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1. 发明专利

JP2018505873A 過免疫反応によって誘発される炎症性疾患治療用組成物审中-公开
公开(公告)号：JP2018505873A
公开(公告)日：2018-03-01
申请号：JP2017538300
申请日：2016-02-05
申请人：コーロンライフサイエンスインコーポレイテッド , KOLON LIFE SCIENCE, INC. , ティシュージーンインコーポレイテッド , TISSUEGENE, INC.
发明人：チョイホンシク , チョイギョンベク , イヒョンヨル , キムデウク , イヘソン , キムミン , キムスジョン
IPC分类号： A61K35/32 , A61K35/28 , A61K48/00 , A61P1/04 , A61P3/10 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , A61P37/06 , A61P43/00 , C12N5/077 , C12N5/0775 , C12N5/10
CPC分类号： A61K35/12 , A61K35/32
摘要：本発明は、過免疫反応によって誘発される炎症性疾患治療用細胞治療剤に関し、より詳しくは(i)軟骨細胞または軟骨細胞に分化可能な細胞;及び(ii)TGF−βをコードする遺伝子が導入された軟骨細胞またはTGF−βをコードする遺伝子が導入された軟骨細胞に分化可能な細胞を含有する、過免疫反応によって誘発される炎症性疾患治療用組成物に関する。

2. 发明专利

JP2009137980A Mixed-cell gene therapy 有权
标题翻译：混合细胞基因治疗
公开(公告)号：JP2009137980A
公开(公告)日：2009-06-25
申请号：JP2008334092
申请日：2008-12-26
申请人： Tissuegene Inc , ティシュージーン,インク
发明人： SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG
IPC分类号： A61K48/00 , C12N15/09 , A61K35/12 , A61K35/32 , A61K35/74 , A61K35/76 , A61K38/00 , A61K38/22 , A61K41/00 , A61P19/02 , C12N5/02 , C12N5/077 , C12N5/10
CPC分类号： C12N5/0656 , A61K35/12 , A61K35/32 , A61K35/33 , A61K48/00 , A61K48/0008 , C12N5/0655 , C12N2501/15 , C12N2501/155 , C12N2502/13 , C12N2502/1317 , C12N2502/99 , C12N2510/02
摘要： PROBLEM TO BE SOLVED: To provide a mixed cell composition to generate a therapeutic protein at a target site. SOLUTION: A first population of mammalian cells transfected or transduced with a gene that is sought to be expressed, and a second population of mammalian cells that have not been transfected or transduced with the gene, wherein endogenously existing forms of the second population of mammalian cells are decreased at the target site, and wherein generation of the therapeutic protein by the first population of mammalian cells at the target site stimulates the second population cells to induce a therapeutic effect. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供混合细胞组合物以在靶位点产生治疗性蛋白质。解决方案：用寻求表达的基因转染或转导的第一群哺乳动物细胞，以及尚未用该基因转染或转导的第二种哺乳动物细胞群，其中第二种群的内生存在形式的哺乳动物细胞在靶位点减少，并且其中在靶位点由哺乳动物细胞的第一群体产生治疗性蛋白质刺激第二群体细胞诱导治疗效果。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2009019039A GENE THERAPY UTILIZING TGF-β 有权
标题翻译：使用TGF-β的基因治疗
公开(公告)号：JP2009019039A
公开(公告)日：2009-01-29
申请号：JP2008176059
申请日：2008-07-04
申请人： Tissuegene Inc , ティシュージェンインコーポレイテッド
发明人： NOH MOON JONG , KANG KYOUNG AE , LEE KWAN HEE
IPC分类号： A61K48/00 , C12N15/09 , A61K35/12 , A61K35/28 , A61K35/32 , A61K35/76 , A61K38/04 , A61K38/18 , A61K38/22 , A61P19/02 , C07K14/495 , C12N5/10
CPC分类号： C07K14/495 , A61K35/12 , A61K38/1841 , A61K48/00
摘要： PROBLEM TO BE SOLVED: To provide a new treating method for treating regressive arthritis. SOLUTION: A cell-mediated gene therapy utilizing one member belonging to a transforming growth factor-β (TGF-β) superfamily is provided for treating orthopedic diseases. After transfection of TGF-β cDNA expression vectors into fibroblasts (NIH 3T3-TGF-β1), the cells were injected into an achilles tendon and a knee joint of a rabbit with artificially-made cartilage defects. Intratendinous injections were performed to determine the optimal concentration for in vivo expression. Partially defected cartilage model was made to confirm stimulation of regressive arthritis of the knee joint. The partial cartilage defect treated with the cell-mediated gene therapy procedure was covered with newly formed hyaline cartilage, which indicates that the cells are survived and stimulated of matrix formation in this region. Completely denuded cartilage areas were covered with fibrous collagen. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供治疗退行性关节炎的新的治疗方法。解决方案：提供一种利用属于转化生长因子-β（TGF-β）超家族的成员的细胞介导的基因治疗用于治疗整形外科疾病。将TGF-βcDNA表达载体转染到成纤维细胞（NIH 3T3-TGF-β1）后，将细胞注射到兔子的跟腱和膝关节中，人工制造的软骨缺损。进行Intratendinous注射以确定体内表达的最佳浓度。进行部分缺陷的软骨模型，以确认膝关节退行性关节炎的刺激。用细胞介导的基因治疗程序处理的部分软骨缺损被新形成的透明软骨覆盖，这表明细胞在该区域存活并刺激基质形成。完全剥落的软骨区域被纤维胶原覆盖。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2007008950A GENE THERAPY USING TGF-β 有权
标题翻译：使用TGF-β进行基因治疗
公开(公告)号：JP2007008950A
公开(公告)日：2007-01-18
申请号：JP2006195771
申请日：2006-07-18
申请人： Tissuegene Inc , ティシュージェンインコーポレイテッド
发明人： NOH MOON JONG , KANG KYOUNG AE , LEE KWAN HEE
IPC分类号： A61K48/00 , C12N15/09 , A61K35/12 , A61K35/32 , A61K35/76 , A61K38/18 , A61K38/22 , A61P19/02 , C07K14/495 , C12N5/10
CPC分类号： C07K14/495 , A61K35/12 , A61K38/1841 , A61K48/00
摘要： PROBLEM TO BE SOLVED: To provide a gene therapy for treatment of degenerative arthritis. SOLUTION: The invention relates to the gene therapy treatment comprising preparation of expression vectors encoding one factor belonging to the transforming growth factor-beta (TGF-beta) superfamily which includes a DNA sequence linked to the promotor, transfection of the expression vectors into cultured connective tissue cells (fibroblasts, etc.), and injection of the transformed connective tissue cells into mammal host's arthritis articular cavity to promote regeneration of the connective tissue, hyaline cartilage or the like in the articular cavity. Partially defected cartilage model was made to stimulate degenerative arthritis of the knee joint. The partial cartilage defect treated with the cell-mediated gene therapy procedure was covered by newly formed hyaline cartilage which indicates that the cells survived and stimulated matrix formation in this area. Completely denuded cartilage areas were covered by fibrous collagen. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供治疗退行性关节炎的基因疗法。解决方案：本发明涉及基因治疗治疗，包括制备编码属于转化生长因子-β（TGF-β）超家族的一个因子的表达载体，其包括与启动子连接的DNA序列，转染表达载体转化为培养的结缔组织细胞（成纤维细胞等），将转化的结缔组织细胞注射到哺乳动物宿主的关节炎关节腔中，以促进关节腔中的结缔组织，透明软骨等的再生。部分缺损的软骨模型被用来刺激膝关节退行性关节炎。用细胞介导的基因治疗程序处理的部分软骨缺损被新形成的透明软骨覆盖，表明细胞存活并刺激了该区域的基质形成。完全剥落的软骨区域被纤维胶原覆盖。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2014088425A Neuroprotective effective compound 有权
标题翻译：神经保护有效化合物
公开(公告)号：JP2014088425A
公开(公告)日：2014-05-15
申请号：JP2014002297
申请日：2014-01-09
申请人： Tissuegene Inc , ティシュージーン,インク
发明人： LEE KWAN HEE , LEE DUK KEUN , YI YOUNGSUK , NOH MOON JONG , KIM HYOUNG CHUN
IPC分类号： A61K35/12 , A61K35/76 , A61K38/00 , A61K48/00 , A61P25/00 , C07K14/495 , C12N5/071 , C12N5/079 , C12N15/09
CPC分类号： A61K48/005 , A61K38/1875
摘要： PROBLEM TO BE SOLVED: To provide a method of preventing degeneration of a nervous system and neuronal cells.SOLUTION: A method of preventing degeneration of nerve comprises the steps of: (a) generating a recombinant viral or plasmid vector comprising a DNA sequence encoding a member of a transforming growth factor superfamily or neurotrophic factor proteins operatively linked to a promoter; (b) transfecting in vitro a population of cultured cells with the recombinant vector, resulting in a population of the cultured cells; and (c) transplanting the transfected cells to an area near an injured nerve, and expressing the DNA sequence within the area near the injured nerve.
摘要翻译：要解决的问题：提供一种防止神经系统和神经细胞变性的方法。解决方案：一种预防神经变性的方法包括以下步骤：（a）产生重组病毒或质粒载体，其包含编码与促进剂可操作地连接的转化生长因子超家族或神经营养因子蛋白的成员; （b）用重组载体体外转染培养的细胞群，导致培养细胞群; 和（c）将转染的细胞移植到受损神经附近的区域，并在损伤的神经附近的区域内表达DNA序列。

7. 发明专利

JP2012236830A Mixed-cell gene therapy 审中-公开
标题翻译：混合细胞基因治疗
公开(公告)号：JP2012236830A
公开(公告)日：2012-12-06
申请号：JP2012155170
申请日：2012-07-11
申请人： Tissuegene Inc , ティシュージーン,インク
发明人： SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG
IPC分类号： A61K35/12 , C12N15/09 , A61K35/32 , A61K35/76 , A61K38/00 , A61K48/00 , A61P19/02 , A61P43/00 , C12M1/00 , C12N5/02 , C12N5/077 , C12N5/10 , C12P21/02
CPC分类号： C12N5/0656 , A61K35/12 , A61K35/32 , A61K35/33 , A61K48/00 , A61K48/0008 , C12N5/0655 , C12N2501/15 , C12N2501/155 , C12N2502/13 , C12N2502/1317 , C12N2502/99 , C12N2510/02
摘要： PROBLEM TO BE SOLVED: To provide a mixed cell composition to generate a therapeutic protein.SOLUTION: The mixed cell composition includes a first population of mammalian cells transfected or transduced with a gene that is sought to be expressed, and a second population of mammalian cells that have not been transfected or transduced with the gene, wherein endogenously existing forms of the second population of mammalian cells are decreased at a target site, and wherein generation of the therapeutic protein by the first population of mammalian cells at the target site stimulates the second population cells to induce a therapeutic effect.
摘要翻译：待解决的问题：提供混合细胞组合物以产生治疗性蛋白质。解决方案：混合细胞组合物包括第一组哺乳动物细胞，其被转染或转导以寻求表达的基因，以及第二组哺乳动物细胞，其未被转染或转导，其中内生存在哺乳动物细胞的第二群体的形式在靶位点减少，并且其中在靶位点由哺乳动物细胞的第一群体产生治疗性蛋白质刺激第二群体细胞以诱导治疗效果。版权所有（C）2013，JPO＆INPIT

8. 发明专利

JP2010069327A Bone generation by gene therapy 审中-公开
标题翻译：骨生成基因治疗
公开(公告)号：JP2010069327A
公开(公告)日：2010-04-02
申请号：JP2009298034
申请日：2009-12-28
申请人： Tissuegene Inc , ティシュージーン,インク
发明人： SONG SUN UK , YI YOUNGSUK , LEE KWAN HEE , NOH MOON JONG , BAE HYUN
IPC分类号： A61L27/00 , A61K35/32 , A61K38/18 , A61K48/00 , A61P19/00 , C07K14/495 , C07K14/51
CPC分类号： A61K38/1841 , A61K38/1875 , A61K48/00 , A61L2430/02 , C07K14/495 , C07K14/51 , C12N2799/027
摘要： PROBLEM TO BE SOLVED: To provide a composition for the sustained expression of such an osteogenic therapeutic protein that performs bone generation at the bone defect site by leading an efficient regeneration of bone.
SOLUTION: This invention discloses a composition for making bone at a bone defect site for a patient suffering from low bone mass, which includes inserting a gene encoding a protein having bone regenerating function into a connective tissue cell operably linked to a promoter, and transplanting the mammalian cell into the bone defect site, and allowing the bone defect site to make the bone.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于持续表达这种成骨治疗蛋白质的组合物，其通过引导骨的有效再生来在骨缺损部位进行骨生成。解决方案：本发明公开了一种用于在患有低骨量的患者的骨缺损部位处制造骨的组合物，其包括将编码具有骨再生功能的蛋白质的基因插入可操作地连接于启动子的结缔组织细胞中，并将哺乳动物细胞移植到骨缺损部位，并使骨缺损部位形成骨。版权所有（C）2010，JPO＆INPIT

9. 发明公开

KR20200139123A 세포치료제의 유효성 평가 방법 审中-公开
公开(公告)号：KR20200139123A
公开(公告)日：2020-12-11
申请号：KR20200168874
申请日：2020-12-04
申请人： KOLON LIFE SCIENCE INC , KOLON TISSUEGENE INC
发明人： KIM SU JEONG , NOH SANG EUN , LEE JUN HO , LEE HYEON YOUL , CHOI KYOUNG BAEK , CHOI HEON SIK
IPC分类号： G01N33/50 , A61K35/32 , C12N5/077 , C12N13/00 , G01N33/68
摘要： 본발명은세포치료제의유효성평가방법에관한것이다. 본발명의세포치료제에대한유효성판단기준으로서 (a) TGF-β로형질전환시킨포유류세포의제1 집단; 및 (b) 상기유전자로형질전환시키지않은포유류세포의제2 집단내 TGF-β및/또는 TSP-1의발현량및/또는발현여부를이용하면, 개개의세포치료제에대한유효성을치료개시전에확실하게판정할수 있어, 치료효과를균일하게유지하는것이가능하다. 또한, 효과가얻어지지않는세포치료제의사용을회피할수 있기때문에불필요한시술및 부작용을회피할수 있다.

10. 发明公开

KR20180057737A 신경보호 효과 화합물 审中-公开
公开(公告)号：KR20180057737A
公开(公告)日：2018-05-30
申请号：KR20187014413
申请日：2006-06-23
申请人： KOLON TISSUEGENE INC
发明人： LEE KWAN HEE , LEE DUK KEUN , YI YOUNG SUK , NOH MOON JONG , KIM HYOUNG CHUN
IPC分类号： C12N15/86 , A61K38/18 , A61K48/00 , C07K14/51 , C12N5/077 , C12N13/00 , C12N15/861 , C12N15/867 , C12N15/869
CPC分类号： A61K48/005 , A61K38/1875
摘要： 본출원은 a) 프로모터에작동가능하게연결된형질전환성장인자(transforming growth factor) 슈퍼패밀리(superfamily) 또는신경영양성인자단백질(neurotrophic factor protein)을암호화하는 DNA 서열을포함하는재조합바이러스벡터또는플라스미드벡터를제조하는단계; b) 상기재조합벡터를배양된세포의군집에형질감염시켜, 배양세포의군집을형성시키는단계; 및 c) 손상된신경의주변영역에상기형질감염된세포군집을이식하여, 상기손상된신경의주변영역에서상기 DNA 서열이발현함으로써, 신경퇴화가예방되는단계를포함하는신경퇴화예방방법을개시한다.

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