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1. 发明申请

WO1987004152A1 NEW ARYL DERIVATIVES 审中-公开
标题翻译：新的ARYL衍生物
公开(公告)号：WO1987004152A1
公开(公告)日：1987-07-16
申请号：PCT/GB1986000791
申请日：1986-12-23
申请人： THE WELLCOME FOUNDATION LTD. , KNEEN, Geoffrey , JACKSON, William, Paul , ISLIP, Peter, John
发明人： THE WELLCOME FOUNDATION LTD.
IPC分类号： C07C83/10
CPC分类号： A61K31/185
摘要： Compounds of formula (I) where k is 0 or 1; one of m and n is 0 and the other is 1; Ar represents a phenyl or a naphthyl group, both of which optionally may be substituted by one or more substituents selected from C1-4 alkyl (which may itself optionally be substituted by one or more halogen atoms), C1-4 alkoxy, halo, nitro, amino, carboxy, C1-4 alkoxycarbonyl and hydroxy; X represents oxygen or sulphur; Y is C1-6 alkylene; and R and R are independently selected from hydrogen and C1-4 alkyl; and salts thereof for use in a method of treatment of the human or animal body by surgery or therapy or of diagnosis practised on the human or animal body have lipoxygenase and cyclooxygenase inhibiting properties.
摘要翻译：其中k为0或1的式（I）化合物; m和n之一是0，另一个是1; Ar表示苯基或萘基，它们都可以被一个或多个选自C 1-4烷基（其本身可任选被一个或多个卤素原子取代），C 1-4烷氧基，卤素，硝基，氨基，羧基，C 1-4烷氧基羰基和羟基; X表示氧或硫; Y是C 1-6亚烷基; R 1和R 2独立地选自氢和C 1-4烷基; 其盐用于通过手术或治疗或在人或动物体上进行的诊断来治疗人或动物体的方法具有脂氧合酶和环氧合酶抑制性质。

2. 发明专利

SA99200688A أرابينوسيدات البيورين المستبدلة واستخدامها في علاج الإصابة بمرض فيروس الحمض النووي (dna) 未知
公开(公告)号：SA99200688A
公开(公告)日：2005-12-03
申请号：SA99200688
申请日：1999-10-18
申请人： THE WELLCOME FOUNDATION LTD
发明人： KRENITSKY THOMAS ANTHONY , KOSZALKA GEORGE WALTER , JONES LYNDA ADDINGTON , AVERETT DEVRON RANDOLPH , MOORMAN ALLAN RAY
IPC分类号： C07H19/19 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61K31/708 , A61P31/12 , C07H19/16 , C07H19/167 , C07H19/20
摘要： يتعلقالاختراعالحاليبمركباتمعينةمنأرابينوسيداتالبيورينالمستبدلةومشتقاتهاالمقبولةصيدلانياخصوصاالإيسترات، واستخدامهافيالعلاجوالوقايةمنالعدوىبفيروسالجديريالمائيوفيروسالحمىالمضخمةللخلايا. ويتضمنالاختراعأيضاتركيياتصيدلانيةوعملياتلتحضيرهذهالمركبات.

3. 发明专利

MY114241A COMBINATION OF ATOVAQUONE WITH PROGUANIL FOR THE TREATMENT OF PROTOZOAL INFECTIONS 未知
公开(公告)号：MY114241A
公开(公告)日：2002-09-30
申请号：MYPI19932479
申请日：1993-11-25
申请人： THE WELLCOME FOUNDATION LTD
发明人： MARY PUDNEY , DAVID BRIAN ASHTON HUTCHINSON , WINSTON EDWARD GUTTERIDGE , VICTORIA SUSAN LATTER
IPC分类号： A61K31/12 , A61K31/122 , A61K31/155 , A61P33/00 , A61P33/02 , A61P43/00
摘要： THE INVENTION RELATES TO COMBINATIONS OF ATOVAQUONE AND PROGUANIL, THEIR USE IN THE TREATMENT AND PROPHYLAXISOF PARASITIC INFECTIONS, SUCH AS PROTOZOAL PARASITIC INFECTIONS, E.G. MALARIA AND TOXOPLASMOSIS, AND INFECTIONS CAUSED BY P .CARINII AND THEIR USE IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT AND/OR PROPHYLAXIS OF SUCH INFECTIONS. THE COMBINATIONS CAN CONVENIENTLY BE ADMINISTERED IN A SINGLE PHARMACEUTICAL FORMULATION. PREFERABLY, ATOVAQUONE AND PROGUANIL ARE ADMINISTERED IN A POTENTIATING RATIO SO THAT THEY ACT IN SYNERGY.

4. 发明专利

MY113775A CHLOROPYRIMIDINE INTERMEDIATES 未知
公开(公告)号：MY113775A
公开(公告)日：2002-05-31
申请号：MYPI19950246
申请日：1995-02-03
申请人： THE WELLCOME FOUNDATION LTD
发明人： SUSAN MARY DALUGE , MICHAEL TOLAR MARIN , MICHELLE JOANNE FERRY FUGETT
IPC分类号： C07D473/00 , C07D239/48 , C07D239/50 , C07D405/12 , C07D473/16 , C07D473/40 , C07D487/04
摘要： THE PRESENT INVENTION RELATES TO CERTAIN NOVEL PYRIMIDINE INTERMEDIATES AND THEIR SALTS, PROCESSES FOR THEIR PREPARATION AND PROCESSES FOR THEIR CONVERSION TO 9-SUBSTITUTED-2-AMINOPURINES WHICH ARE USEFUL IN MEDICAL THERAPY.

5. 发明专利

MY113017A NEUROMUSCULAR BLOCKING AGENTS. 未知
公开(公告)号：MY113017A
公开(公告)日：2001-11-30
申请号：MYPI19911260
申请日：1991-07-12
申请人： THE WELLCOME FOUNDATION LTD
发明人： GEOFFRY LLOYD , DEREK ANTHONY HILL
IPC分类号： A61K31/47 , A61K31/472 , C07D217/20 , A61K31/4725 , A61K31/485 , A61P21/02 , C07B57/00 , C07D217/16
摘要： 1R-PE, 1 ?R-?JS ISOMER OF A 21,21-(3,LL-DIAXO-4,LO-DIAXATRIDECYLENE)-BIS-(1,2,3,4-TETRAHYDRO-6,7- DIMETHOXY-2-METHYL-L-VERATRYLISOQUINALINI-UM) SALT, SUBSTANTIALLY FREE FROM OTHER GEOMETRICAL AND OPTICAL ISOMERS THEREOF. THE IR-CIS, L?R-CA ISOMER HAS BEEN FOUND TO HAVE AN ADVANTAGEOUS COMBINATION OF PHARMACOLOGICAL PROPERTIES, NATABLY GREATER NEUROMUSCULAR BLOCKING POTENCY, WEAKER HISTAMINE-RELEASING POTENCY, AND AT EQUIVALENT LEVELS OF NEUROMUSCULAR BLOCKADE, FEWER POTENTIAL ADVERSE EFFECTS ON THE AUTONOMIC NERVOUS SYSTEM (SYMPATHETIC AND PARASYMPATHETIC BLOCKADE), IN COMPARISON WITH THE KNOWN MIXTURE OF GEOMETRICAL AND OPTICAL ISOMERS.

7. 发明专利

AP9901481A0 Method of testing the purity of lamotrigine. 未知
公开(公告)号：AP9901481A0
公开(公告)日：1999-03-31
申请号：AP9901481
申请日：1999-03-10
申请人： THE WELLCOME FOUNDATION LTD
发明人： EDMEADES LORRAINE MARY , GRIFFITH-SKINNER NIGEL ARTHUR , HILL DEREK ANTHONY , HILL GRAHAM THORNTON , PACKHAM TERENCE WILLIAM
IPC分类号： C07D253/06 , A61K31/53 , C07D253/075 , G01N30/00 , G01N30/02 , G01N30/04 , G01N30/86 , G01N30/88 , G01N30/90 , G01N33/00 , G01N33/15
摘要： A method of testing the purity or stability to degradation of a sample of lamotrigine or a pharmaceutical dosage form comprising lamotrigine comprises assaying th said sample for the presence of a compound selected from 3-amino-6-(2,3-dichlorophenyl)-1,2,4-triazine-5-(4h)-one (compound a)and n-[5-amino-6-(2,3-dichlorophenyl)-1,2,4-triazine3-yl]-2,3-dichlorobenzamide (compound b). A process for producing compound b, which is novel, is also disclosed.

8. 发明专利

AP666A Valaciclovir tablets containing colloidal silicon dioxide. 未知
公开(公告)号：AP666A
公开(公告)日：1998-08-24
申请号：AP9701057
申请日：1996-01-19
申请人： THE WELLCOME FOUNDATION LTD
发明人： HOWARD CARTER BARRY , GARY TILLMAN LLOYD
IPC分类号： A61K9/20 , A61K31/52 , A61K47/02 , A61K47/12 , A61K47/34 , A61K47/38 , A61P31/12
摘要： A tablet comprising of at least 50 w/w valaciclovir, and 0.05 to 3 w/w colloidal silicon dioxide is provided which has excellent hardness and friability properties while still maintaining good lubrication of the tablet granules.

9. 发明专利

AP652A Synergistic combinations of zidovudine, 1592U89 and 3tc or Ftc. 未知
公开(公告)号：AP652A
公开(公告)日：1998-06-19
申请号：AP9701089
申请日：1996-03-28
申请人： THE WELLCOME FOUNDATION LTD
发明人： BARRY DAVID WALTER , ST CLAIR MARTHA HEIDER
IPC分类号： A61K31/505 , A61K20060101 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/39 , A61K31/44 , A61K31/513 , A61K31/52 , A61K31/55 , A61K31/70 , A61K31/706 , A61K31/7072 , A61K31/7076 , A61P20060101 , A61P31/00 , A61P31/12 , A61P31/18 , A61P37/04 , A61P43/00 , C07D411/04 , C07D473/16 , C07H19/073
摘要： The present invention relates to therapeutic combinations of (is,4r)-cis-4-[2-amino-6-(cyclopropylamino)-9h-purin-9-y1]-2-cyclopentene-1-methanol (1592u89), 3'-azido-3'deoxythymidine (zidovudine) and (2r,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1h)-pyrimidin-2-one (3TC)(or, alternatively to 3TC, (2r,cis)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1h)-pyrimidin-2-one (ftc)) which have anti-HIVactivity. The present invention is also concerned with pharmaceutical compositions containing said combinations and their use in the treatment of HIV infections including infections with HIV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors.

10. 发明专利

MY109421A AMIDINO DERIVATIVES AND THEIR USE AS NITRIC OXIDE SYNTHASE INHIBITOR 未知
公开(公告)号：MY109421A
公开(公告)日：1997-01-31
申请号：MYPI19922373
申请日：1992-12-23
申请人： THE WELLCOME FOUNDATION LTD
发明人： HAROLD FRANCIS HODSON , RICHARD MICHAEL JOHN PALMER , RICHARD MANFIELD BEAMS
IPC分类号： A61K31/155 , C07C257/14 , A61K31/195 , C12N9/99 , A61K31/198 , A61K31/275 , A61P9/00 , A61P19/02 , A61P37/06 , A61P43/00 , C07C257/16 , C07C315/04 , C07C317/50 , C07C319/20 , C07C323/58 , C07C323/59
摘要： AMIDINO DERIVATIVES OF THE FORMULA (I) AND SALTS, AND PHARMACEUTICALLY ACCEPTABLE ESTERS AND AMIDES THEREOF, IN WHICH:R1 IS A C1-6 STRAIGHT OR BRANCHED CHAIN ALKYL GROUP, A C2-6ALKENYL GROUP, A C2-6ALKYNYL GROUP, A C3-6CYCLOALKYL GROUP OR A C3-6CYCLOALKYLC3-6CYCLOALKYLC1-6ALKYL GROUP;Q IS AN ALKYLENE, ALKENYLENE OR ALKYLENE GROUP HAVING 3 TO 6 CARBON ATOMS AND WHICH MAY OPTIONALLY BE SUBSTITUTED BY ONE OR MORE C1-3ALKYL GROUPS;A GROUP OF FORMULA -(CH2)PX(CH2)Q-WHERE P IS 2 OR 3, Q IS 1 OR 2 AND X IS C(O)X WHERE X IS O, 1 OR 2, O OR NR2 WHERE R2 IS H OR C1-6 ALKYL; ORA GROUP OF FORMULA -(CH2)RA(CH2)S-WHERE R IS 0, 1 OR 2, S IS 0, 1 OR 2 AND A IS A 3 TO 6 MEMBERED CARBOCYCLIC OR HETEROCYCLIC RING WHICH MAY OPTIONALLY BE SUBSTITUTED BY ONE OR MORE SUITABLE SUBSTITUENTS SUCH AS C1-6ALKYL, C1-6ALKOXY, HYDROXY, HALO, NITRO, CYANO, TRIFLUOROC1-6ALKYL, AMINO, C1-6ALKYLAMINO OR DIC1-6ALKYLAMINO;AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM ARE DESCRIBED FOR USE IN MEDICINE, NOVEL COMPOUNDS OF THE FORMULA (I) AND THE PREPARATION OF SUCH NOVEL COMPOUNDS ARE ALSO DISCLOSED.

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