉及具有作为硫酸乙酰肝素结合蛋白的抑制剂和乙酰肝素酶的抑制剂的活性的多硫酸化寡糖衍生物的化合物; 化合物的制备方法; 包含该化合物的组合物，以及其用于抗血管生成，抗转移，抗炎，抗微生物，抗凝血和/或抗血栓形成治疗的化合物及其组合物的用途，降低血液甘油三酯水平和抑制哺乳动物受试者的心血管疾病。

6. 发明申请

US20070185037A1 Sulfated oligosaccharide derivatives 有权
标题翻译：硫酸寡糖衍生物
公开(公告)号：US20070185037A1
公开(公告)日：2007-08-09
申请号：US10591577
申请日：2005-03-04
申请人： Vito Ferro , Jon Fairweather , Tomislav Karoli , Ligong Liu
发明人： Vito Ferro , Jon Fairweather , Tomislav Karoli , Ligong Liu
IPC分类号： A61K31/702 , C07H3/06
CPC分类号： C07H15/04 , C07H3/04 , C07H3/06 , C07H11/00
摘要： The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
摘要翻译：本发明涉及具有作为硫酸乙酰肝素结合蛋白的抑制剂和乙酰肝素酶的抑制剂的活性的多硫酸化寡糖衍生物的化合物; 化合物的制备方法; 包含该化合物的组合物，以及其用于抗血管生成，抗转移，抗炎，抗微生物，抗凝血和/或抗血栓形成治疗的化合物及其组合物的用途，降低血液甘油三酯水平和抑制哺乳动物受试者的心血管疾病。

7. 发明专利

IL177870D0 SULFATED OLIGOSACCHARIDE DERIVATIVES 未知
公开(公告)号：IL177870D0
公开(公告)日：2006-12-31
申请号：IL17787006
申请日：2006-09-03
申请人： VITO FERRO , JON KRUEGER FAIRWEATHER , TOMISLAV KAROLI , LIGONG LIU , PROGEN PHARMACEUTICALS LTD
IPC分类号： A61K31/7016 , A61K31/702 , A61P7/02 , A61P9/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P35/04 , C07H20100101 , C07H3/04 , C07H3/06 , C07H5/04 , C07H11/00 , C07H15/04
摘要： The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.

8. 发明专利

IL176474D0 GLYCOSAMINOGLYCAN (GAG) MIMETICS 未知
公开(公告)号：IL176474D0
公开(公告)日：2006-10-05
申请号：IL17647406
申请日：2006-06-21
申请人： PROGEN IND LTD , ROBERT HUGH DON , VITO FERRO , IAN BYTHEWAY , SISKA COCHRAN , JON KRUEGER FAIRWEATHER , TOMISLAV KAROLI , EDWARD TIMOTHY HAMMOND , CAI PING LI , LIGONG LIU
IPC分类号： A61K31/70 , A61K31/7012 , A61K31/7016 , A61K31/7028 , A61P7/00 , A61P7/02 , A61P29/00 , A61P31/00 , A61P35/00 , A61P43/00 , C07H20100101 , C07H5/10 , C07H11/04 , C07H13/12 , C07H15/04 , C07H15/18
摘要： The invention relates to compounds that are designed to mimic the structure of GAGs; methods for the preparation of the compounds; compositions comprising the compounds; and use of the compounds and compositions thereof for the anti-angiogenic, anti-metastatic, anti-inflammatory, anticoagulant, antithrombotic, and/or antimicrobial treatment of a mammalian subject.

9. 发明专利

IL205143D0 NOVEL SULFATED OLIGOSACCHARIDE DERIVATIVES 未知
公开(公告)号：IL205143D0
公开(公告)日：2010-11-30
申请号：IL20514310
申请日：2010-04-15
申请人： VITO FERRO , TOMISLAV KAROLI , EDWARD TIMOTHY HAMMOND , LIGONG LIU , PROGEN PHARMACEUTICALS LTD , PAUL NEWTON HANDLEY , KENNETH DAVID JOHNSTONE , NORBERT WIMMER
IPC分类号： C07H20060101
摘要： The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian subject.

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