专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1997031018A1 CRYSTAL STRUCTURE OF APOPAIN AND USES THEREOF 审中-公开
标题翻译： APOPAN的晶体结构及其用途
公开(公告)号：WO1997031018A1
公开(公告)日：1997-08-28
申请号：PCT/US1997002578
申请日：1997-02-19
申请人： MERCK & CO., INC. , MERCK FROSST CANADA INC. , NICHOLSON, Donald, W. , FAZIL, Kimberly, A. , GALLANT, Michel , GAREAU, Yves , LABELLE, Marc , RASPER, Dita, M. , RUEL, Rejean , VAILLANCOURT, John, P. , BECKER, Joseph, W. , ROTONDA, Jennifer , THORNBERRY, Nancy, A. , PETERSON, Erin, P.
发明人： MERCK & CO., INC. , MERCK FROSST CANADA INC.
IPC分类号： C07K14/00
CPC分类号： C12N9/6475 , A61K38/00 , C07K5/1021
摘要： The invention relates to crystallized apopain, the use of that structure to solve the structure of apopain homologues and other crystal forms of apopain, mutants and co-complexes of apopain, and the use of the apopain structure and that of its homologues, mutants, and co-complexes to design modulators of apopain.
摘要翻译：本发明涉及结晶脯氨酸，该结构的用途来解决猿尾草同源物的结构和其他胭脂蛋白的晶体形式，脯氨酸的突变体和共配合物，以及猿尾草结构及其同源物，突变体和共同配合设计apopain的调制器。

2. 发明申请

WO2006119260A3 COMBINATION OF DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND A CANNABINOID CB1 RECEPTOR ANTAGONIST FOR THE TREATMENT OF DIABETES AND OBESITY 审中-公开
标题翻译： DIPEPTIDYL PEPTIDASE-IV抑制剂和一种用于治疗糖尿病和肥胖症的CANNABINOID CB1受体拮抗剂的组合
公开(公告)号：WO2006119260A3
公开(公告)日：2008-02-28
申请号：PCT/US2006016754
申请日：2006-04-28
申请人： MERCK & CO INC , AMATRUDA JOHN M , FONG TUNG M , MOLLER DAVID E , THORNBERRY NANCY A
发明人： AMATRUDA JOHN M , FONG TUNG M , MOLLER DAVID E , THORNBERRY NANCY A
IPC分类号： A61K31/44 , A61K31/277
CPC分类号： A61K31/4709 , A61K31/4985 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a combination of a particular dipeptidyl peptidase-IV (DPP-IV) inhibitor and a particular cannabinoid CB?1#191 receptor antagonist/inverse agonist, kits containing such combinations and methods of using such compositions for the treatment of diabetes, diabetes associated with obesity, diabetes-related disorders, obesity, and obesity-related disorders.
摘要翻译：本发明涉及包含特定二肽基肽酶-IV（DPP-IV）抑制剂和特定大麻素CB 1＃191受体拮抗剂/反向激动剂的组合的药物组合物，其含有这些组合的试剂盒和使用该组合物的方法用于治疗糖尿病，与肥胖相关的糖尿病，糖尿病相关疾病，肥胖症和肥胖相关疾病。

3. 发明申请

WO1996033268A1 APOPAIN 审中-公开
公开(公告)号：WO1996033268A1
公开(公告)日：1996-10-24
申请号：PCT/US1996005282
申请日：1996-04-17
申请人： MERCK & CO., INC. , MERCK FROSST CANADA INC. , MILLER, Douglas, K. , THORNBERRY, Nancy, A. , NICHOLSON, Donald, W. , ALI, Ambereen , VAILLANCOURT, John, P.
发明人： MERCK & CO., INC. , MERCK FROSST CANADA INC.
IPC分类号： C12N09/50
CPC分类号： C12N9/6475 , A61K48/00 , C07K5/1021
摘要： The present invention is directed to an isolated and purified enzyme designated apopain, methods of using apopain to screen for compounds which modulate the activity of apopain, and compounds identified by the screens. A synthetic DNA molecule encoding full length apopain is prepared from the purified enzyme. The synthetic apopain-encoding DNA is formulated so as to optimize expression in a variety of recombinant hosts. The DNA clones produce recombinant full-length apopain and derivatives thereof. Purified native apopain and recombinant apopain are useful for identifying modulators of apopain activity and hence modifiers of pathological conditions related to the pro-inflammatory or pro-apoptotic effects of apopain. Apopain antisense molecules are useful for therapeutically reducing or eliminating the pro-inflammatory or pro-apoptotic effects of apopain, whereas gene transplantation or gene therapy with apopain is useful for enhancing the pro-inflammatory or pro-apoptotic effects of apopain. These therapies are beneficial in the treatment of immune, proliferative and degenerative diseases including, but not limited to, immune deficiency syndromes (such as AIDS), autoimmune diseases, pathogenic infections, cardiovascular and neurological injury, alopecia, aging, cancer, Parkinson's disease and Alzheimer's disease.
摘要翻译：本发明涉及一种分离和纯化的酶，指定的脱辅酶A，使用胭脂苷来筛选调节脯氨酸的活性的化合物的方法，以及筛选鉴定的化合物。从纯化的酶制备编码全长apopain的合成DNA分子。配制的合成的凋亡蛋白编码DNA被配制为优化多种重组宿主中的表达。 DNA克隆产生重组全长脯氨酸及其衍生物。纯化的天然apopain和重组apopain可用于鉴定apopain活性的调节剂，因此可用于与apopain的促炎症或促凋亡作用相关的病理条件的修饰。 Apopain反义分子可用于治疗性降低或消除apopain的促炎症或促凋亡作用，而基因移植或基因治疗与apopain可用于增强apopain的促炎症或促凋亡作用。这些疗法有益于免疫，增殖和退行性疾病的治疗，包括但不限于免疫缺陷综合征（例如艾滋病），自身免疫性疾病，致病性感染，心血管和神经损伤，脱发，衰老，癌症，帕金森病和阿尔茨海默氏病。

4. 发明申请

WO2006119260A2 COMBINATION OF DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND A CANNABINOID CB1 RECEPTOR ANTAGONIST FOR THE TREATMENT OF DIABETES AND OBESITY 审中-公开
标题翻译： DIPEPTIDYL PEPTIDASE-IV抑制剂和用于治疗糖尿病和肥胖症的CANNABINOID CB1受体拮抗剂的组合
公开(公告)号：WO2006119260A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016754
申请日：2006-04-28
申请人： MERCK & CO., INC. , AMATRUDA, John, M. , FONG, Tung, M. , MOLLER, David, E. , THORNBERRY, Nancy, A.
发明人： AMATRUDA, John, M. , FONG, Tung, M. , MOLLER, David, E. , THORNBERRY, Nancy, A.
IPC分类号： A61K31/4709
CPC分类号： A61K31/4709 , A61K31/4985 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a combination of a particular dipeptidyl peptidase-IV (DPP-IV) inhibitor and a particular cannabinoid CB?1#191 receptor antagonist/inverse agonist, kits containing such combinations and methods of using such compositions for the treatment of diabetes, diabetes associated with obesity, diabetes-related disorders, obesity, and obesity-related disorders.
摘要翻译：本发明涉及包含特定二肽基肽酶-IV（DPP-IV）抑制剂和特定大麻素CB 1＃191受体拮抗剂/反向激动剂的组合的药物组合物，其含有这些组合的试剂盒和使用该组合物的方法用于治疗糖尿病，与肥胖相关的糖尿病，糖尿病相关疾病，肥胖症和肥胖相关疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式